Cayman
Showing 45301–45450 of 45550 results
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α-Truxillic acid can be formed by the dimerization of two molecules of α-trans-cinnamic acid.{23826} It is related to incarvillateine, a natural antinociceptive compound derived from the Asian herb I. sinensis.{23827} α-Truxillic acid and some of its derivatives significantly block inflammatory pain while having little effect on neurogenic pain, as indicated by the formalin test in mice.{23827,23828} Related compounds, like SB-FI-26 (Item No. 14191), bind fatty acid binding protein 5 (FABP5).{22111} This may be related to pain suppression, since FABP5 acts as a transporter of the endocannabinoid anandamide.{17092} While certain derivatives of α-truxillic acid can directly activate peroxisome proliferator-activated receptor γ, α-truxillic acid has no such activity.{23829}
Brand:CaymanSKU:- α-Truxillic acid can be formed by the dimerization of two molecules of α-trans-cinnamic acid.{23826} It is related to incarvillateine, a natural antinociceptive compound derived from the Asian herb I. sinensis.{23827} α-Truxillic acid and some of its derivatives significantly block inflammatory pain while having little effect on neurogenic pain, as indicated by the formalin test in mice.{23827,23828} Related compounds, like SB-FI-26 (Item No. 14191), bind fatty acid binding protein 5 (FABP5).{22111} This may be related to pain suppression, since FABP5 acts as a transporter of the endocannabinoid anandamide.{17092} While certain derivatives of α-truxillic acid can directly activate peroxisome proliferator-activated receptor γ, α-truxillic acid has no such activity.{23829}
Brand:CaymanSKU:- α-Truxillic acid can be formed by the dimerization of two molecules of α-trans-cinnamic acid.{23826} It is related to incarvillateine, a natural antinociceptive compound derived from the Asian herb I. sinensis.{23827} α-Truxillic acid and some of its derivatives significantly block inflammatory pain while having little effect on neurogenic pain, as indicated by the formalin test in mice.{23827,23828} Related compounds, like SB-FI-26 (Item No. 14191), bind fatty acid binding protein 5 (FABP5).{22111} This may be related to pain suppression, since FABP5 acts as a transporter of the endocannabinoid anandamide.{17092} While certain derivatives of α-truxillic acid can directly activate peroxisome proliferator-activated receptor γ, α-truxillic acid has no such activity.{23829}
Brand:CaymanSKU:-
Immunogen: Peptide from the C-terminal region of α-tubulin • Host: Rabbit • Species Reactivity: Species independent • Cross Reactivity: (+) α-Tubulin 1A chain , α-Tubulin 1B chain • Applications: ICC, WB • MW = 50 kDa
Brand:CaymanSKU:32126- 100 µg α-Tubulin is a cytoskeletal protein and constituent of microtubules, a cytoskeletal assembly that has roles in a variety of cellular processes, including cell motility, division, differentiation, and intracellular transport.{57121} α-Tubulin is highly conserved in eukaryotes and expressed in a cell- and isotype-specific manner.{57122} There are eight human α-tubulin isotypes that consist of an N-terminal domain, which binds GTP and is required for microtubule self-assembly, and a variable C-terminal tail, which contains interaction sites for microtubule-associated proteins (MAPs) and is subject to a variety of post-translational modifications that regulate microtubule function and stability.{57123,57124,57121,57125} Cayman’s α-Tubulin Monoclonal Antibody can be used for immunocytochemistry (ICC) and Western blot (WB) applications. The antibody recognizes α-tubulin at approximately 50 kDa.
Brand:CaymanSKU:32126 - 100 µgAvailable on backorder
Immunogen: Peptide from the C-terminal region of α-tubulin • Host: Rabbit • Species Reactivity: Species independent • Cross Reactivity: (+) α-Tubulin 1A chain , α-Tubulin 1B chain • Applications: ICC, WB • MW = 50 kDa
Brand:CaymanSKU:32126- 100 µgAvailable on backorder
![An active metabolite of α-zearalenol that acts as an ER agonist; inhibits [3H]estradiol binding to estrogen receptors on calf uterus in a dose-dependent manner; increases endometrial thickness](https://interpriseusa.com/wp-content/uploads/2021/06/23424.png)
α-Zearalanol is an active metabolite formed by reduction of α-zearalenol (Item No. 16549), an estrogen receptor antagonist.{27392} α-Zearalanol inhibits [3H]estradiol binding to estrogen receptors (ERs) on calf uterus in a dose-dependent manner. Dietary α-zearalanol (10 mg/kg per day) increases endometrial thickness, bone mineral density, and serum levels of alkaline phosphatase in ovariectomized rats.{35165} It also decreases sperm count and motility and serum levels of testosterone (Item Nos. 15645 | ISO60154), follicle-stimulating hormone (FSH), and luteinizing hormone (LH) in male mice.{35167}
Brand:CaymanSKU:23424 - 25 mgAvailable on backorder
α-Zearalanol is an active metabolite formed by reduction of α-zearalenol (Item No. 16549), an estrogen receptor antagonist.{27392} α-Zearalanol inhibits [3H]estradiol binding to estrogen receptors (ERs) on calf uterus in a dose-dependent manner. Dietary α-zearalanol (10 mg/kg per day) increases endometrial thickness, bone mineral density, and serum levels of alkaline phosphatase in ovariectomized rats.{35165} It also decreases sperm count and motility and serum levels of testosterone (Item Nos. 15645 | ISO60154), follicle-stimulating hormone (FSH), and luteinizing hormone (LH) in male mice.{35167}
Brand:CaymanSKU:23424 - 5 mgAvailable on backorder
α-Zearalenol is a major hepatic metabolite of zearalenone (Item No. 11353), a mycotoxin produced by fungi in food and animal feeds.{20562,27394} It is a less potent agonist of estrogen receptors than the parent compound.{27392} However, α-zearalenol has pronounced effects on uterotropic activity, sperm motility, and preimplantation embryonic development.{27393,27396,27395}
Brand:CaymanSKU:-Out of stock
α-Zearalenol is a major hepatic metabolite of zearalenone (Item No. 11353), a mycotoxin produced by fungi in food and animal feeds.{20562,27394} It is a less potent agonist of estrogen receptors than the parent compound.{27392} However, α-zearalenol has pronounced effects on uterotropic activity, sperm motility, and preimplantation embryonic development.{27393,27396,27395}
Brand:CaymanSKU:-Out of stock
α-Zearalenol is a major hepatic metabolite of zearalenone (Item No. 11353), a mycotoxin produced by fungi in food and animal feeds.{20562,27394} It is a less potent agonist of estrogen receptors than the parent compound.{27392} However, α-zearalenol has pronounced effects on uterotropic activity, sperm motility, and preimplantation embryonic development.{27393,27396,27395}
Brand:CaymanSKU:-Out of stock
α,β-Methyleneadenosine 5′-triphosphate (αβ-methylene ATP) is a phosphonic analog of ATP that is characterized by the replacement of the bridging oxygen atom between the α- and β-phosphate groups with methylene. It is an agonist of P2X purinoceptors P2X1 and P2X3 (EC50 = ~1 µM) and is ~1,000-fold less potent at P2X2, P2X receptors 4-7, and P2Y receptors.{27693,27688,27691,27687} Persistent activation of purinoceptors results in desensitization, resulting in an antagonist-like effect of αβ-methylene ATP.{27689} αβ-methylene ATP is used as a stable analog of ATP (Item No. 14498) to study the interaction of ATP with kinases and other proteins.{27690,27694} It weakly binds and inhibits adenylate cyclase in a calcium-dependent manner (Ki= ~0.5 mM).{27692,27695}
Brand:CaymanSKU:10008956 - 1 mgAvailable on backorder
α,β-Methyleneadenosine 5′-triphosphate (αβ-methylene ATP) is a phosphonic analog of ATP that is characterized by the replacement of the bridging oxygen atom between the α- and β-phosphate groups with methylene. It is an agonist of P2X purinoceptors P2X1 and P2X3 (EC50 = ~1 µM) and is ~1,000-fold less potent at P2X2, P2X receptors 4-7, and P2Y receptors.{27693,27688,27691,27687} Persistent activation of purinoceptors results in desensitization, resulting in an antagonist-like effect of αβ-methylene ATP.{27689} αβ-methylene ATP is used as a stable analog of ATP (Item No. 14498) to study the interaction of ATP with kinases and other proteins.{27690,27694} It weakly binds and inhibits adenylate cyclase in a calcium-dependent manner (Ki= ~0.5 mM).{27692,27695}
Brand:CaymanSKU:10008956 - 10 mgAvailable on backorder
α,β-Methyleneadenosine 5′-triphosphate (αβ-methylene ATP) is a phosphonic analog of ATP that is characterized by the replacement of the bridging oxygen atom between the α- and β-phosphate groups with methylene. It is an agonist of P2X purinoceptors P2X1 and P2X3 (EC50 = ~1 µM) and is ~1,000-fold less potent at P2X2, P2X receptors 4-7, and P2Y receptors.{27693,27688,27691,27687} Persistent activation of purinoceptors results in desensitization, resulting in an antagonist-like effect of αβ-methylene ATP.{27689} αβ-methylene ATP is used as a stable analog of ATP (Item No. 14498) to study the interaction of ATP with kinases and other proteins.{27690,27694} It weakly binds and inhibits adenylate cyclase in a calcium-dependent manner (Ki= ~0.5 mM).{27692,27695}
Brand:CaymanSKU:10008956 - 5 mgAvailable on backorder
Boswellic acids are pentacyclic triterpenes first isolated from the resin of Boswellia plants. They have anti-inflammatory and anti-arthritic actions in mice.{30046,30045} β-acetyl-Boswellic acid is a non-reducing inhibitor of 5-lipoxygenase (5-LO) that shows selectivity for 5-LO over 12-LO or COX.{6066,30044} When studied as a 1:1 mixture with α-acetyl-boswellic acid, it inhibits topoisomerase II activity and arrests cell cycling or induces apoptosis in cancer cells.{30048,30047}
Brand:CaymanSKU:11674 - 1 mgAvailable on backorder
Boswellic acids are pentacyclic triterpenes first isolated from the resin of Boswellia plants. They have anti-inflammatory and anti-arthritic actions in mice.{30046,30045} β-acetyl-Boswellic acid is a non-reducing inhibitor of 5-lipoxygenase (5-LO) that shows selectivity for 5-LO over 12-LO or COX.{6066,30044} When studied as a 1:1 mixture with α-acetyl-boswellic acid, it inhibits topoisomerase II activity and arrests cell cycling or induces apoptosis in cancer cells.{30048,30047}
Brand:CaymanSKU:11674 - 10 mgAvailable on backorder
Boswellic acids are pentacyclic triterpenes first isolated from the resin of Boswellia plants. They have anti-inflammatory and anti-arthritic actions in mice.{30046,30045} β-acetyl-Boswellic acid is a non-reducing inhibitor of 5-lipoxygenase (5-LO) that shows selectivity for 5-LO over 12-LO or COX.{6066,30044} When studied as a 1:1 mixture with α-acetyl-boswellic acid, it inhibits topoisomerase II activity and arrests cell cycling or induces apoptosis in cancer cells.{30048,30047}
Brand:CaymanSKU:11674 - 5 mgAvailable on backorder
Immunogen: Peptide corresponding to the N-terminus of β-actin • Host: Rabbit • Species Reactivity: (+) Species independent • Applications: ChIP, ICC, IHC, IP, WB
Brand:CaymanSKU:32127- 100 µl β-Actin is a cytoskeletal protein with roles in cell division, migration, and homeostasis that is encoded by ACTB in humans.{52776,52777} It is ubiquitously expressed, localized to the cytosol, and conserved from birds to mammals. β-Actin is enriched at the leading edge of migrating cells and Actb-/- mouse embryonic fibroblasts (MEFs) exhibit decreased migration velocity, increased apoptosis, and decreased proliferation.{52776} Actb knockout is early embryonic lethal in mice, indicating that β-actin is essential for embryonic development. ACTBR183W and ACTBE346K gain-of-function mutations have been found in patients with deafness, developmental mutations, and juvenile-onset dystonia and neutrophil dysfunction, respectively.{52778} Cayman’s β-Actin (N-Term) Rabbit Monoclonal Antibody can be used for chromatin immunoprecipitation (ChIP), immunocytochemistry (ICC), immunohistochemistry (IHC), immunoprecipitation (IP), and Western blot (WB) applications.
Brand:CaymanSKU:32127 - 100 µlAvailable on backorder
Immunogen: Peptide corresponding to the N-terminus of β-actin • Host: Rabbit • Species Reactivity: (+) Species independent • Applications: ChIP, ICC, IHC, IP, WB
Brand:CaymanSKU:32127- 100 µlAvailable on backorder
β-Amanitin is a cyclic peptide found in several species of the Amanita genus, as well as other poisonous fungi.{29215} It inhibits RNA polymerase II and III but not RNA polymerase I or bacterial RNA polymerase, thus preventing mammalian protein synthesis.{29205,20588} The biological activity of this toxin is similar to that of α-amanitin (Item No. 17898) but differs structurally by the presence of a carboxyl group, which is useful for coupling reactions.{29216}
Brand:CaymanSKU:-Available on backorder
β-Amyrin is a natural pentacyclic triterpenoid commonly found in plants. It is a member of the oleanane group of secondary metabolites biosynthesized from squalene in the triterpenoid pathway. β-Amyrin inhibits collagen-induced platelet aggregation (IC50 = 10.5 µM), inhibits acetylcholinesterase (IC50 = 165 µM), and has antifungal and hepatoprotective effects.{33536,33538,33539,33540} Extracts of certain plants, used in herbal medicine to treat inflammation, have been shown to contain β-amyrin, suggesting that this compound contributes to anti-inflammatory actions.{33537}
Brand:CaymanSKU:20949 -Out of stock
β-Amyrin is a natural pentacyclic triterpenoid commonly found in plants. It is a member of the oleanane group of secondary metabolites biosynthesized from squalene in the triterpenoid pathway. β-Amyrin inhibits collagen-induced platelet aggregation (IC50 = 10.5 µM), inhibits acetylcholinesterase (IC50 = 165 µM), and has antifungal and hepatoprotective effects.{33536,33538,33539,33540} Extracts of certain plants, used in herbal medicine to treat inflammation, have been shown to contain β-amyrin, suggesting that this compound contributes to anti-inflammatory actions.{33537}
Brand:CaymanSKU:20949 -Out of stock
β-Amyrin is a natural pentacyclic triterpenoid commonly found in plants. It is a member of the oleanane group of secondary metabolites biosynthesized from squalene in the triterpenoid pathway. β-Amyrin inhibits collagen-induced platelet aggregation (IC50 = 10.5 µM), inhibits acetylcholinesterase (IC50 = 165 µM), and has antifungal and hepatoprotective effects.{33536,33538,33539,33540} Extracts of certain plants, used in herbal medicine to treat inflammation, have been shown to contain β-amyrin, suggesting that this compound contributes to anti-inflammatory actions.{33537}
Brand:CaymanSKU:20949 -Out of stock
β-Apooxytetracycline is a potential impurity found in commercial preparations of oxytetracycline.{43923} β-Apooxytetracycline is a degradation product formed from oxytetracycline (Item No. 18076) via acid hydrolysis. It has a relative potency of 0.1 compared with oxytetracycline for inhibiting the growth of aerobic sludge bacteria, an MIC50 value of 32 mg/L for tetracycline-sensitive strains of Pseudomonas, and MIC50 values of greater than 32 mg/L for tetracycline-sensitive strains of Agrobacterium, Moraxella, and Bacillus, as well as tetracycline-resistant strains of E. coli.{43924} β-Apooxytetracycline (10 mg/kg) is toxic to rats, decreasing body weight, disrupting blood cell counts, and inducing hepatocyte necrosis.{43925}
Brand:CaymanSKU:27099 - 1 mgAvailable on backorder
β-Apooxytetracycline is a potential impurity found in commercial preparations of oxytetracycline.{43923} β-Apooxytetracycline is a degradation product formed from oxytetracycline (Item No. 18076) via acid hydrolysis. It has a relative potency of 0.1 compared with oxytetracycline for inhibiting the growth of aerobic sludge bacteria, an MIC50 value of 32 mg/L for tetracycline-sensitive strains of Pseudomonas, and MIC50 values of greater than 32 mg/L for tetracycline-sensitive strains of Agrobacterium, Moraxella, and Bacillus, as well as tetracycline-resistant strains of E. coli.{43924} β-Apooxytetracycline (10 mg/kg) is toxic to rats, decreasing body weight, disrupting blood cell counts, and inducing hepatocyte necrosis.{43925}
Brand:CaymanSKU:27099 - 10 mgAvailable on backorder
β-Apooxytetracycline is a potential impurity found in commercial preparations of oxytetracycline.{43923} β-Apooxytetracycline is a degradation product formed from oxytetracycline (Item No. 18076) via acid hydrolysis. It has a relative potency of 0.1 compared with oxytetracycline for inhibiting the growth of aerobic sludge bacteria, an MIC50 value of 32 mg/L for tetracycline-sensitive strains of Pseudomonas, and MIC50 values of greater than 32 mg/L for tetracycline-sensitive strains of Agrobacterium, Moraxella, and Bacillus, as well as tetracycline-resistant strains of E. coli.{43924} β-Apooxytetracycline (10 mg/kg) is toxic to rats, decreasing body weight, disrupting blood cell counts, and inducing hepatocyte necrosis.{43925}
Brand:CaymanSKU:27099 - 5 mgAvailable on backorder
β-Apooxytetracycline is a potential impurity found in commercial preparations of oxytetracycline.{43923} β-Apooxytetracycline is a degradation product formed from oxytetracycline (Item No. 18076) via acid hydrolysis. It has a relative potency of 0.1 compared with oxytetracycline for inhibiting the growth of aerobic sludge bacteria, an MIC50 value of 32 mg/L for tetracycline-sensitive strains of Pseudomonas, and MIC50 values of greater than 32 mg/L for tetracycline-sensitive strains of Agrobacterium, Moraxella, and Bacillus, as well as tetracycline-resistant strains of E. coli.{43924} β-Apooxytetracycline (10 mg/kg) is toxic to rats, decreasing body weight, disrupting blood cell counts, and inducing hepatocyte necrosis.{43925}
Brand:CaymanSKU:27099 - 500 µgAvailable on backorder
The asarones, including α-asarone (Item No. 11681) and β-asarone, were first isolated from volatile oils of plants of the genus Acorus, which are used in Ayurvedic medicine. β-Asarone is noted for its neuroprotective effects, as it ameliorates depression, reduces dopamine-induced neurotoxicity, and attenuates damage in a model of stroke.{29162,29165,29164} In isolated neurons and in brains, β-asarone blocks autophagy, reduces inflammation, and inhibits apoptosis.{29165,29164,29163} While β-asarone inhibits apoptosis in neurons, it induces apoptosis in colon cancer cells.{29166} It also has antimicrobial effects.{29161}
Brand:CaymanSKU:11682 - 10 mgAvailable on backorder
The asarones, including α-asarone (Item No. 11681) and β-asarone, were first isolated from volatile oils of plants of the genus Acorus, which are used in Ayurvedic medicine. β-Asarone is noted for its neuroprotective effects, as it ameliorates depression, reduces dopamine-induced neurotoxicity, and attenuates damage in a model of stroke.{29162,29165,29164} In isolated neurons and in brains, β-asarone blocks autophagy, reduces inflammation, and inhibits apoptosis.{29165,29164,29163} While β-asarone inhibits apoptosis in neurons, it induces apoptosis in colon cancer cells.{29166} It also has antimicrobial effects.{29161}
Brand:CaymanSKU:11682 - 100 mgAvailable on backorder
The asarones, including α-asarone (Item No. 11681) and β-asarone, were first isolated from volatile oils of plants of the genus Acorus, which are used in Ayurvedic medicine. β-Asarone is noted for its neuroprotective effects, as it ameliorates depression, reduces dopamine-induced neurotoxicity, and attenuates damage in a model of stroke.{29162,29165,29164} In isolated neurons and in brains, β-asarone blocks autophagy, reduces inflammation, and inhibits apoptosis.{29165,29164,29163} While β-asarone inhibits apoptosis in neurons, it induces apoptosis in colon cancer cells.{29166} It also has antimicrobial effects.{29161}
Brand:CaymanSKU:11682 - 5 mgAvailable on backorder
The asarones, including α-asarone (Item No. 11681) and β-asarone, were first isolated from volatile oils of plants of the genus Acorus, which are used in Ayurvedic medicine. β-Asarone is noted for its neuroprotective effects, as it ameliorates depression, reduces dopamine-induced neurotoxicity, and attenuates damage in a model of stroke.{29162,29165,29164} In isolated neurons and in brains, β-asarone blocks autophagy, reduces inflammation, and inhibits apoptosis.{29165,29164,29163} While β-asarone inhibits apoptosis in neurons, it induces apoptosis in colon cancer cells.{29166} It also has antimicrobial effects.{29161}
Brand:CaymanSKU:11682 - 50 mgAvailable on backorder
β-BHC is an isomer of the organochlorine pesticide γ-lindane (Item No. 23952) that is a potential impurity found in commercial preparations of lindane.{42199} It is estrogenic, inducing estrogen receptor α (ERα) and ERβ reporter gene expression in CHO cells expressing the human receptors with 20% relative effective concentration (REC20) values of 3.5 and 1.1 μM, respectively.{42200} In vitro, β-BHC induces apoptosis of rat Sertoli cells via production of reactive oxygen species (ROS), activation of caspases, and induction of expression of Fas ligand (FasL).{42201} It is a persistent organic pollutant and levels of total body β-BHC are negatively correlated to plasma testosterone levels in male polar bears.{42202}
Brand:CaymanSKU:24134 - 100 mgAvailable on backorder
β-BHC is an isomer of the organochlorine pesticide γ-lindane (Item No. 23952) that is a potential impurity found in commercial preparations of lindane.{42199} It is estrogenic, inducing estrogen receptor α (ERα) and ERβ reporter gene expression in CHO cells expressing the human receptors with 20% relative effective concentration (REC20) values of 3.5 and 1.1 μM, respectively.{42200} In vitro, β-BHC induces apoptosis of rat Sertoli cells via production of reactive oxygen species (ROS), activation of caspases, and induction of expression of Fas ligand (FasL).{42201} It is a persistent organic pollutant and levels of total body β-BHC are negatively correlated to plasma testosterone levels in male polar bears.{42202}
Brand:CaymanSKU:24134 - 50 mgAvailable on backorder
β-Boswellic acid is a pentacyclic triterpene originally isolated from Boswellia that has diverse bioactivities.{30044} It inhibits 5-lipoxygenase (5-LO) with an IC50 value of approximately 5 µM but is less potent than its derivative 3-acetyl-11-keto-β-boswellic acid (Item No. 11672).{6066} It inhibits cell proliferation in HL-60 cells with IC50 values of 3.7, 7.1, and 6.3 µM for DNA, RNA, and protein synthesis, respectively.{38153} In human umbilical vein endothelial cells (HUVECs) transiently deprived of oxygen and glucose, β-boswellic acid increases nitric oxide and increases phosphorylation of enzyme nitric oxide synthase (eNOS).{38155} It also increases calcium mobilization in platelets at concentrations ≥3 µM and induces platelet aggregation (EC50 = 8 µM).{38154}
Brand:CaymanSKU:11693 - 1 mgAvailable on backorder
β-Boswellic acid is a pentacyclic triterpene originally isolated from Boswellia that has diverse bioactivities.{30044} It inhibits 5-lipoxygenase (5-LO) with an IC50 value of approximately 5 µM but is less potent than its derivative 3-acetyl-11-keto-β-boswellic acid (Item No. 11672).{6066} It inhibits cell proliferation in HL-60 cells with IC50 values of 3.7, 7.1, and 6.3 µM for DNA, RNA, and protein synthesis, respectively.{38153} In human umbilical vein endothelial cells (HUVECs) transiently deprived of oxygen and glucose, β-boswellic acid increases nitric oxide and increases phosphorylation of enzyme nitric oxide synthase (eNOS).{38155} It also increases calcium mobilization in platelets at concentrations ≥3 µM and induces platelet aggregation (EC50 = 8 µM).{38154}
Brand:CaymanSKU:11693 - 10 mgAvailable on backorder
β-Boswellic acid is a pentacyclic triterpene originally isolated from Boswellia that has diverse bioactivities.{30044} It inhibits 5-lipoxygenase (5-LO) with an IC50 value of approximately 5 µM but is less potent than its derivative 3-acetyl-11-keto-β-boswellic acid (Item No. 11672).{6066} It inhibits cell proliferation in HL-60 cells with IC50 values of 3.7, 7.1, and 6.3 µM for DNA, RNA, and protein synthesis, respectively.{38153} In human umbilical vein endothelial cells (HUVECs) transiently deprived of oxygen and glucose, β-boswellic acid increases nitric oxide and increases phosphorylation of enzyme nitric oxide synthase (eNOS).{38155} It also increases calcium mobilization in platelets at concentrations ≥3 µM and induces platelet aggregation (EC50 = 8 µM).{38154}
Brand:CaymanSKU:11693 - 5 mgAvailable on backorder
β-Carotene is a red/orange-colored fat-soluble terpenoid with antioxidant properties.{8727} It can be enzymatically cleaved to produce vitamin A and retinoic acid. Vitamin A is important for vision and bone growth, while retinoic acid, through the retinoic acid receptor, plays an important role in cell differentiation.
Brand:CaymanSKU:-Out of stock
β-Carotene is a red/orange-colored fat-soluble terpenoid with antioxidant properties.{8727} It can be enzymatically cleaved to produce vitamin A and retinoic acid. Vitamin A is important for vision and bone growth, while retinoic acid, through the retinoic acid receptor, plays an important role in cell differentiation.
Brand:CaymanSKU:-Out of stock
β-Carotene is a red/orange-colored fat-soluble terpenoid with antioxidant properties.{8727} It can be enzymatically cleaved to produce vitamin A and retinoic acid. Vitamin A is important for vision and bone growth, while retinoic acid, through the retinoic acid receptor, plays an important role in cell differentiation.
Brand:CaymanSKU:-Out of stock
β-Carotene is a red/orange-colored fat-soluble terpenoid with antioxidant properties.{8727} It can be enzymatically cleaved to produce vitamin A and retinoic acid. Vitamin A is important for vision and bone growth, while retinoic acid, through the retinoic acid receptor, plays an important role in cell differentiation.
Brand:CaymanSKU:-Out of stock
β-Caryophyllene (Item No. 21572) is a sesquiterpene that has been found in plants, including C. sativa, C. indica, and hemp, and has diverse biological activities, including lipid metabolic, antioxidant, anti-neuroinflammatory, anti-proliferative, and antinociceptive properties.{41453,42355,42358,42359,42356,42357} It is an agonist of the cannabinoid (CB) receptor CB2 (Ki = 155 nM) that inhibits cAMP production induced by forskolin in CHO-K1 cells expressing CB2 receptors (EC50 = 38 nM).{34255} β-Caryophyllene is also an agonist of peroxisome proliferator-activated receptor α (PPARα; EC50 = 9.58 µM in a reporter assay).{42355} β-Caryophyllene (1 and 2.5 µM) reduces the production of reactive oxygen species (ROS) in and protects against cytotoxicity of SH-SY5Y cells induced by 1-methyl-4-pheylpyridinium (MPP+).{42358} It also decreases the β-amyloid burden in the hippocampus and cerebral cortex and improves memory in an APP/PS1 transgenic mouse model of Alzheimer’s disease, decreasing the latency to find the platform in the Morris water maze during training and increasing the time spent in the target quadrant during testing when administered at a dose of 48 mg/kg per day.{42359} β-Caryophyllene (50 mg/kg) increases the number of entries into and the time spent in the open arms of the elevated plus maze and the time spent immobile in the forced swim test, indicating anxiolytic-like and antidepressant-like activity, effects that can be blocked by the CB2 receptor antagonist AM630 (Item No. 10006974).{42356}
Brand:CaymanSKU:21572 -Out of stock
β-Catenin is a central component of the cadherin cell adhesion complex and plays an essential role in neural development in the Wingless/Wnt signaling pathway.{14334,14336} The role of β-catenin in these processes is thought to be regulated by the sequential phosphorylation of Ser29, Ser33, Ser37, and Thr41 by glycogen synthase kinase 3β (GSK3β).{14335} This hyperphosphorylation promotes the ubiquitylation and targeted destruction of β-catenin. Mutations in components of this phosphorylation-regulated process that prevent β-catenin hyperphosphorylation by GSK3β are strongly associated with cancers.{14335,14336,14337}
Brand:CaymanSKU:10009180 - 1 eaAvailable on backorder
Antigen: phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser33,37 of human β-catenin · Host: rabbit · Cross-reactivity: (+) human β-catenin · Application: WB • β-Catenin is a central component of the cadherin cell adhesion complex and plays an essential role in neural development in the Wingless/Wnt signaling pathway. It is thought to be regulated by the sequential phosphorylation of Ser29, Ser33, Ser37, and Thr41 by GSK3β. This hyperphosphorylation promotes the ubiquitylation and targeted destruction of β-catenin.
Brand:CaymanSKU:10009180- 1 eaAvailable on backorder
Antigen: phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser33,37 of human β-catenin · Host: rabbit · Cross-reactivity: (+) human β-catenin · Application: WB • β-Catenin is a central component of the cadherin cell adhesion complex and plays an essential role in neural development in the Wingless/Wnt signaling pathway. It is thought to be regulated by the sequential phosphorylation of Ser29, Ser33, Ser37, and Thr41 by GSK3β. This hyperphosphorylation promotes the ubiquitylation and targeted destruction of β-catenin.
Brand:CaymanSKU:10009180- 1 ea
Immunogen: synthetic peptide from the N-terminal region of human protein • Host: Rabbit • Cross Reactivity: (+) human, mouse, rat, porcine, and bovine β-catenin • Application(s): IHC and WB
Brand:CaymanSKU:100029- 500 µlAvailable on backorder
Immunogen: synthetic peptide from the N-terminal region of human protein • Host: Rabbit • Cross Reactivity: (+) human, mouse, rat, porcine, and bovine β-catenin • Application(s): IHC and WB
Brand:CaymanSKU:100029- 500 µl β-Catenin is a multifunctional protein known to be part of the Wnt pathway, playing essential roles in development and carcinogenesis.{11352,11347,11344} β-Catenin can act as a regulator of the cell cycle and apoptosis in a variety of different cell systems.{11349,11350} The entire primary amino acid sequence is identical among human, rat, and mouse, indicating critical functions of this protein{11351,11348,11345}. Cayman’s β-catenin polyclonal antibody can be used for Western blot and immunohistochemical (formalin-fixed paraffin-embedded tissue) analysis of β-catenin on samples of human, murine, rat, porcine and bovine origin. The antibody recognizes β-Catenin at 91 kDa from mouse samples.
Brand:CaymanSKU:100029 - 500 µlAvailable on backorder
β-Cembrenediol (β-CBT) is a natural product from tobacco plants that is found in cigarette smoke condensate.{39054} β-CBT inhibits induction of the early antigen of Epstein-Barr virus (EA-EBV) by 12-O-tetradecanoylphorbol-13-acetate (TPA) in vitro (IC50 = 21.9 μM). It inhibits tumor promoting effects of TPA on 7,12-demethylbenz[a]anthracene-induced papilloma formation in vivo.{39054,39053} β-CBT is also released into soil by flue-cured tobacco plants and exerts autotoxicity as well as phytotoxic activity against L. sativa seedlings.{39055}
Brand:CaymanSKU:21031 -Out of stock
β-Cembrenediol (β-CBT) is a natural product from tobacco plants that is found in cigarette smoke condensate.{39054} β-CBT inhibits induction of the early antigen of Epstein-Barr virus (EA-EBV) by 12-O-tetradecanoylphorbol-13-acetate (TPA) in vitro (IC50 = 21.9 μM). It inhibits tumor promoting effects of TPA on 7,12-demethylbenz[a]anthracene-induced papilloma formation in vivo.{39054,39053} β-CBT is also released into soil by flue-cured tobacco plants and exerts autotoxicity as well as phytotoxic activity against L. sativa seedlings.{39055}
Brand:CaymanSKU:21031 -Out of stock
β-Cembrenediol (β-CBT) is a natural product from tobacco plants that is found in cigarette smoke condensate.{39054} β-CBT inhibits induction of the early antigen of Epstein-Barr virus (EA-EBV) by 12-O-tetradecanoylphorbol-13-acetate (TPA) in vitro (IC50 = 21.9 μM). It inhibits tumor promoting effects of TPA on 7,12-demethylbenz[a]anthracene-induced papilloma formation in vivo.{39054,39053} β-CBT is also released into soil by flue-cured tobacco plants and exerts autotoxicity as well as phytotoxic activity against L. sativa seedlings.{39055}
Brand:CaymanSKU:21031 -Out of stock
Hydrogen sulfide (H2S) is a naturally-occurring gasotransmitter with vasodilator and inflammatory modulating activity.{15636,13678} H2S is synthesized naturally in a range of mammalian tissues principally by the activity of two enzymes, cystathionine γ lyase (CSE) and cystathionine β synthetase (CBS). β-cyano-L-Alanine (BCA) is a reversible inhibitor of the H2S-synthesizing enzyme CSE.{16454} BCA blocks H2S synthesis in rat liver preparations with an IC50 value of 6.5 µM and increases blood pressure in anaesthetized rats induced with hemorrhagic shock by inhibiting endogenous H2S synthesis.{16094} BCA at 50 mg/kg blocked both L-cysteine- and LPS-induced hyperalgesia in rats.{16455}
Brand:CaymanSKU:10010947 - 10 mgAvailable on backorder
Hydrogen sulfide (H2S) is a naturally-occurring gasotransmitter with vasodilator and inflammatory modulating activity.{15636,13678} H2S is synthesized naturally in a range of mammalian tissues principally by the activity of two enzymes, cystathionine γ lyase (CSE) and cystathionine β synthetase (CBS). β-cyano-L-Alanine (BCA) is a reversible inhibitor of the H2S-synthesizing enzyme CSE.{16454} BCA blocks H2S synthesis in rat liver preparations with an IC50 value of 6.5 µM and increases blood pressure in anaesthetized rats induced with hemorrhagic shock by inhibiting endogenous H2S synthesis.{16094} BCA at 50 mg/kg blocked both L-cysteine- and LPS-induced hyperalgesia in rats.{16455}
Brand:CaymanSKU:10010947 - 100 mgAvailable on backorder
Hydrogen sulfide (H2S) is a naturally-occurring gasotransmitter with vasodilator and inflammatory modulating activity.{15636,13678} H2S is synthesized naturally in a range of mammalian tissues principally by the activity of two enzymes, cystathionine γ lyase (CSE) and cystathionine β synthetase (CBS). β-cyano-L-Alanine (BCA) is a reversible inhibitor of the H2S-synthesizing enzyme CSE.{16454} BCA blocks H2S synthesis in rat liver preparations with an IC50 value of 6.5 µM and increases blood pressure in anaesthetized rats induced with hemorrhagic shock by inhibiting endogenous H2S synthesis.{16094} BCA at 50 mg/kg blocked both L-cysteine- and LPS-induced hyperalgesia in rats.{16455}
Brand:CaymanSKU:10010947 - 250 mgAvailable on backorder
Hydrogen sulfide (H2S) is a naturally-occurring gasotransmitter with vasodilator and inflammatory modulating activity.{15636,13678} H2S is synthesized naturally in a range of mammalian tissues principally by the activity of two enzymes, cystathionine γ lyase (CSE) and cystathionine β synthetase (CBS). β-cyano-L-Alanine (BCA) is a reversible inhibitor of the H2S-synthesizing enzyme CSE.{16454} BCA blocks H2S synthesis in rat liver preparations with an IC50 value of 6.5 µM and increases blood pressure in anaesthetized rats induced with hemorrhagic shock by inhibiting endogenous H2S synthesis.{16094} BCA at 50 mg/kg blocked both L-cysteine- and LPS-induced hyperalgesia in rats.{16455}
Brand:CaymanSKU:10010947 - 50 mgAvailable on backorder
β-Cyclodextrin (β-CD) is a cyclic oligosaccharide that contains seven D-(+)-glucopyranose units and has been used to improve the aqueous solubility of various compounds, especially those containing a phenyl group.{26620,26432} The circular arrangement of its glucose units produces a torus-shaped ring configuration in which the CH2 groups and ether linkages of the molecule face the hollow interior, resulting in a nonpolar, hydrophobic cavity and a polar, hydrophilic exterior. When combined in solution with other compounds, the nonpolar aromatic portions of that compound interact with the nonpolar interior of the β-CD molecule, thus isolating the aromatic portion of the molecule from the water and thereby increasing its aqueous solubility.{26620,21228}
Brand:CaymanSKU:23387 - 100 gAvailable on backorder
β-Cyclodextrin (β-CD) is a cyclic oligosaccharide that contains seven D-(+)-glucopyranose units and has been used to improve the aqueous solubility of various compounds, especially those containing a phenyl group.{26620,26432} The circular arrangement of its glucose units produces a torus-shaped ring configuration in which the CH2 groups and ether linkages of the molecule face the hollow interior, resulting in a nonpolar, hydrophobic cavity and a polar, hydrophilic exterior. When combined in solution with other compounds, the nonpolar aromatic portions of that compound interact with the nonpolar interior of the β-CD molecule, thus isolating the aromatic portion of the molecule from the water and thereby increasing its aqueous solubility.{26620,21228}
Brand:CaymanSKU:23387 - 25 gAvailable on backorder
β-Cyclodextrin (β-CD) is a cyclic oligosaccharide that contains seven D-(+)-glucopyranose units and has been used to improve the aqueous solubility of various compounds, especially those containing a phenyl group.{26620,26432} The circular arrangement of its glucose units produces a torus-shaped ring configuration in which the CH2 groups and ether linkages of the molecule face the hollow interior, resulting in a nonpolar, hydrophobic cavity and a polar, hydrophilic exterior. When combined in solution with other compounds, the nonpolar aromatic portions of that compound interact with the nonpolar interior of the β-CD molecule, thus isolating the aromatic portion of the molecule from the water and thereby increasing its aqueous solubility.{26620,21228}
Brand:CaymanSKU:23387 - 50 gAvailable on backorder
β-D-Glucosamine pentaacetate is an N-acetylglucosamine derivative that has been shown to promote hyaluronic acid production.{29024,29025}
Brand:CaymanSKU:-Available on backorder
β-D-Glucosamine pentaacetate is an N-acetylglucosamine derivative that has been shown to promote hyaluronic acid production.{29024,29025}
Brand:CaymanSKU:-Available on backorder
β-D-Glucosamine pentaacetate is an N-acetylglucosamine derivative that has been shown to promote hyaluronic acid production.{29024,29025}
Brand:CaymanSKU:-Available on backorder
D-Glucose, a naturally occurring monosaccharide found in plants, is the primary energy source for living organisms.{14802} It is utilized as a metabolic intermediate by cells for either aerobic or anaerobic respiration. D-Glucose exists in two cyclic forms, α-D-glucose and β-D-glucose, based on the position of the substituent at the anomeric center.{19676} α-D-Glucose is the monomer unit in starch, whereas β-D-glucose is the monomer unit in cellulose.{19676} When one of these anomers is added to solution, it undergoes reversible epimerization to the other via an open-chain form, during which the specific rotation of the solution changes gradually until it reaches equilibrium. The existence of multiple binding modes of this single monosaccharide has been studied as a model scaffold to design compounds with increased probability of ligand binding.{27288}
Brand:CaymanSKU:-Out of stock
D-Glucose, a naturally occurring monosaccharide found in plants, is the primary energy source for living organisms.{14802} It is utilized as a metabolic intermediate by cells for either aerobic or anaerobic respiration. D-Glucose exists in two cyclic forms, α-D-glucose and β-D-glucose, based on the position of the substituent at the anomeric center.{19676} α-D-Glucose is the monomer unit in starch, whereas β-D-glucose is the monomer unit in cellulose.{19676} When one of these anomers is added to solution, it undergoes reversible epimerization to the other via an open-chain form, during which the specific rotation of the solution changes gradually until it reaches equilibrium. The existence of multiple binding modes of this single monosaccharide has been studied as a model scaffold to design compounds with increased probability of ligand binding.{27288}
Brand:CaymanSKU:-Out of stock
β-D-Ribofuranose 1,2,3,4-tetraacetate is a precursor in the synthesis of nucleosides with antiproliferative activity against cancer cells.{46967,46968}
Brand:CaymanSKU:30408 - 10 gAvailable on backorder
β-D-Ribofuranose 1,2,3,4-tetraacetate is a precursor in the synthesis of nucleosides with antiproliferative activity against cancer cells.{46967,46968}
Brand:CaymanSKU:30408 - 25 gAvailable on backorder
β-D-Ribofuranose 1,2,3,4-tetraacetate is a precursor in the synthesis of nucleosides with antiproliferative activity against cancer cells.{46967,46968}
Brand:CaymanSKU:30408 - 5 gAvailable on backorder
β-D-Ribofuranose 1,2,3,4-tetraacetate is a precursor in the synthesis of nucleosides with antiproliferative activity against cancer cells.{46967,46968}
Brand:CaymanSKU:30408 - 50 gAvailable on backorder
β-Defensin-4 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.{41472} It induces migration of monocytes in vitro when used at a concentration of 10 nM but does not affect migration of neutrophils and eosinophils.{38795} β-Defensin-4 (30 μg/ml) stimulates gene expression and production of IL-6, IL-10, CXCL10, CCL2, MIP-3α, and RANTES by keratinocytes.{38796} It also stimulates calcium mobilization, migration, and proliferation of keratinocytes when used at concentrations of 30, 10, and 40 μg/ml, respectively. β-Defensin-4 induces IL-31 production by human peripheral blood-derived mast cells in vitro when used at a concentration of 10 μg/ml and by rat mast cells in vivo following a 500 ng intradermal dose.{38797} It also inhibits growth of E. coli, P. aeruginosa, and S. aureus with lethal concentration (LC) values of 5, 12, and 15 μM, respectively, of S. carnosus (MIC = 4.5 μg/ml), and of C. albicans with a minimum fungicidal concentration (MFC) value of 7.5 μM.{38795,38798}
Brand:CaymanSKU:24579 - 100 µgAvailable on backorder
β-Elemene is a monoterpene that has been found in C. sativa.{42314} It is intended for use as an analytical standard for the detection of β-elemene by GC- or LC-MS.
Brand:CaymanSKU:19641 -Available on backorder
β-Elemene is a monoterpene that has been found in C. sativa.{42314} It is intended for use as an analytical standard for the detection of β-elemene by GC- or LC-MS.
Brand:CaymanSKU:19641 -Available on backorder
β-Elemene is a monoterpene that has been found in C. sativa.{42314} It is intended for use as an analytical standard for the detection of β-elemene by GC- or LC-MS.
Brand:CaymanSKU:19641 -Available on backorder
β-Elemene is a monoterpene that has been found in C. sativa.{42314} It is intended for use as an analytical standard for the detection of β-elemene by GC- or LC-MS.
Brand:CaymanSKU:19641 -Available on backorder
β-Elemonic acid is a triterpene isolated from Boswellia (Burseraceae) that exhibits anticancer activity.{35033,35034} It inhibits growth of non-small cell lung cancer (NSCLC) A549 cells (IC50 = 6.92 µM) in vitro.{35034} β-Elemonic acid induces apoptosis and cytotoxicity in A549 cells in a dose-dependent manner but has no effect on normal epithelial WI-38 cells. It inhibits phosphorylation of p42/44, MAPK/JNK, and p38 and induces production of reactive oxygen species (ROS) and COX-2 expression in vitro. β-Elemonic acid also inhibits prolyl endopeptidase (IC50 = 39.74 µM) in vitro.{35033}
Brand:CaymanSKU:11712 - 1 mgAvailable on backorder
β-Elemonic acid is a triterpene isolated from Boswellia (Burseraceae) that exhibits anticancer activity.{35033,35034} It inhibits growth of non-small cell lung cancer (NSCLC) A549 cells (IC50 = 6.92 µM) in vitro.{35034} β-Elemonic acid induces apoptosis and cytotoxicity in A549 cells in a dose-dependent manner but has no effect on normal epithelial WI-38 cells. It inhibits phosphorylation of p42/44, MAPK/JNK, and p38 and induces production of reactive oxygen species (ROS) and COX-2 expression in vitro. β-Elemonic acid also inhibits prolyl endopeptidase (IC50 = 39.74 µM) in vitro.{35033}
Brand:CaymanSKU:11712 - 10 mgAvailable on backorder
β-Elemonic acid is a triterpene isolated from Boswellia (Burseraceae) that exhibits anticancer activity.{35033,35034} It inhibits growth of non-small cell lung cancer (NSCLC) A549 cells (IC50 = 6.92 µM) in vitro.{35034} β-Elemonic acid induces apoptosis and cytotoxicity in A549 cells in a dose-dependent manner but has no effect on normal epithelial WI-38 cells. It inhibits phosphorylation of p42/44, MAPK/JNK, and p38 and induces production of reactive oxygen species (ROS) and COX-2 expression in vitro. β-Elemonic acid also inhibits prolyl endopeptidase (IC50 = 39.74 µM) in vitro.{35033}
Brand:CaymanSKU:11712 - 25 mgAvailable on backorder
β-Elemonic acid is a triterpene isolated from Boswellia (Burseraceae) that exhibits anticancer activity.{35033,35034} It inhibits growth of non-small cell lung cancer (NSCLC) A549 cells (IC50 = 6.92 µM) in vitro.{35034} β-Elemonic acid induces apoptosis and cytotoxicity in A549 cells in a dose-dependent manner but has no effect on normal epithelial WI-38 cells. It inhibits phosphorylation of p42/44, MAPK/JNK, and p38 and induces production of reactive oxygen species (ROS) and COX-2 expression in vitro. β-Elemonic acid also inhibits prolyl endopeptidase (IC50 = 39.74 µM) in vitro.{35033}
Brand:CaymanSKU:11712 - 5 mgAvailable on backorder
β-Endorphin (β-EP) is an endogenous opioid neuropeptide with diverse biological activities.{37350} It is produced via piomelanocortin cleavage in the pituitary gland, hypothalamus, and in lymphocytes, then migrates to its sites of action which include plasma, gut, skin, placenta, cerebrospinal fluid, and cardiac tissues. β-EP induces concentration-dependent decreases in electrically stimulated contraction of the mouse vas deferens that can be reversed by the μ-opioid antagonist CTP and Δ-opioid antagonist ICI 174,864.{37351} In vivo, β-EP (5 μg, i.c.v.) slows gastrointestinal transit in mice. β-EP (0.5 or 5 μg, i.c.v.) stimulates food intake in rats for 4 to 6 hours, however, this effect is not prolonged with continuous infusion.{37352} It antagonizes the appetite-suppressive effects of α-melanocyte-stimulating hormone (α-MSH) for the first three days post administration. β-EP also reduces paralytic demyelination induced by the murine coronavirus MHV-JHM in immunocompetent, but not irradiated or immune-incompetent, mice and rats.{37353}
Brand:CaymanSKU:24153 - 500 µgAvailable on backorder
β-Estradiol 17-valerate is a synthetic estrogen. Formulations containing β-Estradiol 17-valerate in combination with dienogest (Item No. 21257) have been used to treat endometriosis.{37057} Clinical trials have shown improvement in pelvic pain and quality of life as well as reduced dysmenorrhea and bleeding following β-Estradiol 17-valerate administration.{37057},{37058} Formulations containing β-Estradiol 17-valerate have also been used in hormone replacement therapy post oophorectomy as they do not activate the renin-angiotensin system, thereby preventing cardiac hypertension often associated with synthetic estrogen therapies.{37059}
Brand:CaymanSKU:22221 -Out of stock
β-Estradiol 17-valerate is a synthetic estrogen. Formulations containing β-Estradiol 17-valerate in combination with dienogest (Item No. 21257) have been used to treat endometriosis.{37057} Clinical trials have shown improvement in pelvic pain and quality of life as well as reduced dysmenorrhea and bleeding following β-Estradiol 17-valerate administration.{37057},{37058} Formulations containing β-Estradiol 17-valerate have also been used in hormone replacement therapy post oophorectomy as they do not activate the renin-angiotensin system, thereby preventing cardiac hypertension often associated with synthetic estrogen therapies.{37059}
Brand:CaymanSKU:22221 -Out of stock
β-Estradiol 17-valerate is a synthetic estrogen. Formulations containing β-Estradiol 17-valerate in combination with dienogest (Item No. 21257) have been used to treat endometriosis.{37057} Clinical trials have shown improvement in pelvic pain and quality of life as well as reduced dysmenorrhea and bleeding following β-Estradiol 17-valerate administration.{37057},{37058} Formulations containing β-Estradiol 17-valerate have also been used in hormone replacement therapy post oophorectomy as they do not activate the renin-angiotensin system, thereby preventing cardiac hypertension often associated with synthetic estrogen therapies.{37059}
Brand:CaymanSKU:22221 -Out of stock
β-Eudesmol is a sesquiterpene that has been found in a variety of plants, including Cannabis, and has diverse biological activities.{42303,36865} It is a noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs) that decreases the open time and opening frequency of nAChR channels when used at concentrations of 40 and 80 µM and increases the decay phase of depolarization when used at a concentration of 100 µM in isolated mouse diaphragm muscle.{36866} β-Eudesmol (50-100 µM) inhibits VEGF- and bFGF-induced proliferation in human umbilical vein endothelial cells (HUVECs).{36867} It also inhibits proliferation of HeLa, SGC-7901, and BEL-7402 cells when used at concentrations ranging from 10 to 100 µM and reduces tumor growth in H22 and S-180 mouse tumor models when administered at doses ranging from 2.5 to 5 mg/kg. β-Eudesmol is an agonist of the transient receptor potential (TRP) receptor subtypes TRPA1, TRPV3, and TRPM8 and increases food intake and plasma levels of ghrelin in rats.{36868,36869}
Brand:CaymanSKU:25771 - 1 mgAvailable on backorder