A potential impurity found in commercial preparations of lindane; induces ERα and ERβ reporter gene expression in CHO cells expressing the human receptors (REC20s = 3.5 and 1.1 μM

β-BHC – 50 mg

Brand:
Cayman
CAS:
319-85-7
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

β-BHC is an isomer of the organochlorine pesticide γ-lindane (Item No. 23952) that is a potential impurity found in commercial preparations of lindane.{42199} It is estrogenic, inducing estrogen receptor α (ERα) and ERβ reporter gene expression in CHO cells expressing the human receptors with 20% relative effective concentration (REC20) values of 3.5 and 1.1 μM, respectively.{42200} In vitro, β-BHC induces apoptosis of rat Sertoli cells via production of reactive oxygen species (ROS), activation of caspases, and induction of expression of Fas ligand (FasL).{42201} It is a persistent organic pollutant and levels of total body β-BHC are negatively correlated to plasma testosterone levels in male polar bears.{42202}  

 

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SKU: 24134 - 50 mg Category:

Description

A potential impurity found in commercial preparations of lindane; induces ERα and ERβ reporter gene expression in CHO cells expressing the human receptors (REC20s = 3.5 and 1.1 μM, respectively); induces apoptosis of rat Sertoli cells via production of ROS, activation of caspases, and induction of expression of FasL; levels of total body β-BHC are negatively correlated to plasma testosterone levels in male polar bears ,

Formal name: 1α,2β,3α,4β,5α,6β-hexachloro-cyclohexane

Synonyms:  β-HCH|β-Hexachlorocyclohexane|β-Lindane

Molecular weight: 290.8

CAS: 319-85-7

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Ox Stress Reagents|Free Radical Generators||Product Type|Biochemicals|Pesticides||Product Type|Biochemicals|Pharmaceutical Impurities||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Small Molecule Activators|Caspases||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins||Research Area|Endocrinology & Metabolism|Reproductive Biology||Research Area|Toxicology|Cell Health & Viability||Research Area|Toxicology|Environmental|Endocrine Disruption

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