β-Apooxytetracycline – 500 µg

Brand:
Cayman
CAS:
18751-99-0
Storage:
-20
UN-No:
Non-Hazardous - /

β-Apooxytetracycline is a potential impurity found in commercial preparations of oxytetracycline.{43923} β-Apooxytetracycline is a degradation product formed from oxytetracycline (Item No. 18076) via acid hydrolysis. It has a relative potency of 0.1 compared with oxytetracycline for inhibiting the growth of aerobic sludge bacteria, an MIC50 value of 32 mg/L for tetracycline-sensitive strains of Pseudomonas, and MIC50 values of greater than 32 mg/L for tetracycline-sensitive strains of Agrobacterium, Moraxella, and Bacillus, as well as tetracycline-resistant strains of E. coli.{43924} β-Apooxytetracycline (10 mg/kg) is toxic to rats, decreasing body weight, disrupting blood cell counts, and inducing hepatocyte necrosis.{43925}  

 

Available on backorder

SKU: 27099 - 500 µg Category:

Description

A potential impurity found in commercial preparations of oxytetracycline; has a relative potency of 0.1 compared with oxytetracycline for growth inhibition of aerobic sludge bacteria, an MIC50 value of 32 mg/L for tetracycline-sensitive strains of Pseudomonas, and MIC50 values of greater than 32 mg/L for tetracycline-sensitive strains of Agrobacterium, Moraxella, and Bacillus, as well as tetracycline-resistant strains of E. coli; toxic to rats, decreasing body weight, disrupting blood cell counts, and inducing hepatocyte necrosis


Formal name: (3S,4S,5R)-4-[(3R)-1,3-dihydro-4,5-dihydroxy-9-methyl-3-oxonaphtho[2,3-c]furan-1-yl]-3-(dimethylamino)-2,5-dihydroxy-6-oxo-1-cyclohexene-1-carboxamide

Synonyms:  β-Apo-Oxytetracycline|β-Apoterramycin

Molecular weight: 442.4

CAS: 18751-99-0

Purity: ≥98%

Formulation: A crystalline solid


Product Type|Biochemicals|Antibiotics|Tetracyclines||Product Type|Biochemicals|Pharmaceutical Impurities||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases