β-Endorphin (rat) – 500 µg

Brand:
Cayman
CAS:
309246-19-3
Storage:
-20
UN-No:
Non-Hazardous - /

β-Endorphin (β-EP) is an endogenous opioid neuropeptide with diverse biological activities.{37350} It is produced via piomelanocortin cleavage in the pituitary gland, hypothalamus, and in lymphocytes, then migrates to its sites of action which include plasma, gut, skin, placenta, cerebrospinal fluid, and cardiac tissues. β-EP induces concentration-dependent decreases in electrically stimulated contraction of the mouse vas deferens that can be reversed by the μ-opioid antagonist CTP and Δ-opioid antagonist ICI 174,864.{37351} In vivo, β-EP (5 μg, i.c.v.) slows gastrointestinal transit in mice. β-EP (0.5 or 5 μg, i.c.v.) stimulates food intake in rats for 4 to 6 hours, however, this effect is not prolonged with continuous infusion.{37352} It antagonizes the appetite-suppressive effects of α-melanocyte-stimulating hormone (α-MSH) for the first three days post administration. β-EP also reduces paralytic demyelination induced by the murine coronavirus MHV-JHM in immunocompetent, but not irradiated or immune-incompetent, mice and rats.{37353}  

 

Available on backorder

SKU: 24153 - 500 µg Category:

Description

An opioid neuropeptide; induces concentration-dependent decreases in electrically stimulated contraction of the mouse vas deferens; slows gastrointestinal transit in mice; stimulates food intake in rats for 4 to 6 hours (0.5 or 5 μg, i.c.v.); reduces paralytic demyelination induced by the murine coronavirus MHV-JHM in immunocompetent mice and rats


Formal name: L-tyrosylglycylglycyl-L-phenylalanyl-L-methionyl-L-threonyl-L-seryl-L-α-glutamyl-L-lysyl-L-seryl-L-glutaminyl-L-threonyl-L-prolyl-L-leucyl-L-valyl-L-threonyl-L-leucyl-L-phenylalanyl-L-lysyl-L-asparaginyl-L-alanyl-L-isoleucyl-L-isoleucyl-L-lysyl-L-asparaginyl-L-valyl-L-histidyl-L-lysyl-L-lysylglycyl-L-glutamine

Synonyms: 

Molecular weight: 3,466.00

CAS: 309246-19-3

Purity: ≥95%

Formulation: A lyophilized powder


Product Type|Biochemicals|Peptides|Neuropeptides||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors||Research Area|Neuroscience|Behavioral Neuroscience|Food Intake