A sesquiterpene with diverse biological activities; an agonist of the CB2 receptor (Ki = 155 nM) that inhibits forskolin-induced cAMP production in CHO-K1 cells expressing CB2 receptors (EC50 = 38 nM); an agonist of PPARα (EC50 = 9.58 µM in a reporter assay); reduces MPP+-induced production of ROS in and protects against cytotoxicity of SH-SY5Y cells at 1 and 2.5 µM; decreases the β-amyloid burden in the hippocampus and cerebral cortex and improves memory in an APP/PS1 transgenic mouse model of Alzheimer’s disease at 48 mg/kg; has anxiolytic-like and antidepressant-like activity in mice at 50 mg/kg

β-Caryophyllene – 100 mg

Brand:
Cayman
CAS:
87-44-5
Storage:
-20
UN-No:
- /

β-Caryophyllene (Item No. 21572) is a sesquiterpene that has been found in plants, including C. sativa, C. indica, and hemp, and has diverse biological activities, including lipid metabolic, antioxidant, anti-neuroinflammatory, anti-proliferative, and antinociceptive properties.{41453,42355,42358,42359,42356,42357} It is an agonist of the cannabinoid (CB) receptor CB2 (Ki = 155 nM) that inhibits cAMP production induced by forskolin in CHO-K1 cells expressing CB2 receptors (EC50 = 38 nM).{34255} β-Caryophyllene is also an agonist of peroxisome proliferator-activated receptor α (PPARα; EC50 = 9.58 µM in a reporter assay).{42355} β-Caryophyllene (1 and 2.5 µM) reduces the production of reactive oxygen species (ROS) in and protects against cytotoxicity of SH-SY5Y cells induced by 1-methyl-4-pheylpyridinium (MPP+).{42358} It also decreases the β-amyloid burden in the hippocampus and cerebral cortex and improves memory in an APP/PS1 transgenic mouse model of Alzheimer’s disease, decreasing the latency to find the platform in the Morris water maze during training and increasing the time spent in the target quadrant during testing when administered at a dose of 48 mg/kg per day.{42359} β-Caryophyllene (50 mg/kg) increases the number of entries into and the time spent in the open arms of the elevated plus maze and the time spent immobile in the forced swim test, indicating anxiolytic-like and antidepressant-like activity, effects that can be blocked by the CB2 receptor antagonist AM630 (Item No. 10006974).{42356}  

 

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Description

A sesquiterpene with diverse biological activities; an agonist of the CB2 receptor (Ki = 155 nM) that inhibits forskolin-induced cAMP production in CHO-K1 cells expressing CB2 receptors (EC50 = 38 nM); an agonist of PPARα (EC50 = 9.58 µM in a reporter assay); reduces MPP+-induced production of ROS in and protects against cytotoxicity of SH-SY5Y cells at 1 and 2.5 µM; decreases the β-amyloid burden in the hippocampus and cerebral cortex and improves memory in an APP/PS1 transgenic mouse model of Alzheimer’s disease at 48 mg/kg; has anxiolytic-like and antidepressant-like activity in mice at 50 mg/kg

Formal name: (1R,4E,9S)-4,11,11-trimethyl-8-methylene-bicyclo[7.2.0]undec-4-ene

Synonyms:  (−)-trans-Caryophyllene|(−)-β-Caryophyllene|NSC 11906

Molecular weight: 204.4

CAS: 87-44-5

Purity: ≥98%

Formulation: A neat oil

Application||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Natural Products|Phytocannabinoids||Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Immunology & Inflammation||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety||Research Area|Neuroscience|Behavioral Neuroscience|Depression||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Cannabinoid Research|Phytocannabinoids||Research Area|Neuroscience|Pain Research||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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