A phosphonic analog of ATP and agonist of P2X1 and P2X3 (EC50 = ~1 µM); ~1

α,β-Methyleneadenosine 5′-triphosphate (sodium salt) – 10 mg

Brand:
Cayman
CAS:
1343364-54-4
Storage:
-20
UN-No:
Non-Hazardous - /

α,β-Methyleneadenosine 5′-triphosphate (αβ-methylene ATP) is a phosphonic analog of ATP that is characterized by the replacement of the bridging oxygen atom between the α- and β-phosphate groups with methylene. It is an agonist of P2X purinoceptors P2X1 and P2X3 (EC50 = ~1 µM) and is ~1,000-fold less potent at P2X2, P2X receptors 4-7, and P2Y receptors.{27693,27688,27691,27687} Persistent activation of purinoceptors results in desensitization, resulting in an antagonist-like effect of αβ-methylene ATP.{27689} αβ-methylene ATP is used as a stable analog of ATP (Item No. 14498) to study the interaction of ATP with kinases and other proteins.{27690,27694} It weakly binds and inhibits adenylate cyclase in a calcium-dependent manner (Ki= ~0.5 mM).{27692,27695}  

 

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SKU: 10008956 - 10 mg Category:

Description

A phosphonic analog of ATP and agonist of P2X1 and P2X3 (EC50 = ~1 µM); ~1,000-fold less potent at P2X2, P2X receptors 4-7, and P2Y receptors; used as a stable analog of ATP to study the interaction of ATP with kinases and other proteins

Formal name: 5′-[hydrogen P-[[hydroxy(phosphonooxy)phosphinyl]methyl]phosphonate] adenosine, trisodium salt

Synonyms:  αβ-methylene ATP

Molecular weight: 571.2

CAS: 1343364-54-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Epigenetics, Transcription, & Translation|RNA, DNA, & Protein Synthesis

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