Can be formed by the dimerization of two molecules of α-trans-cinnamic acid; significantly blocks inflammatory pain while having little effect on neurogenic pain

α-Truxillic Acid – 100 mg

Brand:
Cayman
CAS:
490-20-0
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

α-Truxillic acid can be formed by the dimerization of two molecules of α-trans-cinnamic acid.{23826} It is related to incarvillateine, a natural antinociceptive compound derived from the Asian herb I. sinensis.{23827} α-Truxillic acid and some of its derivatives significantly block inflammatory pain while having little effect on neurogenic pain, as indicated by the formalin test in mice.{23827,23828} Related compounds, like SB-FI-26 (Item No. 14191), bind fatty acid binding protein 5 (FABP5).{22111} This may be related to pain suppression, since FABP5 acts as a transporter of the endocannabinoid anandamide.{17092} While certain derivatives of α-truxillic acid can directly activate peroxisome proliferator-activated receptor γ, α-truxillic acid has no such activity.{23829}  

 

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Description

Can be formed by the dimerization of two molecules of α-trans-cinnamic acid; significantly blocks inflammatory pain while having little effect on neurogenic pain, as indicated by the formalin test in mice

Formal name: (1α,2α,3β,4β)-2,4-diphenyl-1,3-cyclobutanedicarboxylic acid

Synonyms:  Gratissimic Acid

Molecular weight: 296.3

CAS: 490-20-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Immunology & Inflammation||Research Area|Neuroscience|Pain Research

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