Chemicals
Showing 301–450 of 41137 results
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(±)-5,7-Dimethyltocol is a form of tocopherol.{42661} It has similar antioxidant activity to α-tocol, but lower activity than γ-tocol, in antioxidant assays using menhaden oil or squalene as substrates. It also increases microviscosity of rat liver liposomes containing phosphatidylcholine (PC) by 70.6% when used at a molar ratio of 0.2 to PC.{42660} (±)-Dimethyltocol has been used as an internal standard for the quantification of 5,7-tocol, α- and γ-tocopherol, and α- and γ-tocopheryl quinone by HPLC.{42662} [Matreya, LLC. Catalog No. 1074]
Brand:CaymanSKU:27194 - 50 mgAvailable on backorder
(±)-8-Prenylnaringenin ((±)-8-PN) is a prenylflavonoid with potent estrogenic activity that can be isolated from hops.{29600,29598} It inhibits both isoforms of the human estrogen receptor (ER; IC50s = 57 and 68 nM for ERα and ERβ, respectively).{29601} (±)-8-PN is effective in vivo, suppressing loss of bone mineral density in ovariectomized rats and blocking changes in tail skin temperature in a rat model of postmenopausal hot flashes.{29599}
Brand:CaymanSKU:-Available on backorder
(±)-8-Prenylnaringenin ((±)-8-PN) is a prenylflavonoid with potent estrogenic activity that can be isolated from hops.{29600,29598} It inhibits both isoforms of the human estrogen receptor (ER; IC50s = 57 and 68 nM for ERα and ERβ, respectively).{29601} (±)-8-PN is effective in vivo, suppressing loss of bone mineral density in ovariectomized rats and blocking changes in tail skin temperature in a rat model of postmenopausal hot flashes.{29599}
Brand:CaymanSKU:-Available on backorder
(±)-8-Prenylnaringenin ((±)-8-PN) is a prenylflavonoid with potent estrogenic activity that can be isolated from hops.{29600,29598} It inhibits both isoforms of the human estrogen receptor (ER; IC50s = 57 and 68 nM for ERα and ERβ, respectively).{29601} (±)-8-PN is effective in vivo, suppressing loss of bone mineral density in ovariectomized rats and blocking changes in tail skin temperature in a rat model of postmenopausal hot flashes.{29599}
Brand:CaymanSKU:-Available on backorder
(±)-8-Prenylnaringenin ((±)-8-PN) is a prenylflavonoid with potent estrogenic activity that can be isolated from hops.{29600,29598} It inhibits both isoforms of the human estrogen receptor (ER; IC50s = 57 and 68 nM for ERα and ERβ, respectively).{29601} (±)-8-PN is effective in vivo, suppressing loss of bone mineral density in ovariectomized rats and blocking changes in tail skin temperature in a rat model of postmenopausal hot flashes.{29599}
Brand:CaymanSKU:-Available on backorder
Alliin is a cysteine sulfoxide constituent of garlic that is converted by alliinase to allicin, which imparts its pungent aroma and flavor.{21894,21891} Alliin exhibits anti-cancer, anti-microbial, anti-hypertensive, cardioprotective, and anti-oxidant activities.{21892,21895,21896} It has been shown to inhibit squalene monooxygenase, a rate-limiting step in the downstream pathway of cholesterol biosynthesis, with an IC50 value of 120 μM.{21893,16971}
Brand:CaymanSKU:- Alliin is a cysteine sulfoxide constituent of garlic that is converted by alliinase to allicin, which imparts its pungent aroma and flavor.{21894,21891} Alliin exhibits anti-cancer, anti-microbial, anti-hypertensive, cardioprotective, and anti-oxidant activities.{21892,21895,21896} It has been shown to inhibit squalene monooxygenase, a rate-limiting step in the downstream pathway of cholesterol biosynthesis, with an IC50 value of 120 μM.{21893,16971}
Brand:CaymanSKU:- Alliin is a cysteine sulfoxide constituent of garlic that is converted by alliinase to allicin, which imparts its pungent aroma and flavor.{21894,21891} Alliin exhibits anti-cancer, anti-microbial, anti-hypertensive, cardioprotective, and anti-oxidant activities.{21892,21895,21896} It has been shown to inhibit squalene monooxygenase, a rate-limiting step in the downstream pathway of cholesterol biosynthesis, with an IC50 value of 120 μM.{21893,16971}
Brand:CaymanSKU:-
(±)-Anatoxin A is a bicyclic amine isolated from the blue-green alga A. aquae that displays high affinity for nicotinic acetylcholine receptors (Kd = 0.1-0.2 μM).{23331} It binds α4β2- and α7-type nicotinic receptors with Ki values of 1.3 nM and 1.8 μM, respectively, and stimulates [3H]-dopamine release from striatal synaptosomes with an EC50 value of 134 nM.{23332}
Brand:CaymanSKU:-
(±)-Asenapine is an atypical antipsychotic.{41915,41916} It binds to dopamine D1-4, α-adrenergic, and histamine receptors (Kis = 0.42-1.45, 0.32-1.26, and 1-6.17 nM, respectively), as well as the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT5A, 5-HT6, and 5-HT7 (Kis = 0.03-3.98 nM).{41916} (±)-Asenapine inhibits the suppression of neuron firing induced by the 5-HT2A, dopamine D2, and α2-adrenergic receptor agonists 2,5-dimethoxy-4-iodoamphetamine (DOI), apomorphine, and clonidine (Item No. 15949), respectively, in rat brain (ED50s = 75, 40, and 85 μg/kg, respectively).{41915} In vivo, (±)-asenapine (0.05-0.2 mg/kg, s.c.) increases extracellular dopamine levels in the medial prefrontal cortex (mPFC), nucleus accumbens (NAc), and lateral striatum and suppresses the conditioned avoidance response in rats.{41917} It prevents acute and chronic phencyclidine-induced deficits in cued reversal learning in rats when administered at a dose of 0.075 mg/kg.{41918} Formulations containing asenapine have been used in the treatment of schizophrenia and bipolar I disorder.
Brand:CaymanSKU:9000496 - 1 mgAvailable on backorder
(±)-Asenapine is an atypical antipsychotic.{41915,41916} It binds to dopamine D1-4, α-adrenergic, and histamine receptors (Kis = 0.42-1.45, 0.32-1.26, and 1-6.17 nM, respectively), as well as the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT5A, 5-HT6, and 5-HT7 (Kis = 0.03-3.98 nM).{41916} (±)-Asenapine inhibits the suppression of neuron firing induced by the 5-HT2A, dopamine D2, and α2-adrenergic receptor agonists 2,5-dimethoxy-4-iodoamphetamine (DOI), apomorphine, and clonidine (Item No. 15949), respectively, in rat brain (ED50s = 75, 40, and 85 μg/kg, respectively).{41915} In vivo, (±)-asenapine (0.05-0.2 mg/kg, s.c.) increases extracellular dopamine levels in the medial prefrontal cortex (mPFC), nucleus accumbens (NAc), and lateral striatum and suppresses the conditioned avoidance response in rats.{41917} It prevents acute and chronic phencyclidine-induced deficits in cued reversal learning in rats when administered at a dose of 0.075 mg/kg.{41918} Formulations containing asenapine have been used in the treatment of schizophrenia and bipolar I disorder.
Brand:CaymanSKU:9000496 - 10 mgAvailable on backorder
(±)-Asenapine is an atypical antipsychotic.{41915,41916} It binds to dopamine D1-4, α-adrenergic, and histamine receptors (Kis = 0.42-1.45, 0.32-1.26, and 1-6.17 nM, respectively), as well as the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT5A, 5-HT6, and 5-HT7 (Kis = 0.03-3.98 nM).{41916} (±)-Asenapine inhibits the suppression of neuron firing induced by the 5-HT2A, dopamine D2, and α2-adrenergic receptor agonists 2,5-dimethoxy-4-iodoamphetamine (DOI), apomorphine, and clonidine (Item No. 15949), respectively, in rat brain (ED50s = 75, 40, and 85 μg/kg, respectively).{41915} In vivo, (±)-asenapine (0.05-0.2 mg/kg, s.c.) increases extracellular dopamine levels in the medial prefrontal cortex (mPFC), nucleus accumbens (NAc), and lateral striatum and suppresses the conditioned avoidance response in rats.{41917} It prevents acute and chronic phencyclidine-induced deficits in cued reversal learning in rats when administered at a dose of 0.075 mg/kg.{41918} Formulations containing asenapine have been used in the treatment of schizophrenia and bipolar I disorder.
Brand:CaymanSKU:9000496 - 5 mgAvailable on backorder
(±)-Asenapine-13C-d3 is intended for use as an internal standard for the quantification of (±)-asenapine (Item No. 9000496) by GC- or LC-MS. (±)-Asenapine is an atypical antipsychotic.{41915,41916} It binds to dopamine D1-4, α-adrenergic, and histamine receptors (Kis = 0.42-1.45, 0.32-1.26, and 1-6.17 nM, respectively), as well as the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT5A, 5-HT6, and 5-HT7 (Kis = 0.03-3.98 nM).{41916} (±)-Asenapine inhibits the suppression of neuron firing induced by the 5-HT2A, dopamine D2, and α2-adrenergic receptor agonists 2,5-dimethoxy-4-iodoamphetamine (DOI), apomorphine, and clonidine (Item No. 15949), respectively, in rat brain (ED50s = 75, 40, and 85 μg/kg, respectively).{41915} In vivo, (±)-asenapine (0.05-0.2 mg/kg, s.c.) increases extracellular dopamine levels in the medial prefrontal cortex (mPFC), nucleus accumbens (NAc), and lateral striatum and suppresses the conditioned avoidance response in rats.{41917} It prevents acute and chronic phencyclidine-induced deficits in cued reversal learning in rats when administered at a dose of 0.075 mg/kg.{41918} Formulations containing asenapine have been used in the treatment of schizophrenia and bipolar I disorder.
Brand:CaymanSKU:31980 - 1 mgAvailable on backorder
(±)-Atenolol is an antagonist of the β1-adrenergic receptor (β1-AR; Ki = 1.14 µM).{28226} It is selective for β1-ARs over β2-ARs (Ki = 48.7 µM). (±)-Atenolol (200 mg/kg per day) delays the onset of hypertension in spontaneously hypertensive rats.{49503} Formulations containing atenolol have been used in the treatment of high blood pressure.
Brand:CaymanSKU:-Out of stock
(±)-Atenolol is an antagonist of the β1-adrenergic receptor (β1-AR; Ki = 1.14 µM).{28226} It is selective for β1-ARs over β2-ARs (Ki = 48.7 µM). (±)-Atenolol (200 mg/kg per day) delays the onset of hypertension in spontaneously hypertensive rats.{49503} Formulations containing atenolol have been used in the treatment of high blood pressure.
Brand:CaymanSKU:-Out of stock
(±)-Atenolol is an antagonist of the β1-adrenergic receptor (β1-AR; Ki = 1.14 µM).{28226} It is selective for β1-ARs over β2-ARs (Ki = 48.7 µM). (±)-Atenolol (200 mg/kg per day) delays the onset of hypertension in spontaneously hypertensive rats.{49503} Formulations containing atenolol have been used in the treatment of high blood pressure.
Brand:CaymanSKU:-Out of stock
(±)-Atenolol is an antagonist of the β1-adrenergic receptor (β1-AR; Ki = 1.14 µM).{28226} It is selective for β1-ARs over β2-ARs (Ki = 48.7 µM). (±)-Atenolol (200 mg/kg per day) delays the onset of hypertension in spontaneously hypertensive rats.{49503} Formulations containing atenolol have been used in the treatment of high blood pressure.
Brand:CaymanSKU:-Out of stock
(±)-Atenolol-d7 is intended for use as an internal standard for the quantification of (±)-atenolol (Item No. 17250) by GC- or LC-MS. (±)-Atenolol is an antagonist of the β1-adrenergic receptor (β1-AR; Ki = 1.14 µM).{28226} It is selective for β1-ARs over β2-ARs (Ki = 48.7 µM). (±)-Atenolol (200 mg/kg per day) delays the onset of hypertension in spontaneously hypertensive rats.{49503} Formulations containing atenolol have been used in the treatment of high blood pressure.
Brand:CaymanSKU:30018 - 1 mgAvailable on backorder
(±)-Atenolol-d7 is intended for use as an internal standard for the quantification of (±)-atenolol (Item No. 17250) by GC- or LC-MS. (±)-Atenolol is an antagonist of the β1-adrenergic receptor (β1-AR; Ki = 1.14 µM).{28226} It is selective for β1-ARs over β2-ARs (Ki = 48.7 µM). (±)-Atenolol (200 mg/kg per day) delays the onset of hypertension in spontaneously hypertensive rats.{49503} Formulations containing atenolol have been used in the treatment of high blood pressure.
Brand:CaymanSKU:30018 - 10 mgAvailable on backorder
(±)-Atenolol-d7 is intended for use as an internal standard for the quantification of (±)-atenolol (Item No. 17250) by GC- or LC-MS. (±)-Atenolol is an antagonist of the β1-adrenergic receptor (β1-AR; Ki = 1.14 µM).{28226} It is selective for β1-ARs over β2-ARs (Ki = 48.7 µM). (±)-Atenolol (200 mg/kg per day) delays the onset of hypertension in spontaneously hypertensive rats.{49503} Formulations containing atenolol have been used in the treatment of high blood pressure.
Brand:CaymanSKU:30018 - 25 mgAvailable on backorder
(±)-Atenolol-d7 is intended for use as an internal standard for the quantification of (±)-atenolol (Item No. 17250) by GC- or LC-MS. (±)-Atenolol is an antagonist of the β1-adrenergic receptor (β1-AR; Ki = 1.14 µM).{28226} It is selective for β1-ARs over β2-ARs (Ki = 48.7 µM). (±)-Atenolol (200 mg/kg per day) delays the onset of hypertension in spontaneously hypertensive rats.{49503} Formulations containing atenolol have been used in the treatment of high blood pressure.
Brand:CaymanSKU:30018 - 5 mgAvailable on backorder
(±)-Baclofen is a GABAB receptor agonist (IC50 = 180 nM).{46227} It induces norepinephrine release from isolated rat atria (IC50 = 4.5 μM). (±)-Baclofen (10 mg/kg) increases muscle rigidity in spastic mice.{30075} It inhibits the norepinephrine-induced group II flexor reflex in anesthetized rats.{30078} (±)-Baclofen also reduces cocaine-induced hyperlocomotion in rats and binge-like ethanol intake in mice.{30076,30077} Formulations containing baclofen have been used to treat muscle spasms caused by multiple sclerosis and spinal cord injury.
Brand:CaymanSKU:-Available on backorder
(±)-Baclofen is a GABAB receptor agonist (IC50 = 180 nM).{46227} It induces norepinephrine release from isolated rat atria (IC50 = 4.5 μM). (±)-Baclofen (10 mg/kg) increases muscle rigidity in spastic mice.{30075} It inhibits the norepinephrine-induced group II flexor reflex in anesthetized rats.{30078} (±)-Baclofen also reduces cocaine-induced hyperlocomotion in rats and binge-like ethanol intake in mice.{30076,30077} Formulations containing baclofen have been used to treat muscle spasms caused by multiple sclerosis and spinal cord injury.
Brand:CaymanSKU:-Available on backorder
(±)-Baclofen (Item No. 27326) is an analytical reference standard categorized as a gabapentinoid and a nootropic.{53818,53843} (±)-Baclofen also has analgesic, skeletal muscle relaxant, and sedative properties.{25864,46351} Formulations containing (±)-baclofen have been used in the treatment of spasticity in patients with multiple sclerosis or spinal cord injuries. This product is intended for use in analytical forensic applications. This product is also available as a general research tool (Item No. 18600).
Brand:CaymanSKU:27326 - 10 mgAvailable on backorder
(±)-Baclofen is a GABAB receptor agonist (IC50 = 180 nM).{46227} It induces norepinephrine release from isolated rat atria (IC50 = 4.5 μM). (±)-Baclofen (10 mg/kg) increases muscle rigidity in spastic mice.{30075} It inhibits the norepinephrine-induced group II flexor reflex in anesthetized rats.{30078} (±)-Baclofen also reduces cocaine-induced hyperlocomotion in rats and binge-like ethanol intake in mice.{30076,30077} Formulations containing baclofen have been used to treat muscle spasms caused by multiple sclerosis and spinal cord injury.
Brand:CaymanSKU:-Available on backorder
(±)-Baclofen is a GABAB receptor agonist (IC50 = 180 nM).{46227} It induces norepinephrine release from isolated rat atria (IC50 = 4.5 μM). (±)-Baclofen (10 mg/kg) increases muscle rigidity in spastic mice.{30075} It inhibits the norepinephrine-induced group II flexor reflex in anesthetized rats.{30078} (±)-Baclofen also reduces cocaine-induced hyperlocomotion in rats and binge-like ethanol intake in mice.{30076,30077} Formulations containing baclofen have been used to treat muscle spasms caused by multiple sclerosis and spinal cord injury.
Brand:CaymanSKU:-Available on backorder
(±)-Baclofen (Item No. 27326) is an analytical reference standard categorized as a gabapentinoid and a nootropic.{53818,53843} (±)-Baclofen also has analgesic, skeletal muscle relaxant, and sedative properties.{25864,46351} Formulations containing (±)-baclofen have been used in the treatment of spasticity in patients with multiple sclerosis or spinal cord injuries. This product is intended for use in analytical forensic applications. This product is also available as a general research tool (Item No. 18600).
Brand:CaymanSKU:27326 - 50 mgAvailable on backorder
(±)-Baclofen-d4 is intended for use as an internal standard for the quantification of (±)-baclofen (Item No. 18600) by GC- or LC-MS. (±)-Baclofen is a GABAB receptor agonist (IC50 = 180 nM).{46227} It induces norepinephrine release from isolated rat atria (IC50 = 4.5 μM). (±)-Baclofen (10 mg/kg) increases muscle rigidity in spastic mice.{30075} It inhibits the norepinephrine-induced group II flexor reflex in anesthetized rats.{30078} (±)-Baclofen also reduces cocaine-induced hyperlocomotion in rats and binge-like ethanol intake in mice.{30076,30077} Formulations containing baclofen have been used to treat muscle spasms caused by multiple sclerosis and spinal cord injury.
Brand:CaymanSKU:27811 - 1 mgAvailable on backorder
(±)-BAY 41-4109 is a heteroaryldihydropyrimidine with antiviral activity.{46251} It inhibits hepatitis B virus (HBV) replication in HepG2.2.15 cells (IC50 = 202 nM) without affecting cell growth. (±)-BAY 41-4109 (25 mg/kg) reduces viral replication and viral load in a humanized mouse model of HBV infection.
Brand:CaymanSKU:26907 - 10 mgAvailable on backorder
(±)-BAY 41-4109 is a heteroaryldihydropyrimidine with antiviral activity.{46251} It inhibits hepatitis B virus (HBV) replication in HepG2.2.15 cells (IC50 = 202 nM) without affecting cell growth. (±)-BAY 41-4109 (25 mg/kg) reduces viral replication and viral load in a humanized mouse model of HBV infection.
Brand:CaymanSKU:26907 - 25 mgAvailable on backorder
(±)-BAY 41-4109 is a heteroaryldihydropyrimidine with antiviral activity.{46251} It inhibits hepatitis B virus (HBV) replication in HepG2.2.15 cells (IC50 = 202 nM) without affecting cell growth. (±)-BAY 41-4109 (25 mg/kg) reduces viral replication and viral load in a humanized mouse model of HBV infection.
Brand:CaymanSKU:26907 - 5 mgAvailable on backorder
(±)-BAY 41-4109 is a heteroaryldihydropyrimidine with antiviral activity.{46251} It inhibits hepatitis B virus (HBV) replication in HepG2.2.15 cells (IC50 = 202 nM) without affecting cell growth. (±)-BAY 41-4109 (25 mg/kg) reduces viral replication and viral load in a humanized mouse model of HBV infection.
Brand:CaymanSKU:26907 - 50 mgAvailable on backorder
(±)-BAY-K-8644 is a racemic mixture composed of two optical isomers, (R)-(+)-BAY-K-8644 (Item No. 15263) and (S)-(−)-BAY-K-8644 (Item No. 19988). (±)-BAY-K-8644 has similar effects as (S)-(−)-BAY-K-8644, which activates voltage-sensitive L-type calcium channels.{37139,37140} (±)-BAY-K-8644 and (S)-(−)-BAY-K-8644 also demonstrate vasoconstrictive and positive inotropic effects in vivo as well as behavioral effects, including deficits to motor function.{24673,24674}
Brand:CaymanSKU:21479 -Out of stock
(±)-BAY-K-8644 is a racemic mixture composed of two optical isomers, (R)-(+)-BAY-K-8644 (Item No. 15263) and (S)-(−)-BAY-K-8644 (Item No. 19988). (±)-BAY-K-8644 has similar effects as (S)-(−)-BAY-K-8644, which activates voltage-sensitive L-type calcium channels.{37139,37140} (±)-BAY-K-8644 and (S)-(−)-BAY-K-8644 also demonstrate vasoconstrictive and positive inotropic effects in vivo as well as behavioral effects, including deficits to motor function.{24673,24674}
Brand:CaymanSKU:21479 -Out of stock
(±)-BAY-K-8644 is a racemic mixture composed of two optical isomers, (R)-(+)-BAY-K-8644 (Item No. 15263) and (S)-(−)-BAY-K-8644 (Item No. 19988). (±)-BAY-K-8644 has similar effects as (S)-(−)-BAY-K-8644, which activates voltage-sensitive L-type calcium channels.{37139,37140} (±)-BAY-K-8644 and (S)-(−)-BAY-K-8644 also demonstrate vasoconstrictive and positive inotropic effects in vivo as well as behavioral effects, including deficits to motor function.{24673,24674}
Brand:CaymanSKU:21479 -Out of stock
(±)-BAY-K-8644 is a racemic mixture composed of two optical isomers, (R)-(+)-BAY-K-8644 (Item No. 15263) and (S)-(−)-BAY-K-8644 (Item No. 19988). (±)-BAY-K-8644 has similar effects as (S)-(−)-BAY-K-8644, which activates voltage-sensitive L-type calcium channels.{37139,37140} (±)-BAY-K-8644 and (S)-(−)-BAY-K-8644 also demonstrate vasoconstrictive and positive inotropic effects in vivo as well as behavioral effects, including deficits to motor function.{24673,24674}
Brand:CaymanSKU:21479 -Out of stock
(±)-Blebbistatin is a racemic mixture of (–)-blebbistatin (Item No. 13013) and (+)-blebbistatin (Item No. 13165), the active and inactive forms, respectively. (–)-Blebbistatin is a selective cell-permeable inhibitor of non-muscle myosin II ATPases.{16452,17037} (–)-Blebbistatin rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50s = 0.5-5 µM), while poorly inhibiting smooth muscle myosin (IC50 = 8 µM).{17036} Through these effects, (–)-blebbistatin blocks apoptosis-related bleb formation, directed cell migration, and cytokinesis in vertebrate cells. However, prolonged exposure to blue light (450-490 nm) results in degradation of blebbistatin to an inactive product via cytotoxic intermediates, which may be problematic for its use in fluorescent live cell imaging applications.{17038,24037} (S)-nitro-Blebbistatin (Item No. 13891) and (R)-nitro-blebbistatin (Item No. 9001935) are more stable forms of (–)-blebbistatin and (+)-blebbistatin, respectively. The addition of a nitro group stabilizes the molecules to circumvent their degradation by prolonged blue light exposure.{16725} (S)-nitro-Blebbistatin and (R)-nitro-blebbistatin have the same stereochemistry of the active and inactive enantiomers, respectively.
Brand:CaymanSKU:- (±)-Blebbistatin is a racemic mixture of (–)-blebbistatin (Item No. 13013) and (+)-blebbistatin (Item No. 13165), the active and inactive forms, respectively. (–)-Blebbistatin is a selective cell-permeable inhibitor of non-muscle myosin II ATPases.{16452,17037} (–)-Blebbistatin rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50s = 0.5-5 µM), while poorly inhibiting smooth muscle myosin (IC50 = 8 µM).{17036} Through these effects, (–)-blebbistatin blocks apoptosis-related bleb formation, directed cell migration, and cytokinesis in vertebrate cells. However, prolonged exposure to blue light (450-490 nm) results in degradation of blebbistatin to an inactive product via cytotoxic intermediates, which may be problematic for its use in fluorescent live cell imaging applications.{17038,24037} (S)-nitro-Blebbistatin (Item No. 13891) and (R)-nitro-blebbistatin (Item No. 9001935) are more stable forms of (–)-blebbistatin and (+)-blebbistatin, respectively. The addition of a nitro group stabilizes the molecules to circumvent their degradation by prolonged blue light exposure.{16725} (S)-nitro-Blebbistatin and (R)-nitro-blebbistatin have the same stereochemistry of the active and inactive enantiomers, respectively.
Brand:CaymanSKU:- (±)-Blebbistatin is a racemic mixture of (–)-blebbistatin (Item No. 13013) and (+)-blebbistatin (Item No. 13165), the active and inactive forms, respectively. (–)-Blebbistatin is a selective cell-permeable inhibitor of non-muscle myosin II ATPases.{16452,17037} (–)-Blebbistatin rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50s = 0.5-5 µM), while poorly inhibiting smooth muscle myosin (IC50 = 8 µM).{17036} Through these effects, (–)-blebbistatin blocks apoptosis-related bleb formation, directed cell migration, and cytokinesis in vertebrate cells. However, prolonged exposure to blue light (450-490 nm) results in degradation of blebbistatin to an inactive product via cytotoxic intermediates, which may be problematic for its use in fluorescent live cell imaging applications.{17038,24037} (S)-nitro-Blebbistatin (Item No. 13891) and (R)-nitro-blebbistatin (Item No. 9001935) are more stable forms of (–)-blebbistatin and (+)-blebbistatin, respectively. The addition of a nitro group stabilizes the molecules to circumvent their degradation by prolonged blue light exposure.{16725} (S)-nitro-Blebbistatin and (R)-nitro-blebbistatin have the same stereochemistry of the active and inactive enantiomers, respectively.
Brand:CaymanSKU:- (±)-Blebbistatin is a racemic mixture of (–)-blebbistatin (Item No. 13013) and (+)-blebbistatin (Item No. 13165), the active and inactive forms, respectively. (–)-Blebbistatin is a selective cell-permeable inhibitor of non-muscle myosin II ATPases.{16452,17037} (–)-Blebbistatin rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50s = 0.5-5 µM), while poorly inhibiting smooth muscle myosin (IC50 = 8 µM).{17036} Through these effects, (–)-blebbistatin blocks apoptosis-related bleb formation, directed cell migration, and cytokinesis in vertebrate cells. However, prolonged exposure to blue light (450-490 nm) results in degradation of blebbistatin to an inactive product via cytotoxic intermediates, which may be problematic for its use in fluorescent live cell imaging applications.{17038,24037} (S)-nitro-Blebbistatin (Item No. 13891) and (R)-nitro-blebbistatin (Item No. 9001935) are more stable forms of (–)-blebbistatin and (+)-blebbistatin, respectively. The addition of a nitro group stabilizes the molecules to circumvent their degradation by prolonged blue light exposure.{16725} (S)-nitro-Blebbistatin and (R)-nitro-blebbistatin have the same stereochemistry of the active and inactive enantiomers, respectively.
Brand:CaymanSKU:-
(±)-Bornyl acetate is a racemic mixture of the acetate form of the monoterpene alcohol borneol (Item Nos. 23467 | 23468) that has been found in P. silvestris.{46820,46821} (±)-Bornyl acetate induces an electroantennogram (EAG) response in isolated P. americana (American cockroach) antennae from both male and female cockroaches that is similar to the response induced by sex pheromones.{46822} It also induces hydrogen peroxide production and apoptosis in M. polymorpha plant cells.{46823}
Brand:CaymanSKU:29617 - 10 gAvailable on backorder
(±)-Bornyl acetate is a racemic mixture of the acetate form of the monoterpene alcohol borneol (Item Nos. 23467 | 23468) that has been found in P. silvestris.{46820,46821} (±)-Bornyl acetate induces an electroantennogram (EAG) response in isolated P. americana (American cockroach) antennae from both male and female cockroaches that is similar to the response induced by sex pheromones.{46822} It also induces hydrogen peroxide production and apoptosis in M. polymorpha plant cells.{46823}
Brand:CaymanSKU:29617 - 25 gAvailable on backorder
(±)-Bornyl acetate is a racemic mixture of the acetate form of the monoterpene alcohol borneol (Item Nos. 23467 | 23468) that has been found in P. silvestris.{46820,46821} (±)-Bornyl acetate induces an electroantennogram (EAG) response in isolated P. americana (American cockroach) antennae from both male and female cockroaches that is similar to the response induced by sex pheromones.{46822} It also induces hydrogen peroxide production and apoptosis in M. polymorpha plant cells.{46823}
Brand:CaymanSKU:29617 - 50 gAvailable on backorder
(±)-Butylphthalide is the racemic form of (–)-butylphthalide, a phthalide that has been found in A. graveolens, that has diverse biological activities, including antiplatelet, neuroprotective, and antioxidative properties.{46914,46915} (±)-Butylphthalide inhibits ADP-, thrombin-, and arachidonic acid-induced aggregation of isolated washed human platelets when used at concentrations of 30, 100, and 300 µM, respectively.{46915} It inhibits the phosphorylation of calcium-dependent cytosolic phospholipase A2 (cPLA2) induced by ADP and reduces thromboxane A2 (TXA2) production induced by thrombin or collagen in isolated washed human platelets at concentrations ranging from 30 to 300 µM. (±)-Butylphthalide also inhibits caspase-3 activation, decreases reactive oxygen species (ROS) production and JNK phosphorylation, and prevents cell death induced by serum deprivation in primary mouse cortical neurons when used at a concentration of 10 µM. It reduces infarct volume, as well as caspase-3 activation and JNK phosphorylation in the peri-infarct region, in a mouse model of right middle cerebral artery occlusion (MCAO) with bilateral common carotid artery ligation when administered at a dose of 100 mg/kg one hour following occlusion.
Brand:CaymanSKU:30284 - 1 gAvailable on backorder
(±)-Butylphthalide is the racemic form of (–)-butylphthalide, a phthalide that has been found in A. graveolens, that has diverse biological activities, including antiplatelet, neuroprotective, and antioxidative properties.{46914,46915} (±)-Butylphthalide inhibits ADP-, thrombin-, and arachidonic acid-induced aggregation of isolated washed human platelets when used at concentrations of 30, 100, and 300 µM, respectively.{46915} It inhibits the phosphorylation of calcium-dependent cytosolic phospholipase A2 (cPLA2) induced by ADP and reduces thromboxane A2 (TXA2) production induced by thrombin or collagen in isolated washed human platelets at concentrations ranging from 30 to 300 µM. (±)-Butylphthalide also inhibits caspase-3 activation, decreases reactive oxygen species (ROS) production and JNK phosphorylation, and prevents cell death induced by serum deprivation in primary mouse cortical neurons when used at a concentration of 10 µM. It reduces infarct volume, as well as caspase-3 activation and JNK phosphorylation in the peri-infarct region, in a mouse model of right middle cerebral artery occlusion (MCAO) with bilateral common carotid artery ligation when administered at a dose of 100 mg/kg one hour following occlusion.
Brand:CaymanSKU:30284 - 5 gAvailable on backorder
(±)-Butylphthalide is the racemic form of (–)-butylphthalide, a phthalide that has been found in A. graveolens, that has diverse biological activities, including antiplatelet, neuroprotective, and antioxidative properties.{46914,46915} (±)-Butylphthalide inhibits ADP-, thrombin-, and arachidonic acid-induced aggregation of isolated washed human platelets when used at concentrations of 30, 100, and 300 µM, respectively.{46915} It inhibits the phosphorylation of calcium-dependent cytosolic phospholipase A2 (cPLA2) induced by ADP and reduces thromboxane A2 (TXA2) production induced by thrombin or collagen in isolated washed human platelets at concentrations ranging from 30 to 300 µM. (±)-Butylphthalide also inhibits caspase-3 activation, decreases reactive oxygen species (ROS) production and JNK phosphorylation, and prevents cell death induced by serum deprivation in primary mouse cortical neurons when used at a concentration of 10 µM. It reduces infarct volume, as well as caspase-3 activation and JNK phosphorylation in the peri-infarct region, in a mouse model of right middle cerebral artery occlusion (MCAO) with bilateral common carotid artery ligation when administered at a dose of 100 mg/kg one hour following occlusion.
Brand:CaymanSKU:30284 - 500 mgAvailable on backorder
Inhibition of fatty acid synthase (FASN) by the irreversible inhibitor cerulenin leads to cytotoxicity and apoptosis in human cancer cell lines.{11992} (±)-C75 is a stable inhibitor of FASN that leads to profound weight loss and feeding inhibition in both high-fat diet wild type obese and leptin-deficient ob/ob mice.{7659} (±)-C75 is also cytotoxic to many human cancer cell lines, an effect believed to be mediated by the accumulation of malonyl-coenzyme A in cells with an upregulated FASN pathway.{11993}
Brand:CaymanSKU:10005270 - 1 mgAvailable on backorder
Inhibition of fatty acid synthase (FASN) by the irreversible inhibitor cerulenin leads to cytotoxicity and apoptosis in human cancer cell lines.{11992} (±)-C75 is a stable inhibitor of FASN that leads to profound weight loss and feeding inhibition in both high-fat diet wild type obese and leptin-deficient ob/ob mice.{7659} (±)-C75 is also cytotoxic to many human cancer cell lines, an effect believed to be mediated by the accumulation of malonyl-coenzyme A in cells with an upregulated FASN pathway.{11993}
Brand:CaymanSKU:10005270 - 10 mgAvailable on backorder
Inhibition of fatty acid synthase (FASN) by the irreversible inhibitor cerulenin leads to cytotoxicity and apoptosis in human cancer cell lines.{11992} (±)-C75 is a stable inhibitor of FASN that leads to profound weight loss and feeding inhibition in both high-fat diet wild type obese and leptin-deficient ob/ob mice.{7659} (±)-C75 is also cytotoxic to many human cancer cell lines, an effect believed to be mediated by the accumulation of malonyl-coenzyme A in cells with an upregulated FASN pathway.{11993}
Brand:CaymanSKU:10005270 - 5 mgAvailable on backorder
(±)-Camphene is a bicyclic monoterpene found in a variety of plants, including Cannabis, that has diverse biological activities, including antiproliferative, pro-apoptotic, hypolipidemic, and insecticidal properties.{42303,47119,47120,47121,47122} It inhibits proliferation of B16/F10-Nex2 mouse melanoma, as well as human A2058 melanoma, HL-60 leukemia, U87MG glioblastoma, and SK-BR-3 breast cancer cells (IC50s = 71.2, 35.2, 27, 55.4, and 34.7 μg/ml, respectively).{47119} (±)-Camphene (70 μg/ml) increases caspase-3 activity and induces apoptosis and endoplasmic reticulum stress in B16/F10-Nex2 cells. It lowers plasma levels of total cholesterol, LDL cholesterol, and triglycerides (TGs) in a Triton WR-1339-induced rat model of hyperlipidemia when administered at a dose of 1.5 μg/g.{47120} Dietary administration of (±)-camphene (0.2%) also inhibits hepatic steatosis and insulin resistance in a mouse model of high-fat diet-induced obesity.{47121} It also has larvicidal activity against third instar H. armigera larvae (LC50 = 10.64 μg/ml) and ovicidal activity against H. armigera eggs (EC50 = 35.39 μg/ml).{47122} Formulations containing (±)-camphene have been used as perfume and food additives.
Brand:CaymanSKU:24478 - 100 mgAvailable on backorder
(±)-Cannabichromene (Item No. 26252) is an analytical reference standard categorized as a phytocannabinoid.{24995} (±)-Cannabichromene is a non-psychoactive phytocannabinoid. (±)-Cannabichromene is regulated as a Schedule I compound in the United States. This product is intended for research and forensic applications. This item has been tested to contain ≤0.3% Δ9-THC on a dry weight basis meeting the 2018 Farm Bill requirements to be a non-controlled substance in the U.S.
Brand:CaymanSKU:26252 - 10 mgAvailable on backorder
(±)-Cannabichromene (Item No. 26252) is an analytical reference standard categorized as a phytocannabinoid.{24995} (±)-Cannabichromene is a non-psychoactive phytocannabinoid. (±)-Cannabichromene is regulated as a Schedule I compound in the United States. This product is intended for research and forensic applications. This item has been tested to contain ≤0.3% Δ9-THC on a dry weight basis meeting the 2018 Farm Bill requirements to be a non-controlled substance in the U.S.
Brand:CaymanSKU:26252 - 5 mgAvailable on backorder
(±)-Cannabichromene (Item No. 26252) is an analytical reference standard categorized as a phytocannabinoid.{24995} (±)-Cannabichromene is a non-psychoactive phytocannabinoid. (±)-Cannabichromene is regulated as a Schedule I compound in the United States. This product is intended for research and forensic applications. This item has been tested to contain ≤0.3% Δ9-THC on a dry weight basis meeting the 2018 Farm Bill requirements to be a non-controlled substance in the U.S.
Brand:CaymanSKU:26252 - 50 mgAvailable on backorder
(±)-cis-3-methyl Norfentanyl (Item No. 22617) is an analytical reference standard categorized as an opioid. It is a metabolite of (±)-cis-3-methyl fentanyl (Item Nos. 21676 | 9002747). The physiological and toxicological properties of (±)-cis-3-methyl-norfentanyl are not known. This product is intended for research and forensic applications.
Brand:CaymanSKU:22617 -Out of stock
(±)-cis-3-methyl Norfentanyl (Item No. 22617) is an analytical reference standard categorized as an opioid. It is a metabolite of (±)-cis-3-methyl fentanyl (Item Nos. 21676 | 9002747). The physiological and toxicological properties of (±)-cis-3-methyl-norfentanyl are not known. This product is intended for research and forensic applications.
Brand:CaymanSKU:22617 -Out of stock
(±)-cis-Isofentanyl (hydrochloride) (Item No. 24102) is an analytical reference standard that is structurally similar to known opioids. This product is intended for research and forensic applications.
Brand:CaymanSKU:24102 - 1 mgAvailable on backorder
(±)-cis-Isofentanyl (hydrochloride) (Item No. 24102) is an analytical reference standard that is structurally similar to known opioids. This product is intended for research and forensic applications.
Brand:CaymanSKU:24102 - 5 mgAvailable on backorder
(±)-Climbazole is an imidazole antifungal agent.{47625} It inhibits the growth of C. albicans (MIC = 0.29 μg/ml), as well as clinical isolates of M. pachydermatis (MICs = M. furfur (MICs = in vitro.{48240,48241,47626} It also reduces the size of Malassezia populations on the skin of naturally infected dogs when used at a dose of 2% in shampoo.{47625} (±)-Climbazole (80 mg/kg) increases the levels of cytochrome P450 in rat liver.{48242} Formulations containing climbazole have been used in the treatment of dandruff.
Brand:CaymanSKU:27968 - 100 gAvailable on backorder
(±)-Climbazole is an imidazole antifungal agent.{47625} It inhibits the growth of C. albicans (MIC = 0.29 μg/ml), as well as clinical isolates of M. pachydermatis (MICs = M. furfur (MICs = in vitro.{48240,48241,47626} It also reduces the size of Malassezia populations on the skin of naturally infected dogs when used at a dose of 2% in shampoo.{47625} (±)-Climbazole (80 mg/kg) increases the levels of cytochrome P450 in rat liver.{48242} Formulations containing climbazole have been used in the treatment of dandruff.
Brand:CaymanSKU:27968 - 25 gAvailable on backorder
(±)-Climbazole is an imidazole antifungal agent.{47625} It inhibits the growth of C. albicans (MIC = 0.29 μg/ml), as well as clinical isolates of M. pachydermatis (MICs = M. furfur (MICs = in vitro.{48240,48241,47626} It also reduces the size of Malassezia populations on the skin of naturally infected dogs when used at a dose of 2% in shampoo.{47625} (±)-Climbazole (80 mg/kg) increases the levels of cytochrome P450 in rat liver.{48242} Formulations containing climbazole have been used in the treatment of dandruff.
Brand:CaymanSKU:27968 - 250 gAvailable on backorder
(±)-Climbazole is an imidazole antifungal agent.{47625} It inhibits the growth of C. albicans (MIC = 0.29 μg/ml), as well as clinical isolates of M. pachydermatis (MICs = M. furfur (MICs = in vitro.{48240,48241,47626} It also reduces the size of Malassezia populations on the skin of naturally infected dogs when used at a dose of 2% in shampoo.{47625} (±)-Climbazole (80 mg/kg) increases the levels of cytochrome P450 in rat liver.{48242} Formulations containing climbazole have been used in the treatment of dandruff.
Brand:CaymanSKU:27968 - 50 gAvailable on backorder
(±)-Climbazole-d4 is intended for use as an internal standard for the quantification of climbazole by GC- or LC-MS. Climbazole is an imidazole antifungal.{48239} It inhibits the growth of C. albicans (MIC = 0.29 μg/ml) and various strains of M. pachydermatis (MICs = <0.06-1 μg/ml).{48240,48241} (±)-Climbazole (80 mg/kg) increases the levels of cytochrome P450 in rat liver.{48242} Formulations containing climbazole have been used in the treatment of dandruff.
Brand:CaymanSKU:27616 - 1 mgAvailable on backorder
Clopidogrel is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM).{19256,19258} Clopidogrel inhibits ADP-induced platelet aggregation ex vivo and functions as a prodrug whereupon biotransformation to its active metabolite via CYP2C19 in the liver enables its anti-aggregating activity.{19259} Marketed under the name Plavix®, clopidogrel in combination with aspirin has been shown to be beneficial in the prevention of vascular ischemic events for patients without deficiencies in CYP2C19-related metabolism.{19257}
Brand:CaymanSKU:- Clopidogrel is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM).{19256,19258} Clopidogrel inhibits ADP-induced platelet aggregation ex vivo and functions as a prodrug whereupon biotransformation to its active metabolite via CYP2C19 in the liver enables its anti-aggregating activity.{19259} Marketed under the name Plavix®, clopidogrel in combination with aspirin has been shown to be beneficial in the prevention of vascular ischemic events for patients without deficiencies in CYP2C19-related metabolism.{19257}
Brand:CaymanSKU:-
(±)-Cloprostenol (sodium salt) is a more water solute, crystalline form of cloprostenol than the free acid. Cloprostenol is a synthetic analog of prostaglandin F2α (PGF2α; Item No. 16010). It is 200 times and 100 times more potent than PGF2α in terminating pregnancy in hamsters and rats, respectively, without the side effects associated with PGF2α.{1182} The subcutaneous dose required for interrupting early pregnancy is species dependent, requiring approximately 1.25 µg/kg and 270 µg/kg in hamsters and rats, respectively.{1182} Cloprostenol is also a potent inhibitor of rat adipose precursor differentiation in primary cultures with an IC50 of 3 x 10−12 M.{4404}
Brand:CaymanSKU:-Out of stock
(±)-Cloprostenol (sodium salt) is a more water solute, crystalline form of cloprostenol than the free acid. Cloprostenol is a synthetic analog of prostaglandin F2α (PGF2α; Item No. 16010). It is 200 times and 100 times more potent than PGF2α in terminating pregnancy in hamsters and rats, respectively, without the side effects associated with PGF2α.{1182} The subcutaneous dose required for interrupting early pregnancy is species dependent, requiring approximately 1.25 µg/kg and 270 µg/kg in hamsters and rats, respectively.{1182} Cloprostenol is also a potent inhibitor of rat adipose precursor differentiation in primary cultures with an IC50 of 3 x 10−12 M.{4404}
Brand:CaymanSKU:-Out of stock
(±)-Cloprostenol (sodium salt) is a more water solute, crystalline form of cloprostenol than the free acid. Cloprostenol is a synthetic analog of prostaglandin F2α (PGF2α; Item No. 16010). It is 200 times and 100 times more potent than PGF2α in terminating pregnancy in hamsters and rats, respectively, without the side effects associated with PGF2α.{1182} The subcutaneous dose required for interrupting early pregnancy is species dependent, requiring approximately 1.25 µg/kg and 270 µg/kg in hamsters and rats, respectively.{1182} Cloprostenol is also a potent inhibitor of rat adipose precursor differentiation in primary cultures with an IC50 of 3 x 10−12 M.{4404}
Brand:CaymanSKU:-Out of stock
(±)-Cotinine-d3 is intended for use as an internal standard for the quantification of cotinine by GC- or LC-MS. Cotinine is an alkaloid found in tobacco and a major metabolite of nicotine (Item No. 16535).{43471,20196} It is formed by oxidation of nicotine by the cytochrome P450 (CYP) isoform CYP2A6.{20196}
Brand:CaymanSKU:- (±)-Cotinine-d3 is intended for use as an internal standard for the quantification of cotinine by GC- or LC-MS. Cotinine is an alkaloid found in tobacco and a major metabolite of nicotine (Item No. 16535).{43471,20196} It is formed by oxidation of nicotine by the cytochrome P450 (CYP) isoform CYP2A6.{20196}
Brand:CaymanSKU:- (±)-Cotinine-d3 is intended for use as an internal standard for the quantification of cotinine by GC- or LC-MS. Cotinine is an alkaloid found in tobacco and a major metabolite of nicotine (Item No. 16535).{43471,20196} It is formed by oxidation of nicotine by the cytochrome P450 (CYP) isoform CYP2A6.{20196}
Brand:CaymanSKU:-
CP 47,497 is a monophenol cannabimimetic compound that binds the central cannabinoid (CB1) receptor with a Ki value of 2.2 nM.{16403,6746} It is equivalent in analgesic potency to Δ9-THC and exhibits other CB biological activities as well.
Brand:CaymanSKU:-Out of stock
CP 47,497 is a monophenol cannabimimetic compound that binds the central cannabinoid (CB1) receptor with a Ki value of 2.2 nM.{16403,6746} It is equivalent in analgesic potency to Δ9-THC and exhibits other CB biological activities as well.
Brand:CaymanSKU:-Out of stock
CP 47,497 is a monophenol cannabimimetic compound that binds the central cannabinoid (CB1) receptor with a Ki value of 2.2 nM.{16403,6746} It is equivalent in analgesic potency to Δ9-THC and exhibits other CB biological activities as well.
Brand:CaymanSKU:-Out of stock
(±)-CP 47,497-C8-homolog is a bicyclic cannabinoid (CB) analog that avidly binds the CB1 receptor (Ki = 0.83 nM) and shows high antinociceptive activity.{6746} It is ten-fold more potent than Δ9-tetrahydrocannabinol in analgesic, motor depressant, anticonvulsant, and hypothermic effects in mice.{17059}
Brand:CaymanSKU:- (±)-CP 47,497-C8-homolog is a bicyclic cannabinoid (CB) analog that avidly binds the CB1 receptor (Ki = 0.83 nM) and shows high antinociceptive activity.{6746} It is ten-fold more potent than Δ9-tetrahydrocannabinol in analgesic, motor depressant, anticonvulsant, and hypothermic effects in mice.{17059}
Brand:CaymanSKU:- (±)-CP 47,497-C8-homolog is a bicyclic cannabinoid (CB) analog that avidly binds the CB1 receptor (Ki = 0.83 nM) and shows high antinociceptive activity.{6746} It is ten-fold more potent than Δ9-tetrahydrocannabinol in analgesic, motor depressant, anticonvulsant, and hypothermic effects in mice.{17059}
Brand:CaymanSKU:-
(±)-CP 55,940 is a potent, non-selective cannabinoid (CB) receptor agonist (Kis = 5 and 1.8 nM for human CB1 and CB2, respectively).{7912} It stimulates [35S]GTPγS binding to rat cerebellar membranes (EC50s = 0.22-0.96 nM).{41807} In vivo, (±)-CP 55,940 induces analgesia in the tail clamp, hot plate, tail flick, flinch jump, and PBQ-induced writhing tests with 50% maximum possible effect (MPE50) values of 0.46, 1.11, 0.55, 0.63, and 0.29 mg/kg, respectively.{6752} (±)-CP 55,940 also decreases the discrimination index (DI) of female, but not male, rats in the object location task as well as the DI of male, but not female, rats in the novel object recognition task.{41808}
Brand:CaymanSKU:- (±)-CP 55,940 is a potent, non-selective cannabinoid (CB) receptor agonist (Kis = 5 and 1.8 nM for human CB1 and CB2, respectively).{7912} It stimulates [35S]GTPγS binding to rat cerebellar membranes (EC50s = 0.22-0.96 nM).{41807} In vivo, (±)-CP 55,940 induces analgesia in the tail clamp, hot plate, tail flick, flinch jump, and PBQ-induced writhing tests with 50% maximum possible effect (MPE50) values of 0.46, 1.11, 0.55, 0.63, and 0.29 mg/kg, respectively.{6752} (±)-CP 55,940 also decreases the discrimination index (DI) of female, but not male, rats in the object location task as well as the DI of male, but not female, rats in the novel object recognition task.{41808}
Brand:CaymanSKU:- (±)-CP 55,940 is a potent, non-selective cannabinoid (CB) receptor agonist (Kis = 5 and 1.8 nM for human CB1 and CB2, respectively).{7912} It stimulates [35S]GTPγS binding to rat cerebellar membranes (EC50s = 0.22-0.96 nM).{41807} In vivo, (±)-CP 55,940 induces analgesia in the tail clamp, hot plate, tail flick, flinch jump, and PBQ-induced writhing tests with 50% maximum possible effect (MPE50) values of 0.46, 1.11, 0.55, 0.63, and 0.29 mg/kg, respectively.{6752} (±)-CP 55,940 also decreases the discrimination index (DI) of female, but not male, rats in the object location task as well as the DI of male, but not female, rats in the novel object recognition task.{41808}
Brand:CaymanSKU:- (±)-CP 55,940 is a potent, non-selective cannabinoid (CB) receptor agonist (Kis = 5 and 1.8 nM for human CB1 and CB2, respectively).{7912} It stimulates [35S]GTPγS binding to rat cerebellar membranes (EC50s = 0.22-0.96 nM).{41807} In vivo, (±)-CP 55,940 induces analgesia in the tail clamp, hot plate, tail flick, flinch jump, and PBQ-induced writhing tests with 50% maximum possible effect (MPE50) values of 0.46, 1.11, 0.55, 0.63, and 0.29 mg/kg, respectively.{6752} (±)-CP 55,940 also decreases the discrimination index (DI) of female, but not male, rats in the object location task as well as the DI of male, but not female, rats in the novel object recognition task.{41808}
Brand:CaymanSKU:-
(±)-Cromakalim is a prototypical activator of the ATP-sensitive potassium channel, SUR2-Kir6, that displays anti-ischemic (EC25 = 8.9 μM) and cardioprotective (IC50 = 0.03 μM) effects in rat hearts.{22674} (±)-Cromakalim has also been shown to relax bladder smooth muscle in vitro.{22674} It has been used to investigate potassium channel biology and as a scaffold to develop increasingly selective K+ channel openers with clinical relevance.{22674}
Brand:CaymanSKU:-