An internal standard for the quantification of (±)-baclofen by GC- or LC-MS

(±)-Baclofen-d4 – 1 mg

Brand:
Cayman
CAS:
1189938-30-4
Storage:
-20
UN-No:
- 2811 / 6.1

(±)-Baclofen-d4 is intended for use as an internal standard for the quantification of (±)-baclofen (Item No. 18600) by GC- or LC-MS. (±)-Baclofen is a GABAB receptor agonist (IC50 = 180 nM).{46227} It induces norepinephrine release from isolated rat atria (IC50 = 4.5 μM). (±)-Baclofen (10 mg/kg) increases muscle rigidity in spastic mice.{30075} It inhibits the norepinephrine-induced group II flexor reflex in anesthetized rats.{30078} (±)-Baclofen also reduces cocaine-induced hyperlocomotion in rats and binge-like ethanol intake in mice.{30076,30077} Formulations containing baclofen have been used to treat muscle spasms caused by multiple sclerosis and spinal cord injury.  

 

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SKU: 27811 - 1 mg Category:

Description

An internal standard for the quantification of (±)-baclofen by GC- or LC-MS

Formal name: 4-amino-3-(4-chlorophenyl-2,3,5,6-d4)butanoic acid

Synonyms: 

Molecular weight: 217.7

CAS: 1189938-30-4

Purity: ≥99% deuterated forms (d1-d4)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience|Behavioral Neuroscience|Addiction Research

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