A naphthoquinone with diverse biological activities; exhibits fungicidal activity against ten agriculturally relevant plant fungi in vitro (MICs = 5-20 mg/L) and in infected wheat and barley plants (EC50s = 2-20 mg/L); reduces the growth of T. cruzi epimastigotes (IC50 = 4.01 μM); a substrate of NQO1 that increases production of ROS and induces cell death of A549 lung carcinoma cells (IC50 = 6.1 μM); increases intracellular NAD+ and prevents cisplatin-induced inflammatory cytokine production and small intestinal damage in mice when administered at a dose of 20 mg/kg per day for 4 days

(±)-Dunnione – 25 mg

Brand:
Cayman
CAS:
521-49-3
Storage:
-20
UN-No:
Non-Hazardous - /

(±)-Dunnione is a naturally occurring naphthoquinone with diverse biological activities.{40460,40463,40461,40462} It exhibits fungicidal activity against ten agriculturally relevant plant fungi in vitro (MICs = 5-20 mg/L) and in infected wheat and barley plants (EC50s = 2-20 mg/L).{40460} (±)-Dunnione also reduces the growth of T. cruzi epimastigotes (IC50 = 4.01 μM).{40463} It is a substrate for NAD(P)H:quinone oxidoreductase 1 (NQO1) that increases production of reactive oxygen species (ROS) and induces cell death of A549 lung carcinoma cells (IC50 = 6.1 μM).{40461} (±)-Dunnione (20 mg/kg per day for 4 days) increases intracellular NAD+ (Item No. 16077) and prevents inflammatory cytokine production and small intestinal damage induced by cisplatin (Item No. 13119) in mice.{40462}  

 

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Description

A naphthoquinone with diverse biological activities; exhibits fungicidal activity against ten agriculturally relevant plant fungi in vitro (MICs = 5-20 mg/L) and in infected wheat and barley plants (EC50s = 2-20 mg/L); reduces the growth of T. cruzi epimastigotes (IC50 = 4.01 μM); a substrate of NQO1 that increases production of ROS and induces cell death of A549 lung carcinoma cells (IC50 = 6.1 μM); increases intracellular NAD+ and prevents cisplatin-induced inflammatory cytokine production and small intestinal damage in mice when administered at a dose of 20 mg/kg per day for 4 days

Formal name: 2,3-dihydro-2,3,3-trimethyl-naphtho[1,2-b]furan-4,5-dione

Synonyms:  NSC 95403

Molecular weight: 242.3

CAS: 521-49-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Ox Stress Reagents|Free Radical Generators||Product Type|Biochemicals|Pesticides|Fungicides||Research Area|Cancer|Cell Death||Research Area|Cancer|Tumor Microenvironment||Research Area|Immunology & Inflammation||Research Area|Plant Biology

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