A SIRT1 inhibitor (IC50 = 0.098 µM); selective for SIRT1 over SIRT2

(±)-EX-527 – 5 mg

Brand:
Cayman
CAS:
49843-98-3
Storage:
-20
UN-No:
Non-Hazardous - /

EX-527 is an inhibitor of sirtuin 1 (SIRT1; IC50 = 0.098 µM).{48663} It is selective for SIRT1 over SIRT2, and SIRT3 (IC50s = 19.6 and 48.7 µM, respectively) and the cytochrome P450 (CYP) isoforms CYP3A4, CYP2D6, CYP2C9, CYP2C19, and CYP1A2 at 1 µM. EX-527 (50 µM) induces cell cycle arrest at the G1 phase in MCF-7 cells.{48664}  

 

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SKU: 10009798 - 5 mg Category:

Description

A SIRT1 inhibitor (IC50 = 0.098 µM); selective for SIRT1 over SIRT2, and SIRT3 (IC50s = 19.6 and 48.7 µM, respectively) and CYP3A4, CYP2D6, CYP2C9, CYP2C19, and CYP1A2 at 1 µM; induces cell cycle arrest at the G1 phase in MCF-7 cells at 50 µM

Formal name: 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide

Synonyms: 

Molecular weight: 248.7

CAS: 49843-98-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation

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