A goitrogen; dietary administration increases thyroid weight and decreases thyroid radioactive iodine uptake in rats fed a low-iodine diet at 0.06-0.18% w/w; increases thyroid weight in chicks; inhibits norepinephrine formation by bovine dopamine-β-hydroxylase in vitro at 0.2 mM

(±)-Goitrin – 50 mg

Brand:
Cayman
CAS:
13190-34-6
Storage:
-20
UN-No:
Non-Hazardous - /

(±)-Goitrin is a goitrogen and antithyroid compound that has been found in plants of the Brassica family.{46142,46143} Dietary administration of (±)-goitrin (0.06-0.18% w/w) increases thyroid weight and decreases thyroid radioactive iodine uptake in rats fed a low-iodine diet.{46142} It also increases thyroid weight in chicks in a dose-dependent manner.{46143} (±)-Goitrin inhibits norepinephrine formation by bovine dopamine-β-hydroxylase in vitro when used at a concentration of 0.2 mM.{46144}  

 

Available on backorder

Add to quotes
SKU: 26382 - 50 mg Category:

Description

A goitrogen; dietary administration increases thyroid weight and decreases thyroid radioactive iodine uptake in rats fed a low-iodine diet at 0.06-0.18% w/w; increases thyroid weight in chicks; inhibits norepinephrine formation by bovine dopamine-β-hydroxylase in vitro at 0.2 mM,

Formal name: 5-ethenyl-2-oxazolidinethione

Synonyms:  DL-Goitrin

Molecular weight: 129.2

CAS: 13190-34-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products||Research Area|Toxicology

Related products

  • A potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM; also inhibits Cdk7/cyclin H

    (R)-Roscovitine – 500 µg

    Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. (R)-Roscovitine is a potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM.{14988} It also inhibits Cdk7/cyclin H, Cdk5/p35, and cell division cycle (cdc)/cyclin B with IC50 values of 0.49, 0.16, and 0.65 µM, respectively.{14987,14988,14991} (R)-Roscovitine inhibits the growth of rapidly proliferating cells with an average IC50 value of 15.2 µM against a panel of 19 human tumor cell lines.{14988} In murine models of polycystic kidney disease, (R)-roscovitine effectively inhibited disease progression at doses of 50-100 mg/kg.{14564}  

     

    Brand:
    Cayman
    SKU:10009569 - 500 µg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • PtdIns-(3

    PtdIns-(3,4,5)-P3-biotin (sodium salt) – 10 µg

    The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.  

     

    Brand:
    Cayman
    SKU:10009531 - 10 µg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers

    1,2-Dipalmitoyl-sn-glycero-3-PC – 100 mg

    1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.{14480,24261,14478,14479} It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.{14478} Incorporation of glycosphingolipid antigens into DPPC-containing liposomes increases the immunogenicity of the antigens in mice.{14479}  

     

    Brand:
    Cayman
    SKU:10009473 - 100 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • PtdIns-(3

    PtdIns-(3,4,5)-P3-biotin (sodium salt) – 50 µg

    The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.  

     

    Brand:
    Cayman
    SKU:10009531 - 50 µg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page