Cayman
Showing 45151–45300 of 45550 results
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α-Ecdysone is a prohormone of 20-hydroxy ecdysone (Item No. 16145), an insect-molting, ecdysteroid hormone.{26314} The insect neurohormone, prothoracicotropic hormone, stimulates prothoracic glands to release α-ecdysone, which is then rapidly converted to its active metabolite, 20-hydroxy ecdysone.{29978,29979}
Brand:CaymanSKU:11711 - 25 mgAvailable on backorder
α-Ecdysone is a prohormone of 20-hydroxy ecdysone (Item No. 16145), an insect-molting, ecdysteroid hormone.{26314} The insect neurohormone, prothoracicotropic hormone, stimulates prothoracic glands to release α-ecdysone, which is then rapidly converted to its active metabolite, 20-hydroxy ecdysone.{29978,29979}
Brand:CaymanSKU:11711 - 5 mgAvailable on backorder
α-Endorphin is an endogenous neuropeptide that binds to opioid receptors in guinea pig brain membranes (IC50 = 97 nM).{39621} It induces chemotaxis of human monocytes in vitro when used at a concentration of 0.1 nM and inhibits electrically-induced contractions in guinea pig ileum and mouse vas deferens (IC50s = 325 and 27.6 nM, respectively).{40896,39621} In vivo, α-endorphin delays extinction of pole-jumping avoidance behavior in rats (ED50s = 40 and 2 pM, respectively, for s.c. and i.c.v. administration).{39622}
Brand:CaymanSKU:24958 - 1 mgAvailable on backorder
Immunogen: Full length recombinant human α-enolase • Host: Rabbit • Species Reactivity: (+) Human • Applications: ELISA, IHC, and WB
Brand:CaymanSKU:20491- 1 eaAvailable on backorder
Immunogen: Full length recombinant human α-enolase • Host: Rabbit • Species Reactivity: (+) Human • Applications: ELISA, IHC, and WB
Brand:CaymanSKU:20491- 1 ea α-Enolase, also known as enolase 1, is a glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate.{42086} It is ubiquitously expressed in human tissues, including liver, spleen, kidney, and brain. In cells, α-enolase is primarily localized to the cytoplasm, however, an alternatively translated form localizes to the nucleus and lacks glycolytic enzyme activity.{42086,42087} α-Enolase also functions as a cell surface receptor for plasminogen on pathogens and activated immune cells, as an oxidative stress protein in endothelial cells, and as a chromatin binding partner to facilitate transcription.{42087,42088,42089} The ENO1 promoter contains a hypoxia-response element, allowing α-enolase to facilitate aerobic glycolysis and contribute to the Warburg effect in tumor cells.{42087} α-Enolase is overexpressed in multiple tumors, including glioma, neuroblastoma, pancreatic, prostate, and hepatocellular carcinomas. Its role as a plasminogen receptor facilitates extracellular matrix degradation and cancer invasion.{42089} α-Enolase is an autoantigen in asthma, Hashimoto’s encephalopathy, and rheumatoid arthritis, and has been found in the serum of pediatric patients with juvenile idiopathic arthritis.{42090,42091,42092,36062} Cayman’s α-Enolase Polyclonal Antibody can be used for Western blot and ELISA applications. The antibody recognizes α-enolase at ~47 kDa from human samples.
Brand:CaymanSKU:20491 - 1 eaAvailable on backorder
α-ethyl 2C-D (hydrochloride) (Item No. 26596) is an analytical reference standard categorized as a phenethylamine and amphetamine. α-ethyl 2C-D generalizes to MDMA (Item Nos. ISO60190 | 13971) in drug discrimination studies.{53201} This product is intended for research and forensic applications.
Brand:CaymanSKU:26596 - 1 mgAvailable on backorder
α-ethyl 2C-D (hydrochloride) (Item No. 26596) is an analytical reference standard categorized as a phenethylamine and amphetamine. α-ethyl 2C-D generalizes to MDMA (Item Nos. ISO60190 | 13971) in drug discrimination studies.{53201} This product is intended for research and forensic applications.
Brand:CaymanSKU:26596 - 5 mgAvailable on backorder
Substituted cathinones are psychoactive compounds commonly used as recreational drugs.{19500,19508} α-Ethylaminopentiophenone is a substituted cathinone that is an analog to ethcathinone, differing by having propyl rather than methyl at the α position. The physiological and toxicological properties of this compound have not been characterized. This product is intended for forensic and research purposes.
Brand:CaymanSKU:- Substituted cathinones are psychoactive compounds commonly used as recreational drugs.{19500,19508} α-Ethylaminopentiophenone is a substituted cathinone that is an analog to ethcathinone, differing by having propyl rather than methyl at the α position. The physiological and toxicological properties of this compound have not been characterized. This product is intended for forensic and research purposes.
Brand:CaymanSKU:- Substituted cathinones are psychoactive compounds commonly used as recreational drugs.{19500,19508} α-Ethylaminopentiophenone is a substituted cathinone that is an analog to ethcathinone, differing by having propyl rather than methyl at the α position. The physiological and toxicological properties of this compound have not been characterized. This product is intended for forensic and research purposes.
Brand:CaymanSKU:-
α-Ethyltryptamine (α-ET) is a tryptamine derivative with schedule I status in the United States.{20018,19758} It has been reported to be a potent releaser of serotonin, norepinephrine, and dopamine as well as an inhibitor of monoamine oxidase. α-Ethyltryptamine (α-ET) is a tryptamine derivative with schedule I status in the United States.{20018,19758} It has been reported to be a potent releaser of serotonin, norepinephrine, and dopamine as well as an inhibitor of monoamine oxidase.{23215,23216} In tests of stimulus generalization in rats, α-ET generalized to DOM (Item No. 11145) and PMMA (Item No. 11562) with ED50 values of 0.4 and 0.7 mg/kg, respectively.{23215} This product is intended for forensic and research applications.
Brand:CaymanSKU:-
α-Galactosylceramide analog 8 (α-GalCer analog 8) is a triazole derivative of α-galactosylceramide.{42588} It increases IL-2 secretion by DN32.D3 NKT hybridoma cells when co-cultured with CD1d-transfected RBL cells pre-loaded with α-GalCer analog 8 at a concentration of 32 ng/ml. α-GalCer analog 8 (32 ng/ml) induces IL-4 secretion to a greater extent than the synthetic α-GalCer KRN 7000 (Item No. 11208) in mouse splenocytes in vitro and in mouse serum following administration of a 1 µg per animal dose, indicating a Th2 response.
Brand:CaymanSKU:26660 - 1 mgAvailable on backorder
α-Galactosylceramide analog 8 (α-GalCer analog 8) is a triazole derivative of α-galactosylceramide.{42588} It increases IL-2 secretion by DN32.D3 NKT hybridoma cells when co-cultured with CD1d-transfected RBL cells pre-loaded with α-GalCer analog 8 at a concentration of 32 ng/ml. α-GalCer analog 8 (32 ng/ml) induces IL-4 secretion to a greater extent than the synthetic α-GalCer KRN 7000 (Item No. 11208) in mouse splenocytes in vitro and in mouse serum following administration of a 1 µg per animal dose, indicating a Th2 response.
Brand:CaymanSKU:26660 - 500 µgAvailable on backorder
GGA is a linear mixed-type inhibitor of nNOS having a Ki of 2.69 µM.{1908} It is normally present in small quantities in the cerebral cortex of cats with increased levels following seizure.{1908,4115}
Brand:CaymanSKU:80340 - 10 mgAvailable on backorder
GGA is a linear mixed-type inhibitor of nNOS having a Ki of 2.69 µM.{1908} It is normally present in small quantities in the cerebral cortex of cats with increased levels following seizure.{1908,4115}
Brand:CaymanSKU:80340 - 100 mgAvailable on backorder
GGA is a linear mixed-type inhibitor of nNOS having a Ki of 2.69 µM.{1908} It is normally present in small quantities in the cerebral cortex of cats with increased levels following seizure.{1908,4115}
Brand:CaymanSKU:80340 - 5 mgAvailable on backorder
GGA is a linear mixed-type inhibitor of nNOS having a Ki of 2.69 µM.{1908} It is normally present in small quantities in the cerebral cortex of cats with increased levels following seizure.{1908,4115}
Brand:CaymanSKU:80340 - 50 mgAvailable on backorder
α-Hederin is a triterpenoid saponin that has been found in K. pictus and has diverse biological activities.{51169,51166,51167,51168} It increases spontaneous motoric activity in isolated rat stomach corpus and fundus strips when used at concentrations ranging from 25 to 320 μM.{51169} It is cytotoxic to J82 and T24 human bladder carcinoma, Colon26 murine colon adenocarcinoma, and 3LL Lewis murine lung carcinoma cells (EC50s = 15.5, 16.5, 12.5, and 1.1 μM, respectively).{51166} α-Hederin (7.5 and 15 mg/kg) increases survival time in a 3LL Lewis mouse lung carcinoma model. It reduces acetic acid-induced writhing in mice when administered at doses of 10 and 20 mg/kg.{51167} α-Hederin (5, 10, and 20 mg/kg) reduces paw edema in a rat model of rheumatoid arthritis induced by Freund’s complete adjuvant (FCA). It dose-dependently prevents carbon tetrachloride-induced increases in serum alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) activity, as well as hepatic levels of malondialdehyde (MDA) in a mouse model of hepatic injury.{51168} α-Hederin also decreases levels of the cytochrome P450 (CYP) isoform CYP2E1 in mouse liver.
Brand:CaymanSKU:28164 - 1 mgAvailable on backorder
α-Hederin is a triterpenoid saponin that has been found in K. pictus and has diverse biological activities.{51169,51166,51167,51168} It increases spontaneous motoric activity in isolated rat stomach corpus and fundus strips when used at concentrations ranging from 25 to 320 μM.{51169} It is cytotoxic to J82 and T24 human bladder carcinoma, Colon26 murine colon adenocarcinoma, and 3LL Lewis murine lung carcinoma cells (EC50s = 15.5, 16.5, 12.5, and 1.1 μM, respectively).{51166} α-Hederin (7.5 and 15 mg/kg) increases survival time in a 3LL Lewis mouse lung carcinoma model. It reduces acetic acid-induced writhing in mice when administered at doses of 10 and 20 mg/kg.{51167} α-Hederin (5, 10, and 20 mg/kg) reduces paw edema in a rat model of rheumatoid arthritis induced by Freund’s complete adjuvant (FCA). It dose-dependently prevents carbon tetrachloride-induced increases in serum alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) activity, as well as hepatic levels of malondialdehyde (MDA) in a mouse model of hepatic injury.{51168} α-Hederin also decreases levels of the cytochrome P450 (CYP) isoform CYP2E1 in mouse liver.
Brand:CaymanSKU:28164 - 10 mgAvailable on backorder
α-Hederin is a triterpenoid saponin that has been found in K. pictus and has diverse biological activities.{51169,51166,51167,51168} It increases spontaneous motoric activity in isolated rat stomach corpus and fundus strips when used at concentrations ranging from 25 to 320 μM.{51169} It is cytotoxic to J82 and T24 human bladder carcinoma, Colon26 murine colon adenocarcinoma, and 3LL Lewis murine lung carcinoma cells (EC50s = 15.5, 16.5, 12.5, and 1.1 μM, respectively).{51166} α-Hederin (7.5 and 15 mg/kg) increases survival time in a 3LL Lewis mouse lung carcinoma model. It reduces acetic acid-induced writhing in mice when administered at doses of 10 and 20 mg/kg.{51167} α-Hederin (5, 10, and 20 mg/kg) reduces paw edema in a rat model of rheumatoid arthritis induced by Freund’s complete adjuvant (FCA). It dose-dependently prevents carbon tetrachloride-induced increases in serum alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) activity, as well as hepatic levels of malondialdehyde (MDA) in a mouse model of hepatic injury.{51168} α-Hederin also decreases levels of the cytochrome P450 (CYP) isoform CYP2E1 in mouse liver.
Brand:CaymanSKU:28164 - 25 mgAvailable on backorder
α-Hederin is a triterpenoid saponin that has been found in K. pictus and has diverse biological activities.{51169,51166,51167,51168} It increases spontaneous motoric activity in isolated rat stomach corpus and fundus strips when used at concentrations ranging from 25 to 320 μM.{51169} It is cytotoxic to J82 and T24 human bladder carcinoma, Colon26 murine colon adenocarcinoma, and 3LL Lewis murine lung carcinoma cells (EC50s = 15.5, 16.5, 12.5, and 1.1 μM, respectively).{51166} α-Hederin (7.5 and 15 mg/kg) increases survival time in a 3LL Lewis mouse lung carcinoma model. It reduces acetic acid-induced writhing in mice when administered at doses of 10 and 20 mg/kg.{51167} α-Hederin (5, 10, and 20 mg/kg) reduces paw edema in a rat model of rheumatoid arthritis induced by Freund’s complete adjuvant (FCA). It dose-dependently prevents carbon tetrachloride-induced increases in serum alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) activity, as well as hepatic levels of malondialdehyde (MDA) in a mouse model of hepatic injury.{51168} α-Hederin also decreases levels of the cytochrome P450 (CYP) isoform CYP2E1 in mouse liver.
Brand:CaymanSKU:28164 - 5 mgAvailable on backorder
α-Humulene is a sesquiterpene that has been found in C. sativa, C. indica, and hemp with diverse biological activities.{41453,39866,39867,39868,39869} It is lethal to A. subpictus, A. albopictus, and C. tritaeniorhynchus mosquito larvae (LC50s = 6.19, 7.39, and 12.05 mg/ml, respectively).{39866} α-Humulene reduces growth of MCF-7 breast cancer cells by approximately 50% when used at a concentration of 32 mg/ml.{39867} It also reduces viability of Caco-2 cells in a concentration-dependent manner (IC50 = 24.4 mg/ml) but has no effect on viability of rat hepatocytes.{39868} In vivo, α-humulene (50 mg/kg) reduces histamine-induced paw edema in mice as well as carrageenan-induced TNF-α and IL-1β production and paw edema in mice and rats.{39869} It also reduces carrageenan-induced production of prostaglandin E2 (PGE2) and expression of inducible nitric oxide synthase (iNOS) and COX-2 in rats.
Brand:CaymanSKU:21574 -Out of stock
α-hydroxy Farnesyl phosphonic acid is a nonhydrolyzable analog of farnesyl pyrophosphate which acts as a competitive inhibitor of farnesyl transferase (FTase).{1199,5456} At concentrations greater than 1 µM, α-hydroxy farnesyl phosphonic acid inhibits the processing of Ras in Ha-ras-transformed NIH3T3 cells.{1196}
Brand:CaymanSKU:63420 - 1 mgAvailable on backorder
α-hydroxy Farnesyl phosphonic acid is a nonhydrolyzable analog of farnesyl pyrophosphate which acts as a competitive inhibitor of farnesyl transferase (FTase).{1199,5456} At concentrations greater than 1 µM, α-hydroxy farnesyl phosphonic acid inhibits the processing of Ras in Ha-ras-transformed NIH3T3 cells.{1196}
Brand:CaymanSKU:63420 - 10 mgAvailable on backorder
α-hydroxy Farnesyl phosphonic acid is a nonhydrolyzable analog of farnesyl pyrophosphate which acts as a competitive inhibitor of farnesyl transferase (FTase).{1199,5456} At concentrations greater than 1 µM, α-hydroxy farnesyl phosphonic acid inhibits the processing of Ras in Ha-ras-transformed NIH3T3 cells.{1196}
Brand:CaymanSKU:63420 - 5 mgAvailable on backorder
α-hydroxy Flualprazolam (Item No. 29206) is an analytical reference standard categorized as a benzodiazepine. This product is intended for research and forensic applications.
Brand:CaymanSKU:29206 - 1 mgAvailable on backorder
α-hydroxy Flualprazolam (Item No. 29206) is an analytical reference standard categorized as a benzodiazepine. This product is intended for research and forensic applications.
Brand:CaymanSKU:29206 - 5 mgAvailable on backorder
α-hydroxy Flubromazolam (Item No. 26588) is an analytical reference standard categorized as a benzodiazepine. It is a metabolite of flubromazolam (Item Nos. 26352 | 16435).{45978} This product is intended for research and forensic applications.
Brand:CaymanSKU:26588 - 1 mgAvailable on backorder
α-hydroxy Flubromazolam (Item No. 26588) is an analytical reference standard categorized as a benzodiazepine. It is a metabolite of flubromazolam (Item Nos. 26352 | 16435).{45978} This product is intended for research and forensic applications.
Brand:CaymanSKU:26588 - 5 mgAvailable on backorder
α-hydroxy Metoprolol is an active metabolite of the β1-adrenergic receptor blocker metoprolol (Item No. 15429).{42752} It is formed via metabolism of metoprolol by the cytochrome P450 (CYP) isoform CYP2D6.
Brand:CaymanSKU:28020 - 1 mgAvailable on backorder
α-hydroxy Metoprolol is an active metabolite of the β1-adrenergic receptor blocker metoprolol (Item No. 15429).{42752} It is formed via metabolism of metoprolol by the cytochrome P450 (CYP) isoform CYP2D6.
Brand:CaymanSKU:28020 - 5 mgAvailable on backorder
Tamoxifen (Item No. 13258) is a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer. Although it is an antagonist of ER action in breast tissue, it acts as an ER agonist in bone and blood vessels and a partial ER agonist in uterine tissues. α-hydroxy Tamoxifen is a reactive metabolite of tamoxifen that is formed by the action of cytochrome P450 3A4 in human liver.{28206,28212} It can be further converted into genotoxic DNA adducts though a mechanism involving reversible O-sulfonation of the hydroxyl moiety, which in rats has been linked with hepatocarcinoma.{28206,28207,28208,28209,28211}
Brand:CaymanSKU:-Out of stock
Tamoxifen (Item No. 13258) is a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer. Although it is an antagonist of ER action in breast tissue, it acts as an ER agonist in bone and blood vessels and a partial ER agonist in uterine tissues. α-hydroxy Tamoxifen is a reactive metabolite of tamoxifen that is formed by the action of cytochrome P450 3A4 in human liver.{28206,28212} It can be further converted into genotoxic DNA adducts though a mechanism involving reversible O-sulfonation of the hydroxyl moiety, which in rats has been linked with hepatocarcinoma.{28206,28207,28208,28209,28211}
Brand:CaymanSKU:-Out of stock
Tamoxifen (Item No. 13258) is a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer. Although it is an antagonist of ER action in breast tissue, it acts as an ER agonist in bone and blood vessels and a partial ER agonist in uterine tissues. α-hydroxy Tamoxifen is a reactive metabolite of tamoxifen that is formed by the action of cytochrome P450 3A4 in human liver.{28206,28212} It can be further converted into genotoxic DNA adducts though a mechanism involving reversible O-sulfonation of the hydroxyl moiety, which in rats has been linked with hepatocarcinoma.{28206,28207,28208,28209,28211}
Brand:CaymanSKU:-Out of stock
Tamoxifen (Item No. 13258) is a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer. Although it is an antagonist of ER action in breast tissue, it acts as an ER agonist in bone and blood vessels and a partial ER agonist in uterine tissues. α-hydroxy Tamoxifen is a reactive metabolite of tamoxifen that is formed by the action of cytochrome P450 3A4 in human liver.{28206,28212} It can be further converted into genotoxic DNA adducts though a mechanism involving reversible O-sulfonation of the hydroxyl moiety, which in rats has been linked with hepatocarcinoma.{28206,28207,28208,28209,28211}
Brand:CaymanSKU:-Out of stock
α-Hydroxyglutaric acid (2-HG) is an α-hydroxy acid. It is metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases, and mutations in these enzymes lead to 2-hydroxyglutaric aciduria, a neurometabolic disorder characterized by increased levels of L-2-hydroxyglutaric acid (Item No. 21123).{26770,26771,26772} 2-HG can also be metabolized from isocitrate by mutated forms of isocitrate dehydrogenase 1 (IDH1) and IDH2.{26773,26775} 2-HG is structurally similar to α-ketoglutarate, the product of wild-type isocitrate dehydrogenases, and competitively inhibits α-ketoglutarate-dependent dioxygenases, including histone lysine demethylases and DNA hydroxylases.{26775,26774,26769}
Brand:CaymanSKU:25894 - 10 mgAvailable on backorder
α-Hydroxyglutaric acid (2-HG) is an α-hydroxy acid. It is metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases, and mutations in these enzymes lead to 2-hydroxyglutaric aciduria, a neurometabolic disorder characterized by increased levels of L-2-hydroxyglutaric acid (Item No. 21123).{26770,26771,26772} 2-HG can also be metabolized from isocitrate by mutated forms of isocitrate dehydrogenase 1 (IDH1) and IDH2.{26773,26775} 2-HG is structurally similar to α-ketoglutarate, the product of wild-type isocitrate dehydrogenases, and competitively inhibits α-ketoglutarate-dependent dioxygenases, including histone lysine demethylases and DNA hydroxylases.{26775,26774,26769}
Brand:CaymanSKU:25894 - 25 mgAvailable on backorder
α-Hydroxyglutaric acid (2-HG) is an α-hydroxy acid. It is metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases, and mutations in these enzymes lead to 2-hydroxyglutaric aciduria, a neurometabolic disorder characterized by increased levels of L-2-hydroxyglutaric acid (Item No. 21123).{26770,26771,26772} 2-HG can also be metabolized from isocitrate by mutated forms of isocitrate dehydrogenase 1 (IDH1) and IDH2.{26773,26775} 2-HG is structurally similar to α-ketoglutarate, the product of wild-type isocitrate dehydrogenases, and competitively inhibits α-ketoglutarate-dependent dioxygenases, including histone lysine demethylases and DNA hydroxylases.{26775,26774,26769}
Brand:CaymanSKU:25894 - 5 mgAvailable on backorder
α-Hydroxyglutaric acid (2-HG) is an α-hydroxy acid. It is metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases, and mutations in these enzymes lead to 2-hydroxyglutaric aciduria, a neurometabolic disorder characterized by increased levels of L-2-hydroxyglutaric acid (Item No. 21123).{26770,26771,26772} 2-HG can also be metabolized from isocitrate by mutated forms of isocitrate dehydrogenase 1 (IDH1) and IDH2.{26773,26775} 2-HG is structurally similar to α-ketoglutarate, the product of wild-type isocitrate dehydrogenases, and competitively inhibits α-ketoglutarate-dependent dioxygenases, including histone lysine demethylases and DNA hydroxylases.{26775,26774,26769}
Brand:CaymanSKU:-Out of stock
α-Hydroxyglutaric acid (2-HG) is an α-hydroxy acid. It is metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases, and mutations in these enzymes lead to 2-hydroxyglutaric aciduria, a neurometabolic disorder characterized by increased levels of L-2-hydroxyglutaric acid (Item No. 21123).{26770,26771,26772} 2-HG can also be metabolized from isocitrate by mutated forms of isocitrate dehydrogenase 1 (IDH1) and IDH2.{26773,26775} 2-HG is structurally similar to α-ketoglutarate, the product of wild-type isocitrate dehydrogenases, and competitively inhibits α-ketoglutarate-dependent dioxygenases, including histone lysine demethylases and DNA hydroxylases.{26775,26774,26769}
Brand:CaymanSKU:-Out of stock
α-Hydroxyglutaric acid (2-HG) is an α-hydroxy acid. It is metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases, and mutations in these enzymes lead to 2-hydroxyglutaric aciduria, a neurometabolic disorder characterized by increased levels of L-2-hydroxyglutaric acid (Item No. 21123).{26770,26771,26772} 2-HG can also be metabolized from isocitrate by mutated forms of isocitrate dehydrogenase 1 (IDH1) and IDH2.{26773,26775} 2-HG is structurally similar to α-ketoglutarate, the product of wild-type isocitrate dehydrogenases, and competitively inhibits α-ketoglutarate-dependent dioxygenases, including histone lysine demethylases and DNA hydroxylases.{26775,26774,26769}
Brand:CaymanSKU:-Out of stock
α-Hydroxyglutaric acid (2-HG) is an α-hydroxy acid. It is metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases, and mutations in these enzymes lead to 2-hydroxyglutaric aciduria, a neurometabolic disorder characterized by increased levels of L-2-hydroxyglutaric acid (Item No. 21123).{26770,26771,26772} 2-HG can also be metabolized from isocitrate by mutated forms of isocitrate dehydrogenase 1 (IDH1) and IDH2.{26773,26775} 2-HG is structurally similar to α-ketoglutarate, the product of wild-type isocitrate dehydrogenases, and competitively inhibits α-ketoglutarate-dependent dioxygenases, including histone lysine demethylases and DNA hydroxylases.{26775,26774,26769}
Brand:CaymanSKU:-Out of stock
α-Hydroxymethyl atropine is a byproduct in the synthesis of atropine.{39650} It reduces acetylcholine-induced contractile activity of isolated rat intestine when used at a concentration of 0.025 ng/ml.{39651}
Brand:CaymanSKU:24266 - 25 mgAvailable on backorder
α-Hydroxymethyl atropine is a byproduct in the synthesis of atropine.{39650} It reduces acetylcholine-induced contractile activity of isolated rat intestine when used at a concentration of 0.025 ng/ml.{39651}
Brand:CaymanSKU:24266 - 50 mgAvailable on backorder
α-Isopropylaminohexanophenone (hydrochloride) (Item No. 31005) is an analytical reference standard categorized as a cathinone. This product is intended for research and forensic applications.
Brand:CaymanSKU:31005 - 1 mgAvailable on backorder
α-Isopropylaminohexanophenone (hydrochloride) (Item No. 31005) is an analytical reference standard categorized as a cathinone. This product is intended for research and forensic applications.
Brand:CaymanSKU:31005 - 5 mgAvailable on backorder
α-Isopropylaminopentiophenone (hydrochloride) (Item No. 20021) is an analytical reference standard that is structurally classified as a cathinone. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:20021 -Available on backorder
α-Isopropylaminopentiophenone (hydrochloride) (Item No. 20021) is an analytical reference standard that is structurally classified as a cathinone. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:20021 -Available on backorder
Cayman’s α-Ketoglutarate (α-KG) Fluorometric Detection Assay provides a fluorescence-based method for quantifying α-KG in biological samples such as serum, plasma, urine, and tissue. It can also be utilized to determine intracellular and extracellular α-KG concentrations in cell culture samples. In this assay, alanine transaminase (ALT) deaminates α-KG to form pyruvate.{33073,33074} Pyruvate is then oxidized by pyruvate oxidase to yield acetyl phosphate, hydrogen peroxide (H2O2), and carbon dioxide.{33075} As H2O2 is produced, the cycling mechanism of horseradish peroxidase results in the concurrent reduction of H2O2 to H2O and oxidation of 10-acetyl-3,7-dihydroxyphenoxazine (ADHP) to produce the highly fluorescent compound resorufin.{33076} Resorufin fluorescence is analyzed with an excitation wavelength between 530-540 nm and an emission wavelength between 585-595 nm.
Brand:CaymanSKU:701350 - 96 wellsAvailable on backorder
α-Linolenic acid (ALA) is an essential ω-3 polyunsaturated fatty acid found in plants.{42925} In vivo, it is converted to the longer-chain fatty acids eicosapentaenoic (Item Nos. 90110 | 90110.1 | 21908), docosapentaenoic (Item Nos. 90165 | 21907), and docosahexaenoic acid (Item No. 90310).{42926} It is also catabolized via fatty acid β-oxidation for energy or the synthesis of saturated and monounsaturated fatty acids, or stored in adipose tissue. Dietary consumption of α-linolenic acid-containing foods is positively associated with a moderately lower risk of cardiovascular disease.{42925}
Brand:CaymanSKU:90210 - 100 mgAvailable on backorder
α-Linolenic acid (ALA) is an essential ω-3 polyunsaturated fatty acid found in plants.{42925} In vivo, it is converted to the longer-chain fatty acids eicosapentaenoic (Item Nos. 90110 | 90110.1 | 21908), docosapentaenoic (Item Nos. 90165 | 21907), and docosahexaenoic acid (Item No. 90310).{42926} It is also catabolized via fatty acid β-oxidation for energy or the synthesis of saturated and monounsaturated fatty acids, or stored in adipose tissue. Dietary consumption of α-linolenic acid-containing foods is positively associated with a moderately lower risk of cardiovascular disease.{42925}
Brand:CaymanSKU:90210 - 250 mgAvailable on backorder
α-Linolenic acid (ALA) is an essential ω-3 polyunsaturated fatty acid found in plants.{42925} In vivo, it is converted to the longer-chain fatty acids eicosapentaenoic (Item Nos. 90110 | 90110.1 | 21908), docosapentaenoic (Item Nos. 90165 | 21907), and docosahexaenoic acid (Item No. 90310).{42926} It is also catabolized via fatty acid β-oxidation for energy or the synthesis of saturated and monounsaturated fatty acids, or stored in adipose tissue. Dietary consumption of α-linolenic acid-containing foods is positively associated with a moderately lower risk of cardiovascular disease.{42925}
Brand:CaymanSKU:90210 - 50 mgAvailable on backorder
α-Linolenic acid is an essential ω-3 polyunsaturated fatty acid found in plants.{42925} In vivo, it is converted to the longer-chain fatty acids eicosapentaenoic (Item Nos. 90110 | 90110.1 | 21908), docosapentaenoic (Item Nos. 90165 | 21907), and docosahexaenoic acid (Item No. 90310).{42926} It is also catabolized via fatty acid β-oxidation for energy or the synthesis of saturated and monounsaturated fatty acids, or stored in adipose tissue. Dietary consumption of α-linolenic acid-containing foods is positively associated with a moderately lower risk of cardiovascular disease.{42925}
Brand:CaymanSKU:21910 -Out of stock
α-Linolenic acid is an essential ω-3 polyunsaturated fatty acid found in plants.{42925} In vivo, it is converted to the longer-chain fatty acids eicosapentaenoic (Item Nos. 90110 | 90110.1 | 21908), docosapentaenoic (Item Nos. 90165 | 21907), and docosahexaenoic acid (Item No. 90310).{42926} It is also catabolized via fatty acid β-oxidation for energy or the synthesis of saturated and monounsaturated fatty acids, or stored in adipose tissue. Dietary consumption of α-linolenic acid-containing foods is positively associated with a moderately lower risk of cardiovascular disease.{42925}
Brand:CaymanSKU:21910 -Out of stock
α-Linolenic acid is an essential ω-3 polyunsaturated fatty acid found in plants.{42925} In vivo, it is converted to the longer-chain fatty acids eicosapentaenoic (Item Nos. 90110 | 90110.1 | 21908), docosapentaenoic (Item Nos. 90165 | 21907), and docosahexaenoic acid (Item No. 90310).{42926} It is also catabolized via fatty acid β-oxidation for energy or the synthesis of saturated and monounsaturated fatty acids, or stored in adipose tissue. Dietary consumption of α-linolenic acid-containing foods is positively associated with a moderately lower risk of cardiovascular disease.{42925}
Brand:CaymanSKU:21910 -Out of stock
α-Linolenic acid ethyl ester is an esterified form of α-linolenic acid (Item Nos. 90210 | 21910). It increases cyclin E levels and the activity of Cdk2/cyclin E, ERK, and JNK in hepatic stellate cells when used at a concentration of 50 μM.{14161} α-Linolenic acid ethyl ester (25 μg/ml) inhibits the growth of S. mutans, C. albicans, and P. gingivalis by 98, 72, and 92%, respectively, in vitro.{47493} It has been found in biodiesel produced from castor oil using ethanol.{47494} α-Linolenic acid ethyl ester has been used as a substrate in lipid peroxidation assays for antioxidant activity.{47495}
Brand:CaymanSKU:10008199 - 1 gAvailable on backorder
α-Linolenic acid ethyl ester is an esterified form of α-linolenic acid (Item Nos. 90210 | 21910). It increases cyclin E levels and the activity of Cdk2/cyclin E, ERK, and JNK in hepatic stellate cells when used at a concentration of 50 μM.{14161} α-Linolenic acid ethyl ester (25 μg/ml) inhibits the growth of S. mutans, C. albicans, and P. gingivalis by 98, 72, and 92%, respectively, in vitro.{47493} It has been found in biodiesel produced from castor oil using ethanol.{47494} α-Linolenic acid ethyl ester has been used as a substrate in lipid peroxidation assays for antioxidant activity.{47495}
Brand:CaymanSKU:10008199 - 100 mgAvailable on backorder
α-Linolenic acid ethyl ester is an esterified form of α-linolenic acid (Item Nos. 90210 | 21910). It increases cyclin E levels and the activity of Cdk2/cyclin E, ERK, and JNK in hepatic stellate cells when used at a concentration of 50 μM.{14161} α-Linolenic acid ethyl ester (25 μg/ml) inhibits the growth of S. mutans, C. albicans, and P. gingivalis by 98, 72, and 92%, respectively, in vitro.{47493} It has been found in biodiesel produced from castor oil using ethanol.{47494} α-Linolenic acid ethyl ester has been used as a substrate in lipid peroxidation assays for antioxidant activity.{47495}
Brand:CaymanSKU:10008199 - 50 mgAvailable on backorder
α-Linolenic acid ethyl ester is an esterified form of α-linolenic acid (Item Nos. 90210 | 21910). It increases cyclin E levels and the activity of Cdk2/cyclin E, ERK, and JNK in hepatic stellate cells when used at a concentration of 50 μM.{14161} α-Linolenic acid ethyl ester (25 μg/ml) inhibits the growth of S. mutans, C. albicans, and P. gingivalis by 98, 72, and 92%, respectively, in vitro.{47493} It has been found in biodiesel produced from castor oil using ethanol.{47494} α-Linolenic acid ethyl ester has been used as a substrate in lipid peroxidation assays for antioxidant activity.{47495}
Brand:CaymanSKU:10008199 - 500 mgAvailable on backorder
α-Linolenic acid ethyl ester-d5 is intended for use as an internal standard for the quantification of α-linolenic acid ethyl ester (Item No. 10008199) by GC- or LC-MS. α-Linolenic acid ethyl ester is an esterified form of α-linolenic acid (Item Nos. 90210 | 21910). It increases cyclin E levels and the activity of Cdk2/cyclin E, ERK, and JNK in hepatic stellate cells when used at a concentration of 50 μM.{14161} α-Linolenic acid ethyl ester (25 μg/ml) inhibits the growth of S. mutans, C. albicans, and P. gingivalis by 98, 72, and 92%, respectively, in vitro.{47493} It has been found in biodiesel produced from castor oil using ethanol.{47494} α-Linolenic acid ethyl ester has been used as a substrate in lipid peroxidation assays for antioxidant activity.{47495}
Brand:CaymanSKU:28185 - 1 mgAvailable on backorder
α-Linolenic acid ethyl ester-d5 is intended for use as an internal standard for the quantification of α-linolenic acid ethyl ester (Item No. 10008199) by GC- or LC-MS. α-Linolenic acid ethyl ester is an esterified form of α-linolenic acid (Item Nos. 90210 | 21910). It increases cyclin E levels and the activity of Cdk2/cyclin E, ERK, and JNK in hepatic stellate cells when used at a concentration of 50 μM.{14161} α-Linolenic acid ethyl ester (25 μg/ml) inhibits the growth of S. mutans, C. albicans, and P. gingivalis by 98, 72, and 92%, respectively, in vitro.{47493} It has been found in biodiesel produced from castor oil using ethanol.{47494} α-Linolenic acid ethyl ester has been used as a substrate in lipid peroxidation assays for antioxidant activity.{47495}
Brand:CaymanSKU:28185 - 250 µgAvailable on backorder
α-Linolenic acid ethyl ester-d5 is intended for use as an internal standard for the quantification of α-linolenic acid ethyl ester (Item No. 10008199) by GC- or LC-MS. α-Linolenic acid ethyl ester is an esterified form of α-linolenic acid (Item Nos. 90210 | 21910). It increases cyclin E levels and the activity of Cdk2/cyclin E, ERK, and JNK in hepatic stellate cells when used at a concentration of 50 μM.{14161} α-Linolenic acid ethyl ester (25 μg/ml) inhibits the growth of S. mutans, C. albicans, and P. gingivalis by 98, 72, and 92%, respectively, in vitro.{47493} It has been found in biodiesel produced from castor oil using ethanol.{47494} α-Linolenic acid ethyl ester has been used as a substrate in lipid peroxidation assays for antioxidant activity.{47495}
Brand:CaymanSKU:28185 - 500 µgAvailable on backorder
α-Linolenic acid is an essential ω-3 polyunsaturated fatty acid found in plants.{42925} In vivo, it is converted to the longer-chain fatty acids eicosapentaenoic (Item Nos. 90110 | 90110.1 | 21908), docosapentaenoic (Item Nos. 90165 | 21907), or docosahexaenoic acid (Item No. 90310).{42926} It is also catabolized via fatty acid β-oxidation for energy or the synthesis of saturated and monounsaturated fatty acids, or stored in adipose tissue. Dietary consumption of α-linolenic acid-containing foods is positively associated with a moderately lower risk of cardiovascular disease.{42925} α-Linolenic Acid MaxSpec® standard is a quantitative grade standard of α-linolenic acid (Item Nos. 90210 | 21910) that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This α-linolenic acid MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.
Brand:CaymanSKU:27359 - 1 mgAvailable on backorder
α-Linolenic acid methyl ester is a natural methylated form of α-linolenic acid (Item No. 90210).{14947,32168} Unlike α-linolenic acid, linolenic acid methyl ester is a poor agonist of GPR120, does not inhibit voltage-dependent calcium channels in β-cells, and only weakly inhibits melanogenesis in mouse B16 melanoma cells.{31125,32166,32167}
Brand:CaymanSKU:9000290 - 1 gAvailable on backorder
α-Linolenic acid methyl ester is a natural methylated form of α-linolenic acid (Item No. 90210).{14947,32168} Unlike α-linolenic acid, linolenic acid methyl ester is a poor agonist of GPR120, does not inhibit voltage-dependent calcium channels in β-cells, and only weakly inhibits melanogenesis in mouse B16 melanoma cells.{31125,32166,32167}
Brand:CaymanSKU:9000290 - 100 mgAvailable on backorder
α-Linolenic acid methyl ester is a natural methylated form of α-linolenic acid (Item No. 90210).{14947,32168} Unlike α-linolenic acid, linolenic acid methyl ester is a poor agonist of GPR120, does not inhibit voltage-dependent calcium channels in β-cells, and only weakly inhibits melanogenesis in mouse B16 melanoma cells.{31125,32166,32167}
Brand:CaymanSKU:9000290 - 500 mgAvailable on backorder
α-Linolenic acid-d14 (ALA-d14) contains fourteen deuterium atoms at the 2, 2’, 3, 3’, 4, 4′, 5, 5′, 6, 6′, 7, 7′, 8, and 8′ positions. It is intended for use as an internal standard for the quantification of ALA by GC- or LC-mass spectrometry (MS). ALA is an essential fatty acid found in leafy green vegetables. ALA, as part of a low saturated fat diet, helps prevent cardiovascular disease. ALA decreases blood pressure, serum cholesterol levels, and platelet aggregation.{2786}
Brand:CaymanSKU:9000433 - 1 mgAvailable on backorder
α-Linolenic acid-d14 (ALA-d14) contains fourteen deuterium atoms at the 2, 2’, 3, 3’, 4, 4′, 5, 5′, 6, 6′, 7, 7′, 8, and 8′ positions. It is intended for use as an internal standard for the quantification of ALA by GC- or LC-mass spectrometry (MS). ALA is an essential fatty acid found in leafy green vegetables. ALA, as part of a low saturated fat diet, helps prevent cardiovascular disease. ALA decreases blood pressure, serum cholesterol levels, and platelet aggregation.{2786}
Brand:CaymanSKU:9000433 - 100 µgAvailable on backorder
α-Linolenic acid-d14 (ALA-d14) contains fourteen deuterium atoms at the 2, 2’, 3, 3’, 4, 4′, 5, 5′, 6, 6′, 7, 7′, 8, and 8′ positions. It is intended for use as an internal standard for the quantification of ALA by GC- or LC-mass spectrometry (MS). ALA is an essential fatty acid found in leafy green vegetables. ALA, as part of a low saturated fat diet, helps prevent cardiovascular disease. ALA decreases blood pressure, serum cholesterol levels, and platelet aggregation.{2786}
Brand:CaymanSKU:9000433 - 500 µgAvailable on backorder
α-Linolenic acid-d5 (ALA-d5) is intended for use as an internal standard for the quantification of ALA (Item No. 90210) by GC- or LC-MS. ALA is an essential fatty acid found in leafy green vegetables. ALA, as part of a low saturated fat diet, helps prevent cardiovascular disease. ALA decreases blood pressure, serum cholesterol levels, and platelet aggregation.{2786}
Brand:CaymanSKU:9002286 - 1 mgAvailable on backorder
α-Linolenic acid-d5 (ALA-d5) is intended for use as an internal standard for the quantification of ALA (Item No. 90210) by GC- or LC-MS. ALA is an essential fatty acid found in leafy green vegetables. ALA, as part of a low saturated fat diet, helps prevent cardiovascular disease. ALA decreases blood pressure, serum cholesterol levels, and platelet aggregation.{2786}
Brand:CaymanSKU:9002286 - 100 µgAvailable on backorder
α-Linolenic acid-d5 (ALA-d5) is intended for use as an internal standard for the quantification of ALA (Item No. 90210) by GC- or LC-MS. ALA is an essential fatty acid found in leafy green vegetables. ALA, as part of a low saturated fat diet, helps prevent cardiovascular disease. ALA decreases blood pressure, serum cholesterol levels, and platelet aggregation.{2786}
Brand:CaymanSKU:9002286 - 500 µgAvailable on backorder
α-Linolenic acid-d5 (ALA-d5) is intended for use as an internal standard for the quantification of ALA (Item Nos. 90210 | 21910 | 27359) by GC- or LC-MS. α-Linolenic acid is an essential ω-3 polyunsaturated fatty acid found in plants.{42925} In vivo, it is converted to the longer-chain fatty acids eicosapentaenoic (Item Nos. 90110 | 90110.1 | 21908), docosapentaenoic (Item Nos. 90165 | 21907), and docosahexaenoic acid (Item No. 90310).{42926} It is also catabolized via fatty acid β-oxidation for energy or the synthesis of saturated and monounsaturated fatty acids, or stored in adipose tissue. Dietary consumption of ALA-containing foods is positively associated with a moderately lower risk of cardiovascular disease.{42925} ALA-d5 MaxSpec® standard is a quantitative grade standard of ALA-d5 (Item No. 9002286) that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This ALA-d5 MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.
Brand:CaymanSKU:27360 - 100 µgAvailable on backorder
α-Linolenoyl ethanolamide is an endocannabinoid containing α-linolenic acid in place of the arachidonate moiety of AEA. α-Linolenoyl ethanolamide has been detected in porcine brain, but its specific role and relative importance as a cannabinergic neurotransmitter have not been elucidated.{1172}
Brand:CaymanSKU:90215 - 10 mgAvailable on backorder
α-Linolenoyl ethanolamide is an endocannabinoid containing α-linolenic acid in place of the arachidonate moiety of AEA. α-Linolenoyl ethanolamide has been detected in porcine brain, but its specific role and relative importance as a cannabinergic neurotransmitter have not been elucidated.{1172}
Brand:CaymanSKU:90215 - 100 mgAvailable on backorder
α-Linolenoyl ethanolamide is an endocannabinoid containing α-linolenic acid in place of the arachidonate moiety of AEA. α-Linolenoyl ethanolamide has been detected in porcine brain, but its specific role and relative importance as a cannabinergic neurotransmitter have not been elucidated.{1172}
Brand:CaymanSKU:90215 - 5 mgAvailable on backorder
α-Linolenoyl ethanolamide is an endocannabinoid containing α-linolenic acid in place of the arachidonate moiety of AEA. α-Linolenoyl ethanolamide has been detected in porcine brain, but its specific role and relative importance as a cannabinergic neurotransmitter have not been elucidated.{1172}
Brand:CaymanSKU:90215 - 50 mgAvailable on backorder
α-Linolenoyl ethanolamide-d4 contains four deuterium atoms at the 1,1′,2, and 2′ positions. It is intended for use as an internal standard for the quantification of α-linolenoyl ethanolamide by GC- or LC-mass spectrometry. α-Linolenoyl ethanolamide (Item No. 90215) is an endocannabinoid containing α-linolenic acid in place of the arachidonate moiety of AEA. α-Linolenoyl ethanolamide has been detected in porcine brain, but its specific role and relative importance as a cannabinergic neurotransmitter have not been elucidated.{1172}
Brand:CaymanSKU:9001841 - 1 mgAvailable on backorder
α-Linolenoyl ethanolamide-d4 contains four deuterium atoms at the 1,1′,2, and 2′ positions. It is intended for use as an internal standard for the quantification of α-linolenoyl ethanolamide by GC- or LC-mass spectrometry. α-Linolenoyl ethanolamide (Item No. 90215) is an endocannabinoid containing α-linolenic acid in place of the arachidonate moiety of AEA. α-Linolenoyl ethanolamide has been detected in porcine brain, but its specific role and relative importance as a cannabinergic neurotransmitter have not been elucidated.{1172}
Brand:CaymanSKU:9001841 - 100 µgAvailable on backorder
α-Linolenoyl ethanolamide-d4 contains four deuterium atoms at the 1,1′,2, and 2′ positions. It is intended for use as an internal standard for the quantification of α-linolenoyl ethanolamide by GC- or LC-mass spectrometry. α-Linolenoyl ethanolamide (Item No. 90215) is an endocannabinoid containing α-linolenic acid in place of the arachidonate moiety of AEA. α-Linolenoyl ethanolamide has been detected in porcine brain, but its specific role and relative importance as a cannabinergic neurotransmitter have not been elucidated.{1172}
Brand:CaymanSKU:9001841 - 5 mgAvailable on backorder