Description
A 5-HT receptor agonist; binds selectively to 5-HT1A, 5-HT1B, 5-HT1C, and 5-HT1D receptors over 5-HT1E receptors (Kis = 42, 85, 150, 150, and >10,000 nM, respectively); selective for 5-HT2B and 5-HT2C receptors over 5-HT2A receptors (EC50s = 2.98, 50.1, and 794 nM, respectively); potentiates NMDA-induced motor neuron depolarizations in the presence of the NMDA receptor antagonist memantine in R. pipiens (frog) spinal cord ex vivo at 30 μM; increases dopamine release from rat striatum in vivo in a dose-dependent manner; increases systolic blood pressure and transiently increases heart rate in conscious dogs at 64 μg/kg
Formal name: 3-(2-aminopropyl)-1H-indol-5-ol, (2Z)-2-butenedioate
Synonyms: α-Me-5-HT|α-Methyl-5-HT|α-Methyl-5-hydroxytryptamine|α-Methylserotonin
Molecular weight: 306.3
CAS: 97469-12-0
Purity: ≥98%
Formulation: A solid
