A monoterpene with diverse biological activities; reduces carrageenan-induced neutrophil accumulation and leukocyte rolling and adhesion as well as inhibits production of the pro-inflammatory cytokines TNF-α and IL-6 in a rat model of air pouch inflammation at 50

α-Phellandrene – 1 g

Brand:
Cayman
CAS:
99-83-2
Storage:
-20
UN-No:
Excepted Quantity - 2319 / 3

α-Phellandrene is a cyclic monoterpene that has been found in various plants, including Cannabis, and has diverse biological activities.{36781} In vivo, α-phellandrene (50, 100, and 200 mg/kg, p.o.) reduces carrageenan-induced neutrophil accumulation and leukocyte rolling and adhesion as well as inhibits production of the pro-inflammatory cytokines TNF-α and IL-6 in a rat model of air pouch inflammation.{45024} It decreases spleen weight and increases macrophage phagocytosis and natural killer (NK) cell cytotoxic activity in a murine WEHI-3 leukemia model.{45025} α-Phellandrene has antinociceptive effects in mouse models of pain, reducing acetic acid-induced writhing, paw licking in the capsaicin test, and glutamate-induced licking and biting behavior, as well as increases the paw withdrawal threshold following carrageenan-induced inflammation.{45026}  

 

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SKU: 23179 - 1 g Category:

Description

A monoterpene with diverse biological activities; reduces carrageenan-induced neutrophil accumulation and leukocyte rolling and adhesion as well as inhibits production of the pro-inflammatory cytokines TNF-α and IL-6 in a rat model of air pouch inflammation at 50, 100, and 200 mg/kg; decreases spleen weight and increases macrophage phagocytosis and NK cell cytotoxic activity in a murine WEHI-3 leukemia model; has antinociceptive effects in various mouse models of pain

Formal name: 2-methyl-5-(1-methylethyl)-1,3-cyclohexadiene

Synonyms:  (±)-α-Phellandrene|p-Mentha-1,5-diene

Molecular weight: 136.2

CAS: 99-83-2

Purity: ≥80%

Formulation: An oil

Product Type|Biochemicals|Natural Products|Phytocannabinoids||Product Type|Biochemicals|Natural Products|Terpenes||Research Area|Cancer||Research Area|Immunology & Inflammation|Innate Immunity|Phagocytosis||Research Area|Neuroscience|Cannabinoid Research||Research Area|Neuroscience|Pain Research

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