α-NETA – 5 mg

Brand:
Cayman
CAS:
31059-54-8
Storage:
-20
UN-No:
Non-Hazardous - /

Choline acetyltransferase (ChAT) mediates the synthesis of the neurotransmitter acetylcholine from acetyl-CoA and choline. In addition to its critical role in neurosignaling, deficiencies in ChAT are linked to congenital myasthenic syndromes, Alzheimer’s disease, and multiple sclerosis.{24010,24015,24012} α-NETA is a stable, non-competitive, and slowly reversible inhibitor of ChAT (IC50 = 9 μM).{24013,24014} This naturally fluorescent compound is a poor inhibitor of cholinesterases and carnitine acetyltransferase.{24014} α-NETA is commonly used in cells in culture.{24016,24011}  

 

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Description

A stable, selective, and slowly reversible inhibitor of choline acetyltransferase (IC50 = 9 μM); commonly used in cells in culture


Formal name: N,N,N-trimethyl-γ-oxo-2-naphthalenepropanaminium, monoiodide

Synonyms: 

Molecular weight: 369.2

CAS: 31059-54-8

Purity: ≥97%

Formulation: A solid


Application|Fluorescence||Product Type|Biochemicals|Small Molecule Inhibitors|Acetylcholine Turnover||Product Type|Biochemicals|Small Molecule Inhibitors|Acetyltransferases||Research Area|Neuroscience