A peptide hormone; induces cAMP production in Hepa cells expressing human MC3R and MC4R (EC50s = 0.16 and 56 nM

α-MSH (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt) – 10 mg

Brand:
Cayman
CAS:
171869-93-5
Storage:
-20
UN-No:
Non-Hazardous - /

α-Melanocyte-stimulating hormone (α-MSH) is a 13-amino acid peptide hormone produced by post-translational processing of proopiomelanocortin (POMC) in the pituitary gland, as well as in keratinocytes, astrocytes, monocytes, and gastrointestinal cells.{47500} It is an agonist of melanocortin receptor 3 (MC3R) and MC4R that induces cAMP production in Hepa cells expressing the human receptors (EC50s = 0.16 and 56 nM, respectively).{45139} α-MSH (100 pM) reduces S. aureus colony formation and C. albicans germ tube formation in vitro.{55058} It inhibits endotoxin-, ceramide-, TNF-α-, or okadaic acid-induced activation of NF-κB in U937 cells.{47500} α-MSH reduces IL-6- or TNF-α-induced ear edema in mice.{55059} It also prevents the development of adjuvant-induced arthritis in rats and increases survival in a mouse model of septic shock. Increased plasma levels of α-MSH are positively correlated with delayed disease progression and reduced death in patients with HIV.{47500}  

 

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SKU: 29923 - 10 mg Category:

Description

A peptide hormone; induces cAMP production in Hepa cells expressing human MC3R and MC4R (EC50s = 0.16 and 56 nM, respectively); reduces S. aureus colony formation and C. albicans germ tube formation in vitro at 100 pM; inhibits endotoxin-, ceramide-, TNF-α-, or okadaic acid-induced activation of NF-κB in U937 cells; reduces IL-6- or TNF-α-induced ear edema in mice; prevents the development of adjuvant-induced arthritis in rats and increases survival in a mouse model of septic shock; increased plasma levels are positively correlated with delayed disease progression and reduced death in patients with HIV

Formal name:

Synonyms:  Ac-SYSMEHFRWGKPV-NH2|α-Melanocyte-stimulating Hormone

Molecular weight: 1,664.90

CAS: 171869-93-5

Purity: ≥98%

Formulation: A solid

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