α-Spinasterol – 1 mg

Brand:
Cayman
CAS:
481-18-5
Storage:
-20
UN-No:
Non-Hazardous - /

α-Spinasterol is a bioavailable phytosterol originally isolated from spinach that acts as an antagonist at the transient receptor potential vanilloid type 1 (TRPV1) receptor (IC50 = 1.4 µM).{39108,39112} It has antinociceptive effects in a noxious heat-induced pain test and also reduces hyperalgesia and edema in a complete Freund’s adjuvant-induced inflammatory pain test in mice at a dose of 0.3 µmol/kg. α-Spinastrerol increases the seizure threshold in a dose-dependent manner and reduces depressive-like behavior in mice.{39110,39111} It also has anti-inflammatory activity in vivo and inhibits benign prostatic hyperplasia in rats.{39107,39109}  

 

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Description

A TRPV1 antagonist (IC50 = 1.4 µM); has antinociceptive effects and reduces hyperalgesia and edemia at a dose of 0.3 µmol/kg; increases the seizure threshold; reduces depressive-like behavior in mice; has anti-inflammatory activity; inhibits benign prostatic hyperplasia in rats,


Formal name: (3β,5α,22E)-stigmasta-7,22-dien-3-ol

Synonyms:  Bessisterol|Hitodesterol

Molecular weight: 412.7

CAS: 481-18-5

Purity: ≥95%

Formulation: A crystalline solid


Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Natural Products|Phytosterols||Research Area|Immunology & Inflammation||Research Area|Neuroscience|Behavioral Neuroscience|Depression||Research Area|Neuroscience|Pain Research||Research Area|Neuroscience|Seizure Disorders||Research Area|Plant Biology