An antioxidant with neuroprotective properties; reduces cell death induced by hydrogen peroxide

α-Tocotrienol – 1 mg

Brand:
Cayman
CAS:
58864-81-6
Storage:
-20
UN-No:
De Minimis - 1170 / 3

α-Tocotrienol is an antioxidant and a form of vitamin E that has been found in rice bran and has neuroprotective properties.{3679,14290,14292,52764} It reduces cell death induced by hydrogen peroxide, paraquat, S-nitrocysteine, SIN-1 (Item No. 82220), or L-buthionine-(S,R)-sulfoximine (BSO; Item No. 14484) in rat striatal cultures when used at concentrations ranging from 0.1 to 10 µM.{14290} Cytosolic microinjection of α-tocotrienol prevents glutamate-induced cell death and phosphorylation of 12-lipoxygenase (12-LO) in HT4 neurons.{14292} It reduces glutamate-induced cytosolic and mitochondrial production of reactive oxygen species (ROS), accumulation of N-terminally truncated Bcl-xL (ΔN-Bcl-xL), and cell death in primary rat hippocampal neurons.{52764} α-Tocotrienol (50 mg/kg) reduces infarct size in a spontaneously hypertensive rat model of stroke induced by tandem right common carotid artery and middle cerebral artery occlusion.{14292}  

 

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SKU: 10008377 - 1 mg Category:

Description

An antioxidant with neuroprotective properties; reduces cell death induced by hydrogen peroxide, paraquat, S-nitrocysteine, SIN-1, or BSO in rat striatal cultures from 0.1-10 µM; cytosolic microinjection prevents glutamate-induced cell death and phosphorylation of 12-LO in HT4 neurons; reduces glutamate-induced cytosolic and mitochondrial production of ROS, accumulation of ΔN-Bcl-xL, and cell death in primary rat hippocampal neurons; reduces infarct size in a spontaneously hypertensive rat model of stroke induced by tandem right common carotid artery and middle cerebral artery occlusion at 50 mg/kg

Formal name: 3,4-dihydro-2,5,7,8-tetramethyl-2R-[(3E,7E)-4,8,12-trimethyl-3,7,11-tridecatrienyl)]-2H-1-benzopyran-6-ol

Synonyms: 

Molecular weight: 424.7

CAS: 58864-81-6

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Natural Products|Vitamins||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Cardiovascular Diseases|Stroke||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Neuroscience|Neuroprotection|Ischemia||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Nitrogen||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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