Antibodies
Showing 1801–1950 of 2318 results
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Brand:CaymanSKU:13409- 1 ea Brand:CaymanSKU:13409- 1 eaAvailable on backorder
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Brand:CaymanSKU:13473- 100 μgAvailable on backorder
Brand:CaymanSKU:13473- 100 μg Brand:CaymanSKU:11269- 100 μg Brand:CaymanSKU:11269- 100 μgAvailable on backorder
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Brand:CaymanSKU:11252- 100 μg Brand:CaymanSKU:11252- 100 μgAvailable on backorder
Brand:CaymanSKU:11261- 100 μg Brand:CaymanSKU:11261- 100 μgAvailable on backorder
Brand:CaymanSKU:13407- 1 ea Brand:CaymanSKU:13407- 1 eaAvailable on backorder
Brand:CaymanSKU:11280- 100 μg Brand:CaymanSKU:11280- 100 μgAvailable on backorder
Antigen: phosphopeptide corresponding to amino acid residues surrounding phospho-Ser301 of rat Raf-1 • Host: rabbit • Cross Reactivity: (+) rat Raf-1; expected to react with bovine, canine, chicken, human, mouse, non-human primate, and Xenopus Raf-1 • Application(s): WB • Studies have shown that phosphorylation is required for Raf-1 activation. Phosphorylation also down-regulates Raf with two sites participating: Ser301 and Ser642.
Brand:CaymanSKU:10009504- 1 eaAvailable on backorder
Antigen: phosphopeptide corresponding to amino acid residues surrounding phospho-Ser301 of rat Raf-1 • Host: rabbit • Cross Reactivity: (+) rat Raf-1; expected to react with bovine, canine, chicken, human, mouse, non-human primate, and Xenopus Raf-1 • Application(s): WB • Studies have shown that phosphorylation is required for Raf-1 activation. Phosphorylation also down-regulates Raf with two sites participating: Ser301 and Ser642.
Brand:CaymanSKU:10009504- 1 ea Antigen: phosphopeptide corresponding to amino acid residues surrounding phospho-Ser642 of rat raf-1 • Host: rabbit • Cross Reactivity: (+) rat raf-1; expected to react with bovine, canine, chicken, human, mouse, non-human primate, and Xenopus raf-1 • Application(s): WB • Members of the Raf serine/threonine kinase family function to relay signals from activated Ras to the downstream protein kinases MEK and ERK, which are critical for cellular proliferation, differentiation, survival, and oncogenic transformation. RAf-1 activity is regulated by phophorylation of Ser301 and Ser642.
Brand:CaymanSKU:10009505- 1 eaAvailable on backorder
Antigen: phosphopeptide corresponding to amino acid residues surrounding phospho-Ser642 of rat raf-1 • Host: rabbit • Cross Reactivity: (+) rat raf-1; expected to react with bovine, canine, chicken, human, mouse, non-human primate, and Xenopus raf-1 • Application(s): WB • Members of the Raf serine/threonine kinase family function to relay signals from activated Ras to the downstream protein kinases MEK and ERK, which are critical for cellular proliferation, differentiation, survival, and oncogenic transformation. RAf-1 activity is regulated by phophorylation of Ser301 and Ser642.
Brand:CaymanSKU:10009505- 1 ea
Brand:CaymanSKU:32809- 100 µlAvailable on backorder
Brand:CaymanSKU:32809- 100 µl
Brand:CaymanSKU:32810- 100 µlAvailable on backorder
Brand:CaymanSKU:32810- 100 µl
Brand:CaymanSKU:32811- 100 µlAvailable on backorder
Brand:CaymanSKU:32811- 100 µl
Ciliary Neurotrophic Factor (CNTF) is a cytokine belonging to the Interleukin 6 (IL-6) family, which also includes IL-6, Oncostatin M, Leukemia Inhibitory Factor (LIF), and Cardiotrophin-1. Structurally, CNTF resembles a four-helix bundle composition, similar to the other members of the IL-6 family. The receptor for CNTF is composed of three parts: a gp130-like subunit common in the IL-6 receptor family, a LIF Receptor β subunit, and a CNTF specific α receptor subunit. Upon binding to the CNTF, the β subunit of the CNTF receptorwill undergo tyrosine phosphorylation, and activate the intracellular JAK/STAT pathway. The main function of CNTF in vivo is to promote the differentiation and survival of a variety of neurons and glial cells, including sympathetic precursor cells and spinal motor neurons._x000D_
Recombinant human Ciliary Neurotrophic Factor (rhCNTF) produced in E. coli is a single non-glycosylated polypeptide chain containing 199 amino acids. A fully biologically active molecule, rhCNTF has a molecular mass of 22.8 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript._x000D_Brand:Boster BioSKU:R00609Available on backorder
The Fibroblast Growth Factors (FGFs) are heparin binding glycoproteins that exert a variety of biological activities toward cells of mesenchymal, neuronal, and epithelial origin. FGF-10 belongs to the subgroup of FGFs that also includes FGF-3, -7, and -22 (1). Mature human FGF-10 is an approximately 20 kDa protein that contains a serine-rich region near its N-terminus FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes,including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity ofFGF7. Studiesof the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of limb bud formation. This gene is also implicated to be a primary factor in the process of wound healing.
Brand:Boster BioSKU:R01709Available on backorder
Fibroblast Growth Factor basic (FGF-basic/FGF-2)Â is a single-chain polypeptide growth factor that plays a significant role in the process of wound healing and is a potent inducer of angiogenesis. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FGF-1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor. Other homologous FGF belonging to the same family are int-2 (FGF-3), FGF-5, FGF-6, K-FGF and KGF ( keratinocyte growth factor = FGF-7). All factors are products of different genes, some of which are Oncogene products ( FGF-3, FGF-4, FGF-5 ).
Brand:Boster BioSKU:R00121Available on backorder
KGF (keratinocyte growth factor), also known as FGF-7 (fibroblast growth factor-7), is one of 22 known members. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis.
Brand:Boster BioSKU:R01931Available on backorder
Interferon gamma(IFNγ) is a dimerized soluble cytokine that is the only member of the type II class of interferons. The existence of this interferon, which early in its history was known as immune interferon, was described by E. F. Wheelock as a product of human leukocytes stimulatedwith phytohemagglutinin, and by others as a productofantigen-stimulatedlymphocytes ortuberculin-sensitized mouseperitoneal lymphocytes challenged with PPD.The resulting supernatants were shown toinhibit growth of vesicular stomatitisvirus. IFNγis a cytokine that is critical for innate and adaptive immunityagainst viral, some bacterial and protozoal infections. IFNγ is an important activator of macrophages and inducer of Class II major histocompatibility complex (MHC) molecule expression. The importance of IFNγ in the immune system stems in part from its ability to inhibit viral replication directly, and most importantly from its immunostimulatoryand immunomodulatoryeffects. IFNγ is produced predominantly by natural killer (NK) and natural killer T (NKT) cells as part of the innate immune response, and by CD4 Th1 and CD8 cytotoxic T lymphocyte (CTL) effector T cells once antigen-specific immunity develops.
Brand:Boster BioSKU:R00393Available on backorder
Oncostatin-M(OSM) is amember of the leukemia inhibitory factor/oncostatin-M (LIF/OSM) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a secreted cytokine and growth regulator that inhibits the proliferation of a number of tumor cell lines. This protein also regulates the production of other cytokines, including interleukin 6, granulocyte-colony stimulating factor and granulocyte-macrophagecolony stimulating factor in endothelial cells. This gene and the related gene, leukemia inhibitory factor, also present on chromosome 22, may have resulted from the duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Brand:Boster BioSKU:R00804Available on backorder
Tumor necrosis factor (TNF, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine)involved insystemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocyts, NK cells, neutrophils, mast cells, eosinophils, and neurons. The primary role of TNF is in the regulation of immune cells. TNF, being an endogenous pyrogen, is able to induce fever, apoptotic cell death, cachexia, inflammation and to inhibit tumorigenesis andviral replicatin and respond to sepsis via IL1 & IL6 producing cells. Dysregulation of TNF production has been implicated in a variety of human diseases including Alzheimer’s disease, cancer, major depression, psoriasisand inflammatory bowel disease (IBD).Though controversial, studies of depression and IBD are currentlybeing linked to TNF levels. Recombinant TNF is used as an immunostimulant under the INN tasonermin. TNF can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.
Brand:Boster BioSKU:R00002Available on backorder
Fibroblast Growth Factor basic (FGF-basic/FGF-2) is a single-chain polypeptide growth factor that plays a significant role in the process of wound healing and is a potent inducer of angiogenesis. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FGF-1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor. Other homologous FGF belonging to the same family are int-2 (FGF-3), FGF-5, FGF-6, K-FGF and KGF (keratinocyte growth factor = FGF-7). All factors are products of different genes, some of which are Oncogene products (FGF-3, FGF-4, FGF-5).
Brand:Boster BioSKU:R00121-1Available on backorder
KGF (keratinocyte growth factor), also known as FGF-7 (fibroblast growth factor-7), is one of 22 known members. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis.
Brand:Boster BioSKU:R01931-1Available on backorder
LIF (leukemia inhibitory factor) is a widely expressed pleiotropic member of the IL-6 family of cytokines. The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Brand:Boster BioSKU:R01400-1Available on backorder
Tumor necrosis factor (TNF, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved insystemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocyts, NK cells, neutrophils, mast cells, eosinophils, and neurons. The primary role of TNF is in the regulation of immune cells. TNF, being an endogenous pyrogen, is able to induce fever, apoptotic cell death, cachexia, inflammation and to inhibit tumorigenesis andviral replicatin and respond to sepsis via IL1 & IL6 producing cells. Dysregulation of TNF production has been implicated in a variety of human diseases including Alzheimer’s disease, cancer, major depression, psoriasisand inflammatory bowel disease (IBD).Though controversial, studies of depression and IBD are currentlybeing linked to TNF levels. Recombinant TNF is used as an immunostimulant under the INN tasonermin. TNF can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.
Brand:Boster BioSKU:R00002-1Available on backorder
Immunogen: Recombinant human renin protein • Clone designation: 3G10 • Host: Mouse • Species Reactivity: (+) Human • Isotype: IgG2b • Application: (+) IP; (-) WB
Brand:CaymanSKU:17624- 200 µg Immunogen: Recombinant human renin protein • Clone designation: 3G10 • Host: Mouse • Species Reactivity: (+) Human • Isotype: IgG2b • Application: (+) IP; (-) WB
Brand:CaymanSKU:17624- 200 µgAvailable on backorder
Immunogen: Peptide from the C-terminal region of rat RSK2 • Host: rabbit • Species Reactivity: (+) rat RSK2 • Application(s): WB • RSKs 1-4 are downstream members of the ERK/MAPK cascade. Recent work suggests that RSK2 exerts a tonic regulation on G protein-coupled signaling.
Brand:CaymanSKU:10009411- 1 eaAvailable on backorder
Immunogen: Peptide from the C-terminal region of rat RSK2 • Host: rabbit • Species Reactivity: (+) rat RSK2 • Application(s): WB • RSKs 1-4 are downstream members of the ERK/MAPK cascade. Recent work suggests that RSK2 exerts a tonic regulation on G protein-coupled signaling.
Brand:CaymanSKU:10009411- 1 ea
Immunogen: Synthetic peptide from the N-terminal region of human RICK • Host: Rabbit • Species Reactivity: (+) Human, mouse, and rat; other species not tested • Application: WB • Overexpression of RICK promotes the activation of caspase-8 and Fas-induced apoptosis. RICK represents a novel kinase that regulates Fas-induced apoptosis.
Brand:CaymanSKU:160785- 500 µl Immunogen: Synthetic peptide from the N-terminal region of human RICK • Host: Rabbit • Species Reactivity: (+) Human, mouse, and rat; other species not tested • Application: WB • Overexpression of RICK promotes the activation of caspase-8 and Fas-induced apoptosis. RICK represents a novel kinase that regulates Fas-induced apoptosis.
Brand:CaymanSKU:160785- 500 µlAvailable on backorder
Immunogen: Recombinant human RIG-I protein AA 232-794 • Host: Mouse • Species Reactivity: Human, Mouse • Cross Reactivity: none • Applications: ELISA, WB, immunohistochemistry • MW = 106.6 kDa
Brand:CaymanSKU:25300- 100 µgAvailable on backorder
Immunogen: Recombinant human RIG-I protein AA 232-794 • Host: Mouse • Species Reactivity: Human, Mouse • Cross Reactivity: none • Applications: ELISA, WB, immunohistochemistry • MW = 106.6 kDa
Brand:CaymanSKU:25300- 100 µg
Brand:CaymanSKU:32823- 100 µlAvailable on backorder
Brand:CaymanSKU:32823- 100 µl
Antigen: a peptide within the region of amino acids 1-50 of human RORγ • Host: rabbit • Cross Reactivity: (+) chimpanzee and human RORγ; predicted to react with bovine, canine, mouse, and rat RORγ • Application(s): IHC and WB
Brand:CaymanSKU:11003- 1 eaAvailable on backorder
Antigen: a peptide within the region of amino acids 1-50 of human RORγ • Host: rabbit • Cross Reactivity: (+) chimpanzee and human RORγ; predicted to react with bovine, canine, mouse, and rat RORγ • Application(s): IHC and WB
Brand:CaymanSKU:11003- 1 ea
Immunogen: Peptide corresponding to RSK1 (phospho-Thr359/Ser363) • Host: Rabbit • Species Reactivity: (+) Human • Cross Reactivity: (+) RSK1 (phospho-Thr359/Ser363); (-) RSK1 without phosphorylation at Thr359/Ser363 • Applications: IHC, WB
Brand:CaymanSKU:32193- 100 µlAvailable on backorder
Immunogen: Peptide corresponding to RSK1 (phospho-Thr359/Ser363) • Host: Rabbit • Species Reactivity: (+) Human • Cross Reactivity: (+) RSK1 (phospho-Thr359/Ser363); (-) RSK1 without phosphorylation at Thr359/Ser363 • Applications: IHC, WB
Brand:CaymanSKU:32193- 100 µl
Brand:CaymanSKU:32824- 100 µlAvailable on backorder
Brand:CaymanSKU:32824- 100 µl
Brand:CaymanSKU:32826- 100 µlAvailable on backorder
Brand:CaymanSKU:32826- 100 µl
Brand:CaymanSKU:32827- 100 µlAvailable on backorder
Brand:CaymanSKU:32827- 100 µl
Immunogen: Peptide from an internal cytoplasmic region of human S1P1 • Host: Rabbit • Species Reactivity: (+) Human, mouse, porcine, and rat S1P1 • Application(s): IF, IHC, and WB • S1P exerts its activity by binding to five distinct GPCRs, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8. S1P1 primarily mediates S1P-induced cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. Expression of S1P1 is abundant in embryological vasculature and is ubiquitously expressed in adult cells suggesting diverse physiological functions of this receptor.
Brand:CaymanSKU:10005228- 1 eaAvailable on backorder
Immunogen: Peptide from an internal cytoplasmic region of human S1P1 • Host: Rabbit • Species Reactivity: (+) Human, mouse, porcine, and rat S1P1 • Application(s): IF, IHC, and WB • S1P exerts its activity by binding to five distinct GPCRs, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8. S1P1 primarily mediates S1P-induced cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. Expression of S1P1 is abundant in embryological vasculature and is ubiquitously expressed in adult cells suggesting diverse physiological functions of this receptor.
Brand:CaymanSKU:10005228- 1 ea
Immunogen: Peptide from the internal region of human S1P1 • Host: Rabbit • Species Reactivity: (+) Human S1P1, Mouse S1P1, Porcine S1P1 Rat S1P1 • Application(s): WB
Brand:CaymanSKU:20208- 1 eaAvailable on backorder
Immunogen: Peptide from the internal region of human S1P1 • Host: Rabbit • Species Reactivity: (+) Human S1P1, Mouse S1P1, Porcine S1P1 Rat S1P1 • Application(s): WB
Brand:CaymanSKU:20208- 1 ea
Antigen: Human S1P3 amino acids 12-25 • Host: Rabbit • Cross Reactivity: (+) Human, mouse, and rat S1P3 • Application(s): ICC and WB • S1P3 is one of five GPCRs that are activated by S1P. It couples to Gi/o-ERK, Gq-PLC, and G12/13-Rho axes to mediate S1P-induced cell proliferation, survival, migration, and related signaling events. S1P3 is widely expressed in various tissues, suggesting diverse physiological functions of this receptor.
Brand:CaymanSKU:10006373- 1 eaAvailable on backorder
Antigen: Human S1P3 amino acids 12-25 • Host: Rabbit • Cross Reactivity: (+) Human, mouse, and rat S1P3 • Application(s): ICC and WB • S1P3 is one of five GPCRs that are activated by S1P. It couples to Gi/o-ERK, Gq-PLC, and G12/13-Rho axes to mediate S1P-induced cell proliferation, survival, migration, and related signaling events. S1P3 is widely expressed in various tissues, suggesting diverse physiological functions of this receptor.
Brand:CaymanSKU:10006373- 1 ea
Antigen: synthetic peptide from human S1P4 wihin the region of amino acids 1-50 • Host: rabbit • Cross Reactivity: (+) human and mouse S1P4 • Application(s): ICC, IF, and WB • Binding of S1P to S1P4 activates Erk, leading to the activation of the transcription factor Elk1 and thus the MAPK signal transduction pathway.
Brand:CaymanSKU:13489- 1 eaAvailable on backorder
Antigen: synthetic peptide from human S1P4 wihin the region of amino acids 1-50 • Host: rabbit • Cross Reactivity: (+) human and mouse S1P4 • Application(s): ICC, IF, and WB • Binding of S1P to S1P4 activates Erk, leading to the activation of the transcription factor Elk1 and thus the MAPK signal transduction pathway.
Brand:CaymanSKU:13489- 1 ea
Antigen: peptide from human S1P5 within the region of amino acids 1-50 • Host: rabbit • Cross Reactivity: (+) canine, human, monkey, mouse, and rat S1PR5 • Application(s): IHC and WB • S1P5 is a receptor for the bioactive sphingolipid S1P as well as for LPA and gives diverse physiological effects on most types of cells and tissues.
Brand:CaymanSKU:13490- 1 eaAvailable on backorder
Antigen: peptide from human S1P5 within the region of amino acids 1-50 • Host: rabbit • Cross Reactivity: (+) canine, human, monkey, mouse, and rat S1PR5 • Application(s): IHC and WB • S1P5 is a receptor for the bioactive sphingolipid S1P as well as for LPA and gives diverse physiological effects on most types of cells and tissues.
Brand:CaymanSKU:13490- 1 ea Immunogen: Recombinant SARS-CoV nucleocapsid protein • Host: Rabbit • Species Reactivity: (+) SARS-CoV • Application: ELISA
Brand:CaymanSKU:31430- 100 µl Immunogen: Recombinant SARS-CoV nucleocapsid protein • Host: Rabbit • Species Reactivity: (+) SARS-CoV • Application: ELISA
Brand:CaymanSKU:31430- 100 µlAvailable on backorder