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The major tocopherol obtained from natural dietary sources is γ-tocopherol, whereas α-tocopherol is the form of Vitamin E typically obtained from synthetic supplements. γ-CEHC is a β-oxidized metabolite of dietary γ-tocopherol that functions as a natriuretic hormone.{4779} It was initially purified and characterized from the urine of uremic patients, but it has since been found in urine from both control patients and those with congestive heart failure.{4010} γ-CEHC is also anti-inflammatory, reducing 8-isoprostane and inflammatory eicosanoid synthesis in rat models.{8680}
Brand:CaymanSKU:89630 - 10 mgAvailable on backorder
The major tocopherol obtained from natural dietary sources is γ-tocopherol, whereas α-tocopherol is the form of Vitamin E typically obtained from synthetic supplements. γ-CEHC is a β-oxidized metabolite of dietary γ-tocopherol that functions as a natriuretic hormone.{4779} It was initially purified and characterized from the urine of uremic patients, but it has since been found in urine from both control patients and those with congestive heart failure.{4010} γ-CEHC is also anti-inflammatory, reducing 8-isoprostane and inflammatory eicosanoid synthesis in rat models.{8680}
Brand:CaymanSKU:89630 - 25 mgAvailable on backorder
The major tocopherol obtained from natural dietary sources is γ-tocopherol, whereas α-tocopherol is the form of Vitamin E typically obtained from synthetic supplements. γ-CEHC is a β-oxidized metabolite of dietary γ-tocopherol that functions as a natriuretic hormone.{4779} It was initially purified and characterized from the urine of uremic patients, but it has since been found in urine from both control patients and those with congestive heart failure.{4010} γ-CEHC is also anti-inflammatory, reducing 8-isoprostane and inflammatory eicosanoid synthesis in rat models.{8680}
Brand:CaymanSKU:89630 - 5 mgAvailable on backorder
γ-Lindane is an organochloro insecticide that is an antagonist of GABAA receptors.{37358} It inhibits GABA-stimulated chloride uptake by membrane vesicles isolated from rat cerebral cortex (IC50 = 68 μM). It binds selectively to insect GABAA receptors over mammalian GABAA receptors in membrane preparations (IC50s = 1, 12, 505, 833, and 150-1, 675 nM for fruit fly, house fly, human, mouse, and rat, respectively).{37359,37360} It binds to a human recombinant β3 homooligomer with similar selectivity as α1β3γ2-containing receptors, indicating that the binding site for γ-lindane on GABAA receptors is located on the β3 subunit (IC50s = 0.90, 21, and 306 nM for β3, α1β3γ2, and the native receptor, respectively).{37361} γ-Lindane blocks GABA- and glutamate-induced current responses in American cockroach neurons (IC50s = 1.74 and 148 nM, respectively).{37362} It is toxic to mice and adult house flies (LD50s = 40 and 5.5 mg/kg, respectively) and also kills head lice in vitro and inhibits hatching.{37361,37363}
Brand:CaymanSKU:23952 - 100 mgAvailable on backorder
γ-Linolenic acid (GLA) is an ω-6 fatty acid which can be elongated to arachidonic acid for endogenous eicosanoid synthesis. It is a weak LTB4 receptor antagonist, inhibiting [3H]-LTB4 binding to porcine neutrophil membranes with a Ki of 1 µM. GLA produces 53% inhibition at a 1 mg/kg dose in an in vivo model of LTB4-induced bronchoconstriction.{2361}
Brand:CaymanSKU:90220 - 1 gAvailable on backorder
γ-Linolenic acid (GLA) is an ω-6 fatty acid which can be elongated to arachidonic acid for endogenous eicosanoid synthesis. It is a weak LTB4 receptor antagonist, inhibiting [3H]-LTB4 binding to porcine neutrophil membranes with a Ki of 1 µM. GLA produces 53% inhibition at a 1 mg/kg dose in an in vivo model of LTB4-induced bronchoconstriction.{2361}
Brand:CaymanSKU:90220 - 100 mgAvailable on backorder
γ-Linolenic acid (GLA) is an ω-6 fatty acid which can be elongated to arachidonic acid for endogenous eicosanoid synthesis. It is a weak LTB4 receptor antagonist, inhibiting [3H]-LTB4 binding to porcine neutrophil membranes with a Ki of 1 µM. GLA produces 53% inhibition at a 1 mg/kg dose in an in vivo model of LTB4-induced bronchoconstriction.{2361}
Brand:CaymanSKU:90220 - 250 mgAvailable on backorder
γ-Linolenic acid (GLA) is an ω-6 fatty acid which can be elongated to arachidonic acid for endogenous eicosanoid synthesis. It is a weak LTB4 receptor antagonist, inhibiting [3H]-LTB4 binding to porcine neutrophil membranes with a Ki of 1 µM. GLA produces 53% inhibition at a 1 mg/kg dose in an in vivo model of LTB4-induced bronchoconstriction.{2361}
Brand:CaymanSKU:90220 - 50 mgAvailable on backorder
γ-Linolenic acid (GLA) is an ω-6 fatty acid which can be elongated to arachidonic acid for endogenous eicosanoid synthesis. It is a weak leukotriene B4 (LTB4) receptor antagonist, inhibiting [3H]-LTB4 binding to porcine neutrophil membranes with a Ki value of 1 µM. GLA produces 53% inhibition at a 1 mg/kg dose in an in vivo model of LTB4-induced bronchoconstriction.{2361} GLA ethyl ester is an esterified version of the free acid which is less water soluble but more amenable for the formulation of GLA-containing diets.
Brand:CaymanSKU:9000738 - 1 gAvailable on backorder
γ-Linolenic acid (GLA) is an ω-6 fatty acid which can be elongated to arachidonic acid for endogenous eicosanoid synthesis. It is a weak leukotriene B4 (LTB4) receptor antagonist, inhibiting [3H]-LTB4 binding to porcine neutrophil membranes with a Ki value of 1 µM. GLA produces 53% inhibition at a 1 mg/kg dose in an in vivo model of LTB4-induced bronchoconstriction.{2361} GLA ethyl ester is an esterified version of the free acid which is less water soluble but more amenable for the formulation of GLA-containing diets.
Brand:CaymanSKU:9000738 - 100 mgAvailable on backorder
γ-Linolenic acid (GLA) is an ω-6 fatty acid which can be elongated to arachidonic acid for endogenous eicosanoid synthesis. It is a weak leukotriene B4 (LTB4) receptor antagonist, inhibiting [3H]-LTB4 binding to porcine neutrophil membranes with a Ki value of 1 µM. GLA produces 53% inhibition at a 1 mg/kg dose in an in vivo model of LTB4-induced bronchoconstriction.{2361} GLA ethyl ester is an esterified version of the free acid which is less water soluble but more amenable for the formulation of GLA-containing diets.
Brand:CaymanSKU:9000738 - 250 mgAvailable on backorder
γ-Linolenic acid (GLA) is an ω-6 fatty acid which can be elongated to arachidonic acid for endogenous eicosanoid synthesis. It is a weak leukotriene B4 (LTB4) receptor antagonist, inhibiting [3H]-LTB4 binding to porcine neutrophil membranes with a Ki value of 1 µM. GLA produces 53% inhibition at a 1 mg/kg dose in an in vivo model of LTB4-induced bronchoconstriction.{2361} GLA ethyl ester is an esterified version of the free acid which is less water soluble but more amenable for the formulation of GLA-containing diets.
Brand:CaymanSKU:9000738 - 50 mgAvailable on backorder
Polyunsaturated fatty acids (PUFAs) are essential nutrients that show distinct deficiency syndromes when not present in adequate amounts in the diet.{5525,8460} γ-Linolenic Acid methyl ester (Methyl GLA) is an esterified version of the free acid which is less water soluble but more amenable for the formulation of GLA-containing diets and dietary supplements. GLA is an ω-6 fatty acid which can be elongated to arachidonic acid for endogenous eicosanoid synthesis. It is a weak leukotriene B4 (LTB4) receptor antagonist, inhibiting [3H]-LTB4 binding to porcine neutrophil membranes with a Ki of 1 µM.{2361} GLA produces 53% inhibition at a 1 mg/kg dose in an in vivo model of LTB4-induced bronchoconstriction.{2361}
Brand:CaymanSKU:10006579 - 1 gAvailable on backorder
Polyunsaturated fatty acids (PUFAs) are essential nutrients that show distinct deficiency syndromes when not present in adequate amounts in the diet.{5525,8460} γ-Linolenic Acid methyl ester (Methyl GLA) is an esterified version of the free acid which is less water soluble but more amenable for the formulation of GLA-containing diets and dietary supplements. GLA is an ω-6 fatty acid which can be elongated to arachidonic acid for endogenous eicosanoid synthesis. It is a weak leukotriene B4 (LTB4) receptor antagonist, inhibiting [3H]-LTB4 binding to porcine neutrophil membranes with a Ki of 1 µM.{2361} GLA produces 53% inhibition at a 1 mg/kg dose in an in vivo model of LTB4-induced bronchoconstriction.{2361}
Brand:CaymanSKU:10006579 - 100 mgAvailable on backorder
Polyunsaturated fatty acids (PUFAs) are essential nutrients that show distinct deficiency syndromes when not present in adequate amounts in the diet.{5525,8460} γ-Linolenic Acid methyl ester (Methyl GLA) is an esterified version of the free acid which is less water soluble but more amenable for the formulation of GLA-containing diets and dietary supplements. GLA is an ω-6 fatty acid which can be elongated to arachidonic acid for endogenous eicosanoid synthesis. It is a weak leukotriene B4 (LTB4) receptor antagonist, inhibiting [3H]-LTB4 binding to porcine neutrophil membranes with a Ki of 1 µM.{2361} GLA produces 53% inhibition at a 1 mg/kg dose in an in vivo model of LTB4-induced bronchoconstriction.{2361}
Brand:CaymanSKU:10006579 - 250 mgAvailable on backorder
Polyunsaturated fatty acids (PUFAs) are essential nutrients that show distinct deficiency syndromes when not present in adequate amounts in the diet.{5525,8460} γ-Linolenic Acid methyl ester (Methyl GLA) is an esterified version of the free acid which is less water soluble but more amenable for the formulation of GLA-containing diets and dietary supplements. GLA is an ω-6 fatty acid which can be elongated to arachidonic acid for endogenous eicosanoid synthesis. It is a weak leukotriene B4 (LTB4) receptor antagonist, inhibiting [3H]-LTB4 binding to porcine neutrophil membranes with a Ki of 1 µM.{2361} GLA produces 53% inhibition at a 1 mg/kg dose in an in vivo model of LTB4-induced bronchoconstriction.{2361}
Brand:CaymanSKU:10006579 - 50 mgAvailable on backorder
γ-Linolenoyl ethanolamide is a member of the family of fatty N-acyl ethanolamines collectively called endocannabinoids.{1202,1712,13153,22439} The relative importance of this ethanolamine metabolite has yet to be determined.
Brand:CaymanSKU:9001747 - 10 mgAvailable on backorder
γ-Linolenoyl ethanolamide is a member of the family of fatty N-acyl ethanolamines collectively called endocannabinoids.{1202,1712,13153,22439} The relative importance of this ethanolamine metabolite has yet to be determined.
Brand:CaymanSKU:9001747 - 5 mgAvailable on backorder
γ-Linolenoyl ethanolamide is a member of the family of fatty N-acyl ethanolamines collectively called endocannabinoids.{1202,1712,13153,22439} The relative importance of this ethanolamine metabolite has yet to be determined.
Brand:CaymanSKU:9001747 - 50 mgAvailable on backorder
γ-Mangostin is a xanthone that has been found in G. mangostana and has diverse biological activities.{48253,48254,48255,48256} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in vitro with an IC50 value of 23.6 μM.{48253} γ-Mangostin is cytotoxic to HL-60, SMMC-7721, A549, MCF-7, and SW480 cancer cells and BEAS-2B non-cancerous pulmonary epithelial cells in vitro (IC50s = 7.39, 6.57, 10.07, 5.33, 8.4, and 7.43 μM, respectively).{48254} It inhibits LPS-induced expression of IL-6, IL-10, and TNF-α in human macrophages in a concentration-dependent manner.{48255} Macrophage-conditioned media from macrophages pre-incubated with γ-mangostin (30 μM) prior to stimulation with LPS has a reduced ability to induce inflammation and insulin resistance in primary human adipocytes. γ-Mangostin (5 and 10 mg/kg) inhibits carbon tetrachloride-induced increases in serum levels of aspartate transaminase (AST) and alanine aminotransferase (ALT) and decreases in hepatic superoxide dismutase 2 (SOD2) activity and glutathione (GSH) content in a mouse model of liver fibrosis.{48256}
Brand:CaymanSKU:26675 - 10 mgAvailable on backorder
γ-Mangostin is a xanthone that has been found in G. mangostana and has diverse biological activities.{48253,48254,48255,48256} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in vitro with an IC50 value of 23.6 μM.{48253} γ-Mangostin is cytotoxic to HL-60, SMMC-7721, A549, MCF-7, and SW480 cancer cells and BEAS-2B non-cancerous pulmonary epithelial cells in vitro (IC50s = 7.39, 6.57, 10.07, 5.33, 8.4, and 7.43 μM, respectively).{48254} It inhibits LPS-induced expression of IL-6, IL-10, and TNF-α in human macrophages in a concentration-dependent manner.{48255} Macrophage-conditioned media from macrophages pre-incubated with γ-mangostin (30 μM) prior to stimulation with LPS has a reduced ability to induce inflammation and insulin resistance in primary human adipocytes. γ-Mangostin (5 and 10 mg/kg) inhibits carbon tetrachloride-induced increases in serum levels of aspartate transaminase (AST) and alanine aminotransferase (ALT) and decreases in hepatic superoxide dismutase 2 (SOD2) activity and glutathione (GSH) content in a mouse model of liver fibrosis.{48256}
Brand:CaymanSKU:26675 - 25 mgAvailable on backorder
γ-Mangostin is a xanthone that has been found in G. mangostana and has diverse biological activities.{48253,48254,48255,48256} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in vitro with an IC50 value of 23.6 μM.{48253} γ-Mangostin is cytotoxic to HL-60, SMMC-7721, A549, MCF-7, and SW480 cancer cells and BEAS-2B non-cancerous pulmonary epithelial cells in vitro (IC50s = 7.39, 6.57, 10.07, 5.33, 8.4, and 7.43 μM, respectively).{48254} It inhibits LPS-induced expression of IL-6, IL-10, and TNF-α in human macrophages in a concentration-dependent manner.{48255} Macrophage-conditioned media from macrophages pre-incubated with γ-mangostin (30 μM) prior to stimulation with LPS has a reduced ability to induce inflammation and insulin resistance in primary human adipocytes. γ-Mangostin (5 and 10 mg/kg) inhibits carbon tetrachloride-induced increases in serum levels of aspartate transaminase (AST) and alanine aminotransferase (ALT) and decreases in hepatic superoxide dismutase 2 (SOD2) activity and glutathione (GSH) content in a mouse model of liver fibrosis.{48256}
Brand:CaymanSKU:26675 - 5 mgAvailable on backorder
γ-Mangostin is a xanthone that has been found in G. mangostana and has diverse biological activities.{48253,48254,48255,48256} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in vitro with an IC50 value of 23.6 μM.{48253} γ-Mangostin is cytotoxic to HL-60, SMMC-7721, A549, MCF-7, and SW480 cancer cells and BEAS-2B non-cancerous pulmonary epithelial cells in vitro (IC50s = 7.39, 6.57, 10.07, 5.33, 8.4, and 7.43 μM, respectively).{48254} It inhibits LPS-induced expression of IL-6, IL-10, and TNF-α in human macrophages in a concentration-dependent manner.{48255} Macrophage-conditioned media from macrophages pre-incubated with γ-mangostin (30 μM) prior to stimulation with LPS has a reduced ability to induce inflammation and insulin resistance in primary human adipocytes. γ-Mangostin (5 and 10 mg/kg) inhibits carbon tetrachloride-induced increases in serum levels of aspartate transaminase (AST) and alanine aminotransferase (ALT) and decreases in hepatic superoxide dismutase 2 (SOD2) activity and glutathione (GSH) content in a mouse model of liver fibrosis.{48256}
Brand:CaymanSKU:26675 - 50 mgAvailable on backorder
γ-Terpinene is a monoterpene that has been found in various plants, including C. sativa, with diverse biological activities.{41453,41930,36783,41931,41932,41933} It scavenges 2,2′-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) and 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonate) (ABTS+) free radicals (IC50s = 2.8 and 30 mM, respectively) and reduces hemolysis induced by AAPH (Item No. 82235) in isolated human erythrocytes.{41930} γ-Terpinene reduces the growth of T. evansi in a concentration-dependent manner.{36783} It increases membrane permeability and decreases growth of X. oryzae bacteria.{41931} In vivo, γ-terpinene (100 mg/kg) reduces Triton WR1339-induced increases in serum cholesterol and triglyceride levels in rats.{41932} It reduces paw edema induced by histamine, bradykinin (Item No. 15539), carrageenan, and prostaglandin E2 (PGE2; Item No. 14010) in mice.{41933} It also inhibits fluid extravasation in a mouse model of acetic acid microvascular permeability and reduces neutrophil migration in lung in a mouse model of acute lung injury.
Brand:CaymanSKU:23722 - 100 mgAvailable on backorder
γ-Terpinene is a monoterpene that has been found in various plants, including C. sativa, with diverse biological activities.{41453,41930,36783,41931,41932,41933} It scavenges 2,2′-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) and 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonate) (ABTS+) free radicals (IC50s = 2.8 and 30 mM, respectively) and reduces hemolysis induced by AAPH (Item No. 82235) in isolated human erythrocytes.{41930} γ-Terpinene reduces the growth of T. evansi in a concentration-dependent manner.{36783} It increases membrane permeability and decreases growth of X. oryzae bacteria.{41931} In vivo, γ-terpinene (100 mg/kg) reduces Triton WR1339-induced increases in serum cholesterol and triglyceride levels in rats.{41932} It reduces paw edema induced by histamine, bradykinin (Item No. 15539), carrageenan, and prostaglandin E2 (PGE2; Item No. 14010) in mice.{41933} It also inhibits fluid extravasation in a mouse model of acetic acid microvascular permeability and reduces neutrophil migration in lung in a mouse model of acute lung injury.
Brand:CaymanSKU:23722 - 250 mgAvailable on backorder
γ-Terpinene is a monoterpene that has been found in various plants, including C. sativa, with diverse biological activities.{41453,41930,36783,41931,41932,41933} It scavenges 2,2′-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) and 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonate) (ABTS+) free radicals (IC50s = 2.8 and 30 mM, respectively) and reduces hemolysis induced by AAPH (Item No. 82235) in isolated human erythrocytes.{41930} γ-Terpinene reduces the growth of T. evansi in a concentration-dependent manner.{36783} It increases membrane permeability and decreases growth of X. oryzae bacteria.{41931} In vivo, γ-terpinene (100 mg/kg) reduces Triton WR1339-induced increases in serum cholesterol and triglyceride levels in rats.{41932} It reduces paw edema induced by histamine, bradykinin (Item No. 15539), carrageenan, and prostaglandin E2 (PGE2; Item No. 14010) in mice.{41933} It also inhibits fluid extravasation in a mouse model of acetic acid microvascular permeability and reduces neutrophil migration in lung in a mouse model of acute lung injury.
Brand:CaymanSKU:23722 - 500 mgAvailable on backorder
γ-Tocotrienol is a form of vitamin E that has been found in rice bran and has diverse biological activities.{3679,14290} It reduces cell death induced by hydrogen peroxide, paraquat, S-nitrocysteine, SIN-1 (Item No. 82220), or L-buthionine-(S,R)-sulfoximine (BSO; Item No. 14484) in rat striatal cultures when used at concentrations ranging from 0.1 to 10 µM.{14290} γ-Tocotrienol (20 µM) induces apoptosis in malignant sympathoadrenal (+SA) mouse mammary epithelial cells.{14293} In vivo, γ-tocotrienol (15, 30, and 150 mg/kg) reduces blood pressure and plasma lipid peroxide levels in spontaneously hypertensive rats.{14294}
Brand:CaymanSKU:10008494 - 1 mgAvailable on backorder
γ-Tocotrienol is a form of vitamin E that has been found in rice bran and has diverse biological activities.{3679,14290} It reduces cell death induced by hydrogen peroxide, paraquat, S-nitrocysteine, SIN-1 (Item No. 82220), or L-buthionine-(S,R)-sulfoximine (BSO; Item No. 14484) in rat striatal cultures when used at concentrations ranging from 0.1 to 10 µM.{14290} γ-Tocotrienol (20 µM) induces apoptosis in malignant sympathoadrenal (+SA) mouse mammary epithelial cells.{14293} In vivo, γ-tocotrienol (15, 30, and 150 mg/kg) reduces blood pressure and plasma lipid peroxide levels in spontaneously hypertensive rats.{14294}
Brand:CaymanSKU:10008494 - 10 mgAvailable on backorder
γ-Tocotrienol is a form of vitamin E that has been found in rice bran and has diverse biological activities.{3679,14290} It reduces cell death induced by hydrogen peroxide, paraquat, S-nitrocysteine, SIN-1 (Item No. 82220), or L-buthionine-(S,R)-sulfoximine (BSO; Item No. 14484) in rat striatal cultures when used at concentrations ranging from 0.1 to 10 µM.{14290} γ-Tocotrienol (20 µM) induces apoptosis in malignant sympathoadrenal (+SA) mouse mammary epithelial cells.{14293} In vivo, γ-tocotrienol (15, 30, and 150 mg/kg) reduces blood pressure and plasma lipid peroxide levels in spontaneously hypertensive rats.{14294}
Brand:CaymanSKU:10008494 - 25 mgAvailable on backorder
γ-Tocotrienol is a form of vitamin E that has been found in rice bran and has diverse biological activities.{3679,14290} It reduces cell death induced by hydrogen peroxide, paraquat, S-nitrocysteine, SIN-1 (Item No. 82220), or L-buthionine-(S,R)-sulfoximine (BSO; Item No. 14484) in rat striatal cultures when used at concentrations ranging from 0.1 to 10 µM.{14290} γ-Tocotrienol (20 µM) induces apoptosis in malignant sympathoadrenal (+SA) mouse mammary epithelial cells.{14293} In vivo, γ-tocotrienol (15, 30, and 150 mg/kg) reduces blood pressure and plasma lipid peroxide levels in spontaneously hypertensive rats.{14294}
Brand:CaymanSKU:10008494 - 5 mgAvailable on backorder
γ-Valerolactone (Item No. 28240) is an analytical reference standard categorized as a prodrug form of γ-hydroxyvaleric acid (GHV; Item No. 28241).{34702} This product is intended for research and forensic applications.
Brand:CaymanSKU:28240 - 10 mgAvailable on backorder
γ-Valerolactone (Item No. 28240) is an analytical reference standard categorized as a prodrug form of γ-hydroxyvaleric acid (GHV; Item No. 28241).{34702} This product is intended for research and forensic applications.
Brand:CaymanSKU:28240 - 50 mgAvailable on backorder
Molecules having vitamin E antioxidant activity include four tocopherols (α, β, γ, δ) and four tocotrienols (α, β, γ, δ).{3679} One form, α-tocopherol has the highest biological activity based on fetal resorption assays.{14206} δ-CEHC is a major β-oxidation metabolite of δ-tocopherol.{4779,14205} Approximately 50% of a 3H-δ-tocopherol given as an intraperitoneal dose in rat is recovered in the urine as δ-CEHC, indicating this is the major route of metabolism.{14205}
Brand:CaymanSKU:10007706 - 1 mgAvailable on backorder
Molecules having vitamin E antioxidant activity include four tocopherols (α, β, γ, δ) and four tocotrienols (α, β, γ, δ).{3679} One form, α-tocopherol has the highest biological activity based on fetal resorption assays.{14206} δ-CEHC is a major β-oxidation metabolite of δ-tocopherol.{4779,14205} Approximately 50% of a 3H-δ-tocopherol given as an intraperitoneal dose in rat is recovered in the urine as δ-CEHC, indicating this is the major route of metabolism.{14205}
Brand:CaymanSKU:10007706 - 10 mgAvailable on backorder
Molecules having vitamin E antioxidant activity include four tocopherols (α, β, γ, δ) and four tocotrienols (α, β, γ, δ).{3679} One form, α-tocopherol has the highest biological activity based on fetal resorption assays.{14206} δ-CEHC is a major β-oxidation metabolite of δ-tocopherol.{4779,14205} Approximately 50% of a 3H-δ-tocopherol given as an intraperitoneal dose in rat is recovered in the urine as δ-CEHC, indicating this is the major route of metabolism.{14205}
Brand:CaymanSKU:10007706 - 25 mgAvailable on backorder
Molecules having vitamin E antioxidant activity include four tocopherols (α, β, γ, δ) and four tocotrienols (α, β, γ, δ).{3679} One form, α-tocopherol has the highest biological activity based on fetal resorption assays.{14206} δ-CEHC is a major β-oxidation metabolite of δ-tocopherol.{4779,14205} Approximately 50% of a 3H-δ-tocopherol given as an intraperitoneal dose in rat is recovered in the urine as δ-CEHC, indicating this is the major route of metabolism.{14205}
Brand:CaymanSKU:10007706 - 5 mgAvailable on backorder
δ-Tocotrienol is a form of vitamin E that has been found in rice bran and has diverse biological activities.{3679,14290,14291,58093} It reduces cell death induced by hydrogen peroxide, paraquat, S-nitrocysteine, SIN-1 (Item No. 82220), or L-buthionine-(S,R)-sulfoximine (BSO; Item No. 14484) in rat striatal cultures when used at concentrations ranging from 0.1 to 10 µM.{14290} δ-Tocotrienol (10 µM) reduces 25-hydroxycholesterol-induced surface expression of VCAM-1 in human aortic endothelial cells (HAECs), as well as reduces 25-hydroxycholesterol-induced HAEC adhesion to U937 monocytes.{14291} It inhibits LPS-induced production of nitric oxide (NO), TNF-α, IL-6, IL-1β, and IFN-γ in RAW 264.7 cells. δ-Tocotrienol (60 mg/kg) increases the glomerular filtration rate and decreases renal malondialdehyde (MDA) levels in a rat model of nephrotoxicity induced by ochratoxin A (Item No. 11439).{58094}
Brand:CaymanSKU:10008513 - 1 mgAvailable on backorder
δ-Tocotrienol is a form of vitamin E that has been found in rice bran and has diverse biological activities.{3679,14290,14291,58093} It reduces cell death induced by hydrogen peroxide, paraquat, S-nitrocysteine, SIN-1 (Item No. 82220), or L-buthionine-(S,R)-sulfoximine (BSO; Item No. 14484) in rat striatal cultures when used at concentrations ranging from 0.1 to 10 µM.{14290} δ-Tocotrienol (10 µM) reduces 25-hydroxycholesterol-induced surface expression of VCAM-1 in human aortic endothelial cells (HAECs), as well as reduces 25-hydroxycholesterol-induced HAEC adhesion to U937 monocytes.{14291} It inhibits LPS-induced production of nitric oxide (NO), TNF-α, IL-6, IL-1β, and IFN-γ in RAW 264.7 cells. δ-Tocotrienol (60 mg/kg) increases the glomerular filtration rate and decreases renal malondialdehyde (MDA) levels in a rat model of nephrotoxicity induced by ochratoxin A (Item No. 11439).{58094}
Brand:CaymanSKU:10008513 - 10 mgAvailable on backorder
δ-Tocotrienol is a form of vitamin E that has been found in rice bran and has diverse biological activities.{3679,14290,14291,58093} It reduces cell death induced by hydrogen peroxide, paraquat, S-nitrocysteine, SIN-1 (Item No. 82220), or L-buthionine-(S,R)-sulfoximine (BSO; Item No. 14484) in rat striatal cultures when used at concentrations ranging from 0.1 to 10 µM.{14290} δ-Tocotrienol (10 µM) reduces 25-hydroxycholesterol-induced surface expression of VCAM-1 in human aortic endothelial cells (HAECs), as well as reduces 25-hydroxycholesterol-induced HAEC adhesion to U937 monocytes.{14291} It inhibits LPS-induced production of nitric oxide (NO), TNF-α, IL-6, IL-1β, and IFN-γ in RAW 264.7 cells. δ-Tocotrienol (60 mg/kg) increases the glomerular filtration rate and decreases renal malondialdehyde (MDA) levels in a rat model of nephrotoxicity induced by ochratoxin A (Item No. 11439).{58094}
Brand:CaymanSKU:10008513 - 25 mgAvailable on backorder
δ-Tocotrienol is a form of vitamin E that has been found in rice bran and has diverse biological activities.{3679,14290,14291,58093} It reduces cell death induced by hydrogen peroxide, paraquat, S-nitrocysteine, SIN-1 (Item No. 82220), or L-buthionine-(S,R)-sulfoximine (BSO; Item No. 14484) in rat striatal cultures when used at concentrations ranging from 0.1 to 10 µM.{14290} δ-Tocotrienol (10 µM) reduces 25-hydroxycholesterol-induced surface expression of VCAM-1 in human aortic endothelial cells (HAECs), as well as reduces 25-hydroxycholesterol-induced HAEC adhesion to U937 monocytes.{14291} It inhibits LPS-induced production of nitric oxide (NO), TNF-α, IL-6, IL-1β, and IFN-γ in RAW 264.7 cells. δ-Tocotrienol (60 mg/kg) increases the glomerular filtration rate and decreases renal malondialdehyde (MDA) levels in a rat model of nephrotoxicity induced by ochratoxin A (Item No. 11439).{58094}
Brand:CaymanSKU:10008513 - 5 mgAvailable on backorder
Prostaglandin D2 (PGD2) is one of the five primary enzymatic prostaglandins derived directly from PGH2. PGD2 is produced abundantly in the CSF by the lipocalin-type PGD synthase, and in the periphery by myeloid cells including mast cells and basophils by a second, hematopoietic-type PGD synthase. PGD2 is chemically unstable, and its use and analysis is complicated by its short in vivo half-life. Δ12-PGD2 is one of the initial chemical decomposition products of PGD2. Δ12-PGD2 is an intermediate in the pathway leading to Δ12-PGJ2, which is a cyclopentenone prostaglandin with antimitotic and carcinogenic activities.{870,334} The metabolism of Δ12-PGD2 involves addition of thiol nucleophiles, as is the case with the majority of cyclopentenone prostaglandins.{7193}
Brand:CaymanSKU:12650 - 1 mgAvailable on backorder
Prostaglandin D2 (PGD2) is one of the five primary enzymatic prostaglandins derived directly from PGH2. PGD2 is produced abundantly in the CSF by the lipocalin-type PGD synthase, and in the periphery by myeloid cells including mast cells and basophils by a second, hematopoietic-type PGD synthase. PGD2 is chemically unstable, and its use and analysis is complicated by its short in vivo half-life. Δ12-PGD2 is one of the initial chemical decomposition products of PGD2. Δ12-PGD2 is an intermediate in the pathway leading to Δ12-PGJ2, which is a cyclopentenone prostaglandin with antimitotic and carcinogenic activities.{870,334} The metabolism of Δ12-PGD2 involves addition of thiol nucleophiles, as is the case with the majority of cyclopentenone prostaglandins.{7193}
Brand:CaymanSKU:12650 - 10 mgAvailable on backorder
Prostaglandin D2 (PGD2) is one of the five primary enzymatic prostaglandins derived directly from PGH2. PGD2 is produced abundantly in the CSF by the lipocalin-type PGD synthase, and in the periphery by myeloid cells including mast cells and basophils by a second, hematopoietic-type PGD synthase. PGD2 is chemically unstable, and its use and analysis is complicated by its short in vivo half-life. Δ12-PGD2 is one of the initial chemical decomposition products of PGD2. Δ12-PGD2 is an intermediate in the pathway leading to Δ12-PGJ2, which is a cyclopentenone prostaglandin with antimitotic and carcinogenic activities.{870,334} The metabolism of Δ12-PGD2 involves addition of thiol nucleophiles, as is the case with the majority of cyclopentenone prostaglandins.{7193}
Brand:CaymanSKU:12650 - 5 mgAvailable on backorder
Prostaglandin D2 (PGD2) is one of the five primary enzymatic prostaglandins derived directly from PGH2. PGD2 is produced abundantly in the CSF by the lipocalin-type PGD synthase, and in the periphery by myeloid cells including mast cells and basophils by a second, hematopoietic-type PGD synthase. PGD2 is chemically unstable, and its use and analysis is complicated by its short in vivo half-life. Δ12-PGD2 is one of the initial chemical decomposition products of PGD2. Δ12-PGD2 is an intermediate in the pathway leading to Δ12-PGJ2, which is a cyclopentenone prostaglandin with antimitotic and carcinogenic activities.{870,334} The metabolism of Δ12-PGD2 involves addition of thiol nucleophiles, as is the case with the majority of cyclopentenone prostaglandins.{7193}
Brand:CaymanSKU:12650 - 500 µgAvailable on backorder
Δ12-PGJ2 is a decomposition product of PGD2 in aqueous media in the presence of albumin.{1742} It has antitumor and antiviral activity, inhibiting growth of cultured L1210 cells at with an IC50 value of 0.7 µg/ml.{334} Δ12-PGJ2 is present in normal human urine with a 24 hour excretion rate of 50-150 ng.{1393} It is also a moderately potent PPARγ ligand.{1424}
Brand:CaymanSKU:-Available on backorder
Δ12-PGJ2 is a decomposition product of PGD2 in aqueous media in the presence of albumin.{1742} It has antitumor and antiviral activity, inhibiting growth of cultured L1210 cells at with an IC50 value of 0.7 µg/ml.{334} Δ12-PGJ2 is present in normal human urine with a 24 hour excretion rate of 50-150 ng.{1393} It is also a moderately potent PPARγ ligand.{1424}
Brand:CaymanSKU:-Available on backorder
Δ12-PGJ2 is a decomposition product of PGD2 in aqueous media in the presence of albumin.{1742} It has antitumor and antiviral activity, inhibiting growth of cultured L1210 cells at with an IC50 value of 0.7 µg/ml.{334} Δ12-PGJ2 is present in normal human urine with a 24 hour excretion rate of 50-150 ng.{1393} It is also a moderately potent PPARγ ligand.{1424}
Brand:CaymanSKU:-Available on backorder
Δ14-Triamcinolone acetonide is a potential impurity found in commercial preparations of triamcinolone acetonide.{35063} Triamcinolone acetonide is a synthetic corticosteroid.{43074} It decreases cytokine levels, the firing rate of sensory neurons, and mechanical hypersensitivity in a rat spinal nerve ligation model when used at a dose of 1.5 mg/kg prior to and following surgery for three days. Triamcinolone acetonide also decreases outflow facility in a mouse model of steroid-induced glaucoma when 20 µl of a 40 mg/ml suspension is administered subconjunctivally.{43075} Formulations containing triamcinolone acetonide are used in the treatment of diabetic macular edema.
Brand:CaymanSKU:9000087 - 1 mgAvailable on backorder
Δ14-Triamcinolone acetonide is a potential impurity found in commercial preparations of triamcinolone acetonide.{35063} Triamcinolone acetonide is a synthetic corticosteroid.{43074} It decreases cytokine levels, the firing rate of sensory neurons, and mechanical hypersensitivity in a rat spinal nerve ligation model when used at a dose of 1.5 mg/kg prior to and following surgery for three days. Triamcinolone acetonide also decreases outflow facility in a mouse model of steroid-induced glaucoma when 20 µl of a 40 mg/ml suspension is administered subconjunctivally.{43075} Formulations containing triamcinolone acetonide are used in the treatment of diabetic macular edema.
Brand:CaymanSKU:9000087 - 10 mgAvailable on backorder
Δ14-Triamcinolone acetonide is a potential impurity found in commercial preparations of triamcinolone acetonide.{35063} Triamcinolone acetonide is a synthetic corticosteroid.{43074} It decreases cytokine levels, the firing rate of sensory neurons, and mechanical hypersensitivity in a rat spinal nerve ligation model when used at a dose of 1.5 mg/kg prior to and following surgery for three days. Triamcinolone acetonide also decreases outflow facility in a mouse model of steroid-induced glaucoma when 20 µl of a 40 mg/ml suspension is administered subconjunctivally.{43075} Formulations containing triamcinolone acetonide are used in the treatment of diabetic macular edema.
Brand:CaymanSKU:9000087 - 5 mgAvailable on backorder
Δ14-Triamcinolone acetonide is a potential impurity found in commercial preparations of triamcinolone acetonide.{35063} Triamcinolone acetonide is a synthetic corticosteroid.{43074} It decreases cytokine levels, the firing rate of sensory neurons, and mechanical hypersensitivity in a rat spinal nerve ligation model when used at a dose of 1.5 mg/kg prior to and following surgery for three days. Triamcinolone acetonide also decreases outflow facility in a mouse model of steroid-induced glaucoma when 20 µl of a 40 mg/ml suspension is administered subconjunctivally.{43075} Formulations containing triamcinolone acetonide are used in the treatment of diabetic macular edema.
Brand:CaymanSKU:9000087 - 500 µgAvailable on backorder
Δ17-6-keto Prostaglandin F1α (Δ17-6-keto PGF1α) is a cyclooxygenase (COX) product of eicosapentaenoic acid (EPA) in various tissues such as seminal vesicles, lung, Polymorphonuclear leukocytes, and ocular tissues.{1144,1145} Δ17-6-keto PGF1α and other 3-series COX products from EPA, such as PGF3α, PGE3, and thromboxane B3, may be involved in the reduced incidence of glaucoma in patients on a marine-rich (EPA-rich) diet.
Brand:CaymanSKU:- Δ17-6-keto Prostaglandin F1α (Δ17-6-keto PGF1α) is a cyclooxygenase (COX) product of eicosapentaenoic acid (EPA) in various tissues such as seminal vesicles, lung, Polymorphonuclear leukocytes, and ocular tissues.{1144,1145} Δ17-6-keto PGF1α and other 3-series COX products from EPA, such as PGF3α, PGE3, and thromboxane B3, may be involved in the reduced incidence of glaucoma in patients on a marine-rich (EPA-rich) diet.
Brand:CaymanSKU:- Δ17-6-keto Prostaglandin F1α (Δ17-6-keto PGF1α) is a cyclooxygenase (COX) product of eicosapentaenoic acid (EPA) in various tissues such as seminal vesicles, lung, Polymorphonuclear leukocytes, and ocular tissues.{1144,1145} Δ17-6-keto PGF1α and other 3-series COX products from EPA, such as PGF3α, PGE3, and thromboxane B3, may be involved in the reduced incidence of glaucoma in patients on a marine-rich (EPA-rich) diet.
Brand:CaymanSKU:-
Δ2-cis Eicosenoic acid is an α,β-unsaturated fatty acid that has been extracted from fresh water clams and purified. A related compound, 2-octadecenoic acid, has been shown to improve liver function and decrease blood sugar in streptozocin-induced diabetic rats.{13726} Δ2-cis Eicosenoic acid and its salts have potential medicinal use for treating diabetes and improving lipid metabolism.
Brand:CaymanSKU:10007602 - 10 mgAvailable on backorder
Δ2-cis Eicosenoic acid is an α,β-unsaturated fatty acid that has been extracted from fresh water clams and purified. A related compound, 2-octadecenoic acid, has been shown to improve liver function and decrease blood sugar in streptozocin-induced diabetic rats.{13726} Δ2-cis Eicosenoic acid and its salts have potential medicinal use for treating diabetes and improving lipid metabolism.
Brand:CaymanSKU:10007602 - 100 mgAvailable on backorder
Δ2-cis Eicosenoic acid is an α,β-unsaturated fatty acid that has been extracted from fresh water clams and purified. A related compound, 2-octadecenoic acid, has been shown to improve liver function and decrease blood sugar in streptozocin-induced diabetic rats.{13726} Δ2-cis Eicosenoic acid and its salts have potential medicinal use for treating diabetes and improving lipid metabolism.
Brand:CaymanSKU:10007602 - 5 mgAvailable on backorder
Δ2-cis Eicosenoic acid is an α,β-unsaturated fatty acid that has been extracted from fresh water clams and purified. A related compound, 2-octadecenoic acid, has been shown to improve liver function and decrease blood sugar in streptozocin-induced diabetic rats.{13726} Δ2-cis Eicosenoic acid and its salts have potential medicinal use for treating diabetes and improving lipid metabolism.
Brand:CaymanSKU:10007602 - 50 mgAvailable on backorder
One of the first organisms in which quorum sensing was observed were Myxobacteria, a group of gram-negative bacteria, found mainly in soil and also common to marine and freshwater systems. The cellular membranes of autotrophic bacteria contain mono-unsaturated fatty acids. The specific composition and abundance of membrane fatty acids can be used to identify specific genera of bacterial populations in natural environments (e.g., mining lakes, etc.). Δ2-cis-Hexadecenoic acid is an unusual fatty acid unique to some Myxococcus species.{20341}
Brand:CaymanSKU:11133 - 1 mgAvailable on backorder
One of the first organisms in which quorum sensing was observed were Myxobacteria, a group of gram-negative bacteria, found mainly in soil and also common to marine and freshwater systems. The cellular membranes of autotrophic bacteria contain mono-unsaturated fatty acids. The specific composition and abundance of membrane fatty acids can be used to identify specific genera of bacterial populations in natural environments (e.g., mining lakes, etc.). Δ2-cis-Hexadecenoic acid is an unusual fatty acid unique to some Myxococcus species.{20341}
Brand:CaymanSKU:11133 - 10 mgAvailable on backorder
One of the first organisms in which quorum sensing was observed were Myxobacteria, a group of gram-negative bacteria, found mainly in soil and also common to marine and freshwater systems. The cellular membranes of autotrophic bacteria contain mono-unsaturated fatty acids. The specific composition and abundance of membrane fatty acids can be used to identify specific genera of bacterial populations in natural environments (e.g., mining lakes, etc.). Δ2-cis-Hexadecenoic acid is an unusual fatty acid unique to some Myxococcus species.{20341}
Brand:CaymanSKU:11133 - 5 mgAvailable on backorder
Δ2-Doramectin is a doramectin degradation product formed by the reversible base-catalyzed isomerization of doramectin (Item No. 19467).{40425}
Brand:CaymanSKU:25120 - 1 mgAvailable on backorder
Δ2-Doramectin is a doramectin degradation product formed by the reversible base-catalyzed isomerization of doramectin (Item No. 19467).{40425}
Brand:CaymanSKU:25120 - 5 mgAvailable on backorder
Δ2-trans Eicosenoic acid is an α,β-unsaturated fatty acid that is a bi-product of the synthesis of Δ2-cis eicosenoic acid. Δ2-cis eicosenoic acid and its salts have potential medical use for treating diabetes and improving lipid metabolism. A related compound, 2-octadecenoic acid, has been shown to improve liver function and decrease blood sugar in streptozocin-induced diabetic rats.{13726}
Brand:CaymanSKU:10007622 - 10 mgAvailable on backorder
Δ2-trans Eicosenoic acid is an α,β-unsaturated fatty acid that is a bi-product of the synthesis of Δ2-cis eicosenoic acid. Δ2-cis eicosenoic acid and its salts have potential medical use for treating diabetes and improving lipid metabolism. A related compound, 2-octadecenoic acid, has been shown to improve liver function and decrease blood sugar in streptozocin-induced diabetic rats.{13726}
Brand:CaymanSKU:10007622 - 100 mgAvailable on backorder
Δ2-trans Eicosenoic acid is an α,β-unsaturated fatty acid that is a bi-product of the synthesis of Δ2-cis eicosenoic acid. Δ2-cis eicosenoic acid and its salts have potential medical use for treating diabetes and improving lipid metabolism. A related compound, 2-octadecenoic acid, has been shown to improve liver function and decrease blood sugar in streptozocin-induced diabetic rats.{13726}
Brand:CaymanSKU:10007622 - 5 mgAvailable on backorder
Δ2-trans Eicosenoic acid is an α,β-unsaturated fatty acid that is a bi-product of the synthesis of Δ2-cis eicosenoic acid. Δ2-cis eicosenoic acid and its salts have potential medical use for treating diabetes and improving lipid metabolism. A related compound, 2-octadecenoic acid, has been shown to improve liver function and decrease blood sugar in streptozocin-induced diabetic rats.{13726}
Brand:CaymanSKU:10007622 - 50 mgAvailable on backorder
Formation of cis monoenoic acids from unsaturated fatty acids, such as palmitoleic acid (9-cis-hexadecenoic acid) from palmitic acid occurs readily in animal tissues.{20375} Δ2-trans-Hexadecenoic acid is an intermediate formed in the β-oxidation of palmitic acid.{20376} In a model meant to simulate gastric ulceration, Δ2-trans-hexadecenoic acid at 10 mg/kg significantly inhibits gastric juice secretion in pylorus-ligated rats.{20377}
Brand:CaymanSKU:11132 - 10 mgAvailable on backorder
Formation of cis monoenoic acids from unsaturated fatty acids, such as palmitoleic acid (9-cis-hexadecenoic acid) from palmitic acid occurs readily in animal tissues.{20375} Δ2-trans-Hexadecenoic acid is an intermediate formed in the β-oxidation of palmitic acid.{20376} In a model meant to simulate gastric ulceration, Δ2-trans-hexadecenoic acid at 10 mg/kg significantly inhibits gastric juice secretion in pylorus-ligated rats.{20377}
Brand:CaymanSKU:11132 - 100 mgAvailable on backorder
Formation of cis monoenoic acids from unsaturated fatty acids, such as palmitoleic acid (9-cis-hexadecenoic acid) from palmitic acid occurs readily in animal tissues.{20375} Δ2-trans-Hexadecenoic acid is an intermediate formed in the β-oxidation of palmitic acid.{20376} In a model meant to simulate gastric ulceration, Δ2-trans-hexadecenoic acid at 10 mg/kg significantly inhibits gastric juice secretion in pylorus-ligated rats.{20377}
Brand:CaymanSKU:11132 - 5 mgAvailable on backorder
Formation of cis monoenoic acids from unsaturated fatty acids, such as palmitoleic acid (9-cis-hexadecenoic acid) from palmitic acid occurs readily in animal tissues.{20375} Δ2-trans-Hexadecenoic acid is an intermediate formed in the β-oxidation of palmitic acid.{20376} In a model meant to simulate gastric ulceration, Δ2-trans-hexadecenoic acid at 10 mg/kg significantly inhibits gastric juice secretion in pylorus-ligated rats.{20377}
Brand:CaymanSKU:11132 - 50 mgAvailable on backorder
Δ4-Abiraterone (D4A) is an active metabolite of the CYP17A1 inhibitor abiraterone (Item No. 9002768).{47328} D4A is an androgen receptor antagonist (IC50 = 5.3 nM) that reduces expression of the androgen receptor target genes PSA, TMPRSS2, and FKBP5 in LNCaP, LAPC4, and C4-2 cell lines. It inhibits the cytochrome P450 (CYP) isoform CYP17A1 by 66.5% when used at a concentration of 1 nM. D4A (10 μM) also blocks SRD5A conversion of Δ4-androstenedione to 5α-androstanedione in LAPC4 cells. In vivo, D4A delays tumor progression in a VCaP mouse xenograft model and increases progression-free survival in a C4-2 mouse xenograft model.
Brand:CaymanSKU:27594 - 1 mgAvailable on backorder
Δ4-Abiraterone (D4A) is an active metabolite of the CYP17A1 inhibitor abiraterone (Item No. 9002768).{47328} D4A is an androgen receptor antagonist (IC50 = 5.3 nM) that reduces expression of the androgen receptor target genes PSA, TMPRSS2, and FKBP5 in LNCaP, LAPC4, and C4-2 cell lines. It inhibits the cytochrome P450 (CYP) isoform CYP17A1 by 66.5% when used at a concentration of 1 nM. D4A (10 μM) also blocks SRD5A conversion of Δ4-androstenedione to 5α-androstanedione in LAPC4 cells. In vivo, D4A delays tumor progression in a VCaP mouse xenograft model and increases progression-free survival in a C4-2 mouse xenograft model.
Brand:CaymanSKU:27594 - 10 mgAvailable on backorder
Δ4-Abiraterone (D4A) is an active metabolite of the CYP17A1 inhibitor abiraterone (Item No. 9002768).{47328} D4A is an androgen receptor antagonist (IC50 = 5.3 nM) that reduces expression of the androgen receptor target genes PSA, TMPRSS2, and FKBP5 in LNCaP, LAPC4, and C4-2 cell lines. It inhibits the cytochrome P450 (CYP) isoform CYP17A1 by 66.5% when used at a concentration of 1 nM. D4A (10 μM) also blocks SRD5A conversion of Δ4-androstenedione to 5α-androstanedione in LAPC4 cells. In vivo, D4A delays tumor progression in a VCaP mouse xenograft model and increases progression-free survival in a C4-2 mouse xenograft model.
Brand:CaymanSKU:27594 - 5 mgAvailable on backorder
During unfavorable environmental conditions, C. elegans larvae undergo arrest and form dauer larvae that can attach to other animals as a parasitic strategy for survival.{22033,22027} DAF-12 is an orphan nuclear hormone receptor that regulates dauer larva diapause, reproductive development, fat metabolism, and life cycle/longevity in C. elegans.{22030,22029,22015} DAF-12 is required for entry into dauer when it is not bound to ligand by acting as a transcriptional repressor of target genes that favor reproductive development. Δ4-Dafachronic acid is a racemic version of a sterol-derived hormone that acts as a ligand of DAF-12.{22030,22032,22014,22028} Δ4-Dafachronic acid binds to and transactivates DAF-12, rescuing hormone deficiency in transgenic dauer larvae and promoting reproductive maturation into adults.{22032,22031,22033} The (25S) diastereomer of Δ4-dafachronic acid is significantly more potent than its (25R) counterpart (EC50s = 23 and 66 nM, respectively).{22014}
Brand:CaymanSKU:- During unfavorable environmental conditions, C. elegans larvae undergo arrest and form dauer larvae that can attach to other animals as a parasitic strategy for survival.{22033,22027} DAF-12 is an orphan nuclear hormone receptor that regulates dauer larva diapause, reproductive development, fat metabolism, and life cycle/longevity in C. elegans.{22030,22029,22015} DAF-12 is required for entry into dauer when it is not bound to ligand by acting as a transcriptional repressor of target genes that favor reproductive development. Δ4-Dafachronic acid is a racemic version of a sterol-derived hormone that acts as a ligand of DAF-12.{22030,22032,22014,22028} Δ4-Dafachronic acid binds to and transactivates DAF-12, rescuing hormone deficiency in transgenic dauer larvae and promoting reproductive maturation into adults.{22032,22031,22033} The (25S) diastereomer of Δ4-dafachronic acid is significantly more potent than its (25R) counterpart (EC50s = 23 and 66 nM, respectively).{22014}
Brand:CaymanSKU:- During unfavorable environmental conditions, C. elegans larvae undergo arrest and form dauer larvae that can attach to other animals as a parasitic strategy for survival.{22033,22027} DAF-12 is an orphan nuclear hormone receptor that regulates dauer larva diapause, reproductive development, fat metabolism, and life cycle/longevity in C. elegans.{22030,22029,22015} DAF-12 is required for entry into dauer when it is not bound to ligand by acting as a transcriptional repressor of target genes that favor reproductive development. Δ4-Dafachronic acid is a racemic version of a sterol-derived hormone that acts as a ligand of DAF-12.{22030,22032,22014,22028} Δ4-Dafachronic acid binds to and transactivates DAF-12, rescuing hormone deficiency in transgenic dauer larvae and promoting reproductive maturation into adults.{22032,22031,22033} The (25S) diastereomer of Δ4-dafachronic acid is significantly more potent than its (25R) counterpart (EC50s = 23 and 66 nM, respectively).{22014}
Brand:CaymanSKU:-
Δ5-Avenasterol is a phytosterol that has been found in various plant extracts, including D. metel, D. innoxia, D. stramonium, D. tatula, H. muticus, and H. niger.{48919}
Brand:CaymanSKU:30154 - 1 mgAvailable on backorder
Δ7-Avenasterol is a phytosterol that has been found in a variety of plant oils and grains, including olive and soybean oils and wheat, oats, and rye, and has antioxidant activities.{52392,52393} It reduces temperature-induced oxidation of safflower oil.{52394}
Brand:CaymanSKU:30155 - 500 µgAvailable on backorder
Δ8-Tetrahydrocannabivarin (Item No. 27322) is an analytical reference standard categorized as a cannabinoid.{35714} Δ8-Tetrahydrocannabivarin is regulated as a Schedule I compound in the United States. This product is intended for research and forensic applications. This item has been tested to contain ≤0.3% Δ9-THC on a dry weight basis meeting the 2018 Farm Bill requirements to be a non-controlled substance in the U.S.
Brand:CaymanSKU:27322 - 10 mgAvailable on backorder
Δ8-Tetrahydrocannabivarin (Item No. 27322) is an analytical reference standard categorized as a cannabinoid.{35714} Δ8-Tetrahydrocannabivarin is regulated as a Schedule I compound in the United States. This product is intended for research and forensic applications. This item has been tested to contain ≤0.3% Δ9-THC on a dry weight basis meeting the 2018 Farm Bill requirements to be a non-controlled substance in the U.S.
Brand:CaymanSKU:27322 - 5 mgAvailable on backorder