A monoterpene with diverse biological activities; scavenges DPPH and ABTS+ free radicals (IC50s = 2.8 and 30 mM

γ-Terpinene – 500 mg

Brand:
Cayman
CAS:
99-85-4
Storage:
-20
UN-No:
- 2319 / 3

γ-Terpinene is a monoterpene that has been found in various plants, including C. sativa, with diverse biological activities.{41453,41930,36783,41931,41932,41933} It scavenges 2,2′-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) and 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonate) (ABTS+) free radicals (IC50s = 2.8 and 30 mM, respectively) and reduces hemolysis induced by AAPH (Item No. 82235) in isolated human erythrocytes.{41930} γ-Terpinene reduces the growth of T. evansi in a concentration-dependent manner.{36783} It increases membrane permeability and decreases growth of X. oryzae bacteria.{41931} In vivo, γ-terpinene (100 mg/kg) reduces Triton WR1339-induced increases in serum cholesterol and triglyceride levels in rats.{41932} It reduces paw edema induced by histamine, bradykinin (Item No. 15539), carrageenan, and prostaglandin E2 (PGE2; Item No. 14010) in mice.{41933} It also inhibits fluid extravasation in a mouse model of acetic acid microvascular permeability and reduces neutrophil migration in lung in a mouse model of acute lung injury.  

 

Available on backorder

Add to quotes
SKU: 23722 - 500 mg Category:

Description

A monoterpene with diverse biological activities; scavenges DPPH and ABTS+ free radicals (IC50s = 2.8 and 30 mM, respectively); reduces APPH-induced hemolysis in isolated human erythrocytes; reduces the growth of T. evansi; increases membrane permeability and decreases growth of X. oryzae bacteria; reduces Triton WR1339-induced increases in serum cholesterol and triglyceride levels in rats at 100 mg/kg; reduces histamine-, bradykinin-, carrageenan, and PGE2-induced paw edema in mice; inhibits fluid extravasation in a mouse model of acetic acid microvascular permeability; reduces neutrophil migration in lung in a mouse model of acute lung injury

Formal name: 1-methyl-4-(1-methylethyl)-1,4-cyclohexadiene

Synonyms:  NSC 21448

Molecular weight: 136.2

CAS: 99-85-4

Purity: ≥98%

Formulation: A neat oil

Application||Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Natural Products|Phytocannabinoids||Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Non-enzymatic

Related products

  • A potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM; also inhibits Cdk7/cyclin H

    (R)-Roscovitine – 500 µg

    Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. (R)-Roscovitine is a potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM.{14988} It also inhibits Cdk7/cyclin H, Cdk5/p35, and cell division cycle (cdc)/cyclin B with IC50 values of 0.49, 0.16, and 0.65 µM, respectively.{14987,14988,14991} (R)-Roscovitine inhibits the growth of rapidly proliferating cells with an average IC50 value of 15.2 µM against a panel of 19 human tumor cell lines.{14988} In murine models of polycystic kidney disease, (R)-roscovitine effectively inhibited disease progression at doses of 50-100 mg/kg.{14564}  

     

    Brand:
    Cayman
    SKU:10009569 - 500 µg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A powerful effector in both the TetR and revTetR transcriptional regulator systems

    Anhydrotetracycline (hydrochloride) – 250 mg

    The tetracycline repressor (TetR) is a transcriptional regulator which normally binds tightly to its palindromic tetO operator DNA, blocking gene expression.{17508} Tet causes the repressor to dissociate from the DNA, allowing transcription to occur. A novel reverse TetR (revTetR) requires tetracycline as a co-repressor to bind tetO and block transcription.{17509,17510} Anhydrotetracycline (hydrochloride) is a powerful effector in both the tetracycline repressor (TetR) and reverse TetR (revTetR) systems, binding the Tet repressor 35-fold more strongly than Tet.{17508,17511} Moreover, anhydrotetracycline poorly binds the 30S ribosomal subunit, compared to Tet,{17512} so it does not act as a general inhibitor of translation and is a poor antibiotic. Perhaps related to this, the concentration of anhydrotetracycline that inhibits eukaryotic cell growth is more than a 1,000-fold above the dose that alters transcription through TetR.{17508}  

     

    Brand:
    Cayman
    SKU:10009542 - 250 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM; also inhibits Cdk7/cyclin H

    (R)-Roscovitine – 10 mg

    Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. (R)-Roscovitine is a potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM.{14988} It also inhibits Cdk7/cyclin H, Cdk5/p35, and cell division cycle (cdc)/cyclin B with IC50 values of 0.49, 0.16, and 0.65 µM, respectively.{14987,14988,14991} (R)-Roscovitine inhibits the growth of rapidly proliferating cells with an average IC50 value of 15.2 µM against a panel of 19 human tumor cell lines.{14988} In murine models of polycystic kidney disease, (R)-roscovitine effectively inhibited disease progression at doses of 50-100 mg/kg.{14564}  

     

    Brand:
    Cayman
    SKU:10009569 - 10 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers

    1,2-Dipalmitoyl-sn-glycero-3-PC – 100 mg

    1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.{14480,24261,14478,14479} It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.{14478} Incorporation of glycosphingolipid antigens into DPPC-containing liposomes increases the immunogenicity of the antigens in mice.{14479}  

     

    Brand:
    Cayman
    SKU:10009473 - 100 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page