Description
A xanthone with diverse biological activities: scavenges DPPH radicals in vitro (IC50 = 23.6 μM); is cytotoxic to HL-60, SMMC-7721, A549, MCF-7, SW480, and BEAS-2B cells in vitro (IC50s = 7.39, 6.57, 10.07, 5.33, 8.4, and 7.43 μM, respectively); inhibits LPS-induced expression of IL-6, IL-10, and TNF-α in human macrophages; macrophage-conditioned media from macrophages pre-incubated with γ-mangostin (30 μM) prior to stimulation with LPS has a reduced ability to induce inflammation and insulin resistance in primary human adipocytes; inhibits carbon tetrachloride-induced increases in serum levels of AST and ALT and decreases in hepatic SOD2 activity and GSH content in a mouse model of liver fibrosis
Formal name: 1,3,6,7-tetrahydroxy-2,8-bis(3-methyl-2-buten-1-yl)-9H-xanthen-9-one
Synonyms:
Molecular weight: 396.4
CAS: 31271-07-5
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer|Cell Death||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Myeloperoxidase||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Non-enzymatic||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Superoxide Dismutase
