A racemic version of a sterol-derived hormone that binds to and transactivates DAF-12

Δ4-Dafachronic Acid – 1 mg

Brand:
Cayman
CAS:
23017-97-2
Storage:
-20
UN-No:
De Minimis - 3077 / 9

During unfavorable environmental conditions, C. elegans larvae undergo arrest and form dauer larvae that can attach to other animals as a parasitic strategy for survival.{22033,22027} DAF-12 is an orphan nuclear hormone receptor that regulates dauer larva diapause, reproductive development, fat metabolism, and life cycle/longevity in C. elegans.{22030,22029,22015} DAF-12 is required for entry into dauer when it is not bound to ligand by acting as a transcriptional repressor of target genes that favor reproductive development. Δ4-Dafachronic acid is a racemic version of a sterol-derived hormone that acts as a ligand of DAF-12.{22030,22032,22014,22028} Δ4-Dafachronic acid binds to and transactivates DAF-12, rescuing hormone deficiency in transgenic dauer larvae and promoting reproductive maturation into adults.{22032,22031,22033} The (25S) diastereomer of Δ4-dafachronic acid is significantly more potent than its (25R) counterpart (EC50s = 23 and 66 nM, respectively).{22014}  

 

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Description

A racemic version of a sterol-derived hormone that binds to and transactivates DAF-12, rescuing hormone deficiency in transgenic dauer larvae and promoting reproductive maturation into adults

Formal name: 3-oxo-cholest-4-en-26-oic acid

Synonyms:  3-keto-4-Cholestenoic Acid

Molecular weight: 414.6

CAS: 23017-97-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors||Research Area|Endocrinology & Metabolism|Reproductive Biology||Research Area|Neuroscience

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