Cayman
Showing 20551–20700 of 45550 results
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Fenoldopam is an agonist of dopamine D1A (D1R) and D1B (D5R) receptors (Kds = 17 and 11 nM, respectively).{31154,31157} Fenoldopam is used to study the roles of these receptors, in cells and in vivo, and to alter hemodynamic properties, including hypertension, in animals.{31155,31156}
Brand:CaymanSKU:-Available on backorder
Fenoldopam is an agonist of dopamine D1A (D1R) and D1B (D5R) receptors (Kds = 17 and 11 nM, respectively).{31154,31157} Fenoldopam is used to study the roles of these receptors, in cells and in vivo, and to alter hemodynamic properties, including hypertension, in animals.{31155,31156}
Brand:CaymanSKU:-Available on backorder
Fenoprofen is a non-steroidal anti-inflammatory drug (NSAID).{37334} It inhibits spontaneous and estradiol-stimulated prostaglandin F2α (PGF2α; Item No. 16010) release by 84% in isolated rat uterine horns when used at a concentration of 33 μM. Fenoprofen (10 mg/kg, i.p.) reduces serum PGF2α levels in rats. It reduces acetic acid-induced writhing and stretching as well as formalin-induced licking behaviors, indicating analgesic activity, however, it also induces formation of gastric lesions in mice, a common adverse effect associated with NSAID administration.{37335}
Brand:CaymanSKU:23835 - 10 gAvailable on backorder
Fenoprofen is a non-steroidal anti-inflammatory drug (NSAID).{37334} It inhibits spontaneous and estradiol-stimulated prostaglandin F2α (PGF2α; Item No. 16010) release by 84% in isolated rat uterine horns when used at a concentration of 33 μM. Fenoprofen (10 mg/kg, i.p.) reduces serum PGF2α levels in rats. It reduces acetic acid-induced writhing and stretching as well as formalin-induced licking behaviors, indicating analgesic activity, however, it also induces formation of gastric lesions in mice, a common adverse effect associated with NSAID administration.{37335}
Brand:CaymanSKU:23835 - 25 gAvailable on backorder
Fenoprofen is a non-steroidal anti-inflammatory drug (NSAID).{37334} It inhibits spontaneous and estradiol-stimulated prostaglandin F2α (PGF2α; Item No. 16010) release by 84% in isolated rat uterine horns when used at a concentration of 33 μM. Fenoprofen (10 mg/kg, i.p.) reduces serum PGF2α levels in rats. It reduces acetic acid-induced writhing and stretching as well as formalin-induced licking behaviors, indicating analgesic activity, however, it also induces formation of gastric lesions in mice, a common adverse effect associated with NSAID administration.{37335}
Brand:CaymanSKU:23835 - 5 gAvailable on backorder
Fenoxycarb is a non-neurotoxic carbamate insecticide that acts as an insect growth regulator via juvenile hormone-like activity.{39983} It inhibits terminal development of first instar and newly transformed second instar nymphs of Florida red scale (C. aonidum) when used at a concentration of 0.0125% AI.{39984} Fenoxycarb (5 and 10 mg AI/colony) reduces the colony size index of laboratory colonies of red imported fire ants (S. invicta) by 93.6 to 95.9% at 8 weeks post-treatment.{39985} It is toxic to D. magna (LC50 = 0.5 mg a.s./L) and fish including O. mykiss, L. macrochirus, C. carpio, I. punctatus, and C. variegatus (LC50s = 0.66-1.5 mg a.s./L), but is not toxic to rats (LD50 = >10,000 mg/kg).{39990} Fenoxycarb is also an antagonist of α4β40-, α4β2-, α3β4-, and α3β2-containing rat nicotinic acetylcholine receptors (nAChRs; IC50s = 3, 2.4, 1.8, and 7.6 μM, respectively) but not rat brain acetylcholinesterase (AChE; IC50 = >1,000 μM).{39986}
Brand:CaymanSKU:25607 - 100 mgAvailable on backorder
Fenoxycarb is a non-neurotoxic carbamate insecticide that acts as an insect growth regulator via juvenile hormone-like activity.{39983} It inhibits terminal development of first instar and newly transformed second instar nymphs of Florida red scale (C. aonidum) when used at a concentration of 0.0125% AI.{39984} Fenoxycarb (5 and 10 mg AI/colony) reduces the colony size index of laboratory colonies of red imported fire ants (S. invicta) by 93.6 to 95.9% at 8 weeks post-treatment.{39985} It is toxic to D. magna (LC50 = 0.5 mg a.s./L) and fish including O. mykiss, L. macrochirus, C. carpio, I. punctatus, and C. variegatus (LC50s = 0.66-1.5 mg a.s./L), but is not toxic to rats (LD50 = >10,000 mg/kg).{39990} Fenoxycarb is also an antagonist of α4β40-, α4β2-, α3β4-, and α3β2-containing rat nicotinic acetylcholine receptors (nAChRs; IC50s = 3, 2.4, 1.8, and 7.6 μM, respectively) but not rat brain acetylcholinesterase (AChE; IC50 = >1,000 μM).{39986}
Brand:CaymanSKU:25607 - 50 mgAvailable on backorder
Fenpropimorph is a fungicide that inhibits the sterol pathway.{32934} It inhibits Δ8-Δ7-sterol isomerase in yeast at low concentrations, with Δ14-sterol reductase being blocked at higher levels, preventing the biosynthesis of ergosterol (Item No. 19850).{32935} Fenpropimorph is also able to inhibit sterol synthesis in certain plants and mammalian cells.{32934,32933}
Brand:CaymanSKU:20875 -Out of stock
Fenpropimorph is a fungicide that inhibits the sterol pathway.{32934} It inhibits Δ8-Δ7-sterol isomerase in yeast at low concentrations, with Δ14-sterol reductase being blocked at higher levels, preventing the biosynthesis of ergosterol (Item No. 19850).{32935} Fenpropimorph is also able to inhibit sterol synthesis in certain plants and mammalian cells.{32934,32933}
Brand:CaymanSKU:20875 -Out of stock
Fenpropimorph is a fungicide that inhibits the sterol pathway.{32934} It inhibits Δ8-Δ7-sterol isomerase in yeast at low concentrations, with Δ14-sterol reductase being blocked at higher levels, preventing the biosynthesis of ergosterol (Item No. 19850).{32935} Fenpropimorph is also able to inhibit sterol synthesis in certain plants and mammalian cells.{32934,32933}
Brand:CaymanSKU:20875 -Out of stock
Fenretinide is a synthetic derivative of retinoic acid (Item No. 11017) and an inhibitor of dihydroceramide desaturase (IC50 = 2.32 µM).{39681} It promotes the generation of reactive oxygen species (ROS), the degradation of anti-apoptotic MCL-1, and the cleavage of pro-apoptotic PKCδ.{22943} At 5-20 µM, fenretinide selectively activates retinoic acid receptor γ (RARγ) and is reported to inhibit the growth of Caov-3, OVCAR-3, and SKOV3 ovarian cancer cells with IC50 values of 3.7, 6.9, and 8.2 µM, respectively.{24737,17895} It also increases activity of serine palmitoyl transferase (SPT) by 1.75-fold and induces caspase-dependent apoptosis in BMEC cells (IC50 = 2.4 µM).{12547} Fenretinide prevents lipid-induced reductions in insulin-stimulated glucose uptake in isolated rat soleus muscle.{39682} In vivo, fenretinide (10 mg/ml in drinking water) reduces liver and soleus muscle neutral lipid content and inhibits high-fat diet-induced increases in dihydroceramide desaturase transcription.{39682}
Brand:CaymanSKU:-Available on backorder
Fenretinide is a synthetic derivative of retinoic acid (Item No. 11017) and an inhibitor of dihydroceramide desaturase (IC50 = 2.32 µM).{39681} It promotes the generation of reactive oxygen species (ROS), the degradation of anti-apoptotic MCL-1, and the cleavage of pro-apoptotic PKCδ.{22943} At 5-20 µM, fenretinide selectively activates retinoic acid receptor γ (RARγ) and is reported to inhibit the growth of Caov-3, OVCAR-3, and SKOV3 ovarian cancer cells with IC50 values of 3.7, 6.9, and 8.2 µM, respectively.{24737,17895} It also increases activity of serine palmitoyl transferase (SPT) by 1.75-fold and induces caspase-dependent apoptosis in BMEC cells (IC50 = 2.4 µM).{12547} Fenretinide prevents lipid-induced reductions in insulin-stimulated glucose uptake in isolated rat soleus muscle.{39682} In vivo, fenretinide (10 mg/ml in drinking water) reduces liver and soleus muscle neutral lipid content and inhibits high-fat diet-induced increases in dihydroceramide desaturase transcription.{39682}
Brand:CaymanSKU:-Available on backorder
Fenretinide is a synthetic derivative of retinoic acid (Item No. 11017) and an inhibitor of dihydroceramide desaturase (IC50 = 2.32 µM).{39681} It promotes the generation of reactive oxygen species (ROS), the degradation of anti-apoptotic MCL-1, and the cleavage of pro-apoptotic PKCδ.{22943} At 5-20 µM, fenretinide selectively activates retinoic acid receptor γ (RARγ) and is reported to inhibit the growth of Caov-3, OVCAR-3, and SKOV3 ovarian cancer cells with IC50 values of 3.7, 6.9, and 8.2 µM, respectively.{24737,17895} It also increases activity of serine palmitoyl transferase (SPT) by 1.75-fold and induces caspase-dependent apoptosis in BMEC cells (IC50 = 2.4 µM).{12547} Fenretinide prevents lipid-induced reductions in insulin-stimulated glucose uptake in isolated rat soleus muscle.{39682} In vivo, fenretinide (10 mg/ml in drinking water) reduces liver and soleus muscle neutral lipid content and inhibits high-fat diet-induced increases in dihydroceramide desaturase transcription.{39682}
Brand:CaymanSKU:-Available on backorder
Fenretinide is a synthetic derivative of retinoic acid (Item No. 11017) and an inhibitor of dihydroceramide desaturase (IC50 = 2.32 µM).{39681} It promotes the generation of reactive oxygen species (ROS), the degradation of anti-apoptotic MCL-1, and the cleavage of pro-apoptotic PKCδ.{22943} At 5-20 µM, fenretinide selectively activates retinoic acid receptor γ (RARγ) and is reported to inhibit the growth of Caov-3, OVCAR-3, and SKOV3 ovarian cancer cells with IC50 values of 3.7, 6.9, and 8.2 µM, respectively.{24737,17895} It also increases activity of serine palmitoyl transferase (SPT) by 1.75-fold and induces caspase-dependent apoptosis in BMEC cells (IC50 = 2.4 µM).{12547} Fenretinide prevents lipid-induced reductions in insulin-stimulated glucose uptake in isolated rat soleus muscle.{39682} In vivo, fenretinide (10 mg/ml in drinking water) reduces liver and soleus muscle neutral lipid content and inhibits high-fat diet-induced increases in dihydroceramide desaturase transcription.{39682}
Brand:CaymanSKU:-Available on backorder
Fenretinide is intended for use as an internal standard for the quantification of fenretinide (Item No. 17688) by GC- or LC-MS. Fenretinide is a synthetic derivative of retinoic acid (Item No. 11017) and an inhibitor of dihydroceramide desaturase (IC50 = 2.32 µM).{39681} It promotes the generation of reactive oxygen species (ROS), the degradation of anti-apoptotic MCL-1, and the cleavage of pro-apoptotic PKCδ.{22943} At 5-20 µM, fenretinide selectively activates retinoic acid receptor γ (RARγ) and is reported to inhibit the growth of Caov-3, OVCAR-3, and SKOV3 ovarian cancer cells with IC50 values of 3.7, 6.9, and 8.2 µM, respectively.{24737,17895} It also increases activity of serine palmitoyl transferase (SPT) by 1.75-fold and induces caspase-dependent apoptosis in BMEC cells (IC50 = 2.4 µM).{12547} Fenretinide prevents lipid-induced reductions in insulin-stimulated glucose uptake in isolated rat soleus muscle.{39682} In vivo, fenretinide (10 mg/ml in drinking water) reduces liver and soleus muscle neutral lipid content and inhibits high-fat diet-induced increases in dihydroceramide desaturase transcription.{39682}
Brand:CaymanSKU:26489 - 1 mgAvailable on backorder
Fenretinide is intended for use as an internal standard for the quantification of fenretinide (Item No. 17688) by GC- or LC-MS. Fenretinide is a synthetic derivative of retinoic acid (Item No. 11017) and an inhibitor of dihydroceramide desaturase (IC50 = 2.32 µM).{39681} It promotes the generation of reactive oxygen species (ROS), the degradation of anti-apoptotic MCL-1, and the cleavage of pro-apoptotic PKCδ.{22943} At 5-20 µM, fenretinide selectively activates retinoic acid receptor γ (RARγ) and is reported to inhibit the growth of Caov-3, OVCAR-3, and SKOV3 ovarian cancer cells with IC50 values of 3.7, 6.9, and 8.2 µM, respectively.{24737,17895} It also increases activity of serine palmitoyl transferase (SPT) by 1.75-fold and induces caspase-dependent apoptosis in BMEC cells (IC50 = 2.4 µM).{12547} Fenretinide prevents lipid-induced reductions in insulin-stimulated glucose uptake in isolated rat soleus muscle.{39682} In vivo, fenretinide (10 mg/ml in drinking water) reduces liver and soleus muscle neutral lipid content and inhibits high-fat diet-induced increases in dihydroceramide desaturase transcription.{39682}
Brand:CaymanSKU:26489 - 5 mgAvailable on backorder
Fenretinide is intended for use as an internal standard for the quantification of fenretinide (Item No. 17688) by GC- or LC-MS. Fenretinide is a synthetic derivative of retinoic acid (Item No. 11017) and an inhibitor of dihydroceramide desaturase (IC50 = 2.32 µM).{39681} It promotes the generation of reactive oxygen species (ROS), the degradation of anti-apoptotic MCL-1, and the cleavage of pro-apoptotic PKCδ.{22943} At 5-20 µM, fenretinide selectively activates retinoic acid receptor γ (RARγ) and is reported to inhibit the growth of Caov-3, OVCAR-3, and SKOV3 ovarian cancer cells with IC50 values of 3.7, 6.9, and 8.2 µM, respectively.{24737,17895} It also increases activity of serine palmitoyl transferase (SPT) by 1.75-fold and induces caspase-dependent apoptosis in BMEC cells (IC50 = 2.4 µM).{12547} Fenretinide prevents lipid-induced reductions in insulin-stimulated glucose uptake in isolated rat soleus muscle.{39682} In vivo, fenretinide (10 mg/ml in drinking water) reduces liver and soleus muscle neutral lipid content and inhibits high-fat diet-induced increases in dihydroceramide desaturase transcription.{39682}
Brand:CaymanSKU:26489 - 500 µgAvailable on backorder
Fenticonazole is an imidazole with antimicrobial activity.{46541,46542} It is active against clinical isolates of Candida species, including C. albicans, C. parapsilosis, C. tropicalis, C. krusei, and C. guilliermondii with MIC values ranging from 0.12 to 32 μg/ml.{46541} It is also active against clinical isolates of bacteria, including B. fragilis, associated with bacterial vaginosis (MICs = ≤0.03-16 μg/ml), as well as bacteria, including S. aureus and S. epidermidis, associated with skin infections with MIC values ranging from 0.03 μg/ml or less to greater than 16 μg/ml.{46542} Fenticonazole inhibits fungal growth in a guinea pig model of experimental M. canis dermatomycosis (ED50 = 0.5%, applied topically).{46543}
Brand:CaymanSKU:29002 - 10 mgAvailable on backorder
Fenticonazole is an imidazole with antimicrobial activity.{46541,46542} It is active against clinical isolates of Candida species, including C. albicans, C. parapsilosis, C. tropicalis, C. krusei, and C. guilliermondii with MIC values ranging from 0.12 to 32 μg/ml.{46541} It is also active against clinical isolates of bacteria, including B. fragilis, associated with bacterial vaginosis (MICs = ≤0.03-16 μg/ml), as well as bacteria, including S. aureus and S. epidermidis, associated with skin infections with MIC values ranging from 0.03 μg/ml or less to greater than 16 μg/ml.{46542} Fenticonazole inhibits fungal growth in a guinea pig model of experimental M. canis dermatomycosis (ED50 = 0.5%, applied topically).{46543}
Brand:CaymanSKU:29002 - 100 mgAvailable on backorder
Fenticonazole is an imidazole with antimicrobial activity.{46541,46542} It is active against clinical isolates of Candida species, including C. albicans, C. parapsilosis, C. tropicalis, C. krusei, and C. guilliermondii with MIC values ranging from 0.12 to 32 μg/ml.{46541} It is also active against clinical isolates of bacteria, including B. fragilis, associated with bacterial vaginosis (MICs = ≤0.03-16 μg/ml), as well as bacteria, including S. aureus and S. epidermidis, associated with skin infections with MIC values ranging from 0.03 μg/ml or less to greater than 16 μg/ml.{46542} Fenticonazole inhibits fungal growth in a guinea pig model of experimental M. canis dermatomycosis (ED50 = 0.5%, applied topically).{46543}
Brand:CaymanSKU:29002 - 250 mgAvailable on backorder
Fenticonazole is an imidazole with antimicrobial activity.{46541,46542} It is active against clinical isolates of Candida species, including C. albicans, C. parapsilosis, C. tropicalis, C. krusei, and C. guilliermondii with MIC values ranging from 0.12 to 32 μg/ml.{46541} It is also active against clinical isolates of bacteria, including B. fragilis, associated with bacterial vaginosis (MICs = ≤0.03-16 μg/ml), as well as bacteria, including S. aureus and S. epidermidis, associated with skin infections with MIC values ranging from 0.03 μg/ml or less to greater than 16 μg/ml.{46542} Fenticonazole inhibits fungal growth in a guinea pig model of experimental M. canis dermatomycosis (ED50 = 0.5%, applied topically).{46543}
Brand:CaymanSKU:29002 - 50 mgAvailable on backorder
Fenvalerate is a pyrethroid ester insecticide and acaricide.{36375,48848} It is a slow activator of voltage-gated sodium channel 1.8 (Nav1.8).{36375} It induces mortality in pyrethroid-susceptible and -resistant strains of M. domestica (LD50s = 0.014-5 µg/fly).{42441} Fenvalerate also induces mortality in tobacco budworm larvae but is associated with pyrethroid resistance with an increase in LD50 values from 1.01 to 20.85 µg/g over a six-year timeframe.{45030} It induces mortality in 95.5% of T. macfarlanei spider mites when applied to leaves at a concentration of 0.015%.{48848} Formulations containing fenvalerate have been used in the control of insects in agriculture.
Brand:CaymanSKU:29399 - 100 mgAvailable on backorder
Fenvalerate is a pyrethroid ester insecticide and acaricide.{36375,48848} It is a slow activator of voltage-gated sodium channel 1.8 (Nav1.8).{36375} It induces mortality in pyrethroid-susceptible and -resistant strains of M. domestica (LD50s = 0.014-5 µg/fly).{42441} Fenvalerate also induces mortality in tobacco budworm larvae but is associated with pyrethroid resistance with an increase in LD50 values from 1.01 to 20.85 µg/g over a six-year timeframe.{45030} It induces mortality in 95.5% of T. macfarlanei spider mites when applied to leaves at a concentration of 0.015%.{48848} Formulations containing fenvalerate have been used in the control of insects in agriculture.
Brand:CaymanSKU:29399 - 25 mgAvailable on backorder
Fenvalerate is a pyrethroid ester insecticide and acaricide.{36375,48848} It is a slow activator of voltage-gated sodium channel 1.8 (Nav1.8).{36375} It induces mortality in pyrethroid-susceptible and -resistant strains of M. domestica (LD50s = 0.014-5 µg/fly).{42441} Fenvalerate also induces mortality in tobacco budworm larvae but is associated with pyrethroid resistance with an increase in LD50 values from 1.01 to 20.85 µg/g over a six-year timeframe.{45030} It induces mortality in 95.5% of T. macfarlanei spider mites when applied to leaves at a concentration of 0.015%.{48848} Formulations containing fenvalerate have been used in the control of insects in agriculture.
Brand:CaymanSKU:29399 - 50 mgAvailable on backorder
Feprazone is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor that is 10-fold selective for COX-2 over COX-1.{48049} It reduces LPS-induced prostaglandin E2 (PGE2; Item No. 14010) production in bovine arterial endothelial cells (IC50 = 1 μM). Oral administration of feprazone (25-100 mg/kg) reduces vascular permeability, edema, and nociception in a rat model of adjuvant-induced arthritis.{48050}
Brand:CaymanSKU:20652 -Available on backorder
Feprazone is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor that is 10-fold selective for COX-2 over COX-1.{48049} It reduces LPS-induced prostaglandin E2 (PGE2; Item No. 14010) production in bovine arterial endothelial cells (IC50 = 1 μM). Oral administration of feprazone (25-100 mg/kg) reduces vascular permeability, edema, and nociception in a rat model of adjuvant-induced arthritis.{48050}
Brand:CaymanSKU:20652 -Available on backorder
Feprazone is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor that is 10-fold selective for COX-2 over COX-1.{48049} It reduces LPS-induced prostaglandin E2 (PGE2; Item No. 14010) production in bovine arterial endothelial cells (IC50 = 1 μM). Oral administration of feprazone (25-100 mg/kg) reduces vascular permeability, edema, and nociception in a rat model of adjuvant-induced arthritis.{48050}
Brand:CaymanSKU:20652 -Available on backorder
Ferrichrome is a hydroxamate siderophore produced by various fungi, including U. sphaerogena, that facilitates iron chelation and uptake by these organisms.{45053,45054,45055} It can be utilized as a heterologous siderophore by bacteria, including P. aeruginosa and V. parahaemolyticus.{45056,45057} Ferrichrome (0.8 μM) inhibits proliferation of murine spleen mononuclear cells induced by concanavalin A (Item No. 14951) and reduces the number of concanavalin A-stimulated CD4+ T cells expressing the IL-2 receptor.{45054} It also inhibits heme-catalyzed oxidation of LDL by hydrogen peroxide in a concentration-dependent manner.{45055}
Brand:CaymanSKU:-Available on backorder
Ferrichrome is a hydroxamate siderophore produced by various fungi, including U. sphaerogena, that facilitates iron chelation and uptake by these organisms.{45053,45054,45055} It can be utilized as a heterologous siderophore by bacteria, including P. aeruginosa and V. parahaemolyticus.{45056,45057} Ferrichrome (0.8 μM) inhibits proliferation of murine spleen mononuclear cells induced by concanavalin A (Item No. 14951) and reduces the number of concanavalin A-stimulated CD4+ T cells expressing the IL-2 receptor.{45054} It also inhibits heme-catalyzed oxidation of LDL by hydrogen peroxide in a concentration-dependent manner.{45055}
Brand:CaymanSKU:-Available on backorder
Ferrichrome is a hydroxamate siderophore produced by various fungi, including U. sphaerogena, that facilitates iron chelation and uptake by these organisms.{45053,45054,45055} It can be utilized as a heterologous siderophore by bacteria, including P. aeruginosa and V. parahaemolyticus.{45056,45057} Ferrichrome (0.8 μM) inhibits proliferation of murine spleen mononuclear cells induced by concanavalin A (Item No. 14951) and reduces the number of concanavalin A-stimulated CD4+ T cells expressing the IL-2 receptor.{45054} It also inhibits heme-catalyzed oxidation of LDL by hydrogen peroxide in a concentration-dependent manner.{45055}
Brand:CaymanSKU:-Available on backorder
Ferrioxamine E is a bacterial siderophore produced by a variety of bacteria including S. glaucescens, M. luteus, and P. mendocina.{45166} Ferrioxamines, including ferrioxamine E, are the sole iron source for Salmonella, and have been used as growth enriching agents in the detection of Salmonella in food and industrial applications.{45167,45168}
Brand:CaymanSKU:27275 - 1 mgAvailable on backorder
Ferrioxamine E is a bacterial siderophore produced by a variety of bacteria including S. glaucescens, M. luteus, and P. mendocina.{45166} Ferrioxamines, including ferrioxamine E, are the sole iron source for Salmonella, and have been used as growth enriching agents in the detection of Salmonella in food and industrial applications.{45167,45168}
Brand:CaymanSKU:27275 - 10 mgAvailable on backorder
Ferrioxamine E is a bacterial siderophore produced by a variety of bacteria including S. glaucescens, M. luteus, and P. mendocina.{45166} Ferrioxamines, including ferrioxamine E, are the sole iron source for Salmonella, and have been used as growth enriching agents in the detection of Salmonella in food and industrial applications.{45167,45168}
Brand:CaymanSKU:27275 - 5 mgAvailable on backorder
Ferrostatin-1 is a ferroptosis inhibitor.{28856} It inhibits cell death induced by the ferroptosis inducers erastin (Item No. 17754; EC50 = 60 nM) and RSL3, but not by hydrogen peroxide, rotenone, or staurosporine, in HT-1080 cells when used at a concentration of 0.5 μM. Ferrostatin-1 (0.5 μM) inhibits erastin-induced production of reactive oxygen species (ROS) and lipid peroxidation in HT-1080 cells. It increases cell survival in cell-based models of Huntington’s disease, periventricular leukomalacia, and kidney proximal tubule damage in a concentration-dependent manner.{28857} Ferrostatin-1 (2 μM) inhibits cell death induced by L-glutamate in a rat organotypic hippocampal slice culture (OHSC) model.{28856} It also inhibits autooxidation of lipids by trapping peroxyl radicals.{28856,43395}
Brand:CaymanSKU:-Available on backorder
Ferrostatin-1 is a ferroptosis inhibitor.{28856} It inhibits cell death induced by the ferroptosis inducers erastin (Item No. 17754; EC50 = 60 nM) and RSL3, but not by hydrogen peroxide, rotenone, or staurosporine, in HT-1080 cells when used at a concentration of 0.5 μM. Ferrostatin-1 (0.5 μM) inhibits erastin-induced production of reactive oxygen species (ROS) and lipid peroxidation in HT-1080 cells. It increases cell survival in cell-based models of Huntington’s disease, periventricular leukomalacia, and kidney proximal tubule damage in a concentration-dependent manner.{28857} Ferrostatin-1 (2 μM) inhibits cell death induced by L-glutamate in a rat organotypic hippocampal slice culture (OHSC) model.{28856} It also inhibits autooxidation of lipids by trapping peroxyl radicals.{28856,43395}
Brand:CaymanSKU:-Available on backorder
Ferrostatin-1 is a ferroptosis inhibitor.{28856} It inhibits cell death induced by the ferroptosis inducers erastin (Item No. 17754; EC50 = 60 nM) and RSL3, but not by hydrogen peroxide, rotenone, or staurosporine, in HT-1080 cells when used at a concentration of 0.5 μM. Ferrostatin-1 (0.5 μM) inhibits erastin-induced production of reactive oxygen species (ROS) and lipid peroxidation in HT-1080 cells. It increases cell survival in cell-based models of Huntington’s disease, periventricular leukomalacia, and kidney proximal tubule damage in a concentration-dependent manner.{28857} Ferrostatin-1 (2 μM) inhibits cell death induced by L-glutamate in a rat organotypic hippocampal slice culture (OHSC) model.{28856} It also inhibits autooxidation of lipids by trapping peroxyl radicals.{28856,43395}
Brand:CaymanSKU:-Available on backorder
Ferrostatin-1 diyne is a ferroptosis inhibitor and analog of ferrostatin-1 (Item No. 17729).{44000} It inhibits cell death induced by erastin (Item No. 17754) in HT-1080 cells when used at concentrations ranging from 0.01 to 1 μM. Ferrostatin-1 diyne contains a diyne small vibrational tag and has been used to assess localization of ferrostatin-1 in HT-1080 cells using stimulated Ramen scattering microscopy.
Brand:CaymanSKU:25492 - 10 mgAvailable on backorder
Ferrostatin-1 diyne is a ferroptosis inhibitor and analog of ferrostatin-1 (Item No. 17729).{44000} It inhibits cell death induced by erastin (Item No. 17754) in HT-1080 cells when used at concentrations ranging from 0.01 to 1 μM. Ferrostatin-1 diyne contains a diyne small vibrational tag and has been used to assess localization of ferrostatin-1 in HT-1080 cells using stimulated Ramen scattering microscopy.
Brand:CaymanSKU:25492 - 25 mgAvailable on backorder
Ferrostatin-1 diyne is a ferroptosis inhibitor and analog of ferrostatin-1 (Item No. 17729).{44000} It inhibits cell death induced by erastin (Item No. 17754) in HT-1080 cells when used at concentrations ranging from 0.01 to 1 μM. Ferrostatin-1 diyne contains a diyne small vibrational tag and has been used to assess localization of ferrostatin-1 in HT-1080 cells using stimulated Ramen scattering microscopy.
Brand:CaymanSKU:25492 - 5 mgAvailable on backorder
Ferrostatin-1 diyne is a ferroptosis inhibitor and analog of ferrostatin-1 (Item No. 17729).{44000} It inhibits cell death induced by erastin (Item No. 17754) in HT-1080 cells when used at concentrations ranging from 0.01 to 1 μM. Ferrostatin-1 diyne contains a diyne small vibrational tag and has been used to assess localization of ferrostatin-1 in HT-1080 cells using stimulated Ramen scattering microscopy.
Brand:CaymanSKU:25492 - 50 mgAvailable on backorder
Ferrozine is a colorimetric reagent commonly used in the detection of iron.{52709,52710} Ferrozine forms a complex with ferrous iron that can be quantified by colorimetric detection at 562 nm as a measure of iron concentration.
Brand:CaymanSKU:31465 - 1 gAvailable on backorder
Ferrozine is a colorimetric reagent commonly used in the detection of iron.{52709,52710} Ferrozine forms a complex with ferrous iron that can be quantified by colorimetric detection at 562 nm as a measure of iron concentration.
Brand:CaymanSKU:31465 - 10 gAvailable on backorder
Ferrozine is a colorimetric reagent commonly used in the detection of iron.{52709,52710} Ferrozine forms a complex with ferrous iron that can be quantified by colorimetric detection at 562 nm as a measure of iron concentration.
Brand:CaymanSKU:31465 - 5 gAvailable on backorder
Ferulenol is a prenylated 4-hydroxycoumarin first isolated from F. communis that demonstrates potent antimycobacterial activity.{31216} It does not directly affect blood coagulation but at concentrations less than 100 nM has been shown to impair factor X biosynthesis.{31217} Ferulenol has also been shown to stimulate tubulin polymerization in vitro, rearranging cellular microtubule networks into short fibers and altering nuclear morphology, which leads to cytotoxicity in various human tumor cell lines.{31214} Ferulenol is reported to disrupt oxidative phosphorylation, inhibiting succinate ubiquinone reductase without altering succinate dehydrogenase activity of complex II of the electron chain transport system.{31215}
Brand:CaymanSKU:-Available on backorder
Ferulenol is a prenylated 4-hydroxycoumarin first isolated from F. communis that demonstrates potent antimycobacterial activity.{31216} It does not directly affect blood coagulation but at concentrations less than 100 nM has been shown to impair factor X biosynthesis.{31217} Ferulenol has also been shown to stimulate tubulin polymerization in vitro, rearranging cellular microtubule networks into short fibers and altering nuclear morphology, which leads to cytotoxicity in various human tumor cell lines.{31214} Ferulenol is reported to disrupt oxidative phosphorylation, inhibiting succinate ubiquinone reductase without altering succinate dehydrogenase activity of complex II of the electron chain transport system.{31215}
Brand:CaymanSKU:-Available on backorder
Ferulenol is a prenylated 4-hydroxycoumarin first isolated from F. communis that demonstrates potent antimycobacterial activity.{31216} It does not directly affect blood coagulation but at concentrations less than 100 nM has been shown to impair factor X biosynthesis.{31217} Ferulenol has also been shown to stimulate tubulin polymerization in vitro, rearranging cellular microtubule networks into short fibers and altering nuclear morphology, which leads to cytotoxicity in various human tumor cell lines.{31214} Ferulenol is reported to disrupt oxidative phosphorylation, inhibiting succinate ubiquinone reductase without altering succinate dehydrogenase activity of complex II of the electron chain transport system.{31215}
Brand:CaymanSKU:-Available on backorder
Ferulic acid is a phenol that has been found in apples and has diverse biological activities.{54448,54449,54450,54451} It is active against the yeast S. cerevisiae when used at a concentration of 250 ppm and the bacteria E. coli, S. aureus, and B. cereus when used at a concentration of 500 µg/ml.{54448,54449} Dietary administration of ferulic acid (0.2% w/w) reduces serum total cholesterol levels in a rat model of diet-induced hypercholesterolemia.{54450} It suppresses benzo(a)pyrene-induced forestomach tumor formation in mice.{54451}
Brand:CaymanSKU:19871 -Available on backorder
Ferulic acid is a phenol that has been found in apples and has diverse biological activities.{54448,54449,54450,54451} It is active against the yeast S. cerevisiae when used at a concentration of 250 ppm and the bacteria E. coli, S. aureus, and B. cereus when used at a concentration of 500 µg/ml.{54448,54449} Dietary administration of ferulic acid (0.2% w/w) reduces serum total cholesterol levels in a rat model of diet-induced hypercholesterolemia.{54450} It suppresses benzo(a)pyrene-induced forestomach tumor formation in mice.{54451}
Brand:CaymanSKU:19871 -Available on backorder
Ferulic acid is a phenol that has been found in apples and has diverse biological activities.{54448,54449,54450,54451} It is active against the yeast S. cerevisiae when used at a concentration of 250 ppm and the bacteria E. coli, S. aureus, and B. cereus when used at a concentration of 500 µg/ml.{54448,54449} Dietary administration of ferulic acid (0.2% w/w) reduces serum total cholesterol levels in a rat model of diet-induced hypercholesterolemia.{54450} It suppresses benzo(a)pyrene-induced forestomach tumor formation in mice.{54451}
Brand:CaymanSKU:19871 -Available on backorder
Ferulic acid is a phenol that has been found in apples and has diverse biological activities.{54448,54449,54450,54451} It is active against the yeast S. cerevisiae when used at a concentration of 250 ppm and the bacteria E. coli, S. aureus, and B. cereus when used at a concentration of 500 µg/ml.{54448,54449} Dietary administration of ferulic acid (0.2% w/w) reduces serum total cholesterol levels in a rat model of diet-induced hypercholesterolemia.{54450} It suppresses benzo(a)pyrene-induced forestomach tumor formation in mice.{54451}
Brand:CaymanSKU:19871 -Available on backorder
Ferulic acid is a hydroxycinnamic acid that is abundant in plants and originally derived from giant fennel (F. communis). This naturally-occurring phenolic has antioxidant activities that provide protection against inflammation and cancer.{1430,1420,19116,15917} Ferulic acid ethyl ester is a lipophilic derivative of ferulic acid, demonstrating increased ability to cross cell membranes.{21329} Ferulic acid ethyl ester has less antioxidant capacity than ferulic acid in neuronal PC12 cells (IC50 = 66.7 μM for ferulic acid ethyl ester vs. 44.6 μM for ferulic acid, 2,2-diphenyl-1-picrylhydrazyl radical scavenging).{21327} However, ferulic acid ethyl ester increases the expression of heme oxygenase-1, Hsp70, and Hsp72, providing neuroprotection against amyloid β-peptide.{21330,21328} Moreover, ferulic acid ethyl ester (25 μM) completely prevents cytotoxicity induced by ultraviolet B irradiation of normal human epidermal melanocytes, again associated with an induced expression of heme oxygenase-1 and Hsp70.{21326}
Brand:CaymanSKU:11880 - 1 gAvailable on backorder
Ferulic acid is a hydroxycinnamic acid that is abundant in plants and originally derived from giant fennel (F. communis). This naturally-occurring phenolic has antioxidant activities that provide protection against inflammation and cancer.{1430,1420,19116,15917} Ferulic acid ethyl ester is a lipophilic derivative of ferulic acid, demonstrating increased ability to cross cell membranes.{21329} Ferulic acid ethyl ester has less antioxidant capacity than ferulic acid in neuronal PC12 cells (IC50 = 66.7 μM for ferulic acid ethyl ester vs. 44.6 μM for ferulic acid, 2,2-diphenyl-1-picrylhydrazyl radical scavenging).{21327} However, ferulic acid ethyl ester increases the expression of heme oxygenase-1, Hsp70, and Hsp72, providing neuroprotection against amyloid β-peptide.{21330,21328} Moreover, ferulic acid ethyl ester (25 μM) completely prevents cytotoxicity induced by ultraviolet B irradiation of normal human epidermal melanocytes, again associated with an induced expression of heme oxygenase-1 and Hsp70.{21326}
Brand:CaymanSKU:11880 - 10 gAvailable on backorder
Ferulic acid is a hydroxycinnamic acid that is abundant in plants and originally derived from giant fennel (F. communis). This naturally-occurring phenolic has antioxidant activities that provide protection against inflammation and cancer.{1430,1420,19116,15917} Ferulic acid ethyl ester is a lipophilic derivative of ferulic acid, demonstrating increased ability to cross cell membranes.{21329} Ferulic acid ethyl ester has less antioxidant capacity than ferulic acid in neuronal PC12 cells (IC50 = 66.7 μM for ferulic acid ethyl ester vs. 44.6 μM for ferulic acid, 2,2-diphenyl-1-picrylhydrazyl radical scavenging).{21327} However, ferulic acid ethyl ester increases the expression of heme oxygenase-1, Hsp70, and Hsp72, providing neuroprotection against amyloid β-peptide.{21330,21328} Moreover, ferulic acid ethyl ester (25 μM) completely prevents cytotoxicity induced by ultraviolet B irradiation of normal human epidermal melanocytes, again associated with an induced expression of heme oxygenase-1 and Hsp70.{21326}
Brand:CaymanSKU:11880 - 5 gAvailable on backorder
Ferutinin is a plant-derived ester of a sesquiterpenic alcohol that acts as an agonist for estrogen receptor (ER) α (IC50 = 33.1 nM) and an agonist/antagonist for ERβ (IC50 = 180.5 nM).{26981} It also demonstrates ionophoretic properties, increasing calcium permeability of lipid bilayer membranes, mitochondria, thymocytes, sarcoplasmic reticulum, and liposomes at a concentration range of 1-50 µM.{26982,26983,26984} Ferutinin is cytotoxic to MCF-7 breast and TCC bladder cancer cells as well as human foreskin HFF3 fibroblasts (IC50s = 29, 24, and 36 µg/ml in vitro after 72 hours of exposure).{26983}
Brand:CaymanSKU:-Out of stock
Ferutinin is a plant-derived ester of a sesquiterpenic alcohol that acts as an agonist for estrogen receptor (ER) α (IC50 = 33.1 nM) and an agonist/antagonist for ERβ (IC50 = 180.5 nM).{26981} It also demonstrates ionophoretic properties, increasing calcium permeability of lipid bilayer membranes, mitochondria, thymocytes, sarcoplasmic reticulum, and liposomes at a concentration range of 1-50 µM.{26982,26983,26984} Ferutinin is cytotoxic to MCF-7 breast and TCC bladder cancer cells as well as human foreskin HFF3 fibroblasts (IC50s = 29, 24, and 36 µg/ml in vitro after 72 hours of exposure).{26983}
Brand:CaymanSKU:-Out of stock
Ferutinin is a plant-derived ester of a sesquiterpenic alcohol that acts as an agonist for estrogen receptor (ER) α (IC50 = 33.1 nM) and an agonist/antagonist for ERβ (IC50 = 180.5 nM).{26981} It also demonstrates ionophoretic properties, increasing calcium permeability of lipid bilayer membranes, mitochondria, thymocytes, sarcoplasmic reticulum, and liposomes at a concentration range of 1-50 µM.{26982,26983,26984} Ferutinin is cytotoxic to MCF-7 breast and TCC bladder cancer cells as well as human foreskin HFF3 fibroblasts (IC50s = 29, 24, and 36 µg/ml in vitro after 72 hours of exposure).{26983}
Brand:CaymanSKU:-Out of stock
Fesoterodine is an antagonist of muscarinic acetylcholine receptors (Kis = 15.8, 11.2, 12.6, 22.4, and 25.1 nM for human M1-5, respectively).{41347} In vivo, fesoterodine (0.01 mg/kg, i.v.) reduces micturition pressure and increases bladder capacity and intercontraction interval (ICI) in conscious female rats. Fesoterodine also reduces intermicturition pressure and prevents bladder overactivity in a rat model of spinal cord injury-induced overactive bladder.{41348}
Brand:CaymanSKU:23777 - 1 mgAvailable on backorder
Fesoterodine is an antagonist of muscarinic acetylcholine receptors (Kis = 15.8, 11.2, 12.6, 22.4, and 25.1 nM for human M1-5, respectively).{41347} In vivo, fesoterodine (0.01 mg/kg, i.v.) reduces micturition pressure and increases bladder capacity and intercontraction interval (ICI) in conscious female rats. Fesoterodine also reduces intermicturition pressure and prevents bladder overactivity in a rat model of spinal cord injury-induced overactive bladder.{41348}
Brand:CaymanSKU:23777 - 10 mgAvailable on backorder
Fesoterodine is an antagonist of muscarinic acetylcholine receptors (Kis = 15.8, 11.2, 12.6, 22.4, and 25.1 nM for human M1-5, respectively).{41347} In vivo, fesoterodine (0.01 mg/kg, i.v.) reduces micturition pressure and increases bladder capacity and intercontraction interval (ICI) in conscious female rats. Fesoterodine also reduces intermicturition pressure and prevents bladder overactivity in a rat model of spinal cord injury-induced overactive bladder.{41348}
Brand:CaymanSKU:23777 - 5 mgAvailable on backorder
FeTMPyP is a synthetic porphyrin complexed with iron, which acts as a peroxynitrite decomposition catalyst. The rate constant for decomposition of peroxynitrite by FeTMPyP is 2.2 x 106 M−1s−1 with a turnover number of 360 ± 170 s−1.{3092} The predominant product (>90%) of this reaction is nitrate, with a minor amount of nitrite also formed (~6%), at pH 7.4.{3092}
Brand:CaymanSKU:75854 - 10 mgAvailable on backorder
FeTMPyP is a synthetic porphyrin complexed with iron, which acts as a peroxynitrite decomposition catalyst. The rate constant for decomposition of peroxynitrite by FeTMPyP is 2.2 x 106 M−1s−1 with a turnover number of 360 ± 170 s−1.{3092} The predominant product (>90%) of this reaction is nitrate, with a minor amount of nitrite also formed (~6%), at pH 7.4.{3092}
Brand:CaymanSKU:75854 - 100 mgAvailable on backorder
FeTMPyP is a synthetic porphyrin complexed with iron, which acts as a peroxynitrite decomposition catalyst. The rate constant for decomposition of peroxynitrite by FeTMPyP is 2.2 x 106 M−1s−1 with a turnover number of 360 ± 170 s−1.{3092} The predominant product (>90%) of this reaction is nitrate, with a minor amount of nitrite also formed (~6%), at pH 7.4.{3092}
Brand:CaymanSKU:75854 - 25 mgAvailable on backorder
FeTMPyP is a synthetic porphyrin complexed with iron, which acts as a peroxynitrite decomposition catalyst. The rate constant for decomposition of peroxynitrite by FeTMPyP is 2.2 x 106 M−1s−1 with a turnover number of 360 ± 170 s−1.{3092} The predominant product (>90%) of this reaction is nitrate, with a minor amount of nitrite also formed (~6%), at pH 7.4.{3092}
Brand:CaymanSKU:75854 - 50 mgAvailable on backorder
Peroxynitrite (Item No. 81565) is a highly reactive nitrogen species formed from the reaction of nitric oxide (NO) and superoxide.{28295} FeTPPS is a ferric porphyrin complex that causes the decomposition of peroxynitrite by catalytic isomerization to produce nitrate both in vitro and in vivo.{28292} The conversion of this reactive nitrogen species to nitrate results in cytoprotection (EC50 = 5 µM).{28292,28290} FeTPPS does not complex with NO and does not alter superoxide directly. It is commonly used to elucidate the roles of peroxynitrite in oxidative stress, cell damage, and intracellular signaling.{28294,28291,28293}
Brand:CaymanSKU:-Out of stock
Peroxynitrite (Item No. 81565) is a highly reactive nitrogen species formed from the reaction of nitric oxide (NO) and superoxide.{28295} FeTPPS is a ferric porphyrin complex that causes the decomposition of peroxynitrite by catalytic isomerization to produce nitrate both in vitro and in vivo.{28292} The conversion of this reactive nitrogen species to nitrate results in cytoprotection (EC50 = 5 µM).{28292,28290} FeTPPS does not complex with NO and does not alter superoxide directly. It is commonly used to elucidate the roles of peroxynitrite in oxidative stress, cell damage, and intracellular signaling.{28294,28291,28293}
Brand:CaymanSKU:-Out of stock
Peroxynitrite (Item No. 81565) is a highly reactive nitrogen species formed from the reaction of nitric oxide (NO) and superoxide.{28295} FeTPPS is a ferric porphyrin complex that causes the decomposition of peroxynitrite by catalytic isomerization to produce nitrate both in vitro and in vivo.{28292} The conversion of this reactive nitrogen species to nitrate results in cytoprotection (EC50 = 5 µM).{28292,28290} FeTPPS does not complex with NO and does not alter superoxide directly. It is commonly used to elucidate the roles of peroxynitrite in oxidative stress, cell damage, and intracellular signaling.{28294,28291,28293}
Brand:CaymanSKU:-Out of stock
Fevipiprant is a prostaglandin D2 (PGD2; Item No. 12010) receptor antagonist with a Kd value of 1.14 nM for CRTH2/DP2 and a relatively slow dissociation from this receptor (half-life = 14.4 minutes).{32112} It has been shown to inhibit PGD2-stimulated human eosinophil shape change in whole blood assays (IC50 = 0.44 nM) and to inhibit PGD2-induced cytokine release in human Th2 cells (IC50s = 2.56 and 1.4 nM for IL-5 and IL-13, respectively).{32112} This compound has undergone testing in a phase II clinical study in uncontrolled allergic asthma.{32111}
Brand:CaymanSKU:20263 -Available on backorder
Fevipiprant is a prostaglandin D2 (PGD2; Item No. 12010) receptor antagonist with a Kd value of 1.14 nM for CRTH2/DP2 and a relatively slow dissociation from this receptor (half-life = 14.4 minutes).{32112} It has been shown to inhibit PGD2-stimulated human eosinophil shape change in whole blood assays (IC50 = 0.44 nM) and to inhibit PGD2-induced cytokine release in human Th2 cells (IC50s = 2.56 and 1.4 nM for IL-5 and IL-13, respectively).{32112} This compound has undergone testing in a phase II clinical study in uncontrolled allergic asthma.{32111}
Brand:CaymanSKU:20263 -Available on backorder
Fevipiprant is a prostaglandin D2 (PGD2; Item No. 12010) receptor antagonist with a Kd value of 1.14 nM for CRTH2/DP2 and a relatively slow dissociation from this receptor (half-life = 14.4 minutes).{32112} It has been shown to inhibit PGD2-stimulated human eosinophil shape change in whole blood assays (IC50 = 0.44 nM) and to inhibit PGD2-induced cytokine release in human Th2 cells (IC50s = 2.56 and 1.4 nM for IL-5 and IL-13, respectively).{32112} This compound has undergone testing in a phase II clinical study in uncontrolled allergic asthma.{32111}
Brand:CaymanSKU:20263 -Available on backorder
The farnesoid X receptor (FXR) is a nuclear receptor that acts as a bile acid sensor, protecting cells and organs against bile acid toxicity and coordinating cholesterol metabolism, lipid homeostasis, and absorption of dietary fats and vitamins. Fexaramine is an FXR agonist (EC50 = 25 nM) that demonstrates 100-fold increased affinity to FXR compared to endogenous bile acids and 3-fold increased potency compared to the high affinity FXR agonist GW 4064 (Item No. 10006611; EC50 = 80 nM).{28351} Fexaramine does not display activity at the following nuclear receptors: hRXRα, hPPARαγδ, mPXR, hPXR, hLXRα, hTRβ, hRARβ, mCAR, mERRγ, or hVDR.{28351}
Brand:CaymanSKU:-Available on backorder
The farnesoid X receptor (FXR) is a nuclear receptor that acts as a bile acid sensor, protecting cells and organs against bile acid toxicity and coordinating cholesterol metabolism, lipid homeostasis, and absorption of dietary fats and vitamins. Fexaramine is an FXR agonist (EC50 = 25 nM) that demonstrates 100-fold increased affinity to FXR compared to endogenous bile acids and 3-fold increased potency compared to the high affinity FXR agonist GW 4064 (Item No. 10006611; EC50 = 80 nM).{28351} Fexaramine does not display activity at the following nuclear receptors: hRXRα, hPPARαγδ, mPXR, hPXR, hLXRα, hTRβ, hRARβ, mCAR, mERRγ, or hVDR.{28351}
Brand:CaymanSKU:-Available on backorder
The farnesoid X receptor (FXR) is a nuclear receptor that acts as a bile acid sensor, protecting cells and organs against bile acid toxicity and coordinating cholesterol metabolism, lipid homeostasis, and absorption of dietary fats and vitamins. Fexaramine is an FXR agonist (EC50 = 25 nM) that demonstrates 100-fold increased affinity to FXR compared to endogenous bile acids and 3-fold increased potency compared to the high affinity FXR agonist GW 4064 (Item No. 10006611; EC50 = 80 nM).{28351} Fexaramine does not display activity at the following nuclear receptors: hRXRα, hPPARαγδ, mPXR, hPXR, hLXRα, hTRβ, hRARβ, mCAR, mERRγ, or hVDR.{28351}
Brand:CaymanSKU:-Available on backorder
The farnesoid X receptor (FXR) is a nuclear receptor that acts as a bile acid sensor, protecting cells and organs against bile acid toxicity and coordinating cholesterol metabolism, lipid homeostasis, and absorption of dietary fats and vitamins. Fexaramine is an FXR agonist (EC50 = 25 nM) that demonstrates 100-fold increased affinity to FXR compared to endogenous bile acids and 3-fold increased potency compared to the high affinity FXR agonist GW 4064 (Item No. 10006611; EC50 = 80 nM).{28351} Fexaramine does not display activity at the following nuclear receptors: hRXRα, hPPARαγδ, mPXR, hPXR, hLXRα, hTRβ, hRARβ, mCAR, mERRγ, or hVDR.{28351}
Brand:CaymanSKU:-Available on backorder
Fexinidazole is an antiparasitic drug that, in different preparations, is effective against trypanosomes.{31396,31398} It is orally available and rapidly metabolized to two active metabolites, a sulfone and a sulfoxide.{31398,31395} Fexinidazole has been shown to kill both T. brucei gambiense and T. brucei rhodesiense in animal studies and is being tested for use in human African trypanosomiasis.{31397,31395}
Brand:CaymanSKU:-Available on backorder
Fexinidazole is an antiparasitic drug that, in different preparations, is effective against trypanosomes.{31396,31398} It is orally available and rapidly metabolized to two active metabolites, a sulfone and a sulfoxide.{31398,31395} Fexinidazole has been shown to kill both T. brucei gambiense and T. brucei rhodesiense in animal studies and is being tested for use in human African trypanosomiasis.{31397,31395}
Brand:CaymanSKU:-Available on backorder
Fexinidazole is an antiparasitic drug that, in different preparations, is effective against trypanosomes.{31396,31398} It is orally available and rapidly metabolized to two active metabolites, a sulfone and a sulfoxide.{31398,31395} Fexinidazole has been shown to kill both T. brucei gambiense and T. brucei rhodesiense in animal studies and is being tested for use in human African trypanosomiasis.{31397,31395}
Brand:CaymanSKU:-Available on backorder
Fexinidazole is an antiparasitic drug that, in different preparations, is effective against trypanosomes.{31396,31398} It is orally available and rapidly metabolized to two active metabolites, a sulfone and a sulfoxide.{31398,31395} Fexinidazole has been shown to kill both T. brucei gambiense and T. brucei rhodesiense in animal studies and is being tested for use in human African trypanosomiasis.{31397,31395}
Brand:CaymanSKU:-Available on backorder
Fexofenadine is a histamine H1 receptor antagonist (Ki = 10 nM).{27483} It reverses contraction of isolated rat tracheal strips induced by acetyl-β-methylcholine (Item No. 23092).{36897} Fexofenadine inhibits expression of IL-8 in TNF-α-stimulated HCT116 and COLO 205 cells.{36898} Oral administration of fexofenadine (2 and 10 mg/kg) reduces severity of colitis and phospho-IκB kinase activation in a mouse model of colitis induced by dextran sulfate sodium (DSS; Item No. 23250).
Brand:CaymanSKU:-Available on backorder
Fexofenadine is a histamine H1 receptor antagonist (Ki = 10 nM).{27483} It reverses contraction of isolated rat tracheal strips induced by acetyl-β-methylcholine (Item No. 23092).{36897} Fexofenadine inhibits expression of IL-8 in TNF-α-stimulated HCT116 and COLO 205 cells.{36898} Oral administration of fexofenadine (2 and 10 mg/kg) reduces severity of colitis and phospho-IκB kinase activation in a mouse model of colitis induced by dextran sulfate sodium (DSS; Item No. 23250).
Brand:CaymanSKU:-Available on backorder
Fexofenadine is a histamine H1 receptor antagonist (Ki = 10 nM).{27483} It reverses contraction of isolated rat tracheal strips induced by acetyl-β-methylcholine (Item No. 23092).{36897} Fexofenadine inhibits expression of IL-8 in TNF-α-stimulated HCT116 and COLO 205 cells.{36898} Oral administration of fexofenadine (2 and 10 mg/kg) reduces severity of colitis and phospho-IκB kinase activation in a mouse model of colitis induced by dextran sulfate sodium (DSS; Item No. 23250).
Brand:CaymanSKU:-Available on backorder
Fexofenadine is a histamine H1 receptor antagonist (Ki = 10 nM).{27483} It reverses contraction of isolated rat tracheal strips induced by acetyl-β-methylcholine (Item No. 23092).{36897} Fexofenadine inhibits expression of IL-8 in TNF-α-stimulated HCT116 and COLO 205 cells.{36898} Oral administration of fexofenadine (2 and 10 mg/kg) reduces severity of colitis and phospho-IκB kinase activation in a mouse model of colitis induced by dextran sulfate sodium (DSS; Item No. 23250).
Brand:CaymanSKU:-Available on backorder