Description
GPR120 is a G protein-coupled receptor (GPCR) expressed in adipocytes and pro-inflammatory macrophages that is activated by long chain free fatty acids.{13205} The activation of GPR120 results in elevated calcium ion and activation of the ERK cascade.{13205} ω-3 Fatty acids, such as docosahexaenoic acid and eicosapentaenoic acid initiate GPR120 signaling resulting in inhibition of toll-like receptor and TNF-α inflammatory signaling pathways in a β-arrestin2/TAB1 dependent manner.{22326} The anti-inflammatory effects of GPR120 are indirectly involved with promoting insulin secretion.{13205} GPR120 also mediates free fatty acid induced apoptosis inhibition in the enteroendocrin cell line STC-1.{13205} Cayman’s N-terminal polyclonal antibody detects GPR120 in LoVo and PC3 cell lysates. The predicted size for GPR120 is 42.2 kDa and the observed size is approximately 45 kDa by western blot.
Synonyms: Free Fatty Acid Receptor 4|G Protein-Coupled Receptor 120|GPCR129|GT01|O3FAR1|PGR4
Immunogen: Synthetic peptide from the N-terminal region of human FFAR4 (GPR120)
Formulation: 500 µl of Peptide affinity-purified antibody
Isotype:
Applications: ELISA and WB
Origin:
Stability: 365 days
Application|ELISA||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Signaling|ERK/MAPK Signaling||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition
