Immunogen: Synthetic peptide from the internal region of human STING protein containing the R284M mutation • Host: Mouse • Species Reactivity: (+) Human • Cross Reactivity: (-) Wild-type STING • Applications: ELISA and WB • MW = 28.8/42 kDa

STING M284 variant Monoclonal Antibody (Clone 8E7) – 100 µg

Brand:
Cayman
Storage:

Stimulator of interferon genes (STING) is a component of the innate immune response that binds to cyclic dinucleotides, which are bacterial second messengers, leading to activation of NF-κB and transcription of immunomodulatory genes, including type I interferon (IFN).{22400,22401,24611,24607} The R284M mutation in STING is associated with constitutive activation of downstream signaling. It increases the propensity of STING to dimerize and associate with the kinase TBK1 (Item No. 22817), enhancing the ability of STING to activate IRF3 (Item No. 22811) and NF-κB (Item No. 10009818) and induce a type I IFN response.{41454} However, the R284M mutation occurs outside of the dimerization region between positions 153-177, so rather than a direct effect on dimerization, it is predicted to promote or inhibit binding of a cellular factor that stabilizes or impairs STING dimerization. Cayman’s STING M284 variant Monoclonal Antibody preferentially detects overexpressed STING (R284M) versus wild-type STING by Western blot and ELISA.  

 

Available on backorder

Add to quotes
SKU: 25922 - 100 µg Category:

Description

Immunogen: Synthetic peptide from the internal region of human STING protein containing the R284M mutation • Host: Mouse • Species Reactivity: (+) Human • Cross Reactivity: (-) Wild-type STING • Applications: ELISA and WB • MW = 28.8/42 kDa

Synonyms: Endoplasmic Reticulum Interferon Stimulator|ERIS|Mediator of IRF3 Activation|MITA|MPYS|Stimulator of Interferon Genes|TMEM173|Transmembrane Protein 173

Immunogen: Synthetic peptide from the internal region of human STING protein containing the R284M mutation

Formulation: 100 µg of protein G-purified monoclonal antibody

Isotype: IgG1

Applications: ELISA and WB

Origin:

Stability: 365 days

Application|ELISA||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Immunology & Inflammation|Innate Immunity|STING||Research Area|Infectious Disease

Related products