Small molecule inhibitors of sEH may hold promise as therapeutics for the treatment of hypertension and vascular inflammation. Cayman’s fluorescence-based sEH Inhibitor Screening Assay provides a convenient method for screening epoxide hydrolase inhibitors. The assay utilizes (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME) as a substrate. Hydrolysis of PHOME by epoxide hydrolase produces the highly fluorescent 6-methoxy-2-naphthaldehyde which can be analyzed using an excitation wavelength of 330 nm and emission wavelength of 465 nm. Each kit contains buffer

Soluble Epoxide Hydrolase Inhibitor Screening Assay Kit – 96 wells

Brand:
Cayman
Storage:
-80

Soluble epoxide hydrolase (sEH) catalyzes the hydrolysis of exogenous and endogenous epoxides to vicinal diols. Endogenous substrates for sEH include epoxyeicosatrienoic acids (EETs) which exhibit vasodialatory and anti-inflammatory activity. Small molecule inhibitors of sEH may therefore hold promise as therapeutics for the treatment of hypertension and vascular inflammation. Cayman’s fluorescence-based sEH Inhibitor Screening Assay Kit provides a convenient method for screening epoxide hydrolase inhibitors. The assay utilizes (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME) as a substrate. Hydrolysis of PHOME by epoxide hydrolase produces the highly fluorescent 6-methoxy-2-naphthaldehyde which can be analyzed using an excitation wavelength of 330 nm and emission wavelength of 465 nm. Each kit contains buffer, substrate, and sufficient human recombinant sEH for 100 tests.  

 

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SKU: 10011671 - 96 wells Category:

Description

Small molecule inhibitors of sEH may hold promise as therapeutics for the treatment of hypertension and vascular inflammation. Cayman’s fluorescence-based sEH Inhibitor Screening Assay provides a convenient method for screening epoxide hydrolase inhibitors. The assay utilizes (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME) as a substrate. Hydrolysis of PHOME by epoxide hydrolase produces the highly fluorescent 6-methoxy-2-naphthaldehyde which can be analyzed using an excitation wavelength of 330 nm and emission wavelength of 465 nm. Each kit contains buffer, substrate, and sufficient human recombinant sEH for 100 tests.

Formulation:

Formal name:

Synonyms:  Cytosolic Epoxide Hydrolase (CEH)|EPHX2|Epoxide Hydrolase 2|sEH

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Imunogen:

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Origin: Animal/Fall armyworm

Product Type|Assay Kits|Fluorometric Assays||Product Type|Assay Kits|Inhibitor Screening Assays||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Immunology & Inflammation

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