Antigen: human SIRT7 amino acids 35-51 and 361-377 • Host: rabbit • Cross Reactivity: (+) human SIRT7 • Application(s): WB • SIRT7 is a member of the sirtuin family of proteins

SIRT7 Polyclonal Antibody – 1 ea

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Cayman
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SIRT7 is a member of a famiy of proteins called sirtuins (SIR2-like proteins) and are present in prokaryotes and eukaryotes. All SIR2-like proteins have a sirtuin core domain, which contains a series of sequence motifs conserved in organisms ranging from bacteria to humans. Bacterial, yeast, and mammalian sirtuins are able to metabolize NAD+ and several act as mono-ADP-ribosyltransferases. The enzymatic function of sirtuins is not yet completely understood but recent reports of histone-activated SIR2-mediated NAD+ metabolism and NAD+-activated SIR2-mediated histone deacetylation suggest a possible coupled reciprocal activation mechanism involving interactions of SIR2 with NAD+ and the N-ε-acetyl-lysine groups of acetylated histone.  

 

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SKU: 13477 - 1 ea Category:

Description

Antigen: human SIRT7 amino acids 35-51 and 361-377 • Host: rabbit • Cross Reactivity: (+) human SIRT7 • Application(s): WB • SIRT7 is a member of the sirtuin family of proteins, which are able to metabolize NAD+. Reports of histone-activated SIR2-mediated NAD+ metabolism and NAD+-activated SIR2-mediated histone deacetylation suggest a coupled reciprocal activation mechanism involving interactions of SIR2 with NAD+ and the N-ε-acetyl-lysine groups of acetylated histone.

Synonyms: Silent Information Regulator 7|SIR2|Sirtuin 7

Immunogen: human SIRT7 amino acids 35-51 and 361-377

Formulation: 100 µg of protein G-purified IgG in 200 µl PBS containing 0.2% gelatin and 0.05% sodium azide

Isotype:

Applications: WB

Origin: Animal/Rabbit

Stability: 365 days

Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation

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