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NMDA Receptor NR2A Subunit Polyclonal Antibody – 1 ea

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Cayman
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The ion channels activated by glutamate are typically divided into two classes. Glutamate receptors that are activated by kainate and α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as kainate/AMPA receptors (K/AMPAR). Those that are sensitive to N-methyl-Daspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s, epilepsy and ischemic neuronal cell death. The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS. The NMDAR is also potentiated by protein phosphorylation. The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits.  

 

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SKU: 10608 - 1 ea Category:

Description

Antigen: fusion protein from the C-terminus of the NR2A subunit of rat NMDA receptor • Host: rabbit • Cross Reactivity: (+) human, mouse, and rat NMDA receptor • Application(s): IHC, IP, and WB • The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s, epilepsy and ischemic neuronal cell death. Channels with physiological activity are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits.

Synonyms:

Immunogen: fusion protein from the C-terminus of the NR2A subunit of rat NMDA receptor

Formulation: 10 µg affinity-purified antibody lyophilized from 5 mM ammonium bicarbonate

Isotype:

Applications: IHC, IP, and WB

Origin: Animal/Rabbit

Stability: 365 days

Application|Immunohistochemistry||Application|Immunoprecipitation||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Neuroscience|Behavioral Neuroscience|Addiction Research||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease||Research Area|Neuroscience|Seizure Disorders

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