Immunogen: Recombinant full-length human Hsp90β protein • Host: Rabbit • Species reactivity: (+) Human

Hsp90β Polyclonal Antibody – 500 µL

Brand:
Cayman
Storage:

Heat shock protein 90 β (Hsp90β) is the constitutively active cytosolic isoform of Hsp90 that is encoded by HSP90AB in humans.{17930} Hsp90 is a multidomain protein that functions as a molecular chaperone to assist in folding and activation of nascent peptides, refolding unfolded or misfolded proteins, and preventing protein aggregation.{15502} C-terminal dimerization of Hsp90, coupled with ATPase molecular clamp activity induces a conformational change in the N-terminal nucleotide binding domain that facilitates substrate binding and initiates the chaperone cycle.{17932} Hsp90 interacts with many co-chaperones during its chaperone cycle including p23 and Sba1, which help recruit substrates to the Hsp90 complex, Hsp70 (Item Nos. 22739 | 23002), which loads nascent polypeptides onto the Hsp90 dimer, and the ATPase activator Aha1 that promotes ATP hydrolysis and substrate release.{17931,41851} Hsp90 is overexpressed in cancer cells and stabilizes client proteins that promote oncogenesis, including transcription factors, signaling proteins, and kinases.{17930,41851} Hsp90 also decreases α-synuclein fibril formation and toxicity as well as Q35 aggregation in in vitro models of Parkinson’s and Huntington’s disease, respectively, implying a role in neurodegenerative disease.{41852} Cayman’s Hsp90β Polyclonal Antibody can be used for Western blot, ELISA, IHC, and IF applications. This antibody recognizes Hsp90β at 83 kDa from human, mouse, and rat samples.  

 

Available on backorder

Add to quotes
SKU: 25730 - 500 µL Category:

Description

Immunogen: Recombinant full-length human Hsp90β protein • Host: Rabbit • Species reactivity: (+) Human, mouse, and rat • Cross reactivity: (-) Hsp90α • Applications: ELISA, IHC, IF, and WB

Synonyms: Heat Shock 84 kDa|Heat Shock Protein 90β|Hsp 84

Immunogen: Recombinant full-length human Hsp90β protein

Formulation: 500 µl of protein affinity-purified antibody

Isotype:

Applications:

Origin:

Stability: 365 days

Application|ELISA||Application|Immunofluorescence||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cancer||Research Area|Neuroscience|Neurodegenerative Disorders|Huntington’s Disease||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease

Related products