Immunogen: Full-length human recombinant Hsp90β protein • Host: Mouse • Species reactivity: (+) Human

Hsp90β Monoclonal Antibody (Clone 8D6) – 100 µg

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Cayman
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Heat shock protein 90 β (Hsp90β) is the constitutively active cytosolic isoform of Hsp90 that is encoded by HSP90AB in humans.{17930} Hsp90 is a multidomain protein that functions as a molecular chaperone to assist in folding and activation of nascent peptides, refolding unfolded or misfolded proteins, and preventing protein aggregation.{15502} C-terminal dimerization of Hsp90, coupled with ATPase molecular clamp activity induces a conformational change in the N-terminal nucleotide binding domain that facilitates substrate binding and initiates the chaperone cycle.{17932} Hsp90 interacts with many co-chaperones during its chaperone cycle including p23 and Sba1, which help recruit substrates to the Hsp90 complex, Hsp70 (Item Nos. 22739 | 23002), which loads nascent polypeptides onto the Hsp90 dimer, and the ATPase activator Aha1 that promotes ATP hydrolysis and substrate release.{17931,41851} Hsp90 is overexpressed in cancer cells and stabilizes client proteins that promote oncogenesis, including transcription factors, signaling proteins, and kinases.{17930,41851} Hsp90 also decreases α-synuclein fibril formation and toxicity as well as Q35 aggregation in in vitro models of Parkinson’s and Huntington’s disease, respectively, implying a role in neurodegenerative disease.{41852} Cayman’s Hsp90β Monoclonal Antibody (Clone8D6) can be used for Western blot and ELISA applications. This antibody recognizes Hsp90β at 83 kDa from human, mouse, and rat samples.  

 

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SKU: 25695 - 100 µg Category:

Description

Immunogen: Full-length human recombinant Hsp90β protein • Host: Mouse • Species reactivity: (+) Human, mouse, rat • Cross reactivity: (-) Hsp90α • Applications: ELISA and WB,

Synonyms: Heat Shock 84 kDa|Heat Shock Protein Hsp 90-Beta|Hsp84|Hsp90β

Immunogen: Full length human recombinant Hsp90β protein

Formulation: 100 µg of protein G-purified monoclonal antibody

Isotype: IgG2b

Applications: ELISA, IHC, and WB

Origin:

Stability: 365 days

Application|ELISA||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Cancer||Research Area|Neuroscience|Neurodegenerative Disorders|Huntington’s Disease||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease

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