Antigen: human HMGB1 amino acids 100-150 • Host: rabbit • Cross Reactivity: (+) human

HMGB1 Polyclonal Antibody (aa 100-150) – 1 ea

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Cayman
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High Mobility Group Protein B1 (HMGB1) belongs to the HMGB family and contains two HMG box DNA-binding domains. It is a highly conserved, ubiquitous protein present in the nuclei and cytoplasm of nearly all cell types, and is a necessary and sufficient mediator of inflammation during sterile and infection-associated responses. HMGB1 also act as DNA nuclear binding protein that has recently been shown to be an early trigger of sterile inflammation in animal models of trauma-hemorrhage via the activation of the Toll-like receptor 4 (TLR4) and the receptor for the advanced glycation endproducts (RAGE).{20300} It is reported that the level of HMGB1 is elevated during sterile tissue injury, infection, lethal endotoxemia or sepsis, collagen-induced arthritis, and ischemia-reperfusion induced tissue injury.{20304}  

 

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SKU: 11515 - 1 ea Category:

Description

Antigen: human HMGB1 amino acids 100-150 • Host: rabbit • Cross Reactivity: (+) human, bovine, chicken, mouse, New World monkey, and rat HMGB1 • Applications: FC, IHC (paraffin-embedded tissue), and WB • HMGB1 is a necessary and sufficient mediator of inflammation during sterile and infection-associated responses. HMGB1 also act as DNA nuclear binding protein that has been shown to be an early trigger of sterile inflammation in animal models of trauma-hemorrhage via the activation of the Toll-like receptor 4 (TLR4) and the receptor for the advanced glycation endproducts (RAGE).

Synonyms: High Mobility Group Protein B1|HMG1

Immunogen: human HMGB1 amino acids 100-150

Formulation: 100 µg of Protein A purified IgG in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide

Isotype:

Applications: FC, IHC (paraffin-embedded tissue), and WB

Origin: Animal/Rabbit

Stability: 365 days

Application|Flow Cytometry||Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Immunology & Inflammation|Innate Immunity|Sepsis/Shock||Research Area|Infectious Disease

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