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Histone H3K9Me2 Monoclonal Antibody (Clone 5E2) – 100 µg

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Cayman
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Histones are nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. The basic structure is a 146 bp strand of DNA wrapped around a histone octamer containing pairs of the four core histones (H2A, H2B, H3, and H4). Histones are subjected to numerous post-translational modifications including methylation. Histone lysine methylation is an important post-translational modification linked to diverse biological pathways including gene transcription, heterochromatin maintenance, and double stranded DNA break repair.{20250} Most lysine methylation events are carried out by a SET domain containing HMTase, and methylation at lysine 9 of histone 3 (H3K9) is important for the recruitment of the heterochromatin protein 1 and the establishment of heterochromatin.{20252,17726,29238} The SET1/MLL (KMT2) family of methyltransferases is the principal enzyme family responsible for H3K9 methylations.{19551,19556} The WDR5/RbBP5/Ash21/DPY-30 subcomplex is required for the H3K9 dimethylation activity of the MLL1 core complex.{20268}  

 

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SKU: 18071 - 100 µg Category:

Description

Antigen: human • Host: mouse • Cross Reactivity: (-) H3K4Me2, H3K27Me2, H3K36Me2, H3K9Me, H3K9Me3 • Species Reactivity: (+) human • Isotype: IgG3κ • Application(s): ELISA

Synonyms: Histone H3 containing dimethylated lysine 9

Immunogen: Synthetic peptide from human Histone H3 aa 1-30 (di-methyl K9) conjugated to KLH

Formulation: 100 µg of protein G-purified antibody

Isotype: IgG3κ

Applications: ELISA

Origin:

Stability: 365 days

Application|ELISA||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Demethylation||Research Area|Epigenetics, Transcription, & Translation|Histones/Histone Peptides|Methylated||Research Area|Epigenetics, Transcription, & Translation|Writers|Histone Methylation

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