Immunogen: Human citrullinated fibrinogen • Host: Mouse • Species Reactivity: (+) Human • Cross Reactivity: (-) Human fibrinogen • Applications: ELISA

Citrullinated Fibrinogen Monoclonal Antibody (Clone 10E9.3) – 100 µg

Brand:
Cayman
Storage:

Fibrinogen is a hexameric glycoprotein that has roles in coagulation and hemostasis.{53514,53515} It is comprised of two sets of Aα, Bβ, and γ polypeptide chains encoded by FGA, FGB, and FGG, respectively, in humans.{53514} Fibrinogen is synthesized in hepatocytes and secreted into the plasma. Following thrombin-mediated cleavage of N-terminal fibrinopeptides from the Aα and Bβ chains, yielding the α and β chains, respectively, fibrinogen assembles into fibrin protofibrils and then mature fibers, which provide structure and viscoelasticity to blood clots.{53515,53516,53518} Mutations in FGA, FGB, or FGG have been found in patients with afibrinogenemia or hypofibrinogenemia.{53514} Elevated plasma fibrinogen levels are associated with an increased risk of cardiovascular disease.{53517} Fibrinogen can be citrullinated by protein arginine deiminase 2 (PAD2) and PAD4.{31655} Immune complexes containing citrullinated fibrinogen have been found in patients with anti-citrullinated protein antibody-positive rheumatoid arthritis.{21643} Cayman’s Citrullinated Fibrinogen Monoclonal Antibody (Clone 10E9.3) can be used for ELISA and Western blot (WB) applications. The antibody recognizes citrullinated fibrinogen at 56 kDa from human samples.  

 

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SKU: 17088 - 100 µg Category:

Description

Immunogen: Human citrullinated fibrinogen • Host: Mouse • Species Reactivity: (+) Human • Cross Reactivity: (-) Human fibrinogen • Applications: ELISA, WB • MW = 56 kDa

Synonyms: cFBG|cFG

Immunogen: Human citrullinated fibrinogen

Formulation: 100 µg of protein G-purified antibody

Isotype: IgG2b

Applications: ELISA, WB

Origin:

Stability: 365 days

Application|ELISA||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cardiovascular System|Cardiovascular Diseases||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis

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