Description
Cayman’s Caspase-1 Inhibitor Screening Assay Kit provides a robust and easy-to-use platform for identifying novel inhibitors of human caspase-1, the major downstream effector following inflammasome activation. The assay uses a caspase-1-specific fluorogenic substrate, Ac-YVAD-AFC. Caspase-1 cleaves this substrate generating free AFC, which can be easily quantified using a fluorescence plate reader at excitation and emission wavelengths of 400 and 505 nm, respectively. The potent and reversible caspase-1 inhibitor Ac-YVAD-CHO is included as a positive control.
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Application|Fluorescence||Product Type|Assay Kits|Fluorometric Assays||Product Type|Assay Kits|Inhibitor Screening Assays||Research Area|Cell Biology|Cell Death|Pyroptosis||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias||Research Area|Endocrinology & Metabolism|Metabolic Diseases|NAFLD & NASH||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Arthritis (Non-autoimmune)||Research Area|Immunology & Inflammation|Gastric Disease|Ulcerative Colitis||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition
