Immunogen: Phosphopeptide corresponding to amino acid residues surrounding phospho-Thr286 of rat CaM Kinase II • Host: Rabbit • Species Reactivity: (+) Human

CaMKII (Phospho-Thr286) Polyclonal Antibody – 100 µl

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Cayman
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Calcium/calmodulin-dependent protein kinase II (CaMKII) is a serine/threonine protein kinase and member of the calcium/calmodulin-activated protein kinase family.{53680,15705,15706} There are four isoforms of CaMKII, α, β, γ, and δ, encoded by CaMK2A, CaMK2B, CaMK2G, and CaMK2D in humans.{53680} CaMKIIα and CaMKIIβ are predominantly expressed in neuronal tissue, while CaMKIIγ and CaMKIIδ are primarily found in cardiac tissue, however, the various isoforms of CaMKII can be found in nearly all cell types. Upon calcium binding, CaMKII undergoes a conformational switch that displaces the autoinhibitory domain inducing autophosphorylation of threonine 286 (Thr286) and autonomous activation of the kinase.{15712} Activation of CaMKII in dendritic spines in response to increased calcium concentration facilitates the induction of long term potentiation (LTP) and memory formation in rodents.{53681} Phospho-site mutant Camk2aT286A knock-in mice exhibit impaired LTP, as well as learning and memory deficits.{53681} Cayman’s CaMKII (Phospho-Thr286) Polyclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes CaMKIIα phospho-Thr286 and CaMKIIβ phospho-Thr286 at approximately 50 and 60 kDa, respectively, from human, mouse, rabbit, and rat samples.  

 

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SKU: 29253 - 100 µl Category:

Description

Immunogen: Phosphopeptide corresponding to amino acid residues surrounding phospho-Thr286 of rat CaM Kinase II • Host: Rabbit • Species Reactivity: (+) Human, Mouse, Rabbit, Rat • Applications: IHC and WB • MW = ~50 and 60 kDa for CaMKIIα phospho-Thr286 and CaMKIIβ phospho-Thr286, respectively

Synonyms: Calcium/Calmodulin-dependent Protein Kinase II

Immunogen: Phosphopeptide corresponding to amino acid residues surrounding phospho-Thr286 of rat CaM Kinase II

Formulation: 100 µl of Affinity-purified rabbit polyclonal antibody

Isotype:

Applications: IHC, WB

Origin:

Stability: 365 days

Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cell Biology|Cell Signaling||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory

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