Chemicals
Showing 13651–13800 of 41137 results
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CAY10727 is an inhibitor of protein arginine deiminase 3 (PAD3; kinact/KI = 15,600 M-1min-1).{48907} It is selective for PAD3 over PAD1, -2, and -4 (kinact/KIs = 360, 1,110, and 1,460 M-1min-1, respectively).
Brand:CaymanSKU:26543 - 100 µgAvailable on backorder
CAY10727 is an inhibitor of protein arginine deiminase 3 (PAD3; kinact/KI = 15,600 M-1min-1).{48907} It is selective for PAD3 over PAD1, -2, and -4 (kinact/KIs = 360, 1,110, and 1,460 M-1min-1, respectively).
Brand:CaymanSKU:26543 - 250 µgAvailable on backorder
CAY10727 is an inhibitor of protein arginine deiminase 3 (PAD3; kinact/KI = 15,600 M-1min-1).{48907} It is selective for PAD3 over PAD1, -2, and -4 (kinact/KIs = 360, 1,110, and 1,460 M-1min-1, respectively).
Brand:CaymanSKU:26543 - 500 µgAvailable on backorder
CAY10730 is a turn-on fluorescent probe for the detection of nitroreductase activity, a marker of hypoxia.{48243} In the presence of nitroreductase, CAY10730 is transformed into a highly fluorescent molecule that displays excitation/emission maxima of 454/520 nm, respectively. It is selective for nitroreductase over a variety of bioanalytes, including glutathione, ascorbic acid, and reactive oxygen species such as H2O2. CAY10730 (1 µM) has been used to detect hypoxia in A549 human lung carcinoma cells.
Brand:CaymanSKU:26547 - 10 mgAvailable on backorder
CAY10730 is a turn-on fluorescent probe for the detection of nitroreductase activity, a marker of hypoxia.{48243} In the presence of nitroreductase, CAY10730 is transformed into a highly fluorescent molecule that displays excitation/emission maxima of 454/520 nm, respectively. It is selective for nitroreductase over a variety of bioanalytes, including glutathione, ascorbic acid, and reactive oxygen species such as H2O2. CAY10730 (1 µM) has been used to detect hypoxia in A549 human lung carcinoma cells.
Brand:CaymanSKU:26547 - 25 mgAvailable on backorder
CAY10730 is a turn-on fluorescent probe for the detection of nitroreductase activity, a marker of hypoxia.{48243} In the presence of nitroreductase, CAY10730 is transformed into a highly fluorescent molecule that displays excitation/emission maxima of 454/520 nm, respectively. It is selective for nitroreductase over a variety of bioanalytes, including glutathione, ascorbic acid, and reactive oxygen species such as H2O2. CAY10730 (1 µM) has been used to detect hypoxia in A549 human lung carcinoma cells.
Brand:CaymanSKU:26547 - 5 mgAvailable on backorder
CAY10730 is a turn-on fluorescent probe for the detection of nitroreductase activity, a marker of hypoxia.{48243} In the presence of nitroreductase, CAY10730 is transformed into a highly fluorescent molecule that displays excitation/emission maxima of 454/520 nm, respectively. It is selective for nitroreductase over a variety of bioanalytes, including glutathione, ascorbic acid, and reactive oxygen species such as H2O2. CAY10730 (1 µM) has been used to detect hypoxia in A549 human lung carcinoma cells.
Brand:CaymanSKU:26547 - 50 mgAvailable on backorder
CAY10731 is a fluorescent probe for hydrogen sulfide (H2S).{48317} Upon reaction with H2S, fluorescein (FITC) is released and its fluorescence can be used to detect H2S. FITC displays excitation/emission maxima of 485/535 nm, respectively. CAY10731 is selective for H2S over glutathione (GSH), cysteine, H2O3-, SO3-, and H2O2 as well as tBuO and OH radicals. It has been used to detect H2S in rat hippocampal slices and nematodes.
Brand:CaymanSKU:26548 - 1 mgAvailable on backorder
CAY10731 is a fluorescent probe for hydrogen sulfide (H2S).{48317} Upon reaction with H2S, fluorescein (FITC) is released and its fluorescence can be used to detect H2S. FITC displays excitation/emission maxima of 485/535 nm, respectively. CAY10731 is selective for H2S over glutathione (GSH), cysteine, H2O3-, SO3-, and H2O2 as well as tBuO and OH radicals. It has been used to detect H2S in rat hippocampal slices and nematodes.
Brand:CaymanSKU:26548 - 10 mgAvailable on backorder
CAY10731 is a fluorescent probe for hydrogen sulfide (H2S).{48317} Upon reaction with H2S, fluorescein (FITC) is released and its fluorescence can be used to detect H2S. FITC displays excitation/emission maxima of 485/535 nm, respectively. CAY10731 is selective for H2S over glutathione (GSH), cysteine, H2O3-, SO3-, and H2O2 as well as tBuO and OH radicals. It has been used to detect H2S in rat hippocampal slices and nematodes.
Brand:CaymanSKU:26548 - 25 mgAvailable on backorder
CAY10731 is a fluorescent probe for hydrogen sulfide (H2S).{48317} Upon reaction with H2S, fluorescein (FITC) is released and its fluorescence can be used to detect H2S. FITC displays excitation/emission maxima of 485/535 nm, respectively. CAY10731 is selective for H2S over glutathione (GSH), cysteine, H2O3-, SO3-, and H2O2 as well as tBuO and OH radicals. It has been used to detect H2S in rat hippocampal slices and nematodes.
Brand:CaymanSKU:26548 - 5 mgAvailable on backorder
CAY10732 is a fluorescent probe for the detection of carbon monoxide.{49090} In the presence of palladium (Pd) and carbon monoxide, CAY10732 undergoes the Pd0-mediated Tsuji-Trost reaction to release 2,7-dichlorofluorescein, and its fluorescence can be used to detect carbon monoxide production in vitro and in live cells. 2,7-Dichlorofluorescein displays excitation/emission maxima of 493/527 nm, respectively.
Brand:CaymanSKU:26750 - 1 mgAvailable on backorder
CAY10732 is a fluorescent probe for the detection of carbon monoxide.{49090} In the presence of palladium (Pd) and carbon monoxide, CAY10732 undergoes the Pd0-mediated Tsuji-Trost reaction to release 2,7-dichlorofluorescein, and its fluorescence can be used to detect carbon monoxide production in vitro and in live cells. 2,7-Dichlorofluorescein displays excitation/emission maxima of 493/527 nm, respectively.
Brand:CaymanSKU:26750 - 10 mgAvailable on backorder
CAY10732 is a fluorescent probe for the detection of carbon monoxide.{49090} In the presence of palladium (Pd) and carbon monoxide, CAY10732 undergoes the Pd0-mediated Tsuji-Trost reaction to release 2,7-dichlorofluorescein, and its fluorescence can be used to detect carbon monoxide production in vitro and in live cells. 2,7-Dichlorofluorescein displays excitation/emission maxima of 493/527 nm, respectively.
Brand:CaymanSKU:26750 - 5 mgAvailable on backorder
CAY10732 is a fluorescent probe for the detection of carbon monoxide.{49090} In the presence of palladium (Pd) and carbon monoxide, CAY10732 undergoes the Pd0-mediated Tsuji-Trost reaction to release 2,7-dichlorofluorescein, and its fluorescence can be used to detect carbon monoxide production in vitro and in live cells. 2,7-Dichlorofluorescein displays excitation/emission maxima of 493/527 nm, respectively.
Brand:CaymanSKU:26750 - 50 mgAvailable on backorder
CAY10733 is a fluorescent probe for the detection of carbon monoxide.{49090} In the presence of palladium (Pd) and carbon monoxide, CAY10733 undergoes the Pd0-mediated Tsuji-Trost reaction to release 2,7-dichlorofluorescein, and its fluorescence can be used to detect carbon monoxide production in vitro and in live cells. 2,7-Dichlorofluorescein displays excitation/emission maxima of 493/527 nm, respectively.
Brand:CaymanSKU:26751 - 1 mgAvailable on backorder
CAY10733 is a fluorescent probe for the detection of carbon monoxide.{49090} In the presence of palladium (Pd) and carbon monoxide, CAY10733 undergoes the Pd0-mediated Tsuji-Trost reaction to release 2,7-dichlorofluorescein, and its fluorescence can be used to detect carbon monoxide production in vitro and in live cells. 2,7-Dichlorofluorescein displays excitation/emission maxima of 493/527 nm, respectively.
Brand:CaymanSKU:26751 - 10 mgAvailable on backorder
CAY10733 is a fluorescent probe for the detection of carbon monoxide.{49090} In the presence of palladium (Pd) and carbon monoxide, CAY10733 undergoes the Pd0-mediated Tsuji-Trost reaction to release 2,7-dichlorofluorescein, and its fluorescence can be used to detect carbon monoxide production in vitro and in live cells. 2,7-Dichlorofluorescein displays excitation/emission maxima of 493/527 nm, respectively.
Brand:CaymanSKU:26751 - 5 mgAvailable on backorder
CAY10733 is a fluorescent probe for the detection of carbon monoxide.{49090} In the presence of palladium (Pd) and carbon monoxide, CAY10733 undergoes the Pd0-mediated Tsuji-Trost reaction to release 2,7-dichlorofluorescein, and its fluorescence can be used to detect carbon monoxide production in vitro and in live cells. 2,7-Dichlorofluorescein displays excitation/emission maxima of 493/527 nm, respectively.
Brand:CaymanSKU:26751 - 50 mgAvailable on backorder
CAY10734 is an agonist of sphingosine-1-phosphate receptor 1 (S1P1; IC50 = 0.6 nM).{13377} It selectively binds S1P1 over S1P2, S1P3, and S1P4 receptors (IC50s = >10,000, 12,000, and 70 nM, respectively) but does also bind S1P5 receptors (IC50 = 1 nM) in radioligand binding assays. CAY10734 reduces the number of peripheral blood lymphocytes in mice, rats, and dogs, with the maximal response achieved when administered at doses of 10, 0.5, and 0.5 mg/kg, respectively. It increases graft survival in a rat skin allograft model when administered at a dose of 5 mg/kg per day in combination with cyclosporin A (CsA; Item No. 12088).
Brand:CaymanSKU:10007833 - 1 mgAvailable on backorder
CAY10734 is an agonist of sphingosine-1-phosphate receptor 1 (S1P1; IC50 = 0.6 nM).{13377} It selectively binds S1P1 over S1P2, S1P3, and S1P4 receptors (IC50s = >10,000, 12,000, and 70 nM, respectively) but does also bind S1P5 receptors (IC50 = 1 nM) in radioligand binding assays. CAY10734 reduces the number of peripheral blood lymphocytes in mice, rats, and dogs, with the maximal response achieved when administered at doses of 10, 0.5, and 0.5 mg/kg, respectively. It increases graft survival in a rat skin allograft model when administered at a dose of 5 mg/kg per day in combination with cyclosporin A (CsA; Item No. 12088).
Brand:CaymanSKU:10007833 - 10 mgAvailable on backorder
CAY10734 is an agonist of sphingosine-1-phosphate receptor 1 (S1P1; IC50 = 0.6 nM).{13377} It selectively binds S1P1 over S1P2, S1P3, and S1P4 receptors (IC50s = >10,000, 12,000, and 70 nM, respectively) but does also bind S1P5 receptors (IC50 = 1 nM) in radioligand binding assays. CAY10734 reduces the number of peripheral blood lymphocytes in mice, rats, and dogs, with the maximal response achieved when administered at doses of 10, 0.5, and 0.5 mg/kg, respectively. It increases graft survival in a rat skin allograft model when administered at a dose of 5 mg/kg per day in combination with cyclosporin A (CsA; Item No. 12088).
Brand:CaymanSKU:10007833 - 25 mgAvailable on backorder
CAY10734 is an agonist of sphingosine-1-phosphate receptor 1 (S1P1; IC50 = 0.6 nM).{13377} It selectively binds S1P1 over S1P2, S1P3, and S1P4 receptors (IC50s = >10,000, 12,000, and 70 nM, respectively) but does also bind S1P5 receptors (IC50 = 1 nM) in radioligand binding assays. CAY10734 reduces the number of peripheral blood lymphocytes in mice, rats, and dogs, with the maximal response achieved when administered at doses of 10, 0.5, and 0.5 mg/kg, respectively. It increases graft survival in a rat skin allograft model when administered at a dose of 5 mg/kg per day in combination with cyclosporin A (CsA; Item No. 12088).
Brand:CaymanSKU:10007833 - 5 mgAvailable on backorder
CAY10735 is an anticancer compound.{48452} It inhibits proliferation in a panel of melanoma and breast, pancreatic, and lung cancer cell lines (IC50s = 0.674-11.56 μM). CAY10735 inhibits migration of and the epithelial-to-mesenchymal transition (EMT) in A375 and B16/F10 melanoma cells in vitro in a concentration-dependent manner. It reduces the viability of spheroid A375 and B16/F10 cells (IC50s = 3.04 and 1.24 μM, respectively) and increases production of reactive oxygen species (ROS) in these cells in a concentration-dependent manner. CAY10735 (5 mg/kg) reduces tumor growth in B16/F10 melanoma and Lewis lung carcinoma mouse models and an A375 mouse xenograft model.
Brand:CaymanSKU:26753 - 1 mgAvailable on backorder
CAY10735 is an anticancer compound.{48452} It inhibits proliferation in a panel of melanoma and breast, pancreatic, and lung cancer cell lines (IC50s = 0.674-11.56 μM). CAY10735 inhibits migration of and the epithelial-to-mesenchymal transition (EMT) in A375 and B16/F10 melanoma cells in vitro in a concentration-dependent manner. It reduces the viability of spheroid A375 and B16/F10 cells (IC50s = 3.04 and 1.24 μM, respectively) and increases production of reactive oxygen species (ROS) in these cells in a concentration-dependent manner. CAY10735 (5 mg/kg) reduces tumor growth in B16/F10 melanoma and Lewis lung carcinoma mouse models and an A375 mouse xenograft model.
Brand:CaymanSKU:26753 - 10 mgAvailable on backorder
CAY10735 is an anticancer compound.{48452} It inhibits proliferation in a panel of melanoma and breast, pancreatic, and lung cancer cell lines (IC50s = 0.674-11.56 μM). CAY10735 inhibits migration of and the epithelial-to-mesenchymal transition (EMT) in A375 and B16/F10 melanoma cells in vitro in a concentration-dependent manner. It reduces the viability of spheroid A375 and B16/F10 cells (IC50s = 3.04 and 1.24 μM, respectively) and increases production of reactive oxygen species (ROS) in these cells in a concentration-dependent manner. CAY10735 (5 mg/kg) reduces tumor growth in B16/F10 melanoma and Lewis lung carcinoma mouse models and an A375 mouse xenograft model.
Brand:CaymanSKU:26753 - 5 mgAvailable on backorder
CAY10736 is an anticancer compound.{48452} It inhibits proliferation in a panel of melanoma and breast, pancreatic, and lung cancer cell lines (IC50s = 0.827-9.89 μM). CAY10736 inhibits migration and epithelial-to-mesenchymal transition (EMT) of A375 and B16/F10 melanoma cells in vitro in a concentration-dependent manner. It reduces the viability of spheroid A375 and B16/F10 cells (IC50s = 2.4 and 1.59 μM, respectively) and increases the production of reactive oxygen species (ROS) in these cells in a concentration-dependent manner. CAY10736 (5 mg/kg) reduces tumor growth in B16/F10 melanoma and Lewis lung carcinoma mouse models and an A375 mouse xenograft model.
Brand:CaymanSKU:26754 - 1 mgAvailable on backorder
CAY10736 is an anticancer compound.{48452} It inhibits proliferation in a panel of melanoma and breast, pancreatic, and lung cancer cell lines (IC50s = 0.827-9.89 μM). CAY10736 inhibits migration and epithelial-to-mesenchymal transition (EMT) of A375 and B16/F10 melanoma cells in vitro in a concentration-dependent manner. It reduces the viability of spheroid A375 and B16/F10 cells (IC50s = 2.4 and 1.59 μM, respectively) and increases the production of reactive oxygen species (ROS) in these cells in a concentration-dependent manner. CAY10736 (5 mg/kg) reduces tumor growth in B16/F10 melanoma and Lewis lung carcinoma mouse models and an A375 mouse xenograft model.
Brand:CaymanSKU:26754 - 500 µgAvailable on backorder
CAY10737 is a turn-on fluorescent probe for the detection of carbon monoxide (CO).{51116} It is selective for CO over a variety of anions, amino acids, amines, biothiols, and reactive species. In the presence of palladium (Pd) and CO, CAY10737 undergoes the Pd0-mediated Tsuji-Trost reaction to release a fluorescent compound that has absorption and emission maxima of 678/714 nm, respectively. This fluorescence can be used to detect CO production in vitro and in vivo. CAY10737 has low cytotoxicity, decreasing viability of HeLa cells by less than 25% when used at a concentration of 50 µM with PdCl2 for 24 hours.
Brand:CaymanSKU:27026 - 1 mgAvailable on backorder
CAY10737 is a turn-on fluorescent probe for the detection of carbon monoxide (CO).{51116} It is selective for CO over a variety of anions, amino acids, amines, biothiols, and reactive species. In the presence of palladium (Pd) and CO, CAY10737 undergoes the Pd0-mediated Tsuji-Trost reaction to release a fluorescent compound that has absorption and emission maxima of 678/714 nm, respectively. This fluorescence can be used to detect CO production in vitro and in vivo. CAY10737 has low cytotoxicity, decreasing viability of HeLa cells by less than 25% when used at a concentration of 50 µM with PdCl2 for 24 hours.
Brand:CaymanSKU:27026 - 500 µgAvailable on backorder
CAY10739 is a soft-drug agonist of the sphingosine-1-phosphate receptor 1 (S1P1; IC50 = 25.12 nM in a β-arrestin recruitment assay) that was designed to prevent systemic effects following topical application.{35828} It is selective for S1P1 over S1P2, S1P3, and S1P4 (IC50s = 1,000, >10,000, >10,000 nM, respectively, in a β-arrestin recruitment assay). In human S9 skin subcellular fractions, an ester group that protects an unstable phenol group is cleaved to release the active soft drug. The active soft drug and its nonenzymatically formed isomers are rapidly metabolized in isolated human hepatocytes.
Brand:CaymanSKU:27837 - 10 mgAvailable on backorder
CAY10739 is a soft-drug agonist of the sphingosine-1-phosphate receptor 1 (S1P1; IC50 = 25.12 nM in a β-arrestin recruitment assay) that was designed to prevent systemic effects following topical application.{35828} It is selective for S1P1 over S1P2, S1P3, and S1P4 (IC50s = 1,000, >10,000, >10,000 nM, respectively, in a β-arrestin recruitment assay). In human S9 skin subcellular fractions, an ester group that protects an unstable phenol group is cleaved to release the active soft drug. The active soft drug and its nonenzymatically formed isomers are rapidly metabolized in isolated human hepatocytes.
Brand:CaymanSKU:27837 - 25 mgAvailable on backorder
CAY10739 is a soft-drug agonist of the sphingosine-1-phosphate receptor 1 (S1P1; IC50 = 25.12 nM in a β-arrestin recruitment assay) that was designed to prevent systemic effects following topical application.{35828} It is selective for S1P1 over S1P2, S1P3, and S1P4 (IC50s = 1,000, >10,000, >10,000 nM, respectively, in a β-arrestin recruitment assay). In human S9 skin subcellular fractions, an ester group that protects an unstable phenol group is cleaved to release the active soft drug. The active soft drug and its nonenzymatically formed isomers are rapidly metabolized in isolated human hepatocytes.
Brand:CaymanSKU:27837 - 5 mgAvailable on backorder
CAY10739 is a soft-drug agonist of the sphingosine-1-phosphate receptor 1 (S1P1; IC50 = 25.12 nM in a β-arrestin recruitment assay) that was designed to prevent systemic effects following topical application.{35828} It is selective for S1P1 over S1P2, S1P3, and S1P4 (IC50s = 1,000, >10,000, >10,000 nM, respectively, in a β-arrestin recruitment assay). In human S9 skin subcellular fractions, an ester group that protects an unstable phenol group is cleaved to release the active soft drug. The active soft drug and its nonenzymatically formed isomers are rapidly metabolized in isolated human hepatocytes.
Brand:CaymanSKU:27837 - 50 mgAvailable on backorder
CAY10742 is an orally bioavailable oxadiazole antibiotic.{50791} It is active against the Gram-positive bacteria S. aureus, S. epidermidis, S. haemolyticus, B. cereus, B. licheniformis, E. faecalis, and E. faecium (MICs = 1-4 μg/ml), including laboratory strains and clinical isolates with varying degrees of resistance to methicillin, vancomycin, linezolid, and other antibiotics. CAY10742 (40 mg/kg) reduces the number of bacteria in mouse neutropenic thigh models of linezolid-sensitive or -resistant methicillin-resistant S. aureus (MRSA) infection.
Brand:CaymanSKU:29800 - 1 mgAvailable on backorder
CAY10742 is an orally bioavailable oxadiazole antibiotic.{50791} It is active against the Gram-positive bacteria S. aureus, S. epidermidis, S. haemolyticus, B. cereus, B. licheniformis, E. faecalis, and E. faecium (MICs = 1-4 μg/ml), including laboratory strains and clinical isolates with varying degrees of resistance to methicillin, vancomycin, linezolid, and other antibiotics. CAY10742 (40 mg/kg) reduces the number of bacteria in mouse neutropenic thigh models of linezolid-sensitive or -resistant methicillin-resistant S. aureus (MRSA) infection.
Brand:CaymanSKU:29800 - 10 mgAvailable on backorder
CAY10742 is an orally bioavailable oxadiazole antibiotic.{50791} It is active against the Gram-positive bacteria S. aureus, S. epidermidis, S. haemolyticus, B. cereus, B. licheniformis, E. faecalis, and E. faecium (MICs = 1-4 μg/ml), including laboratory strains and clinical isolates with varying degrees of resistance to methicillin, vancomycin, linezolid, and other antibiotics. CAY10742 (40 mg/kg) reduces the number of bacteria in mouse neutropenic thigh models of linezolid-sensitive or -resistant methicillin-resistant S. aureus (MRSA) infection.
Brand:CaymanSKU:29800 - 25 mgAvailable on backorder
CAY10742 is an orally bioavailable oxadiazole antibiotic.{50791} It is active against the Gram-positive bacteria S. aureus, S. epidermidis, S. haemolyticus, B. cereus, B. licheniformis, E. faecalis, and E. faecium (MICs = 1-4 μg/ml), including laboratory strains and clinical isolates with varying degrees of resistance to methicillin, vancomycin, linezolid, and other antibiotics. CAY10742 (40 mg/kg) reduces the number of bacteria in mouse neutropenic thigh models of linezolid-sensitive or -resistant methicillin-resistant S. aureus (MRSA) infection.
Brand:CaymanSKU:29800 - 5 mgAvailable on backorder
CAY10744 is a topoisomerase II-α poison.{50794} It inhibits topoisomerase II-α by 78.9% when used at a concentration of 20 µM. CAY10744 is selective for topoisomerase II-α over topoisomerase I providing 100 and 0% inhibition, respectively, at 100 µM. It inhibits proliferation of HCT15 colon, T47D breast, DU145 prostate, and HeLa cervical cancer cells (IC50s = 0.014, 0.00267, 0.072, and 2.46 µM, respectively). CAY10744 induces apoptosis in T47D cells when used at concentrations of 10 and 30 µM. CAY10744 (12 mg/kg per day) reduces tumor growth in an MDA-MB-231 orthotopic mouse model of breast cancer.
Brand:CaymanSKU:29802 - 1 mgAvailable on backorder
CAY10744 is a topoisomerase II-α poison.{50794} It inhibits topoisomerase II-α by 78.9% when used at a concentration of 20 µM. CAY10744 is selective for topoisomerase II-α over topoisomerase I providing 100 and 0% inhibition, respectively, at 100 µM. It inhibits proliferation of HCT15 colon, T47D breast, DU145 prostate, and HeLa cervical cancer cells (IC50s = 0.014, 0.00267, 0.072, and 2.46 µM, respectively). CAY10744 induces apoptosis in T47D cells when used at concentrations of 10 and 30 µM. CAY10744 (12 mg/kg per day) reduces tumor growth in an MDA-MB-231 orthotopic mouse model of breast cancer.
Brand:CaymanSKU:29802 - 10 mgAvailable on backorder
CAY10744 is a topoisomerase II-α poison.{50794} It inhibits topoisomerase II-α by 78.9% when used at a concentration of 20 µM. CAY10744 is selective for topoisomerase II-α over topoisomerase I providing 100 and 0% inhibition, respectively, at 100 µM. It inhibits proliferation of HCT15 colon, T47D breast, DU145 prostate, and HeLa cervical cancer cells (IC50s = 0.014, 0.00267, 0.072, and 2.46 µM, respectively). CAY10744 induces apoptosis in T47D cells when used at concentrations of 10 and 30 µM. CAY10744 (12 mg/kg per day) reduces tumor growth in an MDA-MB-231 orthotopic mouse model of breast cancer.
Brand:CaymanSKU:29802 - 5 mgAvailable on backorder
CAY10746 is an inhibitor of Rho-associated kinase I (ROCK-I) and ROCK-II (IC50s = 14 and 3 nM, respectively).{50804} It is selective for ROCK-I and ROCK-II over PKA (IC50 = >10,000 nM) and over 387 recombinant human protein kinases in a panel of 394 kinases (IC50s = >10,000 nM for all) but does inhibit LIM kinase 2 (LIMK2), Aurora A, Aurora B, cGMP-dependent protein kinase 1α (PKG1α), and PKG1β (IC50s = 46, 1,072, 1,239, 517, and 660 nM, respectively). CAY10746 (0.1-10 µM) inhibits phosphorylation of the ROCK target protein MYPT1 in SH-SY5Y cells. It also inhibits migration of human umbilical vein endothelial cells (HUVECs) when used at a concentration of 1 µM. CAY10746 (1 µM) protects isolated mouse retinal neurons from apoptosis and oxidative stress induced by high glucose in an in vitro model of diabetic retinopathy. It also promotes high glucose-induced vessel regression in mouse retinal explants.
Brand:CaymanSKU:29814 - 1 mgAvailable on backorder
CAY10746 is an inhibitor of Rho-associated kinase I (ROCK-I) and ROCK-II (IC50s = 14 and 3 nM, respectively).{50804} It is selective for ROCK-I and ROCK-II over PKA (IC50 = >10,000 nM) and over 387 recombinant human protein kinases in a panel of 394 kinases (IC50s = >10,000 nM for all) but does inhibit LIM kinase 2 (LIMK2), Aurora A, Aurora B, cGMP-dependent protein kinase 1α (PKG1α), and PKG1β (IC50s = 46, 1,072, 1,239, 517, and 660 nM, respectively). CAY10746 (0.1-10 µM) inhibits phosphorylation of the ROCK target protein MYPT1 in SH-SY5Y cells. It also inhibits migration of human umbilical vein endothelial cells (HUVECs) when used at a concentration of 1 µM. CAY10746 (1 µM) protects isolated mouse retinal neurons from apoptosis and oxidative stress induced by high glucose in an in vitro model of diabetic retinopathy. It also promotes high glucose-induced vessel regression in mouse retinal explants.
Brand:CaymanSKU:29814 - 10 mgAvailable on backorder
CAY10746 is an inhibitor of Rho-associated kinase I (ROCK-I) and ROCK-II (IC50s = 14 and 3 nM, respectively).{50804} It is selective for ROCK-I and ROCK-II over PKA (IC50 = >10,000 nM) and over 387 recombinant human protein kinases in a panel of 394 kinases (IC50s = >10,000 nM for all) but does inhibit LIM kinase 2 (LIMK2), Aurora A, Aurora B, cGMP-dependent protein kinase 1α (PKG1α), and PKG1β (IC50s = 46, 1,072, 1,239, 517, and 660 nM, respectively). CAY10746 (0.1-10 µM) inhibits phosphorylation of the ROCK target protein MYPT1 in SH-SY5Y cells. It also inhibits migration of human umbilical vein endothelial cells (HUVECs) when used at a concentration of 1 µM. CAY10746 (1 µM) protects isolated mouse retinal neurons from apoptosis and oxidative stress induced by high glucose in an in vitro model of diabetic retinopathy. It also promotes high glucose-induced vessel regression in mouse retinal explants.
Brand:CaymanSKU:29814 - 5 mgAvailable on backorder
CAY10748 is an agonist of stimulator of interferon genes (STING; IC50 = 0.3794 µM in a competition binding assay).{50883} It activates STING in STING-expressing, but not STING knockout, THP-1 cells (EC50s = 0.287 and >100 µM, respectively, in a reporter assay). It induces phosphorylation of STING at the serine in position 366, as well as phosphorylation of TBK1 and IFN regulatory factor 3 (IRF3), indicating activation of the STING-TBK1-IRF3 signaling pathway. CAY10748 increases the secretion of IFN-β and the levels of chemokine (C-X-C motif) ligand 10 (CXCL10), and IL-6 in peripheral blood mononuclear cells (PBMCs) when used at a concentration of 10 µM. It also reduces tumor growth in a CT26 murine colon cancer model when administered at a dose of 0.15, but not 1.5, mg/kg.
Brand:CaymanSKU:30022 - 1 mgAvailable on backorder
CAY10748 is an agonist of stimulator of interferon genes (STING; IC50 = 0.3794 µM in a competition binding assay).{50883} It activates STING in STING-expressing, but not STING knockout, THP-1 cells (EC50s = 0.287 and >100 µM, respectively, in a reporter assay). It induces phosphorylation of STING at the serine in position 366, as well as phosphorylation of TBK1 and IFN regulatory factor 3 (IRF3), indicating activation of the STING-TBK1-IRF3 signaling pathway. CAY10748 increases the secretion of IFN-β and the levels of chemokine (C-X-C motif) ligand 10 (CXCL10), and IL-6 in peripheral blood mononuclear cells (PBMCs) when used at a concentration of 10 µM. It also reduces tumor growth in a CT26 murine colon cancer model when administered at a dose of 0.15, but not 1.5, mg/kg.
Brand:CaymanSKU:30022 - 10 mgAvailable on backorder
CAY10748 is an agonist of stimulator of interferon genes (STING; IC50 = 0.3794 µM in a competition binding assay).{50883} It activates STING in STING-expressing, but not STING knockout, THP-1 cells (EC50s = 0.287 and >100 µM, respectively, in a reporter assay). It induces phosphorylation of STING at the serine in position 366, as well as phosphorylation of TBK1 and IFN regulatory factor 3 (IRF3), indicating activation of the STING-TBK1-IRF3 signaling pathway. CAY10748 increases the secretion of IFN-β and the levels of chemokine (C-X-C motif) ligand 10 (CXCL10), and IL-6 in peripheral blood mononuclear cells (PBMCs) when used at a concentration of 10 µM. It also reduces tumor growth in a CT26 murine colon cancer model when administered at a dose of 0.15, but not 1.5, mg/kg.
Brand:CaymanSKU:30022 - 5 mgAvailable on backorder
CAY10748 is an agonist of stimulator of interferon genes (STING; IC50 = 0.3794 µM in a competition binding assay).{50883} It activates STING in STING-expressing, but not STING knockout, THP-1 cells (EC50s = 0.287 and >100 µM, respectively, in a reporter assay). It induces phosphorylation of STING at the serine in position 366, as well as phosphorylation of TBK1 and IFN regulatory factor 3 (IRF3), indicating activation of the STING-TBK1-IRF3 signaling pathway. CAY10748 increases the secretion of IFN-β and the levels of chemokine (C-X-C motif) ligand 10 (CXCL10), and IL-6 in peripheral blood mononuclear cells (PBMCs) when used at a concentration of 10 µM. It also reduces tumor growth in a CT26 murine colon cancer model when administered at a dose of 0.15, but not 1.5, mg/kg.
Brand:CaymanSKU:30022 - 500 µgAvailable on backorder
CAY10749 is a dual inhibitor of poly(ADP-ribose) polymerase (PARP) and PI3K (IC50s = 6.03, 3.63, 5.62, and 7.41 nM for PARP1, PARP2, PI3Kα, and PI3Kδ, respectively).{50888} It is selective for these enzymes over PI3Kβ and PI3Kγ (IC50s = 288.4 and 831.76 nM, respectively), as well as a panel of 374 additional kinases at 1 µM. CAY10749 (1 µM) induces dsDNA break formation in a neutral comet assay and apoptosis in MDA-MB-468 breast cancer cells. It inhibits proliferation of eight cancer cell lines, including pancreatic, ovarian, lymphoma, leukemia, and lung cancer cells, with IC50 values ranging from 398.11 to 2,818.38 nM. CAY10749 (50 mg/kg twice per day) reduces tumor growth by 73.4% in an MDA-MB-468 mouse xenograft model.
Brand:CaymanSKU:30058 - 1 mgAvailable on backorder
CAY10749 is a dual inhibitor of poly(ADP-ribose) polymerase (PARP) and PI3K (IC50s = 6.03, 3.63, 5.62, and 7.41 nM for PARP1, PARP2, PI3Kα, and PI3Kδ, respectively).{50888} It is selective for these enzymes over PI3Kβ and PI3Kγ (IC50s = 288.4 and 831.76 nM, respectively), as well as a panel of 374 additional kinases at 1 µM. CAY10749 (1 µM) induces dsDNA break formation in a neutral comet assay and apoptosis in MDA-MB-468 breast cancer cells. It inhibits proliferation of eight cancer cell lines, including pancreatic, ovarian, lymphoma, leukemia, and lung cancer cells, with IC50 values ranging from 398.11 to 2,818.38 nM. CAY10749 (50 mg/kg twice per day) reduces tumor growth by 73.4% in an MDA-MB-468 mouse xenograft model.
Brand:CaymanSKU:30058 - 10 mgAvailable on backorder
CAY10749 is a dual inhibitor of poly(ADP-ribose) polymerase (PARP) and PI3K (IC50s = 6.03, 3.63, 5.62, and 7.41 nM for PARP1, PARP2, PI3Kα, and PI3Kδ, respectively).{50888} It is selective for these enzymes over PI3Kβ and PI3Kγ (IC50s = 288.4 and 831.76 nM, respectively), as well as a panel of 374 additional kinases at 1 µM. CAY10749 (1 µM) induces dsDNA break formation in a neutral comet assay and apoptosis in MDA-MB-468 breast cancer cells. It inhibits proliferation of eight cancer cell lines, including pancreatic, ovarian, lymphoma, leukemia, and lung cancer cells, with IC50 values ranging from 398.11 to 2,818.38 nM. CAY10749 (50 mg/kg twice per day) reduces tumor growth by 73.4% in an MDA-MB-468 mouse xenograft model.
Brand:CaymanSKU:30058 - 5 mgAvailable on backorder
CAY10755 is a fungal metabolite that has been found in P. macrospinosa and has anticancer activity.{52412} It is cytotoxic to A549, H116, PSN-1, and T98G cancer cells (IC50s = 4.6, 4, 2.2, and 7.7 μM, respectively).
Brand:CaymanSKU:28464 - 1 mgAvailable on backorder
CAY10756 is a brain-penetrant inhibitor of apoptosis signal-regulating kinase 1 (ASK1; IC50 = 21 nM).{55331} It inhibits autophosphorylation of ASK1 in HEK293T cells (IC50 = 138 nM).
Brand:CaymanSKU:30382 - 1 mgAvailable on backorder
CAY10756 is a brain-penetrant inhibitor of apoptosis signal-regulating kinase 1 (ASK1; IC50 = 21 nM).{55331} It inhibits autophosphorylation of ASK1 in HEK293T cells (IC50 = 138 nM).
Brand:CaymanSKU:30382 - 5 mgAvailable on backorder
CAY10756 is a brain-penetrant inhibitor of apoptosis signal-regulating kinase 1 (ASK1; IC50 = 21 nM).{55331} It inhibits autophosphorylation of ASK1 in HEK293T cells (IC50 = 138 nM).
Brand:CaymanSKU:30382 - 500 µgAvailable on backorder
CAY10760 is an inhibitor of the protein-protein interaction between RAD51 recombinase and BRCA2 (EC50 = 19 µM in a cell-free competitive ELISA).{46810} It decreases homologous recombination by 54% in wild-type BRCA2-expressing BxPC-3 pancreatic cancer cells when used at a concentration of 20 µM. CAY10760 (20 µM) decreases proliferation of BxPC-3, as well as mutant BRCA2-expressing Capan-1, cancer cells when used alone or in combination with the poly(ADP-ribose) polymerase (PARP) inhibitor olaparib (Item No. 10621).
Brand:CaymanSKU:30532 - 10 mgAvailable on backorder
CAY10760 is an inhibitor of the protein-protein interaction between RAD51 recombinase and BRCA2 (EC50 = 19 µM in a cell-free competitive ELISA).{46810} It decreases homologous recombination by 54% in wild-type BRCA2-expressing BxPC-3 pancreatic cancer cells when used at a concentration of 20 µM. CAY10760 (20 µM) decreases proliferation of BxPC-3, as well as mutant BRCA2-expressing Capan-1, cancer cells when used alone or in combination with the poly(ADP-ribose) polymerase (PARP) inhibitor olaparib (Item No. 10621).
Brand:CaymanSKU:30532 - 25 mgAvailable on backorder
CAY10760 is an inhibitor of the protein-protein interaction between RAD51 recombinase and BRCA2 (EC50 = 19 µM in a cell-free competitive ELISA).{46810} It decreases homologous recombination by 54% in wild-type BRCA2-expressing BxPC-3 pancreatic cancer cells when used at a concentration of 20 µM. CAY10760 (20 µM) decreases proliferation of BxPC-3, as well as mutant BRCA2-expressing Capan-1, cancer cells when used alone or in combination with the poly(ADP-ribose) polymerase (PARP) inhibitor olaparib (Item No. 10621).
Brand:CaymanSKU:30532 - 5 mgAvailable on backorder
CAY10760 is an inhibitor of the protein-protein interaction between RAD51 recombinase and BRCA2 (EC50 = 19 µM in a cell-free competitive ELISA).{46810} It decreases homologous recombination by 54% in wild-type BRCA2-expressing BxPC-3 pancreatic cancer cells when used at a concentration of 20 µM. CAY10760 (20 µM) decreases proliferation of BxPC-3, as well as mutant BRCA2-expressing Capan-1, cancer cells when used alone or in combination with the poly(ADP-ribose) polymerase (PARP) inhibitor olaparib (Item No. 10621).
Brand:CaymanSKU:30532 - 50 mgAvailable on backorder
CAY10761 is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1; IC50s = 467 and 429 μM for the human and snake venom enzymes, respectively).{48884,50816} It also inhibits mushroom tyrosinase (Ki = 1.9 μM) and urease from jack bean, P. mirabilis, and B. pasteurii (IC50s = 0.093, <0.125, and 0.089 mM, respectively, at pH 8.2).{48885,48886}
Brand:CaymanSKU:29865 - 1 mgAvailable on backorder
CAY10761 is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1; IC50s = 467 and 429 μM for the human and snake venom enzymes, respectively).{48884,50816} It also inhibits mushroom tyrosinase (Ki = 1.9 μM) and urease from jack bean, P. mirabilis, and B. pasteurii (IC50s = 0.093, <0.125, and 0.089 mM, respectively, at pH 8.2).{48885,48886}
Brand:CaymanSKU:29865 - 10 mgAvailable on backorder
CAY10761 is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1; IC50s = 467 and 429 μM for the human and snake venom enzymes, respectively).{48884,50816} It also inhibits mushroom tyrosinase (Ki = 1.9 μM) and urease from jack bean, P. mirabilis, and B. pasteurii (IC50s = 0.093, <0.125, and 0.089 mM, respectively, at pH 8.2).{48885,48886}
Brand:CaymanSKU:29865 - 25 mgAvailable on backorder
CAY10761 is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1; IC50s = 467 and 429 μM for the human and snake venom enzymes, respectively).{48884,50816} It also inhibits mushroom tyrosinase (Ki = 1.9 μM) and urease from jack bean, P. mirabilis, and B. pasteurii (IC50s = 0.093, <0.125, and 0.089 mM, respectively, at pH 8.2).{48885,48886}
Brand:CaymanSKU:29865 - 5 mgAvailable on backorder
CAY10762 is an inhibitor of monoacylglycerol lipase (MAGL; IC50 = 34.1 nM).{46960} It reduces hydrogen peroxide-induced lactate dehydrogenase (LDH) release from Neuro2a cells when used at a concentration of 1 µM. CAY10762 (10 mg/kg) increases levels of 2-arachidonoyl glycerol (2-AG; Item No. 62160) in mouse brain.
Brand:CaymanSKU:30576 - 1 mgAvailable on backorder
CAY10762 is an inhibitor of monoacylglycerol lipase (MAGL; IC50 = 34.1 nM).{46960} It reduces hydrogen peroxide-induced lactate dehydrogenase (LDH) release from Neuro2a cells when used at a concentration of 1 µM. CAY10762 (10 mg/kg) increases levels of 2-arachidonoyl glycerol (2-AG; Item No. 62160) in mouse brain.
Brand:CaymanSKU:30576 - 10 mgAvailable on backorder
CAY10762 is an inhibitor of monoacylglycerol lipase (MAGL; IC50 = 34.1 nM).{46960} It reduces hydrogen peroxide-induced lactate dehydrogenase (LDH) release from Neuro2a cells when used at a concentration of 1 µM. CAY10762 (10 mg/kg) increases levels of 2-arachidonoyl glycerol (2-AG; Item No. 62160) in mouse brain.
Brand:CaymanSKU:30576 - 5 mgAvailable on backorder
CAY10763 is a dual inhibitor of indolamine 2,3-dioxygenase 1 (IDO1; IC50 = 46 nM) and STAT3 activation.{59050} It binds to STAT3 (Kd = 530 nM) and selectively reduces the levels of STAT3 phosphorylated at the tyrosine in position 705 (STAT3Y705) over phosphorylated STAT3S727, STAT1, and STAT5 in SKOV3 cells when used at a concentration of 500 nM. It also inhibits STAT3 nuclear translocation in SKOV3 cells. CAY10763 is cytotoxic to HCT116, SKOV3, A549, and HepG2 cancer cells (IC50s = 37, 28, 33, and 12 nM, respectively). It reduces tumor growth in B16/F10 mouse melanoma and HepG2 mouse xenograft models when administered at doses of 100 and 10 mg/kg, respectively.
Brand:CaymanSKU:30593 - 1 mgAvailable on backorder
CAY10763 is a dual inhibitor of indolamine 2,3-dioxygenase 1 (IDO1; IC50 = 46 nM) and STAT3 activation.{59050} It binds to STAT3 (Kd = 530 nM) and selectively reduces the levels of STAT3 phosphorylated at the tyrosine in position 705 (STAT3Y705) over phosphorylated STAT3S727, STAT1, and STAT5 in SKOV3 cells when used at a concentration of 500 nM. It also inhibits STAT3 nuclear translocation in SKOV3 cells. CAY10763 is cytotoxic to HCT116, SKOV3, A549, and HepG2 cancer cells (IC50s = 37, 28, 33, and 12 nM, respectively). It reduces tumor growth in B16/F10 mouse melanoma and HepG2 mouse xenograft models when administered at doses of 100 and 10 mg/kg, respectively.
Brand:CaymanSKU:30593 - 5 mgAvailable on backorder
CAY10763 is a dual inhibitor of indolamine 2,3-dioxygenase 1 (IDO1; IC50 = 46 nM) and STAT3 activation.{59050} It binds to STAT3 (Kd = 530 nM) and selectively reduces the levels of STAT3 phosphorylated at the tyrosine in position 705 (STAT3Y705) over phosphorylated STAT3S727, STAT1, and STAT5 in SKOV3 cells when used at a concentration of 500 nM. It also inhibits STAT3 nuclear translocation in SKOV3 cells. CAY10763 is cytotoxic to HCT116, SKOV3, A549, and HepG2 cancer cells (IC50s = 37, 28, 33, and 12 nM, respectively). It reduces tumor growth in B16/F10 mouse melanoma and HepG2 mouse xenograft models when administered at doses of 100 and 10 mg/kg, respectively.
Brand:CaymanSKU:30593 - 500 µgAvailable on backorder
CAY10767 is an agonist of peroxisome proliferator-activated receptor α (PPARα; EC50 = 37 nM in a reporter assay).{52631} It is greater than 2,700-fold selective for PPARα over PPARγ or PPARδ.
Brand:CaymanSKU:30605 - 1 mgAvailable on backorder
CAY10767 is an agonist of peroxisome proliferator-activated receptor α (PPARα; EC50 = 37 nM in a reporter assay).{52631} It is greater than 2,700-fold selective for PPARα over PPARγ or PPARδ.
Brand:CaymanSKU:30605 - 5 mgAvailable on backorder
CAY10767 is an agonist of peroxisome proliferator-activated receptor α (PPARα; EC50 = 37 nM in a reporter assay).{52631} It is greater than 2,700-fold selective for PPARα over PPARγ or PPARδ.
Brand:CaymanSKU:30605 - 500 µgAvailable on backorder
CAY10770 is an inhibitor of the cytochrome P450 (CYP) isoform CYP4Z1 (IC50 = 5.9 µM).{57196} It is selective for CYP4Z1 over CYP4A11, CYP4F2, CYP4F3a, CYP4F3b (IC50s = 187-282 µM) but does inhibit CYP4F8 and CYP4F12 (IC50s = 167 and 91 µM, respectively). CAY10770 (3 µM) inhibits the production of 14(15)-EET, 19-HETE, and 14(15)-DiHET by 83, 86, and 80%, respectively, in T47D breast cancer cells expressing CYP4Z1.
Brand:CaymanSKU:31216 - 1 mgAvailable on backorder
CAY10770 is an inhibitor of the cytochrome P450 (CYP) isoform CYP4Z1 (IC50 = 5.9 µM).{57196} It is selective for CYP4Z1 over CYP4A11, CYP4F2, CYP4F3a, CYP4F3b (IC50s = 187-282 µM) but does inhibit CYP4F8 and CYP4F12 (IC50s = 167 and 91 µM, respectively). CAY10770 (3 µM) inhibits the production of 14(15)-EET, 19-HETE, and 14(15)-DiHET by 83, 86, and 80%, respectively, in T47D breast cancer cells expressing CYP4Z1.
Brand:CaymanSKU:31216 - 250 µgAvailable on backorder
CAY10770 is an inhibitor of the cytochrome P450 (CYP) isoform CYP4Z1 (IC50 = 5.9 µM).{57196} It is selective for CYP4Z1 over CYP4A11, CYP4F2, CYP4F3a, CYP4F3b (IC50s = 187-282 µM) but does inhibit CYP4F8 and CYP4F12 (IC50s = 167 and 91 µM, respectively). CAY10770 (3 µM) inhibits the production of 14(15)-EET, 19-HETE, and 14(15)-DiHET by 83, 86, and 80%, respectively, in T47D breast cancer cells expressing CYP4Z1.
Brand:CaymanSKU:31216 - 500 µgAvailable on backorder
CAY10773 is a derivative of the ferroptosis inducer sorafenib (Item No. 10009644).{54492} It selectively inhibits proliferation of BEL-7402, MGC803, and T24 bladder cancer cells (IC50s = 5.77, 5.21 and 3.97 µM, respectively) over non-cancerous HCV-29 cells (IC50 = 23.19 µM). CAY10773 induces apoptosis in T24 cells when used at concentrations ranging from 2 to 6 µM but induces ferroptosis at concentrations greater than or equal to 6 µM with 10 hour or longer incubation times. It increases the production of reactive oxygen species (ROS) and decreases the mitochondrial membrane potential in T24 cells. CAY10773 (≥6 µM) also induces autophagy with incubation times longer than eight hours.
Brand:CaymanSKU:31806 - 1 mgAvailable on backorder
CAY10773 is a derivative of the ferroptosis inducer sorafenib (Item No. 10009644).{54492} It selectively inhibits proliferation of BEL-7402, MGC803, and T24 bladder cancer cells (IC50s = 5.77, 5.21 and 3.97 µM, respectively) over non-cancerous HCV-29 cells (IC50 = 23.19 µM). CAY10773 induces apoptosis in T24 cells when used at concentrations ranging from 2 to 6 µM but induces ferroptosis at concentrations greater than or equal to 6 µM with 10 hour or longer incubation times. It increases the production of reactive oxygen species (ROS) and decreases the mitochondrial membrane potential in T24 cells. CAY10773 (≥6 µM) also induces autophagy with incubation times longer than eight hours.
Brand:CaymanSKU:31806 - 10 mgAvailable on backorder
CAY10773 is a derivative of the ferroptosis inducer sorafenib (Item No. 10009644).{54492} It selectively inhibits proliferation of BEL-7402, MGC803, and T24 bladder cancer cells (IC50s = 5.77, 5.21 and 3.97 µM, respectively) over non-cancerous HCV-29 cells (IC50 = 23.19 µM). CAY10773 induces apoptosis in T24 cells when used at concentrations ranging from 2 to 6 µM but induces ferroptosis at concentrations greater than or equal to 6 µM with 10 hour or longer incubation times. It increases the production of reactive oxygen species (ROS) and decreases the mitochondrial membrane potential in T24 cells. CAY10773 (≥6 µM) also induces autophagy with incubation times longer than eight hours.
Brand:CaymanSKU:31806 - 5 mgAvailable on backorder
CAY10777 is an antiproliferative agent.{60154} It inhibits the proliferation of HepG2 cells in vitro (IC50 = 0.78 µM).
Brand:CaymanSKU:32712 - 1 mgAvailable on backorder
CAY10777 is an antiproliferative agent.{60154} It inhibits the proliferation of HepG2 cells in vitro (IC50 = 0.78 µM).
Brand:CaymanSKU:32712 - 10 mgAvailable on backorder
CAY10777 is an antiproliferative agent.{60154} It inhibits the proliferation of HepG2 cells in vitro (IC50 = 0.78 µM).
Brand:CaymanSKU:32712 - 5 mgAvailable on backorder