Chemicals
Showing 12601–12750 of 41137 results
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C16 dihydro Ceramide is a bioactive sphingolipid and precursor in the de novo synthesis of C16 ceramide (d18:0/16:0) (Item No. 10681) that lacks the 4,5-trans double bond.{41404} C16 dihydro Ceramide (0-46 nM) inhibits C16 ceramide-induced membrane permeabilization, measured as cytochrome C oxidation, in rat liver mitochondria in a concentration-dependent manner. It also inhibits C16 ceramide-induced channel formation in liposomes. C16 dihydro ceramide is biologically inactive as a single agent, lacking the ability to induce apoptosis, cytochrome C release, or channel formation in phospholipid membranes in the absence of C16 ceramide. [Matreya, LLC. Catalog No. 2078]
Brand:CaymanSKU:24369 - 1 mgAvailable on backorder
C16 dihydro Ceramide is a bioactive sphingolipid and precursor in the de novo synthesis of C16 ceramide (d18:0/16:0) (Item No. 10681) that lacks the 4,5-trans double bond.{41404} C16 dihydro Ceramide (0-46 nM) inhibits C16 ceramide-induced membrane permeabilization, measured as cytochrome C oxidation, in rat liver mitochondria in a concentration-dependent manner. It also inhibits C16 ceramide-induced channel formation in liposomes. C16 dihydro ceramide is biologically inactive as a single agent, lacking the ability to induce apoptosis, cytochrome C release, or channel formation in phospholipid membranes in the absence of C16 ceramide. [Matreya, LLC. Catalog No. 2078]
Brand:CaymanSKU:24369 - 10 mgAvailable on backorder
C16 dihydro Ceramide is a bioactive sphingolipid and precursor in the de novo synthesis of C16 ceramide (d18:0/16:0) (Item No. 10681) that lacks the 4,5-trans double bond.{41404} C16 dihydro Ceramide (0-46 nM) inhibits C16 ceramide-induced membrane permeabilization, measured as cytochrome C oxidation, in rat liver mitochondria in a concentration-dependent manner. It also inhibits C16 ceramide-induced channel formation in liposomes. C16 dihydro ceramide is biologically inactive as a single agent, lacking the ability to induce apoptosis, cytochrome C release, or channel formation in phospholipid membranes in the absence of C16 ceramide. [Matreya, LLC. Catalog No. 2078]
Brand:CaymanSKU:24369 - 5 mgAvailable on backorder
C16 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from C16 lactosylceramide (Item No. 24352).{38975} C16 globotriaosylceramide acts as a receptor for Shiga toxin in B cell-derived Raji cells and THP-1 monocytes.{39721} It accumulates in endothelial cells, pericytes, vascular smooth muscle cells, renal epithelial cells, dorsal ganglia neuronal cells, and myocardial cells in patients with Fabry disease.{38977} C16 globotriaosylceramide is also upregulated in plasma of patients with ovarian carcinoma compared to those with benign ovarian tumors or uterine fibroids.{39712} [Matreya, LLC. Catalog No. 1528]
Brand:CaymanSKU:24875 - 500 µgAvailable on backorder
C16 Lactosylceramide is an endogenous bioactive sphingolipid.{41044} It forms membrane microdomains with Lyn kinase and the αi subunits of inhibitory G protein-coupled receptors (GPCRs), suggesting a role in cell signaling. Plasma levels of C16 lactosylceramide are elevated in insulin-resistant cattle.{38685} C16 Lactosylceramide is also upregulated in a mouse model of Niemann-Pick type C1 disease, a neurodegenerative cholesterol-sphingolipid lysosomal storage disorder.{40751} [Matreya, LLC. Catalog No. 1532]
Brand:CaymanSKU:24352 - 1 mgAvailable on backorder
C16 Lactosylceramide is an endogenous bioactive sphingolipid.{41044} It forms membrane microdomains with Lyn kinase and the αi subunits of inhibitory G protein-coupled receptors (GPCRs), suggesting a role in cell signaling. Plasma levels of C16 lactosylceramide are elevated in insulin-resistant cattle.{38685} C16 Lactosylceramide is also upregulated in a mouse model of Niemann-Pick type C1 disease, a neurodegenerative cholesterol-sphingolipid lysosomal storage disorder.{40751} [Matreya, LLC. Catalog No. 1532]
Brand:CaymanSKU:24352 - 5 mgAvailable on backorder
C16 Lactosylceramide is an endogenous bioactive sphingolipid.{41044} It forms membrane microdomains with Lyn kinase and the αi subunits of inhibitory G protein-coupled receptors (GPCRs), suggesting a role in cell signaling. Plasma levels of C16 lactosylceramide are elevated in insulin-resistant cattle.{38685} C16 Lactosylceramide is also upregulated in a mouse model of Niemann-Pick type C1 disease, a neurodegenerative cholesterol-sphingolipid lysosomal storage disorder.{40751} [Matreya, LLC. Catalog No. 1532]
Brand:CaymanSKU:24352 - 500 µgAvailable on backorder
C16 Phytoceramide (t18:0/16:0) is a phytoceramide, which is a family of sphingolipids found in the intestine, kidney, and extracellular spaces of the stratum corneum of the mammalian epidermis.{39255, 39257,39256} C16 Phytoceramide (t18:0/16:0) is composed of a phytosphingosine (Item No. 20217) backbone amine-linked to a C16 fatty acid chain. The levels of C16 phytoceramide (t18:0/16:0) increase following heat stress in S. cerevisiae.{39241} It has been used with other ceramides to create stratum corneum substitutes to study percutaneous penetration and psoriasis in vitro.{39242,39254} [Matreya, LLC. Catalog No. 2035]
Brand:CaymanSKU:22826 -Out of stock
C16 Sphingomyelin is a naturally occurring sphingolipid.{37418,40751,37417} Levels of C16 sphingomyelin are elevated in the prefrontal cortex and cerebellum in a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104), as well as in the liver in mouse models of Niemann-Pick type C1 disease.{37418,40751} Plasma levels of C16 sphingomyelin are decreased in patients with prostate cancer.{37417} Model membranes containing C16 sphingomyelin, 1-palmitoyl-2-oleoyl-sn-glycero-3-PC (POPC; Item No. 15102), and cholesterol (Item No. 9003100) have been used in the study of lipid raft dynamics and membrane organization.{48564,48565}
Brand:CaymanSKU:10007946 - 1 mgAvailable on backorder
C16 Sphingomyelin is a naturally occurring sphingolipid.{37418,40751,37417} Levels of C16 sphingomyelin are elevated in the prefrontal cortex and cerebellum in a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104), as well as in the liver in mouse models of Niemann-Pick type C1 disease.{37418,40751} Plasma levels of C16 sphingomyelin are decreased in patients with prostate cancer.{37417} Model membranes containing C16 sphingomyelin, 1-palmitoyl-2-oleoyl-sn-glycero-3-PC (POPC; Item No. 15102), and cholesterol (Item No. 9003100) have been used in the study of lipid raft dynamics and membrane organization.{48564,48565}
Brand:CaymanSKU:10007946 - 10 mgAvailable on backorder
C16 Sphingomyelin is a naturally occurring sphingolipid.{37418,40751,37417} Levels of C16 sphingomyelin are elevated in the prefrontal cortex and cerebellum in a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104), as well as in the liver in mouse models of Niemann-Pick type C1 disease.{37418,40751} Plasma levels of C16 sphingomyelin are decreased in patients with prostate cancer.{37417} Model membranes containing C16 sphingomyelin, 1-palmitoyl-2-oleoyl-sn-glycero-3-PC (POPC; Item No. 15102), and cholesterol (Item No. 9003100) have been used in the study of lipid raft dynamics and membrane organization.{48564,48565}
Brand:CaymanSKU:10007946 - 5 mgAvailable on backorder
C16 Sphingomyelin is a naturally occurring sphingolipid.{37418,40751,37417} Levels of C16 sphingomyelin are elevated in the prefrontal cortex and cerebellum in a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104), as well as in the liver in mouse models of Niemann-Pick type C1 disease.{37418,40751} Plasma levels of C16 sphingomyelin are decreased in patients with prostate cancer.{37417} Model membranes containing C16 sphingomyelin, 1-palmitoyl-2-oleoyl-sn-glycero-3-PC (POPC; Item No. 15102), and cholesterol (Item No. 9003100) have been used in the study of lipid raft dynamics and membrane organization.{48564,48565} C16 Sphingomyelin (d18:1/16:0) MaxSpec® standard is a quantitative grade standard of C16 sphingomyelin (d18:1/16:0) (Item No. 10007946) that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This C16 sphingomyelin (d18:1/16:0) MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.
Brand:CaymanSKU:30357 - 100 µgAvailable on backorder
C16 Sphingomyelin-13C (d18:1/16:0-13C) is intended for use as an internal standard for the quantification of C16sphingomyelin (Item No. 10007946) by GC- or LC-MS. C16 Sphingomyelin is a naturally occurring sphingolipid.{37418,40751,37417} Levels of C16 sphingomyelin are elevated in the prefrontal cortex and cerebellum in a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104), as well as in the liver in mouse models of Niemann-Pick type C1 disease.{37418,40751} Plasma levels of C16 sphingomyelin are decreased in patients with prostate cancer.{37417} Model membranes containing C16 sphingomyelin, 1-palmitoyl-2-oleoyl-sn-glycero-3-PC (POPC; Item No. 15102), and cholesterol (Item No. 9003100) have been used in the study of lipid raft dynamics and membrane organization.{48564,48565}
Brand:CaymanSKU:24452 - 1 mgAvailable on backorder
C16((±)-2′-hydroxy) dihydro Ceramide (d18:0/16:0) is a 2′-hydroxylated form of C16 dihydro ceramide (Item No. 24369). [Matreya, LLC. Catalog No. 2047]
Brand:CaymanSKU:24436 - 5 mgAvailable on backorder
C17 3′-sulfo Galactosylceramide is a synthetic sulfated glycolipid, which are also known as sulfatides (Item No. 24323). C17 3′-sulfo Galactosylceramide has been used as an internal standard for the quantification of sulfatides in urine and blood samples from patients with metachromatic leukodystrophy, a disorder characterized by arylsulfatase A deficiency, leading to sulfatide accumulation.{38645,41048} [Matreya, LLC. Catalog No. 1934]
Brand:CaymanSKU:24348 - 1 mgAvailable on backorder
C17 Ceramide is a synthetic ceramide that contains a non-natural C17:0 fatty acid acylated to sphingosine.{41048} It has been used as a marker of arylsulfatase A and sphingolipid activator B activity in patients undergoing enzyme replacement therapy for the genetic disease metachromatic leukodystrophy. [Matreya, LLC. Catalog No. 2038]
Brand:CaymanSKU:22532 -Out of stock
C17 Ceramide is a synthetic ceramide that contains a non-natural C17:0 fatty acid acylated to sphingosine.{41048} It has been used as a marker of arylsulfatase A and sphingolipid activator B activity in patients undergoing enzyme replacement therapy for the genetic disease metachromatic leukodystrophy. [Matreya, LLC. Catalog No. 2038]
Brand:CaymanSKU:22532 -Out of stock
C17 dihydro Ceramide is a synthetic ceramide that contains a non-natural C17:0 fatty acid acylated to sphingosine.{37367,37370} Conversion of C17 dihydro ceramide to C17 ceramide (Item No. 22532) has been used to study dihydroceramide desaturase activity and ceramide metabolism in cells. [Matreya, LLC. Catalog No. 2083]
Brand:CaymanSKU:24427 - 5 mgAvailable on backorder
C17 Globotriaosylceramide is a sphingolipid that has been used as an internal standard for the quantification of globotriaosylceramides (Item Nos. 24870 | 24871 | 24872) in plasma and urine from patients with Fabry disease by GC-MS.{43015} [Matreya, LLC. Catalog No. 1523]
Brand:CaymanSKU:24876 - 500 µgAvailable on backorder
C17 Lactosylceramide is a naturally occurring sphingolipid that has been found in human brain metastases of lung adenocarcinomas but not in healthy brain tissue.{39504} [Matreya, LLC. Catalog No. 1538]
Brand:CaymanSKU:24356 - 1 mgAvailable on backorder
C17 Sphingomyelin is a synthetic derivative of sphingomyelin (Item Nos. 22674 | 24345) that has been used as an internal standard for the quantification of sphingomyelin.{43294,43295}
Brand:CaymanSKU:25592 - 10 mgAvailable on backorder
C17 Sphingomyelin is a synthetic derivative of sphingomyelin (Item Nos. 22674 | 24345) that has been used as an internal standard for the quantification of sphingomyelin.{43294,43295}
Brand:CaymanSKU:25592 - 25 mgAvailable on backorder
C17 Sphingomyelin is a synthetic derivative of sphingomyelin (Item Nos. 22674 | 24345) that has been used as an internal standard for the quantification of sphingomyelin.{43294,43295}
Brand:CaymanSKU:25592 - 5 mgAvailable on backorder
C18 ((±)-2′-hydroxy) Ceramide (d18:1/18:0) (18:0 (2R/S-OH)-Ceramide) is a bioactive sphingolipid found in the stratum corneum layer of mammalian epidermis.{34750} 18:0 (2R/S-OH)-Ceramide plays an important role in maintaining normal hydration levels for physiological function of the epidermis. [Matreya, LLC. Catalog No. 2044]
Brand:CaymanSKU:22687 -Out of stock
C18 ((±)-2′-hydroxy) dihydro Ceramide (d18:0/18:0) is a 2′-hydroxylated form of C18 dihydro ceramide (Item No. 24379). [Matreya, LLC. Catalog No. 2045]
Brand:CaymanSKU:24437 - 5 mgAvailable on backorder
C18 3′-sulfo Galactosylceramide is a member of the sulfatide class of glycolipids. Levels of short-chain sulfatides, including C18 3’-sulfo galactosylceramide, decrease with age in mice and humans.{43012,40648} It is increased in brain from mice with an arylsulfatase A deficiency (ASA-KO), particularly in lipid raft fractions.{43012,36639} Plasma levels of C18 3’-sulfo galactosylceramide positively correlate with disability progression in patients with relapsing-remitting multiple sclerosis using the Expanded Disability Status Scale.{36640} It is also increased in plasma from patients with metachromatic leukodystrophy (MLD).{40650} [Matreya, LLC. Catalog No. 1932]
Brand:CaymanSKU:24863 - 1 mgAvailable on backorder
C18 3′-sulfo Lactosylceramide (d18:1/18:0) is a sulfated glycosphingolipid. [Matreya, LLC. Catalog No. 1540]
Brand:CaymanSKU:27201 - 1 mgAvailable on backorder
C18 Ceramide is an endogenous bioactive sphingolipid. It is the primary short-chain ceramide found in brain tissue whose synthesis is regulated by longevity-assurance homologue 1 (Lass1) in mice.{40029} Increased expression of C18 ceramide reduces cell growth in UM-SCC-22A squamous cell carcinoma cells.{13918} It is selectively downregulated in 32 human head and neck squamous cell carcinoma tumor tissues as compared to non-squamous tumor tissues. C18 Ceramide concentration is significantly higher in muscle tissue of type 2 diabetic patients compared with non-diabetic patients and is positively correlated to body mass index and inversely related to insulin sensitivity.{40030}
Brand:CaymanSKU:-Available on backorder
C18 Ceramide is an endogenous bioactive sphingolipid. It is the primary short-chain ceramide found in brain tissue whose synthesis is regulated by longevity-assurance homologue 1 (Lass1) in mice.{40029} Increased expression of C18 ceramide reduces cell growth in UM-SCC-22A squamous cell carcinoma cells.{13918} It is selectively downregulated in 32 human head and neck squamous cell carcinoma tumor tissues as compared to non-squamous tumor tissues. C18 Ceramide concentration is significantly higher in muscle tissue of type 2 diabetic patients compared with non-diabetic patients and is positively correlated to body mass index and inversely related to insulin sensitivity.{40030}
Brand:CaymanSKU:-Available on backorder
C18 Ceramide is an endogenous bioactive sphingolipid. It is the primary short-chain ceramide found in brain tissue whose synthesis is regulated by longevity-assurance homologue 1 (Lass1) in mice.{40029} Increased expression of C18 ceramide reduces cell growth in UM-SCC-22A squamous cell carcinoma cells.{13918} It is selectively downregulated in 32 human head and neck squamous cell carcinoma tumor tissues as compared to non-squamous tumor tissues. C18 Ceramide concentration is significantly higher in muscle tissue of type 2 diabetic patients compared with non-diabetic patients and is positively correlated to body mass index and inversely related to insulin sensitivity.{40030}
Brand:CaymanSKU:-Available on backorder
C18 Ceramide is an endogenous bioactive sphingolipid. It is the primary short-chain ceramide found in brain tissue whose synthesis is regulated by longevity-assurance homologue 1 (Lass1) in mice.{40029} Increased expression of C18 ceramide reduces cell growth in UM-SCC-22A squamous cell carcinoma cells.{13918} It is selectively downregulated in 32 human head and neck squamous cell carcinoma tumor tissues as compared to non-squamous tumor tissues. C18 Ceramide concentration is significantly higher in muscle tissue of type 2 diabetic patients compared with non-diabetic patients and is positively correlated to body mass index and inversely related to insulin sensitivity.{40030}
Brand:CaymanSKU:-Available on backorder
C18 Ceramide-d3 (d18:1/18:0) is intended for use as an internal standard for the quantification of C18 Ceramide (d18:1/18:0) (Item No. 19556) by GC- or LC-MS. C18 Ceramide is an endogenous bioactive sphingolipid. It is the primary short-chain ceramide found in brain tissue whose synthesis is regulated by longevity-assurance homologue 1 (Lass1) in mice.{40029} Increased expression of C18 ceramide reduces cell growth in UM-SCC-22A squamous cell carcinoma cells.{13918} It is selectively downregulated in 32 human head and neck squamous cell carcinoma tumor tissues as compared to non-squamous tumor tissues. C18 Ceramide concentration is significantly higher in muscle tissue of type 2 diabetic patients compared with non-diabetic patients and is positively correlated to body mass index and inversely related to insulin sensitivity.{40030} [Matreya, LLC. Catalog No. 2201]
Brand:CaymanSKU:24396 - 1 mgAvailable on backorder
C18 Ceramide-d7 is intended for use as an internal standard for the quantification of C18 ceramide (Item No. 19556) by GC- or LC-MS. C18 Ceramide is an endogenous bioactive sphingolipid. It is the primary short-chain ceramide found in brain tissue whose synthesis is regulated by longevity-assurance homologue 1 (Lass1) in mice.{40029} Increased expression of C18 ceramide reduces cell growth in UM-SCC-22A squamous cell carcinoma cells.{13918} It is selectively down-regulated in 32 human head and neck squamous cell carcinoma tumor tissues as compared to non-squamous tumor tissues. C18 Ceramide concentration is significantly higher in muscle tissue of type 2 diabetic patients compared with non-diabetic patients and is positively correlated to body mass index and inversely related to insulin sensitivity.{40030}
Brand:CaymanSKU:22788 -Out of stock
C18 Ceramide-d7 is intended for use as an internal standard for the quantification of C18 ceramide (Item No. 19556) by GC- or LC-MS. C18 Ceramide is an endogenous bioactive sphingolipid. It is the primary short-chain ceramide found in brain tissue whose synthesis is regulated by longevity-assurance homologue 1 (Lass1) in mice.{40029} Increased expression of C18 ceramide reduces cell growth in UM-SCC-22A squamous cell carcinoma cells.{13918} It is selectively down-regulated in 32 human head and neck squamous cell carcinoma tumor tissues as compared to non-squamous tumor tissues. C18 Ceramide concentration is significantly higher in muscle tissue of type 2 diabetic patients compared with non-diabetic patients and is positively correlated to body mass index and inversely related to insulin sensitivity.{40030}
Brand:CaymanSKU:22788 -Out of stock
C18 dihydro Ceramide is a bioactive sphingolipid and precursor in the de novo synthesis of C18 ceramide (Item No. 19556) that lacks the 4,5-trans double bond.{40697} Increased C18 dihydroceramide lipid levels lead to increased triacylglycerol storage and autophagosome accumulation as well as upregulation of the fibrosis markers α-SMA and FGF2 in Chang and LX-2 liver cells. C18 dihydro Ceramide is elevated in the plasma of pre-diabetics up to 9 years prior to the onset of type 2 diabetes.{40698} It is also elevated in the skin of patients with lesional atopic dermatitis.{40696}
Brand:CaymanSKU:24379 - 10 mgAvailable on backorder
C18 dihydro Ceramide is a bioactive sphingolipid and precursor in the de novo synthesis of C18 ceramide (Item No. 19556) that lacks the 4,5-trans double bond.{40697} Increased C18 dihydroceramide lipid levels lead to increased triacylglycerol storage and autophagosome accumulation as well as upregulation of the fibrosis markers α-SMA and FGF2 in Chang and LX-2 liver cells. C18 dihydro Ceramide is elevated in the plasma of pre-diabetics up to 9 years prior to the onset of type 2 diabetes.{40698} It is also elevated in the skin of patients with lesional atopic dermatitis.{40696}
Brand:CaymanSKU:24379 - 25 mgAvailable on backorder
C18 dihydro Ceramide is a bioactive sphingolipid and precursor in the de novo synthesis of C18 ceramide (Item No. 19556) that lacks the 4,5-trans double bond.{40697} Increased C18 dihydroceramide lipid levels lead to increased triacylglycerol storage and autophagosome accumulation as well as upregulation of the fibrosis markers α-SMA and FGF2 in Chang and LX-2 liver cells. C18 dihydro Ceramide is elevated in the plasma of pre-diabetics up to 9 years prior to the onset of type 2 diabetes.{40698} It is also elevated in the skin of patients with lesional atopic dermatitis.{40696}
Brand:CaymanSKU:24379 - 5 mgAvailable on backorder
C18 Galactosylceramide-d35 is intended for use as an internal standard for the quantification of C18 galactosylceramide by GC- or LC-MS. C18 Galactosylceramide is a naturally occurring sphingolipid that has been found in the cerebellum of rats and humans.{36597,36598} It is selectively localized with cholesterol over potassium, sodium, or phosphocholine in rat cerebellum white matter.{36597} [Matreya, LLC. Catalog No. 1914]
Brand:CaymanSKU:24467 - 5 mgAvailable on backorder
C18 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from lactosylceramide (Item No. 16983).{38975} It inhibits aggregation of human neutrophils induced by phorbol 12-myristate 13-acetate (PMA; 10008014) when used at a concentration of 1 μM.{38972} C18 globotriaosylceramide acts as a receptor for Shiga toxin in B cell-derived Raji cells and THP-1 monocytes.{39721} It accumulates in the brain, heart, kidney, liver, lung, and spleen in a mouse model of Fabry disease, a lysosomal storage disorder characterized by a deficiency in the enzyme α-galactosidase A.{41495} C18 globotriaosylceramide also accumulates in endothelial cells, pericytes, vascular smooth muscle cells, renal epithelial cells, dorsal ganglia neuronal cells, and myocardial cells in patients with Fabry disease.{38977} [Matreya, LLC. Catalog No. 1529]
Brand:CaymanSKU:24877 - 500 µgAvailable on backorder
C18 L-erythro Ceramide is a naturally occurring ceramide and stereoisomer of C18 ceramide (Item No. 19556).{40647} It inhibits rat brain mitochondrial ceramidase (mt-CDase) with an IC50 value of 0.11 mol% (8.8 μM). [Matreya, LLC. Catalog No. 1850]
Brand:CaymanSKU:24398 - 1 mgAvailable on backorder
C18 L-threo Ceramide is a synthetic ceramide and stereoisomer of C18 ceramide (Item No. 19556) that has been used for structural characterization of natural sphingolipids.{40662} It inhibits rat brain mitochondrial ceramidase (mt-CDase) with an IC50 value of 0.21 mol% (16.8 μM).{40647} [Matreya, LLC. Catalog No. 1843]
Brand:CaymanSKU:24399 - 1 mgAvailable on backorder
C18 Phytoceramide (t18:0/18:0) (Cer(t18:0/18:0)) is a bioactive sphingolipid found in S. cerevisiae, wheat grains, and the stratum corneum layer of mammalian epidermis.{35021,35022,35023,35024} Cer(t18:0/18:0) is composed of a phytosphingosine (Item No. 20217) backbone amine-linked to a C18 fatty acid chain. Cer(t18:0/18:0) has a role in regulation of apoptosis, cell differentiation, proliferation of smooth muscle cells, and inhibition of the mitochondrial respiratory chain.{4469,3512,5031} It also inhibits expression of the allergic cytokines IL-4, TNF-α, and transcription factors c-Jun and NF-κB in histone-stimulated murine skin tissue.{35021} Formulations containing cer(t18:0/18:0) have been used used in cosmetics as a skin protectants as they reduce water loss to prevent epidermal dehydration and irritation.{35022,35023} [Matreya, LLC. Catalog No. 2034]
Brand:CaymanSKU:22686 -Out of stock
C18 Phytoceramide-d3 (t18:0/18:0-d3) is intended for use as an internal standard for the quantification of C18 phytoceramide (t18:0/18:0) (Item No. 22686) by GC- or LC-MS. C18 Phytoceramide (t18:0/18:0) (Cer(t18:0/18:0)) is a bioactive sphingolipid found in S. cerevisiae, wheat grains, and the stratum corneum layer of mammalian epidermis.{35021,35022,35023,35024} Cer(t18:0/18:0) is composed of a phytosphingosine (Item No. 20217) backbone amine-linked to a C18 fatty acid chain. Cer(t18:0/18:0) has a role in regulation of apoptosis, cell differentiation, proliferation of smooth muscle cells, and inhibition of the mitochondrial respiratory chain.{4469,3512,5031} It also inhibits expression of the allergic cytokines IL-4, TNF-α, and transcription factors c-Jun and NF-κB in histone-stimulated murine skin tissue.{35021} Formulations containing cer(t18:0/18:0) have been used used in cosmetics as a skin protectants as they reduce water loss to prevent epidermal dehydration and irritation.{35022,35023} [Matreya, LLC. Catalog No. 2210]
Brand:CaymanSKU:27199 - 1 mgAvailable on backorder
C18 Sphingomyelin is a naturally occurring form of sphingomyelin (Item Nos. 22674 | 24345). C18 Sphingomyelin is increased by approximately 35-fold in CCD-112 colon fibroblasts compared with HCT116 human colorectal carcinoma cells.{38689} C18 Sphingomyelin has been used as an internal standard for the quantification of sphingolipid metabolites.{38690} This product is a mixture of the D-erythro and L-threo isomers of C18 sphingomyelin. [Matreya, LLC. Catalog No. 1911]
Brand:CaymanSKU:24355 - 5 mgAvailable on backorder
C18:1 3’-sulfo Galactosylceramide is a member of the sulfatide class of glycolipids. It has been found in mouse brain.{36641} It has been used as a standard for the quantification of C18:1 3’-sulfo galactosylceramide in dried blood spots from patients with metachromatic leukodystrophy (MLD) by UPLC-MS.{36642} [Matreya, LLC. Catalog No. 1933]
Brand:CaymanSKU:24864 - 1 mgAvailable on backorder
C18:1 Ceramide is a naturally occurring ceramide.{38684,38685,38686} Levels of C18:1 ceramide are elevated in overweight and insulin-resistant mice and cattle.{38684,38685} C18:1 Ceramide is also increased in the plasma and ovarian tissue of patients with advanced ovarian cancer.{38686}
Brand:CaymanSKU:24397 - 5 mgAvailable on backorder
C188-9 is a STAT3 inhibitor.{59189,59190} It binds to the phosphotyrosyl peptide binding site in the STAT3 Src homology 2 (SH2) domain (Ki = 136 nM) and inhibits G-CSF-induced activation of STAT3 in patient-derived acute myeloid leukemia (AML) cells (IC50s = 8-18 µM). C188-9 induces apoptosis in patient-derived AML cells (EC50s = 6-50 µM) and reduces viability of HepG2, Huh7, and PLC/PRF/5 hepatoma cells (IC50s = 10.19, 11.27, and 11.83 µM, respectively).{59190,59191} In vivo, C188-9 (100 mg/kg) reduces hepatic Pten deletion-induced hepatic macro- and microsteatosis, which reduces the development of hepatocellular carcinomas in mice. C188-9 (12.5 mg/kg) increases muscle fiber size in a murine Lewis lung carcinoma model of cancer cachexia.{59189}
Brand:CaymanSKU:30928 - 10 mgAvailable on backorder
C188-9 is a STAT3 inhibitor.{59189,59190} It binds to the phosphotyrosyl peptide binding site in the STAT3 Src homology 2 (SH2) domain (Ki = 136 nM) and inhibits G-CSF-induced activation of STAT3 in patient-derived acute myeloid leukemia (AML) cells (IC50s = 8-18 µM). C188-9 induces apoptosis in patient-derived AML cells (EC50s = 6-50 µM) and reduces viability of HepG2, Huh7, and PLC/PRF/5 hepatoma cells (IC50s = 10.19, 11.27, and 11.83 µM, respectively).{59190,59191} In vivo, C188-9 (100 mg/kg) reduces hepatic Pten deletion-induced hepatic macro- and microsteatosis, which reduces the development of hepatocellular carcinomas in mice. C188-9 (12.5 mg/kg) increases muscle fiber size in a murine Lewis lung carcinoma model of cancer cachexia.{59189}
Brand:CaymanSKU:30928 - 25 mgAvailable on backorder
C188-9 is a STAT3 inhibitor.{59189,59190} It binds to the phosphotyrosyl peptide binding site in the STAT3 Src homology 2 (SH2) domain (Ki = 136 nM) and inhibits G-CSF-induced activation of STAT3 in patient-derived acute myeloid leukemia (AML) cells (IC50s = 8-18 µM). C188-9 induces apoptosis in patient-derived AML cells (EC50s = 6-50 µM) and reduces viability of HepG2, Huh7, and PLC/PRF/5 hepatoma cells (IC50s = 10.19, 11.27, and 11.83 µM, respectively).{59190,59191} In vivo, C188-9 (100 mg/kg) reduces hepatic Pten deletion-induced hepatic macro- and microsteatosis, which reduces the development of hepatocellular carcinomas in mice. C188-9 (12.5 mg/kg) increases muscle fiber size in a murine Lewis lung carcinoma model of cancer cachexia.{59189}
Brand:CaymanSKU:30928 - 5 mgAvailable on backorder
C188-9 is a STAT3 inhibitor.{59189,59190} It binds to the phosphotyrosyl peptide binding site in the STAT3 Src homology 2 (SH2) domain (Ki = 136 nM) and inhibits G-CSF-induced activation of STAT3 in patient-derived acute myeloid leukemia (AML) cells (IC50s = 8-18 µM). C188-9 induces apoptosis in patient-derived AML cells (EC50s = 6-50 µM) and reduces viability of HepG2, Huh7, and PLC/PRF/5 hepatoma cells (IC50s = 10.19, 11.27, and 11.83 µM, respectively).{59190,59191} In vivo, C188-9 (100 mg/kg) reduces hepatic Pten deletion-induced hepatic macro- and microsteatosis, which reduces the development of hepatocellular carcinomas in mice. C188-9 (12.5 mg/kg) increases muscle fiber size in a murine Lewis lung carcinoma model of cancer cachexia.{59189}
Brand:CaymanSKU:30928 - 50 mgAvailable on backorder
C19 Ceramide is a naturally occurring ceramide that has been found in J. juncea extracts as well as rat brain and mouse heart.{36541,36539,36540} It is elevated in adult and decreased in juvenile whole rat brain extracts by 114 and 37%, respectively, following chronic ethanol exposure.{36539} C19 Ceramide is also increased in mouse hearts following administration of angiotensin II (Item No. 17150).{36540} [Matreya, LLC. Catalog No. 2039]
Brand:CaymanSKU:24395 - 1 mgAvailable on backorder
C19 Ceramide is a naturally occurring ceramide that has been found in J. juncea extracts as well as rat brain and mouse heart.{36541,36539,36540} It is elevated in adult and decreased in juvenile whole rat brain extracts by 114 and 37%, respectively, following chronic ethanol exposure.{36539} C19 Ceramide is also increased in mouse hearts following administration of angiotensin II (Item No. 17150).{36540} [Matreya, LLC. Catalog No. 2039]
Brand:CaymanSKU:24395 - 10 mgAvailable on backorder
C19 Ceramide is a naturally occurring ceramide that has been found in J. juncea extracts as well as rat brain and mouse heart.{36541,36539,36540} It is elevated in adult and decreased in juvenile whole rat brain extracts by 114 and 37%, respectively, following chronic ethanol exposure.{36539} C19 Ceramide is also increased in mouse hearts following administration of angiotensin II (Item No. 17150).{36540} [Matreya, LLC. Catalog No. 2039]
Brand:CaymanSKU:24395 - 5 mgAvailable on backorder
C2 3’-sulfo Galactosylceramide is a member of the sulfatide class of glycolipids. It has been used as an internal standard in the quantification of lysosulfatides in mouse brain tissue and plasma.{38965} [Matreya, LLC. Catalog No. 2076]
Brand:CaymanSKU:24861 - 1 mgAvailable on backorder
C2 Adamantanyl Galactosylceramide (d18:1/2:0) (AdaGalCer) is a bioactive sphingolipid.{38688} It reduces globotriaosylceramide 3 synthesis from exogenous lactosylceramide in microsomes. AdaGalCer stimulates recombinant glucocerebrosidase activity in a pH-dependent manner. It activates glucocerebrosidase to decrease glucosylceramide accumulation in fibroblasts and lymphoblasts isolated from patients with Gaucher and Fabry disease, respectively. [Matreya, LLC. Catalog No. 1946]
Brand:CaymanSKU:24472 - 5 mgAvailable on backorder
C2 Adamantanyl globotriaosylceramide (AdaGb3) is a bioactive sphingolipid and water-soluble form of globotriaosylceramide (Item Nos. 24870 | 24871 | 24872) that contains an adamantanyl group in place of the fatty acyl chain.{39713} It inhibits Vero toxin binding to globotriaosylceramide in an ELISA assay when used at a concentration of 10 μM. AdaGb3 decreases cell surface expression of P-glycoprotein (P-gp) and reduces efflux of rhodamine 123 (Item No. 16672) in MDCK cells.{39714} It also increases apical-to-basal transport of vinblastine (Item No. 11762) in human intestinal C2BBe1 cells. [Matreya, LLC. Catalog No. 1947]
Brand:CaymanSKU:24879 - 1 mgAvailable on backorder
C2 Ceramide (d14:1/2:0) is a bioactive sphingolipid.{40857} Dietary administration of C2 ceramide (d14:1/2:0) (100 μM) induces lipotoxic cardiomyopathy via increasing diastolic and systolic diameter as well as reducing fractional shortening and the number of normal cardiac contractile events in Drosophila. [Matreya, LLC. Catalog No. 1842]
Brand:CaymanSKU:24425 - 5 mgAvailable on backorder
C2 ceramide is a cell-permeable analog of naturally occurring ceramides. It mediates many diverse biological activities, as do natural ceramides. These processes include differentiation of HL-60 cells,{2751} induction of apoptosis,{884} activation of protein phosphatase 2A,{2757} and inhibition of the mitochondrial respiratory chain.{5031} C2 ceramide also enhances the expression of COX-2 in human dermal fibroblasts{2759} and stimulates the growth of bovine aortic smooth muscle cells.{3512} The ability of C2 ceramide to destabilize membranes may be responsible for its inhibition of platelet aggregation.{6012}
Brand:CaymanSKU:62510 - 1 mgAvailable on backorder
C2 ceramide is a cell-permeable analog of naturally occurring ceramides. It mediates many diverse biological activities, as do natural ceramides. These processes include differentiation of HL-60 cells,{2751} induction of apoptosis,{884} activation of protein phosphatase 2A,{2757} and inhibition of the mitochondrial respiratory chain.{5031} C2 ceramide also enhances the expression of COX-2 in human dermal fibroblasts{2759} and stimulates the growth of bovine aortic smooth muscle cells.{3512} The ability of C2 ceramide to destabilize membranes may be responsible for its inhibition of platelet aggregation.{6012}
Brand:CaymanSKU:62510 - 10 mgAvailable on backorder
C2 ceramide is a cell-permeable analog of naturally occurring ceramides. It mediates many diverse biological activities, as do natural ceramides. These processes include differentiation of HL-60 cells,{2751} induction of apoptosis,{884} activation of protein phosphatase 2A,{2757} and inhibition of the mitochondrial respiratory chain.{5031} C2 ceramide also enhances the expression of COX-2 in human dermal fibroblasts{2759} and stimulates the growth of bovine aortic smooth muscle cells.{3512} The ability of C2 ceramide to destabilize membranes may be responsible for its inhibition of platelet aggregation.{6012}
Brand:CaymanSKU:62510 - 25 mgAvailable on backorder
C2 ceramide is a cell-permeable analog of naturally occurring ceramides. It mediates many diverse biological activities, as do natural ceramides. These processes include differentiation of HL-60 cells,{2751} induction of apoptosis,{884} activation of protein phosphatase 2A,{2757} and inhibition of the mitochondrial respiratory chain.{5031} C2 ceramide also enhances the expression of COX-2 in human dermal fibroblasts{2759} and stimulates the growth of bovine aortic smooth muscle cells.{3512} The ability of C2 ceramide to destabilize membranes may be responsible for its inhibition of platelet aggregation.{6012}
Brand:CaymanSKU:62510 - 5 mgAvailable on backorder
C2 dihydro Ceramide is a metabolically inactive analog of C-2 ceramide (Item No. 62510).{32481,32482} It is used as a negative control in experiments investigating the biological activity of C-2 ceramide. [Matreya, LLC. Catalog No. 1834]
Brand:CaymanSKU:20168 -Available on backorder
C2 dihydro Ceramide is a metabolically inactive analog of C-2 ceramide (Item No. 62510).{32481,32482} It is used as a negative control in experiments investigating the biological activity of C-2 ceramide. [Matreya, LLC. Catalog No. 1834]
Brand:CaymanSKU:20168 -Available on backorder
C2 dihydro Ceramide is a metabolically inactive analog of C-2 ceramide (Item No. 62510).{32481,32482} It is used as a negative control in experiments investigating the biological activity of C-2 ceramide. [Matreya, LLC. Catalog No. 1834]
Brand:CaymanSKU:20168 -Available on backorder
C2 Galactosylceramide is a bioactive sphingolipid.{13011,38647,39566} It inhibits IL-4 production by 23.24% in EL4 T cells when used at a concentration of 10 μM.{13011} C2 Galactosylceramide stimulates NF-κB activity in C6 glioma cells and activates mast cells in a concentration-dependent manner. It is cytotoxic to U937 cells in vitro (IC50 = 33 μM). C2 Galactosylceramide also suppresses the allogeneic mixed leukocyte reaction (MLR) response in murine spleen cells in a concentration-dependent manner.{39566} [Matreya, LLC. Catalog No. 1325]
Brand:CaymanSKU:24465 - 10 mgAvailable on backorder
C2 L-erythro Ceramide is a bioactive sphingolipid and a cell-permeable analog of naturally occurring ceramides.{37337} It stimulates cholesterol efflux in CHO cells expressing the human ABCA1 receptor when used at a concentration of 10 μM, however, this efflux is >50% less than that stimulated by C2 ceramide (Item No. 62510). C2 L-erythro Ceramide also induces cell cycle arrest in the G0G1 phase and a 50-fold increase in sphingosine accumulation as well as inhibits growth of HL-60 leukemia cells.{37336,37339} [Matreya, LLC. Catalog No. 1847]
Brand:CaymanSKU:24387 - 1 mgAvailable on backorder
C2 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides.{37337} It stimulates cholesterol efflux in CHO cells expressing the human ABCA1 receptor when used at a concentration of 10 μM, however, this efflux is 50% less than that stimulated by C2 ceramide (Item No. 62510). C2 L-threo Ceramide inhibits IL-4 production by 17% in EL4 T cells stimulated with phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) when used at a concentration of 10 μM.{13011} It also induces cell cycle arrest in the G0/G1 phase and a 7-fold increase in sphingosine accumulation as well as inhibits growth of HL-60 leukemia cells.{37336,37339} [Matreya, LLC. Catalog No. 1829]
Brand:CaymanSKU:24386 - 1 mgAvailable on backorder
C2 Sphingomyelin is a synthetic cell-permeable derivative of sphingomyelin (Item Nos. 22674 | 24345). It is composed of a sphingomyelin backbone amine-linked to a C2 fatty acid chain. This product is a mixture of the D-erythro and L-threo isomers of C2 sphingomyelin. [Matreya, LLC. Catalog No. 1907]
Brand:CaymanSKU:24353 - 5 mgAvailable on backorder
C2-8 is an inhibitor of polyglutamine (polyQ) aggregation (IC50s = 25 and 0.05 μM for recombinant HDQ51 and in PC12 cells, respectively).{38917} It also inhibits polyQ aggregation in organotypic hippocampal slice cultures isolated from R6/2 transgenic mice and reduces neurodegeneration in a dose-dependent manner in a Drosophila model of Huntington’s disease. C2-8 (100 and 200 mg/kg) reduces huntingtin aggregate size, reduces neuronal atrophy, and improves motor performance in a rotarod test in the R6/2 transgenic mouse model of Huntington’s disease.{38918}
Brand:CaymanSKU:21177 -Out of stock
C2-8 is an inhibitor of polyglutamine (polyQ) aggregation (IC50s = 25 and 0.05 μM for recombinant HDQ51 and in PC12 cells, respectively).{38917} It also inhibits polyQ aggregation in organotypic hippocampal slice cultures isolated from R6/2 transgenic mice and reduces neurodegeneration in a dose-dependent manner in a Drosophila model of Huntington’s disease. C2-8 (100 and 200 mg/kg) reduces huntingtin aggregate size, reduces neuronal atrophy, and improves motor performance in a rotarod test in the R6/2 transgenic mouse model of Huntington’s disease.{38918}
Brand:CaymanSKU:21177 -Out of stock
C2-8 is an inhibitor of polyglutamine (polyQ) aggregation (IC50s = 25 and 0.05 μM for recombinant HDQ51 and in PC12 cells, respectively).{38917} It also inhibits polyQ aggregation in organotypic hippocampal slice cultures isolated from R6/2 transgenic mice and reduces neurodegeneration in a dose-dependent manner in a Drosophila model of Huntington’s disease. C2-8 (100 and 200 mg/kg) reduces huntingtin aggregate size, reduces neuronal atrophy, and improves motor performance in a rotarod test in the R6/2 transgenic mouse model of Huntington’s disease.{38918}
Brand:CaymanSKU:21177 -Out of stock
C2-8 is an inhibitor of polyglutamine (polyQ) aggregation (IC50s = 25 and 0.05 μM for recombinant HDQ51 and in PC12 cells, respectively).{38917} It also inhibits polyQ aggregation in organotypic hippocampal slice cultures isolated from R6/2 transgenic mice and reduces neurodegeneration in a dose-dependent manner in a Drosophila model of Huntington’s disease. C2-8 (100 and 200 mg/kg) reduces huntingtin aggregate size, reduces neuronal atrophy, and improves motor performance in a rotarod test in the R6/2 transgenic mouse model of Huntington’s disease.{38918}
Brand:CaymanSKU:21177 -Out of stock
C20 Sphingomyelin is a naturally occurring sphingolipid.{40751,37416,37417,37418} Levels of C20 sphingomyelin are upregulated in the hippocampus of rats with diabetes induced by streptozotocin (Item No. 13104) and in human plasma where it is positively correlated with insulin resistance in obese humans.{37416} C20 sphingomyelin is also upregulated in the liver of a mouse model of Niemann-Pick type C1 disease, a neurodegenerative cholesterol-sphingolipid lysosomal storage disorder.{40751} The plasma concentration of C20 sphingomyelin is decreased in men with prostate cancer.{37417} [Matreya, LLC. Catalog No. 1917]
Brand:CaymanSKU:24450 - 500 µgAvailable on backorder
C-22 ceramide is an endogenous bioactive sphingolipid. Ceramides are involved in permeabilization of the mitochondrial outer membrane during apoptosis via the intrinsic pathway.{37099} C-22 ceramide forms small channels in liposomes, whereas C-16 ceramide (Item No. 10681) forms channels that can grow in size, suggesting that acyl chain length of ceramides is important in mitochondrial-mediated apoptosis. In addition, the mitochondrial-to-cytosolic stress response (MCSR) in C. elegans fed C-22 ceramide decreases following inhibition of Hsp6 (mortalin/Grp75/mtHsp70) using RNAi.{37098}
Brand:CaymanSKU:22533 -Out of stock
C-22 ceramide is an endogenous bioactive sphingolipid. Ceramides are involved in permeabilization of the mitochondrial outer membrane during apoptosis via the intrinsic pathway.{37099} C-22 ceramide forms small channels in liposomes, whereas C-16 ceramide (Item No. 10681) forms channels that can grow in size, suggesting that acyl chain length of ceramides is important in mitochondrial-mediated apoptosis. In addition, the mitochondrial-to-cytosolic stress response (MCSR) in C. elegans fed C-22 ceramide decreases following inhibition of Hsp6 (mortalin/Grp75/mtHsp70) using RNAi.{37098}
Brand:CaymanSKU:22533 -Out of stock
C-22 ceramide is an endogenous bioactive sphingolipid. Ceramides are involved in permeabilization of the mitochondrial outer membrane during apoptosis via the intrinsic pathway.{37099} C-22 ceramide forms small channels in liposomes, whereas C-16 ceramide (Item No. 10681) forms channels that can grow in size, suggesting that acyl chain length of ceramides is important in mitochondrial-mediated apoptosis. In addition, the mitochondrial-to-cytosolic stress response (MCSR) in C. elegans fed C-22 ceramide decreases following inhibition of Hsp6 (mortalin/Grp75/mtHsp70) using RNAi.{37098}
Brand:CaymanSKU:22533 -Out of stock
C22 Galactosylceramide is a sphingolipid that has been found in the central nervous system.{41138,46936} C22 Galactosylceramide levels are increased in the spinal cord, but not the brain or liver, of mice fed a methionine-restricted diet.{41138} C22 Galactosylceramide has been found in postmortem hippocampus from patients with Alzheimer’s disease.{46936}
Brand:CaymanSKU:9003458 - 1 mgAvailable on backorder
C22 Glucosylceramide is an endogenous glucosylceramide.{41137,41138,41139} Glucosylceramides are major constituents of skin lipid membranes where they play a role in maintaining the water permeability barrier. They are precursors in the synthesis of lactosylceramide (Item No. 16983), as well as oligoglycolipids and gangliosides. Phospholipase A2 (PLA2) type XIIA knockdown increases C22 glucosylceramide expression in rat brain.{41139} It is also increased in the brain, but not the liver or spinal cord, of mice fed a methionine-restricted diet.{41138} In human athletes, plasma levels of C22 glucosylceramide increase during exercise and return to basal levels during recovery.{41137} This product contains C22 glucosylceramide isolated from bovine buttermilk. [Matreya, LLC. Catalog No. 1531]
Brand:CaymanSKU:23210 - 1 mgAvailable on backorder
C22 Phytoceramide is a sphingolipid that has been found in Moro blood orange (C. sinensis) peels.{53677} It has also been found in primary human astrocytes.{53678}
Brand:CaymanSKU:9003464 - 1 mgAvailable on backorder
C22 Phytoceramide is a sphingolipid that has been found in Moro blood orange (C. sinensis) peels.{53677} It has also been found in primary human astrocytes.{53678}
Brand:CaymanSKU:9003464 - 5 mgAvailable on backorder
C22 Phytoceramide-d3 is intended for use as an internal standard for the quantification of C22 phytoceramide (Item No. 9003464) by GC- or LC-MS. C22 Phytoceramide is a sphingolipid that has been found in Moro blood orange (C. sinensis) peels.{53677} It has also been found in primary human astrocytes.{53678}
Brand:CaymanSKU:9003465 - 1 mgAvailable on backorder