Chemicals
Showing 11251–11400 of 41137 results
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Bestatin is an aminopeptidase inhibitor originally isolated from S. olivoreticuli.{33261} It inhibits aminopeptidase B (IC50 = 0.05 µg/ml), aminopeptidase N (IC50 = 16.9 µM), leucine aminopeptidase (IC50 = 0.01 µg/ml), and the aminopeptidase activity of leukotriene A4 (LTA4) hydrolase (Kapp = 172 nM).{33261,48771,91} It is selective for these aminopeptidases over aminopeptidase A, trypsin, chymotrypsin, elastase, papain, pepsin, and thermolysin.{33261} Bestatin inhibits the production of LTB4 (Item No. 20110) in erythrocytes when used at a concentration of 70 µM.{91} It increases the expression of Akt, inhibits proliferation, migration, and invasion, and induces autophagy and apoptosis in 5637 bladder cancer cells.{48772} Bestatin (5 and 15 mg/kg) decreases serum levels of LTB4 and reduces tumor growth in a patient-derived xenograft (PDX) mouse model of colorectal cancer.{48773}
Brand:CaymanSKU:70520 - 100 mgAvailable on backorder
Bestatin is an aminopeptidase inhibitor originally isolated from S. olivoreticuli.{33261} It inhibits aminopeptidase B (IC50 = 0.05 µg/ml), aminopeptidase N (IC50 = 16.9 µM), leucine aminopeptidase (IC50 = 0.01 µg/ml), and the aminopeptidase activity of leukotriene A4 (LTA4) hydrolase (Kapp = 172 nM).{33261,48771,91} It is selective for these aminopeptidases over aminopeptidase A, trypsin, chymotrypsin, elastase, papain, pepsin, and thermolysin.{33261} Bestatin inhibits the production of LTB4 (Item No. 20110) in erythrocytes when used at a concentration of 70 µM.{91} It increases the expression of Akt, inhibits proliferation, migration, and invasion, and induces autophagy and apoptosis in 5637 bladder cancer cells.{48772} Bestatin (5 and 15 mg/kg) decreases serum levels of LTB4 and reduces tumor growth in a patient-derived xenograft (PDX) mouse model of colorectal cancer.{48773}
Brand:CaymanSKU:70520 - 5 mgAvailable on backorder
Bestatin is an aminopeptidase inhibitor originally isolated from S. olivoreticuli.{33261} It inhibits aminopeptidase B (IC50 = 0.05 µg/ml), aminopeptidase N (IC50 = 16.9 µM), leucine aminopeptidase (IC50 = 0.01 µg/ml), and the aminopeptidase activity of leukotriene A4 (LTA4) hydrolase (Kapp = 172 nM).{33261,48771,91} It is selective for these aminopeptidases over aminopeptidase A, trypsin, chymotrypsin, elastase, papain, pepsin, and thermolysin.{33261} Bestatin inhibits the production of LTB4 (Item No. 20110) in erythrocytes when used at a concentration of 70 µM.{91} It increases the expression of Akt, inhibits proliferation, migration, and invasion, and induces autophagy and apoptosis in 5637 bladder cancer cells.{48772} Bestatin (5 and 15 mg/kg) decreases serum levels of LTB4 and reduces tumor growth in a patient-derived xenograft (PDX) mouse model of colorectal cancer.{48773}
Brand:CaymanSKU:70520 - 50 mgAvailable on backorder
Betahistine is a histamine H3 receptor antagonist and histamine H1 receptor agonist.{45328} In vivo, betahistine dilates pre-capillary arterioles and increases blood flow to the stria vascularis in guinea pigs.{45329,45330} Betahistine (8 mg/kg) reduces weight gain and increased feeding behavior induced by olanzapine (Item No. 11937) in female rats.{45331} Formulations containing betahistine have been used in the treatment of balance disorders and vertigo symptoms associated with Meniere’s disease.
Brand:CaymanSKU:27602 - 1 gAvailable on backorder
Betahistine is a histamine H3 receptor antagonist and histamine H1 receptor agonist.{45328} In vivo, betahistine dilates pre-capillary arterioles and increases blood flow to the stria vascularis in guinea pigs.{45329,45330} Betahistine (8 mg/kg) reduces weight gain and increased feeding behavior induced by olanzapine (Item No. 11937) in female rats.{45331} Formulations containing betahistine have been used in the treatment of balance disorders and vertigo symptoms associated with Meniere’s disease.
Brand:CaymanSKU:27602 - 10 gAvailable on backorder
Betahistine is a histamine H3 receptor antagonist and histamine H1 receptor agonist.{45328} In vivo, betahistine dilates pre-capillary arterioles and increases blood flow to the stria vascularis in guinea pigs.{45329,45330} Betahistine (8 mg/kg) reduces weight gain and increased feeding behavior induced by olanzapine (Item No. 11937) in female rats.{45331} Formulations containing betahistine have been used in the treatment of balance disorders and vertigo symptoms associated with Meniere’s disease.
Brand:CaymanSKU:27602 - 5 gAvailable on backorder
Betaine is a quaternary ammonium compound with diverse biological activities.{47329,47330,47331} It has been found in spinach and can be acquired through the diet or formed via oxidation of betaine aldehyde (Item No. 17270) during choline metabolism in the liver and kidney.{47329,47332} Betaine has roles in osmoregulation and serves as a methyl donor in the conversion of homocysteine to methionine.{47329} Betaine (1.5% w/v in drinking water) reduces serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity, increases serum HDL levels, decreases serum LDL levels, and reduces hepatic steatosis and inflammation in a mouse model of non-alcoholic fatty liver disease (NAFLD) induced by a methionine- and choline-deficient diet.{47330} It also reduces plasma levels of total homocysteine (tHcy), S-adenosylmethionine (AdoMet), S-adenosylhomocysteine (AdoHcy; Item No. 13603), and cystathionine, and attenuates hypercoagulation in a mouse model of homocystinuria.{47331} Formulations containing betaine have been used in the treatment of homocystinuria.
Brand:CaymanSKU:26814 - 100 gAvailable on backorder
Betaine is a quaternary ammonium compound with diverse biological activities.{47329,47330,47331} It has been found in spinach and can be acquired through the diet or formed via oxidation of betaine aldehyde (Item No. 17270) during choline metabolism in the liver and kidney.{47329,47332} Betaine has roles in osmoregulation and serves as a methyl donor in the conversion of homocysteine to methionine.{47329} Betaine (1.5% w/v in drinking water) reduces serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity, increases serum HDL levels, decreases serum LDL levels, and reduces hepatic steatosis and inflammation in a mouse model of non-alcoholic fatty liver disease (NAFLD) induced by a methionine- and choline-deficient diet.{47330} It also reduces plasma levels of total homocysteine (tHcy), S-adenosylmethionine (AdoMet), S-adenosylhomocysteine (AdoHcy; Item No. 13603), and cystathionine, and attenuates hypercoagulation in a mouse model of homocystinuria.{47331} Formulations containing betaine have been used in the treatment of homocystinuria.
Brand:CaymanSKU:26814 - 250 gAvailable on backorder
Betaine is a quaternary ammonium compound with diverse biological activities.{47329,47330,47331} It has been found in spinach and can be acquired through the diet or formed via oxidation of betaine aldehyde (Item No. 17270) during choline metabolism in the liver and kidney.{47329,47332} Betaine has roles in osmoregulation and serves as a methyl donor in the conversion of homocysteine to methionine.{47329} Betaine (1.5% w/v in drinking water) reduces serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity, increases serum HDL levels, decreases serum LDL levels, and reduces hepatic steatosis and inflammation in a mouse model of non-alcoholic fatty liver disease (NAFLD) induced by a methionine- and choline-deficient diet.{47330} It also reduces plasma levels of total homocysteine (tHcy), S-adenosylmethionine (AdoMet), S-adenosylhomocysteine (AdoHcy; Item No. 13603), and cystathionine, and attenuates hypercoagulation in a mouse model of homocystinuria.{47331} Formulations containing betaine have been used in the treatment of homocystinuria.
Brand:CaymanSKU:26814 - 500 gAvailable on backorder
Betaine aldehyde is the physiological intermediate in the oxidation of choline to betaine. This step is involved in glycine, serine, and threonine metabolism.
Brand:CaymanSKU:-Out of stock
Betaine aldehyde is the physiological intermediate in the oxidation of choline to betaine. This step is involved in glycine, serine, and threonine metabolism.
Brand:CaymanSKU:-Available on backorder
Betaine aldehyde is the physiological intermediate in the oxidation of choline to betaine. This step is involved in glycine, serine, and threonine metabolism.
Brand:CaymanSKU:-Available on backorder
Betaine aldehyde is the physiological intermediate in the oxidation of choline to betaine. This step is involved in glycine, serine, and threonine metabolism.
Brand:CaymanSKU:-Out of stock
Betamethasone is a synthetic corticosteroid. Like other corticosteroids, betamethasone has anti-inflammatory actions.{32497} Betamethasone also accelerates fetal lung maturation and has been used to decrease neonatal mortality and morbidity in infants born before 34 weeks of gestation.{32498}
Brand:CaymanSKU:20363 -Available on backorder
Betamethasone is a synthetic corticosteroid. Like other corticosteroids, betamethasone has anti-inflammatory actions.{32497} Betamethasone also accelerates fetal lung maturation and has been used to decrease neonatal mortality and morbidity in infants born before 34 weeks of gestation.{32498}
Brand:CaymanSKU:20363 -Available on backorder
Betamethasone is a synthetic corticosteroid. Like other corticosteroids, betamethasone has anti-inflammatory actions.{32497} Betamethasone also accelerates fetal lung maturation and has been used to decrease neonatal mortality and morbidity in infants born before 34 weeks of gestation.{32498}
Brand:CaymanSKU:20363 -Available on backorder
Betamethasone is a synthetic corticosteroid. Like other corticosteroids, betamethasone has anti-inflammatory actions.{32497} Betamethasone also accelerates fetal lung maturation and has been used to decrease neonatal mortality and morbidity in infants born before 34 weeks of gestation.{32498}
Brand:CaymanSKU:20363 -Available on backorder
Betamethasone 17-valerate is a glucocorticoid with anti-inflammatory activity.{48033,40484} It inhibits the binding of the radiolabeled glucocorticoid dexamethasone to human epidermis and mouse skin (IC50s = 5 and 6 nM, respectively).{48033} Topical application of betamethasone 17-valerate ointment (0.12%) blocks increases in ear weight in a rat model of ear edema induced by croton oil.{40484} Formulations containing betamethasone 17-valerate have been used in the treatment of corticosteroid-responsive dermatoses of the scalp.
Brand:CaymanSKU:25640 - 100 mgAvailable on backorder
Betamethasone 17-valerate is a glucocorticoid with anti-inflammatory activity.{48033,40484} It inhibits the binding of the radiolabeled glucocorticoid dexamethasone to human epidermis and mouse skin (IC50s = 5 and 6 nM, respectively).{48033} Topical application of betamethasone 17-valerate ointment (0.12%) blocks increases in ear weight in a rat model of ear edema induced by croton oil.{40484} Formulations containing betamethasone 17-valerate have been used in the treatment of corticosteroid-responsive dermatoses of the scalp.
Brand:CaymanSKU:25640 - 25 mgAvailable on backorder
Betamethasone 17-valerate is a glucocorticoid with anti-inflammatory activity.{48033,40484} It inhibits the binding of the radiolabeled glucocorticoid dexamethasone to human epidermis and mouse skin (IC50s = 5 and 6 nM, respectively).{48033} Topical application of betamethasone 17-valerate ointment (0.12%) blocks increases in ear weight in a rat model of ear edema induced by croton oil.{40484} Formulations containing betamethasone 17-valerate have been used in the treatment of corticosteroid-responsive dermatoses of the scalp.
Brand:CaymanSKU:25640 - 50 mgAvailable on backorder
Betamethasone 17-valerate is a glucocorticoid with anti-inflammatory activity.{48033,40484} It inhibits the binding of the radiolabeled glucocorticoid dexamethasone to human epidermis and mouse skin (IC50s = 5 and 6 nM, respectively).{48033} Topical application of betamethasone 17-valerate ointment (0.12%) blocks increases in ear weight in a rat model of ear edema induced by croton oil.{40484} Formulations containing betamethasone 17-valerate have been used in the treatment of corticosteroid-responsive dermatoses of the scalp.
Brand:CaymanSKU:25640 - 500 mgAvailable on backorder
Betaxolol (hydrochloride) (Item No. 26285) is an analytical reference standard categorized as a β1-adrenergic receptor antagonist.{25151} Formulations containing β-adrenergic receptor antagonists have been used to enhance physical performance in athletes.{48104,46103} This product is intended for use in analytical forensic applications. This product is also available as a general research tool (Item No. 18625).
Brand:CaymanSKU:26285 - 1 mgAvailable on backorder
Betaxolol is a selective β1-adrenergic receptor antagonist (log KDs = -8.21, -7.38, and -5.97 for β1, β2, and β3, respectively).{25151} This beta-blocker has been used to reduce intraocular pressure in research models of ocular hypertension and glaucoma.{30089,30088,30087} It is also reported to act as a neuroprotective agent in animals, attenuating excitotoxicity or ischemia-induced damage to retinal ganglion cells.{30086}
Brand:CaymanSKU:-Available on backorder
Betaxolol is a selective β1-adrenergic receptor antagonist (log KDs = -8.21, -7.38, and -5.97 for β1, β2, and β3, respectively).{25151} This beta-blocker has been used to reduce intraocular pressure in research models of ocular hypertension and glaucoma.{30089,30088,30087} It is also reported to act as a neuroprotective agent in animals, attenuating excitotoxicity or ischemia-induced damage to retinal ganglion cells.{30086}
Brand:CaymanSKU:-Available on backorder
Betaxolol (hydrochloride) (Item No. 26285) is an analytical reference standard categorized as a β1-adrenergic receptor antagonist.{25151} Formulations containing β-adrenergic receptor antagonists have been used to enhance physical performance in athletes.{48104,46103} This product is intended for use in analytical forensic applications. This product is also available as a general research tool (Item No. 18625).
Brand:CaymanSKU:26285 - 5 mgAvailable on backorder
Betaxolol is a selective β1-adrenergic receptor antagonist (log KDs = -8.21, -7.38, and -5.97 for β1, β2, and β3, respectively).{25151} This beta-blocker has been used to reduce intraocular pressure in research models of ocular hypertension and glaucoma.{30089,30088,30087} It is also reported to act as a neuroprotective agent in animals, attenuating excitotoxicity or ischemia-induced damage to retinal ganglion cells.{30086}
Brand:CaymanSKU:-Available on backorder
Betaxolol is a selective β1-adrenergic receptor antagonist (log KDs = -8.21, -7.38, and -5.97 for β1, β2, and β3, respectively).{25151} This beta-blocker has been used to reduce intraocular pressure in research models of ocular hypertension and glaucoma.{30089,30088,30087} It is also reported to act as a neuroprotective agent in animals, attenuating excitotoxicity or ischemia-induced damage to retinal ganglion cells.{30086}
Brand:CaymanSKU:-Available on backorder
Bethanechol is an agonist of muscarinic acetylcholine receptors with IC50 values of 1,837, 25, 631, 317, and 393 µM for M1-5, respectively, in a radioligand binding assay using CHO cells expressing the human receptors.{40682} It inhibits M2-mediated increases in cyclic AMP induced by isoproterenol (Item No. 15592) in isolated guinea pig small intestine (IC50 = 127 µM).{18340} Bethanechol increases basal tone of isolated porcine intravesical ureter (EC50 = 4.27 µM).{27105} It also induces fluid secretion in the ileum, duodenum, and jejunum of anesthetized rats when administered at a dose of 60 µg/kg.{40787} Formulations containing bethanechol have been used to increase urination and improve smooth muscle tone in the gastrointestinal tract.
Brand:CaymanSKU:23830 - 1 gAvailable on backorder
Bethanechol is an agonist of muscarinic acetylcholine receptors with IC50 values of 1,837, 25, 631, 317, and 393 µM for M1-5, respectively, in a radioligand binding assay using CHO cells expressing the human receptors.{40682} It inhibits M2-mediated increases in cyclic AMP induced by isoproterenol (Item No. 15592) in isolated guinea pig small intestine (IC50 = 127 µM).{18340} Bethanechol increases basal tone of isolated porcine intravesical ureter (EC50 = 4.27 µM).{27105} It also induces fluid secretion in the ileum, duodenum, and jejunum of anesthetized rats when administered at a dose of 60 µg/kg.{40787} Formulations containing bethanechol have been used to increase urination and improve smooth muscle tone in the gastrointestinal tract.
Brand:CaymanSKU:23830 - 10 gAvailable on backorder
Bethanechol is an agonist of muscarinic acetylcholine receptors with IC50 values of 1,837, 25, 631, 317, and 393 µM for M1-5, respectively, in a radioligand binding assay using CHO cells expressing the human receptors.{40682} It inhibits M2-mediated increases in cyclic AMP induced by isoproterenol (Item No. 15592) in isolated guinea pig small intestine (IC50 = 127 µM).{18340} Bethanechol increases basal tone of isolated porcine intravesical ureter (EC50 = 4.27 µM).{27105} It also induces fluid secretion in the ileum, duodenum, and jejunum of anesthetized rats when administered at a dose of 60 µg/kg.{40787} Formulations containing bethanechol have been used to increase urination and improve smooth muscle tone in the gastrointestinal tract.
Brand:CaymanSKU:23830 - 25 gAvailable on backorder
Bethanechol is an agonist of muscarinic acetylcholine receptors with IC50 values of 1,837, 25, 631, 317, and 393 µM for M1-5, respectively, in a radioligand binding assay using CHO cells expressing the human receptors.{40682} It inhibits M2-mediated increases in cyclic AMP induced by isoproterenol (Item No. 15592) in isolated guinea pig small intestine (IC50 = 127 µM).{18340} Bethanechol increases basal tone of isolated porcine intravesical ureter (EC50 = 4.27 µM).{27105} It also induces fluid secretion in the ileum, duodenum, and jejunum of anesthetized rats when administered at a dose of 60 µg/kg.{40787} Formulations containing bethanechol have been used to increase urination and improve smooth muscle tone in the gastrointestinal tract.
Brand:CaymanSKU:23830 - 5 gAvailable on backorder
BETP is a positive allosteric modulator of glucagon-like peptide 1 receptor (GLP-1R; EC50 = 0.66 µM in a reporter assay).{58027} It is selective for GLP-1R over GLP-2R, as well as glucose-dependent insulinotropic polypeptide, glucagon, and the parathyroid hormone receptors. BETP induces cAMP accumulation and intracellular calcium mobilization in CHO cells expressing human GLP-1R (EC50s = 5 and 6.3 µM, respectively).{58028} It increases glucose-induced insulin secretion in pancreatic islets isolated from patients with type 2 diabetes when used at concentrations of 3 and 10 µM. BETP (10 mg/kg) increases plasma insulin levels in an intravenous glucose tolerance test in rats.
Brand:CaymanSKU:31116 - 1 mgAvailable on backorder
BETP is a positive allosteric modulator of glucagon-like peptide 1 receptor (GLP-1R; EC50 = 0.66 µM in a reporter assay).{58027} It is selective for GLP-1R over GLP-2R, as well as glucose-dependent insulinotropic polypeptide, glucagon, and the parathyroid hormone receptors. BETP induces cAMP accumulation and intracellular calcium mobilization in CHO cells expressing human GLP-1R (EC50s = 5 and 6.3 µM, respectively).{58028} It increases glucose-induced insulin secretion in pancreatic islets isolated from patients with type 2 diabetes when used at concentrations of 3 and 10 µM. BETP (10 mg/kg) increases plasma insulin levels in an intravenous glucose tolerance test in rats.
Brand:CaymanSKU:31116 - 10 mgAvailable on backorder
BETP is a positive allosteric modulator of glucagon-like peptide 1 receptor (GLP-1R; EC50 = 0.66 µM in a reporter assay).{58027} It is selective for GLP-1R over GLP-2R, as well as glucose-dependent insulinotropic polypeptide, glucagon, and the parathyroid hormone receptors. BETP induces cAMP accumulation and intracellular calcium mobilization in CHO cells expressing human GLP-1R (EC50s = 5 and 6.3 µM, respectively).{58028} It increases glucose-induced insulin secretion in pancreatic islets isolated from patients with type 2 diabetes when used at concentrations of 3 and 10 µM. BETP (10 mg/kg) increases plasma insulin levels in an intravenous glucose tolerance test in rats.
Brand:CaymanSKU:31116 - 25 mgAvailable on backorder
BETP is a positive allosteric modulator of glucagon-like peptide 1 receptor (GLP-1R; EC50 = 0.66 µM in a reporter assay).{58027} It is selective for GLP-1R over GLP-2R, as well as glucose-dependent insulinotropic polypeptide, glucagon, and the parathyroid hormone receptors. BETP induces cAMP accumulation and intracellular calcium mobilization in CHO cells expressing human GLP-1R (EC50s = 5 and 6.3 µM, respectively).{58028} It increases glucose-induced insulin secretion in pancreatic islets isolated from patients with type 2 diabetes when used at concentrations of 3 and 10 µM. BETP (10 mg/kg) increases plasma insulin levels in an intravenous glucose tolerance test in rats.
Brand:CaymanSKU:31116 - 5 mgAvailable on backorder
Betrixaban is an inhibitor of the serine protease Factor Xa (Ki = 0.117 nM; IC50 = 1.5 nM), the enzyme that activates prothrombin in the blood coagulation cascade.{36456} It is selective for Factor Xa over hERG channels (Ki = 1.8 µM; IC50 = 8.9 µM), indicating a low potential for adverse cardiac effects. In vitro, betrixaban inhibits thrombin generation when used at concentrations ranging from 5 to 25 ng/mL in a tissue factor-induced thrombin generation assay.{36457} In vivo, it inhibits thrombus mass formation by 76% in a rabbit clot accretion model when used at a dose of 3 mg/kg. Formulations containing betrixaban have been used as anticoagulants in the treatment and prevention of venous thromboembolism.{36458}
Brand:CaymanSKU:21563 -Out of stock
Betrixaban is an inhibitor of the serine protease Factor Xa (Ki = 0.117 nM; IC50 = 1.5 nM), the enzyme that activates prothrombin in the blood coagulation cascade.{36456} It is selective for Factor Xa over hERG channels (Ki = 1.8 µM; IC50 = 8.9 µM), indicating a low potential for adverse cardiac effects. In vitro, betrixaban inhibits thrombin generation when used at concentrations ranging from 5 to 25 ng/mL in a tissue factor-induced thrombin generation assay.{36457} In vivo, it inhibits thrombus mass formation by 76% in a rabbit clot accretion model when used at a dose of 3 mg/kg. Formulations containing betrixaban have been used as anticoagulants in the treatment and prevention of venous thromboembolism.{36458}
Brand:CaymanSKU:21563 -Out of stock
Betrixaban is an inhibitor of the serine protease Factor Xa (Ki = 0.117 nM; IC50 = 1.5 nM), the enzyme that activates prothrombin in the blood coagulation cascade.{36456} It is selective for Factor Xa over hERG channels (Ki = 1.8 µM; IC50 = 8.9 µM), indicating a low potential for adverse cardiac effects. In vitro, betrixaban inhibits thrombin generation when used at concentrations ranging from 5 to 25 ng/mL in a tissue factor-induced thrombin generation assay.{36457} In vivo, it inhibits thrombus mass formation by 76% in a rabbit clot accretion model when used at a dose of 3 mg/kg. Formulations containing betrixaban have been used as anticoagulants in the treatment and prevention of venous thromboembolism.{36458}
Brand:CaymanSKU:21563 -Out of stock
Betrixaban is an inhibitor of the serine protease Factor Xa (Ki = 0.117 nM; IC50 = 1.5 nM), the enzyme that activates prothrombin in the blood coagulation cascade.{36456} It is selective for Factor Xa over hERG channels (Ki = 1.8 µM; IC50 = 8.9 µM), indicating a low potential for adverse cardiac effects. In vitro, betrixaban inhibits thrombin generation when used at concentrations ranging from 5 to 25 ng/mL in a tissue factor-induced thrombin generation assay.{36457} In vivo, it inhibits thrombus mass formation by 76% in a rabbit clot accretion model when used at a dose of 3 mg/kg. Formulations containing betrixaban have been used as anticoagulants in the treatment and prevention of venous thromboembolism.{36458}
Brand:CaymanSKU:21563 -Out of stock
Sterol regulatory element binding protein 2 (SREBP-2) regulates cholesterol synthesis by activating the transcription of genes for HMG-CoA reductase and other enzymes of the cholesterol synthetic pathway.{13851,13853} When cellular sterol levels are high, SREBP is bound by SCAP and Insig to ER membranes as a glycosylated precursor protein. Upon cholesterol depletion, the protein is cleaved to its active form and translocated into the nucleus to stimulate transcription of genes involved in the uptake and synthesis of cholesterol.{13148} Betulin, the precursor of betulinic acid, is a pentacyclic triterpene found in the bark of birch trees. Betulin inhibits the SREBP-driven pathway of cholesterol and fatty acid biosynthesis by promoting SCAP–Insig binding which prevents the activation and release of SREBP-2 from the ER.{19894} At 15-30 mg/kg/day, betulin has been shown to decrease lipid levels and increase insulin sensitivity in mice fed a western-type diet.{19894} In an atherosclerosis disease model, 30 mg/kg/day betulin can reduce the size and improve the stability of atherosclerotic plaques in LDLR-knockout mice.{19894} At 2.5-5 μg/ml betulin, in combination with cholesterol, demonstrates anticancer effects by inducing apoptosis in Jurkat cells, A549 lung carcinoma cells, and HeLa cervical carcinoma cells.{22046}
Brand:CaymanSKU:11041 - 1 gAvailable on backorder
Sterol regulatory element binding protein 2 (SREBP-2) regulates cholesterol synthesis by activating the transcription of genes for HMG-CoA reductase and other enzymes of the cholesterol synthetic pathway.{13851,13853} When cellular sterol levels are high, SREBP is bound by SCAP and Insig to ER membranes as a glycosylated precursor protein. Upon cholesterol depletion, the protein is cleaved to its active form and translocated into the nucleus to stimulate transcription of genes involved in the uptake and synthesis of cholesterol.{13148} Betulin, the precursor of betulinic acid, is a pentacyclic triterpene found in the bark of birch trees. Betulin inhibits the SREBP-driven pathway of cholesterol and fatty acid biosynthesis by promoting SCAP–Insig binding which prevents the activation and release of SREBP-2 from the ER.{19894} At 15-30 mg/kg/day, betulin has been shown to decrease lipid levels and increase insulin sensitivity in mice fed a western-type diet.{19894} In an atherosclerosis disease model, 30 mg/kg/day betulin can reduce the size and improve the stability of atherosclerotic plaques in LDLR-knockout mice.{19894} At 2.5-5 μg/ml betulin, in combination with cholesterol, demonstrates anticancer effects by inducing apoptosis in Jurkat cells, A549 lung carcinoma cells, and HeLa cervical carcinoma cells.{22046}
Brand:CaymanSKU:11041 - 250 mgAvailable on backorder
Sterol regulatory element binding protein 2 (SREBP-2) regulates cholesterol synthesis by activating the transcription of genes for HMG-CoA reductase and other enzymes of the cholesterol synthetic pathway.{13851,13853} When cellular sterol levels are high, SREBP is bound by SCAP and Insig to ER membranes as a glycosylated precursor protein. Upon cholesterol depletion, the protein is cleaved to its active form and translocated into the nucleus to stimulate transcription of genes involved in the uptake and synthesis of cholesterol.{13148} Betulin, the precursor of betulinic acid, is a pentacyclic triterpene found in the bark of birch trees. Betulin inhibits the SREBP-driven pathway of cholesterol and fatty acid biosynthesis by promoting SCAP–Insig binding which prevents the activation and release of SREBP-2 from the ER.{19894} At 15-30 mg/kg/day, betulin has been shown to decrease lipid levels and increase insulin sensitivity in mice fed a western-type diet.{19894} In an atherosclerosis disease model, 30 mg/kg/day betulin can reduce the size and improve the stability of atherosclerotic plaques in LDLR-knockout mice.{19894} At 2.5-5 μg/ml betulin, in combination with cholesterol, demonstrates anticancer effects by inducing apoptosis in Jurkat cells, A549 lung carcinoma cells, and HeLa cervical carcinoma cells.{22046}
Brand:CaymanSKU:11041 - 5 gAvailable on backorder
Sterol regulatory element binding protein 2 (SREBP-2) regulates cholesterol synthesis by activating the transcription of genes for HMG-CoA reductase and other enzymes of the cholesterol synthetic pathway.{13851,13853} When cellular sterol levels are high, SREBP is bound by SCAP and Insig to ER membranes as a glycosylated precursor protein. Upon cholesterol depletion, the protein is cleaved to its active form and translocated into the nucleus to stimulate transcription of genes involved in the uptake and synthesis of cholesterol.{13148} Betulin, the precursor of betulinic acid, is a pentacyclic triterpene found in the bark of birch trees. Betulin inhibits the SREBP-driven pathway of cholesterol and fatty acid biosynthesis by promoting SCAP–Insig binding which prevents the activation and release of SREBP-2 from the ER.{19894} At 15-30 mg/kg/day, betulin has been shown to decrease lipid levels and increase insulin sensitivity in mice fed a western-type diet.{19894} In an atherosclerosis disease model, 30 mg/kg/day betulin can reduce the size and improve the stability of atherosclerotic plaques in LDLR-knockout mice.{19894} At 2.5-5 μg/ml betulin, in combination with cholesterol, demonstrates anticancer effects by inducing apoptosis in Jurkat cells, A549 lung carcinoma cells, and HeLa cervical carcinoma cells.{22046}
Brand:CaymanSKU:11041 - 500 mgAvailable on backorder
Betulinic acid is a natural plant triterpenoid that is structurally related to mammalian bile acids. It is an agonist of the G protein-coupled bile acid receptor TGR5 (EC50 = 1 µM), which might be linked with its ability to alter gene expression and fatty liver development in cells and mice given ethanol.{24274,24272,24270} Betulinic acid also reduces NF-κB signaling and expression of microRNA-33 in LPS-treated macrophages, increasing levels of the ATP-binding cassette (ABC) cholesterol transporter ABCA1.{24273} It also inhibits replication of HIV-1 (IC50 = 1.4 µM) and has cytotoxic effects against cancer cells.{24270,22046}
Brand:CaymanSKU:11686 - 100 mgAvailable on backorder
Betulinic acid is a natural plant triterpenoid that is structurally related to mammalian bile acids. It is an agonist of the G protein-coupled bile acid receptor TGR5 (EC50 = 1 µM), which might be linked with its ability to alter gene expression and fatty liver development in cells and mice given ethanol.{24274,24272,24270} Betulinic acid also reduces NF-κB signaling and expression of microRNA-33 in LPS-treated macrophages, increasing levels of the ATP-binding cassette (ABC) cholesterol transporter ABCA1.{24273} It also inhibits replication of HIV-1 (IC50 = 1.4 µM) and has cytotoxic effects against cancer cells.{24270,22046}
Brand:CaymanSKU:11686 - 250 mgAvailable on backorder
Betulinic acid is a natural plant triterpenoid that is structurally related to mammalian bile acids. It is an agonist of the G protein-coupled bile acid receptor TGR5 (EC50 = 1 µM), which might be linked with its ability to alter gene expression and fatty liver development in cells and mice given ethanol.{24274,24272,24270} Betulinic acid also reduces NF-κB signaling and expression of microRNA-33 in LPS-treated macrophages, increasing levels of the ATP-binding cassette (ABC) cholesterol transporter ABCA1.{24273} It also inhibits replication of HIV-1 (IC50 = 1.4 µM) and has cytotoxic effects against cancer cells.{24270,22046}
Brand:CaymanSKU:11686 - 50 mgAvailable on backorder
Betulinic acid is a natural plant triterpenoid that is structurally related to mammalian bile acids. It is an agonist of the G protein-coupled bile acid receptor TGR5 (EC50 = 1 µM), which might be linked with its ability to alter gene expression and fatty liver development in cells and mice given ethanol.{24274,24272,24270} Betulinic acid also reduces NF-κB signaling and expression of microRNA-33 in LPS-treated macrophages, increasing levels of the ATP-binding cassette (ABC) cholesterol transporter ABCA1.{24273} It also inhibits replication of HIV-1 (IC50 = 1.4 µM) and has cytotoxic effects against cancer cells.{24270,22046}
Brand:CaymanSKU:11686 - 500 mgAvailable on backorder
Betulinic aldehyde is a triterpenoid that has been found in Z. cambodiana and has diverse biological activities.{48464,48465,48466,48467} It is active against P. falciparum (IC50 = 6.5 μg/ml) and M. tuberculosis (MIC = 25 μg/ml) in vitro, as well as laboratory and clinical isolates of methicillin-resistant and -sensitive S. aureus (MICs = 128-512 and 8-512 μg/ml, respectively).{48464,48465} Betulinic aldehyde inhibits dengue virus non-structural protein 5 (NS5) RNA-dependent RNA polymerase (IC50 = 6.1 μM) and inhibits dengue virus type 2 replication by 20 and 55% when used at concentrations of 5 and 10 μg/ml, respectively.{48466} It also inhibits growth of leukemia, melanoma, neuroblastoma, and normal fibroblast cell lines (IC50s = 1.1-4.9, 9.6-10.6, 7.5-8.8, and 18.5 μM, respectively).{48467}
Brand:CaymanSKU:27810 - 1 mgAvailable on backorder
Betulinic aldehyde is a triterpenoid that has been found in Z. cambodiana and has diverse biological activities.{48464,48465,48466,48467} It is active against P. falciparum (IC50 = 6.5 μg/ml) and M. tuberculosis (MIC = 25 μg/ml) in vitro, as well as laboratory and clinical isolates of methicillin-resistant and -sensitive S. aureus (MICs = 128-512 and 8-512 μg/ml, respectively).{48464,48465} Betulinic aldehyde inhibits dengue virus non-structural protein 5 (NS5) RNA-dependent RNA polymerase (IC50 = 6.1 μM) and inhibits dengue virus type 2 replication by 20 and 55% when used at concentrations of 5 and 10 μg/ml, respectively.{48466} It also inhibits growth of leukemia, melanoma, neuroblastoma, and normal fibroblast cell lines (IC50s = 1.1-4.9, 9.6-10.6, 7.5-8.8, and 18.5 μM, respectively).{48467}
Brand:CaymanSKU:27810 - 10 mgAvailable on backorder
Betulinic aldehyde is a triterpenoid that has been found in Z. cambodiana and has diverse biological activities.{48464,48465,48466,48467} It is active against P. falciparum (IC50 = 6.5 μg/ml) and M. tuberculosis (MIC = 25 μg/ml) in vitro, as well as laboratory and clinical isolates of methicillin-resistant and -sensitive S. aureus (MICs = 128-512 and 8-512 μg/ml, respectively).{48464,48465} Betulinic aldehyde inhibits dengue virus non-structural protein 5 (NS5) RNA-dependent RNA polymerase (IC50 = 6.1 μM) and inhibits dengue virus type 2 replication by 20 and 55% when used at concentrations of 5 and 10 μg/ml, respectively.{48466} It also inhibits growth of leukemia, melanoma, neuroblastoma, and normal fibroblast cell lines (IC50s = 1.1-4.9, 9.6-10.6, 7.5-8.8, and 18.5 μM, respectively).{48467}
Brand:CaymanSKU:27810 - 25 mgAvailable on backorder
Betulinic aldehyde is a triterpenoid that has been found in Z. cambodiana and has diverse biological activities.{48464,48465,48466,48467} It is active against P. falciparum (IC50 = 6.5 μg/ml) and M. tuberculosis (MIC = 25 μg/ml) in vitro, as well as laboratory and clinical isolates of methicillin-resistant and -sensitive S. aureus (MICs = 128-512 and 8-512 μg/ml, respectively).{48464,48465} Betulinic aldehyde inhibits dengue virus non-structural protein 5 (NS5) RNA-dependent RNA polymerase (IC50 = 6.1 μM) and inhibits dengue virus type 2 replication by 20 and 55% when used at concentrations of 5 and 10 μg/ml, respectively.{48466} It also inhibits growth of leukemia, melanoma, neuroblastoma, and normal fibroblast cell lines (IC50s = 1.1-4.9, 9.6-10.6, 7.5-8.8, and 18.5 μM, respectively).{48467}
Brand:CaymanSKU:27810 - 5 mgAvailable on backorder
Betulonic acid is a triterpenoid that has been found in B. chinensis and has diverse biological activities, including antiparasitic, antiviral, and anticancer properties.{52273,52274,52275,52276} It is active against the chloroquine-resistant P. falciparum W2 clone (IC50 = 10.01 µM), as well as L. infantum and L. donovani promastigotes when used at a concentration of 50 µM.{52275,52274} Betulonic acid inhibits replication of herpes simplex virus I (HSV-I), echovirus 6, and the H7N1 strain of influenza A (EC50s = 0.9, 73.32, and 5.7 µM, respectively).{52276} It inhibits proliferation of MGC803, Bcap-37, MCF-7, PC3, and NIH3T3 cancer cells by 68.1, 44.9, 56.1, 52.4, and 22.1%, respectively, when used at a concentration of 20 µM.{52273}
Brand:CaymanSKU:29765 - 10 mgAvailable on backorder
Betulonic acid is a triterpenoid that has been found in B. chinensis and has diverse biological activities, including antiparasitic, antiviral, and anticancer properties.{52273,52274,52275,52276} It is active against the chloroquine-resistant P. falciparum W2 clone (IC50 = 10.01 µM), as well as L. infantum and L. donovani promastigotes when used at a concentration of 50 µM.{52275,52274} Betulonic acid inhibits replication of herpes simplex virus I (HSV-I), echovirus 6, and the H7N1 strain of influenza A (EC50s = 0.9, 73.32, and 5.7 µM, respectively).{52276} It inhibits proliferation of MGC803, Bcap-37, MCF-7, PC3, and NIH3T3 cancer cells by 68.1, 44.9, 56.1, 52.4, and 22.1%, respectively, when used at a concentration of 20 µM.{52273}
Brand:CaymanSKU:29765 - 25 mgAvailable on backorder
Betulonic acid is a triterpenoid that has been found in B. chinensis and has diverse biological activities, including antiparasitic, antiviral, and anticancer properties.{52273,52274,52275,52276} It is active against the chloroquine-resistant P. falciparum W2 clone (IC50 = 10.01 µM), as well as L. infantum and L. donovani promastigotes when used at a concentration of 50 µM.{52275,52274} Betulonic acid inhibits replication of herpes simplex virus I (HSV-I), echovirus 6, and the H7N1 strain of influenza A (EC50s = 0.9, 73.32, and 5.7 µM, respectively).{52276} It inhibits proliferation of MGC803, Bcap-37, MCF-7, PC3, and NIH3T3 cancer cells by 68.1, 44.9, 56.1, 52.4, and 22.1%, respectively, when used at a concentration of 20 µM.{52273}
Brand:CaymanSKU:29765 - 5 mgAvailable on backorder
Betulonic acid is a triterpenoid that has been found in B. chinensis and has diverse biological activities, including antiparasitic, antiviral, and anticancer properties.{52273,52274,52275,52276} It is active against the chloroquine-resistant P. falciparum W2 clone (IC50 = 10.01 µM), as well as L. infantum and L. donovani promastigotes when used at a concentration of 50 µM.{52275,52274} Betulonic acid inhibits replication of herpes simplex virus I (HSV-I), echovirus 6, and the H7N1 strain of influenza A (EC50s = 0.9, 73.32, and 5.7 µM, respectively).{52276} It inhibits proliferation of MGC803, Bcap-37, MCF-7, PC3, and NIH3T3 cancer cells by 68.1, 44.9, 56.1, 52.4, and 22.1%, respectively, when used at a concentration of 20 µM.{52273}
Brand:CaymanSKU:29765 - 50 mgAvailable on backorder
Bevantolol is an antagonist of the β1-adrenergic receptor (β1-AR; Ki = 14.79 nM in rat cortical membranes).{52361} It is selective for β1- over β2-ARs (Ki = 588.84 nM), as well as α2-ARs up to 100 μM, but is an antagonist of α1-ARs (Ki = 125.89 nM). Bevantolol inhibits low voltage-activated calcium currents (LVA-ICa) in dissociated rat ventro-medial hypothalamic neurons (IC50 = 40 μM).{52362} It inhibits norepinephrine-induced contraction of isolated rabbit thoracic aorta (pA2 = 4.77), isoprenaline-induced inotropic effects in isolated guinea pig right atria (pA2 = 7.74), and isoprenaline-induced relaxation of isolated guinea pig trachea (pA2 = 6.69).{52363} Bevantolol (250 mg/kg per day) prevents immobilization stress-induced increases in systolic blood pressure in a rat model of stress-induced hypertension.{52364}
Brand:CaymanSKU:29792 - 100 mgAvailable on backorder
Bevantolol is an antagonist of the β1-adrenergic receptor (β1-AR; Ki = 14.79 nM in rat cortical membranes).{52361} It is selective for β1- over β2-ARs (Ki = 588.84 nM), as well as α2-ARs up to 100 μM, but is an antagonist of α1-ARs (Ki = 125.89 nM). Bevantolol inhibits low voltage-activated calcium currents (LVA-ICa) in dissociated rat ventro-medial hypothalamic neurons (IC50 = 40 μM).{52362} It inhibits norepinephrine-induced contraction of isolated rabbit thoracic aorta (pA2 = 4.77), isoprenaline-induced inotropic effects in isolated guinea pig right atria (pA2 = 7.74), and isoprenaline-induced relaxation of isolated guinea pig trachea (pA2 = 6.69).{52363} Bevantolol (250 mg/kg per day) prevents immobilization stress-induced increases in systolic blood pressure in a rat model of stress-induced hypertension.{52364}
Brand:CaymanSKU:29792 - 250 mgAvailable on backorder
Bevantolol is an antagonist of the β1-adrenergic receptor (β1-AR; Ki = 14.79 nM in rat cortical membranes).{52361} It is selective for β1- over β2-ARs (Ki = 588.84 nM), as well as α2-ARs up to 100 μM, but is an antagonist of α1-ARs (Ki = 125.89 nM). Bevantolol inhibits low voltage-activated calcium currents (LVA-ICa) in dissociated rat ventro-medial hypothalamic neurons (IC50 = 40 μM).{52362} It inhibits norepinephrine-induced contraction of isolated rabbit thoracic aorta (pA2 = 4.77), isoprenaline-induced inotropic effects in isolated guinea pig right atria (pA2 = 7.74), and isoprenaline-induced relaxation of isolated guinea pig trachea (pA2 = 6.69).{52363} Bevantolol (250 mg/kg per day) prevents immobilization stress-induced increases in systolic blood pressure in a rat model of stress-induced hypertension.{52364}
Brand:CaymanSKU:29792 - 500 mgAvailable on backorder
Bexarotene is an agonist of retinoid X receptors (RXRs; EC50s = 28, 25, and 20 nM for RXRα, RXRβ, and RXRγ, respectively, in reporter assays).{20758} It is selective for RXRs over retinoic acid receptors (RARs; EC50s = >10 µM for RARα, RARβ, and RARγ). Bexarotene (10 µM) induces apoptosis in MJ, HuT 78, and HH cutaneous T cell lymphoma (CTCL) cells, as well as inhibits lung metastasis and angiogenesis in A549 and MDA-MB-231 mouse xenograft models when administered at a dose of 100 mg/kg per day.{58126,58127} It reduces increased brain interstitial fluid levels of amyloid-β (1-40) (Aβ40) and Aβ42 in the APP/PS1 transgenic mouse model of Alzheimer’s disease.{20759} It also reduces viral load in the culture supernatant of Vero E6 cells infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; EC90 = 9.4 µM) and inhibits SARS-CoV-2 replication in a plaque reduction assay (EC50 = 2.01 µM).{59330} Formulations containing bexarotene have been used in the treatment of CTCL.
Brand:CaymanSKU:11571 - 10 mgAvailable on backorder
Bexarotene is an agonist of retinoid X receptors (RXRs; EC50s = 28, 25, and 20 nM for RXRα, RXRβ, and RXRγ, respectively, in reporter assays).{20758} It is selective for RXRs over retinoic acid receptors (RARs; EC50s = >10 µM for RARα, RARβ, and RARγ). Bexarotene (10 µM) induces apoptosis in MJ, HuT 78, and HH cutaneous T cell lymphoma (CTCL) cells, as well as inhibits lung metastasis and angiogenesis in A549 and MDA-MB-231 mouse xenograft models when administered at a dose of 100 mg/kg per day.{58126,58127} It reduces increased brain interstitial fluid levels of amyloid-β (1-40) (Aβ40) and Aβ42 in the APP/PS1 transgenic mouse model of Alzheimer’s disease.{20759} It also reduces viral load in the culture supernatant of Vero E6 cells infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; EC90 = 9.4 µM) and inhibits SARS-CoV-2 replication in a plaque reduction assay (EC50 = 2.01 µM).{59330} Formulations containing bexarotene have been used in the treatment of CTCL.
Brand:CaymanSKU:11571 - 5 mgAvailable on backorder
Bexarotene is an agonist of retinoid X receptors (RXRs; EC50s = 28, 25, and 20 nM for RXRα, RXRβ, and RXRγ, respectively, in reporter assays).{20758} It is selective for RXRs over retinoic acid receptors (RARs; EC50s = >10 µM for RARα, RARβ, and RARγ). Bexarotene (10 µM) induces apoptosis in MJ, HuT 78, and HH cutaneous T cell lymphoma (CTCL) cells, as well as inhibits lung metastasis and angiogenesis in A549 and MDA-MB-231 mouse xenograft models when administered at a dose of 100 mg/kg per day.{58126,58127} It reduces increased brain interstitial fluid levels of amyloid-β (1-40) (Aβ40) and Aβ42 in the APP/PS1 transgenic mouse model of Alzheimer’s disease.{20759} It also reduces viral load in the culture supernatant of Vero E6 cells infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; EC90 = 9.4 µM) and inhibits SARS-CoV-2 replication in a plaque reduction assay (EC50 = 2.01 µM).{59330} Formulations containing bexarotene have been used in the treatment of CTCL.
Brand:CaymanSKU:11571 - 50 mgAvailable on backorder
Bezafibrate is a non-selective agonist of peroxisome proliferator-activated receptors (PPARs; EC50s = 50, 60, and 20 μM for human PPARα, PPARγ, and PPARδ, respectively).{10670} It reduces triglyceride levels and the size of lipid droplets in an oleic acid-induced HepaRG hepatocyte model of steatosis when used at a concentration of 25 μM.{42456} Bezafibrate (10 mg/kg per day) reduces plasma VLDL and LDL mass and triglyceride and free fatty acid levels in a high-fructose plus lard diet-induced rat model of insulin resistance.{42937}
Brand:CaymanSKU:10009145 - 1 gAvailable on backorder
Bezafibrate is a non-selective agonist of peroxisome proliferator-activated receptors (PPARs; EC50s = 50, 60, and 20 μM for human PPARα, PPARγ, and PPARδ, respectively).{10670} It reduces triglyceride levels and the size of lipid droplets in an oleic acid-induced HepaRG hepatocyte model of steatosis when used at a concentration of 25 μM.{42456} Bezafibrate (10 mg/kg per day) reduces plasma VLDL and LDL mass and triglyceride and free fatty acid levels in a high-fructose plus lard diet-induced rat model of insulin resistance.{42937}
Brand:CaymanSKU:10009145 - 10 gAvailable on backorder
Bezafibrate is a non-selective agonist of peroxisome proliferator-activated receptors (PPARs; EC50s = 50, 60, and 20 μM for human PPARα, PPARγ, and PPARδ, respectively).{10670} It reduces triglyceride levels and the size of lipid droplets in an oleic acid-induced HepaRG hepatocyte model of steatosis when used at a concentration of 25 μM.{42456} Bezafibrate (10 mg/kg per day) reduces plasma VLDL and LDL mass and triglyceride and free fatty acid levels in a high-fructose plus lard diet-induced rat model of insulin resistance.{42937}
Brand:CaymanSKU:10009145 - 5 gAvailable on backorder
Bezafibrate is a non-selective agonist of peroxisome proliferator-activated receptors (PPARs; EC50s = 50, 60, and 20 μM for human PPARα, PPARγ, and PPARδ, respectively).{10670} It reduces triglyceride levels and the size of lipid droplets in an oleic acid-induced HepaRG hepatocyte model of steatosis when used at a concentration of 25 μM.{42456} Bezafibrate (10 mg/kg per day) reduces plasma VLDL and LDL mass and triglyceride and free fatty acid levels in a high-fructose plus lard diet-induced rat model of insulin resistance.{42937}
Brand:CaymanSKU:10009145 - 500 mgAvailable on backorder
Bezafibrate-d4 is intended for use as an internal standard for the quantification of bezafibrate (Item No. 10009145) by GC- or LC-MS. Bezafibrate is a non-selective agonist of peroxisome proliferator-activated receptors (PPARs; EC50s = 50, 60, and 20 μM for human PPARα, PPARγ, and PPARδ, respectively).{10670} It reduces triglyceride levels and the size of lipid droplets in an oleic acid-induced HepaRG hepatocyte model of steatosis when used at a concentration of 25 μM.{42456} Bezafibrate (10 mg/kg per day) reduces plasma VLDL and LDL mass and triglyceride and free fatty acid levels in a high-fructose plus lard diet-induced rat model of insulin resistance.{42937}
Brand:CaymanSKU:28526 - 1 mgAvailable on backorder
BFH772 is an inhibitor of VEGF receptor 2 (VEGFR2; IC50 = 0.0027 μM for the human receptor).{42999} It is selective for human VEGFR2 over mouse VEGFR2 and human VEGFR1 and VEGFR3 (IC50s = 1.5, 1.7, and 1.1 μM, respectively), as well as 40-fold selective over B-RAF, RET, and Tie2. BFH772 inhibits VEGF-induced proliferation of human umbilical vein endothelial cells (HUVECs; IC50 = <0.01 nM). It inhibits VEGF-induced increases in tissue weight and Tie2 levels in an angiogenesis chamber implant model in mice when administered at doses of 1 and 3 mg/kg per day. BFH772 (3 mg/kg per day) inhibits primary tumor and metastasis growth in a B16 melanoma mouse model.
Brand:CaymanSKU:21386 -Out of stock
BFH772 is an inhibitor of VEGF receptor 2 (VEGFR2; IC50 = 0.0027 μM for the human receptor).{42999} It is selective for human VEGFR2 over mouse VEGFR2 and human VEGFR1 and VEGFR3 (IC50s = 1.5, 1.7, and 1.1 μM, respectively), as well as 40-fold selective over B-RAF, RET, and Tie2. BFH772 inhibits VEGF-induced proliferation of human umbilical vein endothelial cells (HUVECs; IC50 = <0.01 nM). It inhibits VEGF-induced increases in tissue weight and Tie2 levels in an angiogenesis chamber implant model in mice when administered at doses of 1 and 3 mg/kg per day. BFH772 (3 mg/kg per day) inhibits primary tumor and metastasis growth in a B16 melanoma mouse model.
Brand:CaymanSKU:21386 -Out of stock
BFH772 is an inhibitor of VEGF receptor 2 (VEGFR2; IC50 = 0.0027 μM for the human receptor).{42999} It is selective for human VEGFR2 over mouse VEGFR2 and human VEGFR1 and VEGFR3 (IC50s = 1.5, 1.7, and 1.1 μM, respectively), as well as 40-fold selective over B-RAF, RET, and Tie2. BFH772 inhibits VEGF-induced proliferation of human umbilical vein endothelial cells (HUVECs; IC50 = <0.01 nM). It inhibits VEGF-induced increases in tissue weight and Tie2 levels in an angiogenesis chamber implant model in mice when administered at doses of 1 and 3 mg/kg per day. BFH772 (3 mg/kg per day) inhibits primary tumor and metastasis growth in a B16 melanoma mouse model.
Brand:CaymanSKU:21386 -Out of stock
BFH772 is an inhibitor of VEGF receptor 2 (VEGFR2; IC50 = 0.0027 μM for the human receptor).{42999} It is selective for human VEGFR2 over mouse VEGFR2 and human VEGFR1 and VEGFR3 (IC50s = 1.5, 1.7, and 1.1 μM, respectively), as well as 40-fold selective over B-RAF, RET, and Tie2. BFH772 inhibits VEGF-induced proliferation of human umbilical vein endothelial cells (HUVECs; IC50 = <0.01 nM). It inhibits VEGF-induced increases in tissue weight and Tie2 levels in an angiogenesis chamber implant model in mice when administered at doses of 1 and 3 mg/kg per day. BFH772 (3 mg/kg per day) inhibits primary tumor and metastasis growth in a B16 melanoma mouse model.
Brand:CaymanSKU:21386 -Out of stock
BG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50 = 289 nM). It inhibits HDAC1, HDAC2, and HDAC6 with greatly reduced potency (IC50s = 2, 2.2, and >20 µM, respectively).{27757} At concentrations up to 50 mg/kg, BG45 alone or in combination with bortezomib has been shown to dose-dependently inhibit tumor growth in a mouse model of multiple myeloma.{27757}
Brand:CaymanSKU:-Out of stock
BG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50 = 289 nM). It inhibits HDAC1, HDAC2, and HDAC6 with greatly reduced potency (IC50s = 2, 2.2, and >20 µM, respectively).{27757} At concentrations up to 50 mg/kg, BG45 alone or in combination with bortezomib has been shown to dose-dependently inhibit tumor growth in a mouse model of multiple myeloma.{27757}
Brand:CaymanSKU:-Out of stock
BG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50 = 289 nM). It inhibits HDAC1, HDAC2, and HDAC6 with greatly reduced potency (IC50s = 2, 2.2, and >20 µM, respectively).{27757} At concentrations up to 50 mg/kg, BG45 alone or in combination with bortezomib has been shown to dose-dependently inhibit tumor growth in a mouse model of multiple myeloma.{27757}
Brand:CaymanSKU:-Out of stock
BG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50 = 289 nM). It inhibits HDAC1, HDAC2, and HDAC6 with greatly reduced potency (IC50s = 2, 2.2, and >20 µM, respectively).{27757} At concentrations up to 50 mg/kg, BG45 alone or in combination with bortezomib has been shown to dose-dependently inhibit tumor growth in a mouse model of multiple myeloma.{27757}
Brand:CaymanSKU:-Out of stock
BGC 20-1531 is a potent and selective antagonist of the prostaglandin E2 (PGE2; Item No. 14010) receptor subtype 4 (EP4) with Ki values of 11.7, >10,000, and >10,000 nM for EP4, EP2, and EP3, respectively.{17141} It is selective for EP4, exhibiting 2-induced cAMP accumulation in a dose-dependent manner in HEK293 EBNA cells that stably express human EP4 receptors. It also reverses PGE2-induced vasorelaxation (Kb = 15.85 nM) in human middle cerebral and middle meningeal arterial rings. BGC 20-1531 prevents PGE2-induced increases in carotid blood flow and decreases in carotid resistance with an ID50 value of 5 mg/kg in dogs.
Brand:CaymanSKU:19742 -Available on backorder
BGC 20-1531 is a potent and selective antagonist of the prostaglandin E2 (PGE2; Item No. 14010) receptor subtype 4 (EP4) with Ki values of 11.7, >10,000, and >10,000 nM for EP4, EP2, and EP3, respectively.{17141} It is selective for EP4, exhibiting 2-induced cAMP accumulation in a dose-dependent manner in HEK293 EBNA cells that stably express human EP4 receptors. It also reverses PGE2-induced vasorelaxation (Kb = 15.85 nM) in human middle cerebral and middle meningeal arterial rings. BGC 20-1531 prevents PGE2-induced increases in carotid blood flow and decreases in carotid resistance with an ID50 value of 5 mg/kg in dogs.
Brand:CaymanSKU:19742 -Available on backorder
BGC 20-1531 is a potent and selective antagonist of the prostaglandin E2 (PGE2; Item No. 14010) receptor subtype 4 (EP4) with Ki values of 11.7, >10,000, and >10,000 nM for EP4, EP2, and EP3, respectively.{17141} It is selective for EP4, exhibiting 2-induced cAMP accumulation in a dose-dependent manner in HEK293 EBNA cells that stably express human EP4 receptors. It also reverses PGE2-induced vasorelaxation (Kb = 15.85 nM) in human middle cerebral and middle meningeal arterial rings. BGC 20-1531 prevents PGE2-induced increases in carotid blood flow and decreases in carotid resistance with an ID50 value of 5 mg/kg in dogs.
Brand:CaymanSKU:19742 -Available on backorder
BGC 20-1531 is a potent and selective antagonist of the prostaglandin E2 (PGE2; Item No. 14010) receptor subtype 4 (EP4) with Ki values of 11.7, >10,000, and >10,000 nM for EP4, EP2, and EP3, respectively.{17141} It is selective for EP4, exhibiting 2-induced cAMP accumulation in a dose-dependent manner in HEK293 EBNA cells that stably express human EP4 receptors. It also reverses PGE2-induced vasorelaxation (Kb = 15.85 nM) in human middle cerebral and middle meningeal arterial rings. BGC 20-1531 prevents PGE2-induced increases in carotid blood flow and decreases in carotid resistance with an ID50 value of 5 mg/kg in dogs.
Brand:CaymanSKU:19742 -Available on backorder
BGJ398 is an orally available inhibitor of human FGFRs (IC50s = 0.9, 1.4, and 1 nM for FGFR1, FGFR2, and FGFR3, respectively).{31102,30600} It inhibits FGFR4 and VEGFR2 with IC50 values of 60 and 180 nM, respectively, and displays comparatively little activity towards Abl, Fyn, Kit, Lck, Lyn, and Yes (IC50s = 0.3-2.5 µM).{31102} BGJ398 has been shown to suppress proliferation of cancer cells with wild-type FGFR3 overexpression (IC50s = 5, 30, 32, and 15 nM, for RT112, RT4, SW780, and JMSU1 cells, respectively).{31102} In an RT112 bladder cancer xenograft mouse model overexpressing wild-type FGFR3, BGJ398 inhibited tumor growth after oral administration of 10-30 mg/kg.{31102}
Brand:CaymanSKU:-Available on backorder
BGJ398 is an orally available inhibitor of human FGFRs (IC50s = 0.9, 1.4, and 1 nM for FGFR1, FGFR2, and FGFR3, respectively).{31102,30600} It inhibits FGFR4 and VEGFR2 with IC50 values of 60 and 180 nM, respectively, and displays comparatively little activity towards Abl, Fyn, Kit, Lck, Lyn, and Yes (IC50s = 0.3-2.5 µM).{31102} BGJ398 has been shown to suppress proliferation of cancer cells with wild-type FGFR3 overexpression (IC50s = 5, 30, 32, and 15 nM, for RT112, RT4, SW780, and JMSU1 cells, respectively).{31102} In an RT112 bladder cancer xenograft mouse model overexpressing wild-type FGFR3, BGJ398 inhibited tumor growth after oral administration of 10-30 mg/kg.{31102}
Brand:CaymanSKU:-Available on backorder
BGJ398 is an orally available inhibitor of human FGFRs (IC50s = 0.9, 1.4, and 1 nM for FGFR1, FGFR2, and FGFR3, respectively).{31102,30600} It inhibits FGFR4 and VEGFR2 with IC50 values of 60 and 180 nM, respectively, and displays comparatively little activity towards Abl, Fyn, Kit, Lck, Lyn, and Yes (IC50s = 0.3-2.5 µM).{31102} BGJ398 has been shown to suppress proliferation of cancer cells with wild-type FGFR3 overexpression (IC50s = 5, 30, 32, and 15 nM, for RT112, RT4, SW780, and JMSU1 cells, respectively).{31102} In an RT112 bladder cancer xenograft mouse model overexpressing wild-type FGFR3, BGJ398 inhibited tumor growth after oral administration of 10-30 mg/kg.{31102}
Brand:CaymanSKU:-Available on backorder