Chemicals
Showing 11101–11250 of 41137 results
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Beauveriolide I is a cyclodepsipeptide that has been found in Beauveria and an inhibitor of lipid droplet formation.{57337} It inhibits lipid droplet formation when used at concentrations of 3 and 10 µM, as well as inhibits cholesterol synthesis (IC50 = 0.78 µM), in primary mouse peritoneal macrophages.{57337,11643} Beauveriolide I also inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity in mouse macrophage membranes (IC50 = 6 µM).{11643}
Brand:CaymanSKU:31774 - 1 mgAvailable on backorder
Beauveriolide I is a cyclodepsipeptide that has been found in Beauveria and an inhibitor of lipid droplet formation.{57337} It inhibits lipid droplet formation when used at concentrations of 3 and 10 µM, as well as inhibits cholesterol synthesis (IC50 = 0.78 µM), in primary mouse peritoneal macrophages.{57337,11643} Beauveriolide I also inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity in mouse macrophage membranes (IC50 = 6 µM).{11643}
Brand:CaymanSKU:31774 - 250 µgAvailable on backorder
Beauveriolide III is a cyclodepsipeptide that has been found in Beauveria and an inhibitor of lipid droplet formation.{57337} It inhibits lipid droplet formation when used at concentrations of 3 and 10 µM, as well as inhibits cholesterol synthesis (IC50 = 0.41 µM), in primary mouse peritoneal macrophages.{57337,11643} Beauveriolide III also inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity in mouse macrophage membranes (IC50 = 5.5 µM).{11643} Beauveriolide III (25 and 50 mg/kg) reduces the size of aortic atherosclerotic lesions in Ldlr-/- and ApoE-/- mouse models of atherosclerosis.
Brand:CaymanSKU:31775 - 2.5 mgAvailable on backorder
Beauveriolide III is a cyclodepsipeptide that has been found in Beauveria and an inhibitor of lipid droplet formation.{57337} It inhibits lipid droplet formation when used at concentrations of 3 and 10 µM, as well as inhibits cholesterol synthesis (IC50 = 0.41 µM), in primary mouse peritoneal macrophages.{57337,11643} Beauveriolide III also inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity in mouse macrophage membranes (IC50 = 5.5 µM).{11643} Beauveriolide III (25 and 50 mg/kg) reduces the size of aortic atherosclerotic lesions in Ldlr-/- and ApoE-/- mouse models of atherosclerosis.
Brand:CaymanSKU:31775 - 500 µgAvailable on backorder
BEC is a potent slow-binding competitive inhibitor of recombinant rat liver arginase I with Ki values of 0.4 and 0.6 µM from kinetic analyses.{13099} It is also a potent inhibitor of human arginase II with Ki values of 310 and 30 nM at pH 7.5 and 9.5, respectively.{13124} It does not inhibit murine iNOS at concentrations up to 1 mM. BEC significantly enhances nitric oxide-dependent relaxation of human penile corpus cavernosum smooth muscle in vitro when used at concentrations ranging from 0.1 to 1 mM.{13099}
Brand:CaymanSKU:10170 - 1 mgAvailable on backorder
BEC is a potent slow-binding competitive inhibitor of recombinant rat liver arginase I with Ki values of 0.4 and 0.6 µM from kinetic analyses.{13099} It is also a potent inhibitor of human arginase II with Ki values of 310 and 30 nM at pH 7.5 and 9.5, respectively.{13124} It does not inhibit murine iNOS at concentrations up to 1 mM. BEC significantly enhances nitric oxide-dependent relaxation of human penile corpus cavernosum smooth muscle in vitro when used at concentrations ranging from 0.1 to 1 mM.{13099}
Brand:CaymanSKU:10170 - 10 mgAvailable on backorder
BEC is a potent slow-binding competitive inhibitor of recombinant rat liver arginase I with Ki values of 0.4 and 0.6 µM from kinetic analyses.{13099} It is also a potent inhibitor of human arginase II with Ki values of 310 and 30 nM at pH 7.5 and 9.5, respectively.{13124} It does not inhibit murine iNOS at concentrations up to 1 mM. BEC significantly enhances nitric oxide-dependent relaxation of human penile corpus cavernosum smooth muscle in vitro when used at concentrations ranging from 0.1 to 1 mM.{13099}
Brand:CaymanSKU:10170 - 25 mgAvailable on backorder
BEC is a potent slow-binding competitive inhibitor of recombinant rat liver arginase I with Ki values of 0.4 and 0.6 µM from kinetic analyses.{13099} It is also a potent inhibitor of human arginase II with Ki values of 310 and 30 nM at pH 7.5 and 9.5, respectively.{13124} It does not inhibit murine iNOS at concentrations up to 1 mM. BEC significantly enhances nitric oxide-dependent relaxation of human penile corpus cavernosum smooth muscle in vitro when used at concentrations ranging from 0.1 to 1 mM.{13099}
Brand:CaymanSKU:10170 - 5 mgAvailable on backorder
BEC is a potent slow-binding competitive inhibitor of recombinant rat liver arginase I with Ki values of 0.4 and 0.6 µM from kinetic analyses.{13099} It is also a potent inhibitor of human arginase II with Ki values of 310 and 30 nM at pH 7.5 and 9.5, respectively.{13124} It does not inhibit murine iNOS at concentrations up to 1 mM. BEC significantly enhances nitric oxide-dependent relaxation of human penile corpus cavernosum smooth muscle in vitro when used at concentrations ranging from 0.1 to 1 mM.{13099}
Brand:CaymanSKU:22145 -Out of stock
BEC is a potent slow-binding competitive inhibitor of recombinant rat liver arginase I with Ki values of 0.4 and 0.6 µM from kinetic analyses.{13099} It is also a potent inhibitor of human arginase II with Ki values of 310 and 30 nM at pH 7.5 and 9.5, respectively.{13124} It does not inhibit murine iNOS at concentrations up to 1 mM. BEC significantly enhances nitric oxide-dependent relaxation of human penile corpus cavernosum smooth muscle in vitro when used at concentrations ranging from 0.1 to 1 mM.{13099}
Brand:CaymanSKU:22145 -Out of stock
BEC is a potent slow-binding competitive inhibitor of recombinant rat liver arginase I with Ki values of 0.4 and 0.6 µM from kinetic analyses.{13099} It is also a potent inhibitor of human arginase II with Ki values of 310 and 30 nM at pH 7.5 and 9.5, respectively.{13124} It does not inhibit murine iNOS at concentrations up to 1 mM. BEC significantly enhances nitric oxide-dependent relaxation of human penile corpus cavernosum smooth muscle in vitro when used at concentrations ranging from 0.1 to 1 mM.{13099}
Brand:CaymanSKU:22145 -Out of stock
BEC is a potent slow-binding competitive inhibitor of recombinant rat liver arginase I with Ki values of 0.4 and 0.6 µM from kinetic analyses.{13099} It is also a potent inhibitor of human arginase II with Ki values of 310 and 30 nM at pH 7.5 and 9.5, respectively.{13124} It does not inhibit murine iNOS at concentrations up to 1 mM. BEC significantly enhances nitric oxide-dependent relaxation of human penile corpus cavernosum smooth muscle in vitro when used at concentrations ranging from 0.1 to 1 mM.{13099}
Brand:CaymanSKU:22145 -Out of stock
Becatecarin is a water-soluble, diethylaminoethyl analog of the antineoplastic antibiotic rebeccamycin.{25394} It intercalates into DNA, stabilizing the DNA-topoisomerase complex.{25390} This results in the potent catalytic inhibition of both topoisomerases I and II, initiating DNA cleavage and apoptosis.{25390} Becatecarin, alone or in combination with other compounds, has anti-cancer as well as myelosuppressive effects in vivo.{25391,25392} It is also a transport substrate of the ATP-binding cassette (ABC) transporter ABCG2.{25393}
Brand:CaymanSKU:- Becatecarin is a water-soluble, diethylaminoethyl analog of the antineoplastic antibiotic rebeccamycin.{25394} It intercalates into DNA, stabilizing the DNA-topoisomerase complex.{25390} This results in the potent catalytic inhibition of both topoisomerases I and II, initiating DNA cleavage and apoptosis.{25390} Becatecarin, alone or in combination with other compounds, has anti-cancer as well as myelosuppressive effects in vivo.{25391,25392} It is also a transport substrate of the ATP-binding cassette (ABC) transporter ABCG2.{25393}
Brand:CaymanSKU:-
Begacestat is an inhibitor of γ-secretase that inhibits cleavage of amyloid precursor protein (APP) to amyloid-β (1-40) (Aβ40; Item No. 21617) in vitro (IC50 = 15 nM).{35876} It is 14-fold selective for γ-secretase over Notch-1. Begacestat (5 mg/kg) reduces brain levels of Aβ40 and Aβ42 (Item No. 20574) in the Tg2576 transgenic mouse model of Alzheimer’s disease. It also increases contextual fear conditioning freezing time, indicating reversal of contextual memory deficits, in Tg2576 mice in a dose-dependent manner.{48451}
Brand:CaymanSKU:27916 - 1 mgAvailable on backorder
Begacestat is an inhibitor of γ-secretase that inhibits cleavage of amyloid precursor protein (APP) to amyloid-β (1-40) (Aβ40; Item No. 21617) in vitro (IC50 = 15 nM).{35876} It is 14-fold selective for γ-secretase over Notch-1. Begacestat (5 mg/kg) reduces brain levels of Aβ40 and Aβ42 (Item No. 20574) in the Tg2576 transgenic mouse model of Alzheimer’s disease. It also increases contextual fear conditioning freezing time, indicating reversal of contextual memory deficits, in Tg2576 mice in a dose-dependent manner.{48451}
Brand:CaymanSKU:27916 - 5 mgAvailable on backorder
Belizatinib is an inhibitor of anaplastic lymphoma kinase (ALK) and tropomyosin-related kinases A/B/C (IC50s = 0.7 and <3 nM, respectively).{47633}
Brand:CaymanSKU:28458 - 1 mgAvailable on backorder
Belizatinib is an inhibitor of anaplastic lymphoma kinase (ALK) and tropomyosin-related kinases A/B/C (IC50s = 0.7 and <3 nM, respectively).{47633}
Brand:CaymanSKU:28458 - 10 mgAvailable on backorder
Belizatinib is an inhibitor of anaplastic lymphoma kinase (ALK) and tropomyosin-related kinases A/B/C (IC50s = 0.7 and <3 nM, respectively).{47633}
Brand:CaymanSKU:28458 - 25 mgAvailable on backorder
Belizatinib is an inhibitor of anaplastic lymphoma kinase (ALK) and tropomyosin-related kinases A/B/C (IC50s = 0.7 and <3 nM, respectively).{47633}
Brand:CaymanSKU:28458 - 5 mgAvailable on backorder
Belvarafenib is an inhibitor of B-RAF and C-RAF (IC50s = 41, 7, and 2 nM for wild-type B-RAF, B-RAFV600E, and wild-type C-RAF, respectively).{61044} It is cytotoxic to B-RAFV600E-expressing A375 and SK-MEL-28 melanoma cells (IC50s = 57 and 69 nM, respectively), as well as COLO 205 and HCT116 colon and B-CPAP and CAL-62 thyroid cancer cells (IC50s = 116, 65, 43, and 479 nM, respectively). Belvarafenib reduces tumor growth in A375, SK-MEL-28, SK-MEL-2, and SK-MEL-30 mouse xenograft models.
Brand:CaymanSKU:31460 - 1 mgAvailable on backorder
Belvarafenib is an inhibitor of B-RAF and C-RAF (IC50s = 41, 7, and 2 nM for wild-type B-RAF, B-RAFV600E, and wild-type C-RAF, respectively).{61044} It is cytotoxic to B-RAFV600E-expressing A375 and SK-MEL-28 melanoma cells (IC50s = 57 and 69 nM, respectively), as well as COLO 205 and HCT116 colon and B-CPAP and CAL-62 thyroid cancer cells (IC50s = 116, 65, 43, and 479 nM, respectively). Belvarafenib reduces tumor growth in A375, SK-MEL-28, SK-MEL-2, and SK-MEL-30 mouse xenograft models.
Brand:CaymanSKU:31460 - 10 mgAvailable on backorder
Belvarafenib is an inhibitor of B-RAF and C-RAF (IC50s = 41, 7, and 2 nM for wild-type B-RAF, B-RAFV600E, and wild-type C-RAF, respectively).{61044} It is cytotoxic to B-RAFV600E-expressing A375 and SK-MEL-28 melanoma cells (IC50s = 57 and 69 nM, respectively), as well as COLO 205 and HCT116 colon and B-CPAP and CAL-62 thyroid cancer cells (IC50s = 116, 65, 43, and 479 nM, respectively). Belvarafenib reduces tumor growth in A375, SK-MEL-28, SK-MEL-2, and SK-MEL-30 mouse xenograft models.
Brand:CaymanSKU:31460 - 25 mgAvailable on backorder
Belvarafenib is an inhibitor of B-RAF and C-RAF (IC50s = 41, 7, and 2 nM for wild-type B-RAF, B-RAFV600E, and wild-type C-RAF, respectively).{61044} It is cytotoxic to B-RAFV600E-expressing A375 and SK-MEL-28 melanoma cells (IC50s = 57 and 69 nM, respectively), as well as COLO 205 and HCT116 colon and B-CPAP and CAL-62 thyroid cancer cells (IC50s = 116, 65, 43, and 479 nM, respectively). Belvarafenib reduces tumor growth in A375, SK-MEL-28, SK-MEL-2, and SK-MEL-30 mouse xenograft models.
Brand:CaymanSKU:31460 - 5 mgAvailable on backorder
Benazepril is a prodrug of the angiotensin converting enzyme (ACE) inhibitor benazeprilat (Item No. 21796).{38021} It is metabolized to benazeprilat by hepatic esterases. Benazepril inhibits the in vitro enzymatic activity of partially purified ACE isolated from rabbit lung (IC50 = 2 nM).{26178} It decreases the triglyceride and total cholesterol levels in normotensive rats when administered at a dose of 30 mg/kg and decreases aortic atherosclerosis in cholesterol-fed rabbits when administered at a dose of 3 mg/kg per day.{41556} Benazepril (0.1-10 mg/kg per day) reduces blood pressure in spontaneously hypertensive rats.{41557} It also decreases proteinuria in cats with chronic kidney disease when administered at doses ranging from 0.5 to 1 mg/kg per day.{41558} Formulations containing benazepril have been used to treat hypertension, congestive heart failure, and chronic kidney disease in both human and veterinary medicine.
Brand:CaymanSKU:23804 - 1 gAvailable on backorder
Benazepril is a prodrug of the angiotensin converting enzyme (ACE) inhibitor benazeprilat (Item No. 21796).{38021} It is metabolized to benazeprilat by hepatic esterases. Benazepril inhibits the in vitro enzymatic activity of partially purified ACE isolated from rabbit lung (IC50 = 2 nM).{26178} It decreases the triglyceride and total cholesterol levels in normotensive rats when administered at a dose of 30 mg/kg and decreases aortic atherosclerosis in cholesterol-fed rabbits when administered at a dose of 3 mg/kg per day.{41556} Benazepril (0.1-10 mg/kg per day) reduces blood pressure in spontaneously hypertensive rats.{41557} It also decreases proteinuria in cats with chronic kidney disease when administered at doses ranging from 0.5 to 1 mg/kg per day.{41558} Formulations containing benazepril have been used to treat hypertension, congestive heart failure, and chronic kidney disease in both human and veterinary medicine.
Brand:CaymanSKU:23804 - 100 mgAvailable on backorder
Benazepril is a prodrug of the angiotensin converting enzyme (ACE) inhibitor benazeprilat (Item No. 21796).{38021} It is metabolized to benazeprilat by hepatic esterases. Benazepril inhibits the in vitro enzymatic activity of partially purified ACE isolated from rabbit lung (IC50 = 2 nM).{26178} It decreases the triglyceride and total cholesterol levels in normotensive rats when administered at a dose of 30 mg/kg and decreases aortic atherosclerosis in cholesterol-fed rabbits when administered at a dose of 3 mg/kg per day.{41556} Benazepril (0.1-10 mg/kg per day) reduces blood pressure in spontaneously hypertensive rats.{41557} It also decreases proteinuria in cats with chronic kidney disease when administered at doses ranging from 0.5 to 1 mg/kg per day.{41558} Formulations containing benazepril have been used to treat hypertension, congestive heart failure, and chronic kidney disease in both human and veterinary medicine.
Brand:CaymanSKU:23804 - 50 mgAvailable on backorder
Benazepril is a prodrug of the angiotensin converting enzyme (ACE) inhibitor benazeprilat (Item No. 21796).{38021} It is metabolized to benazeprilat by hepatic esterases. Benazepril inhibits the in vitro enzymatic activity of partially purified ACE isolated from rabbit lung (IC50 = 2 nM).{26178} It decreases the triglyceride and total cholesterol levels in normotensive rats when administered at a dose of 30 mg/kg and decreases aortic atherosclerosis in cholesterol-fed rabbits when administered at a dose of 3 mg/kg per day.{41556} Benazepril (0.1-10 mg/kg per day) reduces blood pressure in spontaneously hypertensive rats.{41557} It also decreases proteinuria in cats with chronic kidney disease when administered at doses ranging from 0.5 to 1 mg/kg per day.{41558} Formulations containing benazepril have been used to treat hypertension, congestive heart failure, and chronic kidney disease in both human and veterinary medicine.
Brand:CaymanSKU:23804 - 500 mgAvailable on backorder
Benazepril-d5 is intended for use as an internal standard for the quantification of benazepril (Item No. 23804). Benazepril is a prodrug of the angiotensin converting enzyme (ACE) inhibitor benazeprilat (Item No. 21796).{38021} It is metabolized to benazeprilat by hepatic esterases. Benazepril inhibits the in vitro enzymatic activity of partially purified ACE isolated from rabbit lung (IC50 = 2 nM).{26178} It decreases the triglyceride and total cholesterol levels in normotensive rats when administered at a dose of 30 mg/kg and decreases aortic atherosclerosis in cholesterol-fed rabbits when administered at a dose of 3 mg/kg per day.{41556} Benazepril (0.1-10 mg/kg per day) reduces blood pressure in spontaneously hypertensive rats.{41557} It also decreases proteinuria in cats with chronic kidney disease when administered at doses ranging from 0.5 to 1 mg/kg per day.{41558} Formulations containing benazepril have been used to treat hypertension, congestive heart failure, and chronic kidney disease in both human and veterinary medicine.
Brand:CaymanSKU:30978 - 1 mgAvailable on backorder
Benazeprilat is an inhibitor of angiotensin-converting enzyme (ACE; IC50 = 0.28 nM in plasma from dog) and the active metabolite of the prodrug benazepril.{38021} Benazeprilat is produced in the liver following cleavage of the ester group from benazepril. Formulations containing the prodrug benazepril have been used to treat hypertension in human and veterinary medicine.
Brand:CaymanSKU:21796 -Out of stock
Benazeprilat is an inhibitor of angiotensin-converting enzyme (ACE; IC50 = 0.28 nM in plasma from dog) and the active metabolite of the prodrug benazepril.{38021} Benazeprilat is produced in the liver following cleavage of the ester group from benazepril. Formulations containing the prodrug benazepril have been used to treat hypertension in human and veterinary medicine.
Brand:CaymanSKU:21796 -Out of stock
Benazeprilat is an inhibitor of angiotensin-converting enzyme (ACE; IC50 = 0.28 nM in plasma from dog) and the active metabolite of the prodrug benazepril.{38021} Benazeprilat is produced in the liver following cleavage of the ester group from benazepril. Formulations containing the prodrug benazepril have been used to treat hypertension in human and veterinary medicine.
Brand:CaymanSKU:21796 -Out of stock
Bendamustine is a purine analog and DNA alkylating agent.{41416} It inhibits growth of SKW-3, Reh, CML-T1, BV-173, and HL-60 leukemia cell lines (IC50s = 27.0, 28.6, 15.6, 20.8, and 57.7 μM, respectively) but not MCF-7 and MDA-MB-231 breast cancer cell lines (IC50s = >200 and >200 μM, respectively).{41417} It kills B cell-chronic lymphocytic leukemia (B-CLL) cells derived from naïve and bendamustine-pretreated patients (LD50s = 6.8-8.3 and 3.8-4.9 mg/ml, respectively).{41418} Bendamustine (50 mg/kg) inhibits tumor growth by 9% and 96% alone and in combination with ofatumumab, respectively, in a JVM-3 CLL mouse xenograft model.{41419} It activates the DNA-damage stress response, the base excision DNA repair pathway, and apoptosis, as well as inhibits mitotic checkpoints and induces mitotic catastrophe.{41416} Formulations containing bendamustine have been used to treat CLL and non-Hodgkin lymphoma.
Brand:CaymanSKU:23693 - 100 mgAvailable on backorder
Bendamustine is a purine analog and DNA alkylating agent.{41416} It inhibits growth of SKW-3, Reh, CML-T1, BV-173, and HL-60 leukemia cell lines (IC50s = 27.0, 28.6, 15.6, 20.8, and 57.7 μM, respectively) but not MCF-7 and MDA-MB-231 breast cancer cell lines (IC50s = >200 and >200 μM, respectively).{41417} It kills B cell-chronic lymphocytic leukemia (B-CLL) cells derived from naïve and bendamustine-pretreated patients (LD50s = 6.8-8.3 and 3.8-4.9 mg/ml, respectively).{41418} Bendamustine (50 mg/kg) inhibits tumor growth by 9% and 96% alone and in combination with ofatumumab, respectively, in a JVM-3 CLL mouse xenograft model.{41419} It activates the DNA-damage stress response, the base excision DNA repair pathway, and apoptosis, as well as inhibits mitotic checkpoints and induces mitotic catastrophe.{41416} Formulations containing bendamustine have been used to treat CLL and non-Hodgkin lymphoma.
Brand:CaymanSKU:23693 - 25 mgAvailable on backorder
Bendamustine is a purine analog and DNA alkylating agent.{41416} It inhibits growth of SKW-3, Reh, CML-T1, BV-173, and HL-60 leukemia cell lines (IC50s = 27.0, 28.6, 15.6, 20.8, and 57.7 μM, respectively) but not MCF-7 and MDA-MB-231 breast cancer cell lines (IC50s = >200 and >200 μM, respectively).{41417} It kills B cell-chronic lymphocytic leukemia (B-CLL) cells derived from naïve and bendamustine-pretreated patients (LD50s = 6.8-8.3 and 3.8-4.9 mg/ml, respectively).{41418} Bendamustine (50 mg/kg) inhibits tumor growth by 9% and 96% alone and in combination with ofatumumab, respectively, in a JVM-3 CLL mouse xenograft model.{41419} It activates the DNA-damage stress response, the base excision DNA repair pathway, and apoptosis, as well as inhibits mitotic checkpoints and induces mitotic catastrophe.{41416} Formulations containing bendamustine have been used to treat CLL and non-Hodgkin lymphoma.
Brand:CaymanSKU:23693 - 250 mgAvailable on backorder
Bendamustine is a purine analog and DNA alkylating agent.{41416} It inhibits growth of SKW-3, Reh, CML-T1, BV-173, and HL-60 leukemia cell lines (IC50s = 27.0, 28.6, 15.6, 20.8, and 57.7 μM, respectively) but not MCF-7 and MDA-MB-231 breast cancer cell lines (IC50s = >200 and >200 μM, respectively).{41417} It kills B cell-chronic lymphocytic leukemia (B-CLL) cells derived from naïve and bendamustine-pretreated patients (LD50s = 6.8-8.3 and 3.8-4.9 mg/ml, respectively).{41418} Bendamustine (50 mg/kg) inhibits tumor growth by 9% and 96% alone and in combination with ofatumumab, respectively, in a JVM-3 CLL mouse xenograft model.{41419} It activates the DNA-damage stress response, the base excision DNA repair pathway, and apoptosis, as well as inhibits mitotic checkpoints and induces mitotic catastrophe.{41416} Formulations containing bendamustine have been used to treat CLL and non-Hodgkin lymphoma.
Brand:CaymanSKU:23693 - 50 mgAvailable on backorder
Bendiocarb is a broad-spectrum carbamate insecticide and an inhibitor of acetylcholinesterase (Ki = 111 nM for the human enzyme).{39790} It is active against several species, including second stage nymph German cockroaches (B. germanica; IC50 = 2) and adult yellow fever mosquitoes (A. aegypti; IC50 = 2).{39791} It is toxic to mammalian species with an oral LD50 value of 45 mg/kg for male rats and female mice, but it is metabolized and excreted rapidly and has a dermal LD50 of 800 mg/kg after a 24-hour exposure. Formulations containing bendiocarb have been used in the indoor control of insects, including for mosquitoes in areas with malaria transmission.
Brand:CaymanSKU:24133 - 100 mgAvailable on backorder
Bendroflumethiazide (Item No. 21311) is an analytical reference standard categorized as a diuretic.{33145,33146} Diuretics, including bendroflumethiazide, have been abused as performance-enhancing drugs and masking agents in sports doping.{33139} This product is intended for research and forensic applications.
Brand:CaymanSKU:21311 -Out of stock
Bendroflumethiazide (Item No. 21311) is an analytical reference standard categorized as a diuretic.{33145,33146} Diuretics, including bendroflumethiazide, have been abused as performance-enhancing drugs and masking agents in sports doping.{33139} This product is intended for research and forensic applications.
Brand:CaymanSKU:21311 -Out of stock
Benfotiamine is a lipid-soluble form of vitamin B1 (thiamine).{37093} In vitro, it corrects defective replication of, and prevents formation of advanced glycosylation end products (AGEs) in, human umbilical vein endothelial cells (HUVECs) grown under high glucose conditions.{37094} In vivo, administration of benfotiamine increases nerve conduction velocity (NCV) and prevents microalbuminuria, proteinuria, and formation of AGEs in mice with streptozotocin-induced diabetes.{37093,37095} Benfotiamine reduces liver levels of aspartate and alanine aminotransferases, markers of hepatic damage, and lipid peroxidation in a rat model of acute ethanol intoxication.{37096} Administration of benfotiamine reduces the number of amyloid plaques and amount of phosphorylated tau in a transgenic mouse model of Alzheimer’s disease.{37097} It also improves spatial memory performance in the Morris water maze.
Brand:CaymanSKU:22192 -Out of stock
Benfotiamine is a lipid-soluble form of vitamin B1 (thiamine).{37093} In vitro, it corrects defective replication of, and prevents formation of advanced glycosylation end products (AGEs) in, human umbilical vein endothelial cells (HUVECs) grown under high glucose conditions.{37094} In vivo, administration of benfotiamine increases nerve conduction velocity (NCV) and prevents microalbuminuria, proteinuria, and formation of AGEs in mice with streptozotocin-induced diabetes.{37093,37095} Benfotiamine reduces liver levels of aspartate and alanine aminotransferases, markers of hepatic damage, and lipid peroxidation in a rat model of acute ethanol intoxication.{37096} Administration of benfotiamine reduces the number of amyloid plaques and amount of phosphorylated tau in a transgenic mouse model of Alzheimer’s disease.{37097} It also improves spatial memory performance in the Morris water maze.
Brand:CaymanSKU:22192 -Out of stock
Benfotiamine is a lipid-soluble form of vitamin B1 (thiamine).{37093} In vitro, it corrects defective replication of, and prevents formation of advanced glycosylation end products (AGEs) in, human umbilical vein endothelial cells (HUVECs) grown under high glucose conditions.{37094} In vivo, administration of benfotiamine increases nerve conduction velocity (NCV) and prevents microalbuminuria, proteinuria, and formation of AGEs in mice with streptozotocin-induced diabetes.{37093,37095} Benfotiamine reduces liver levels of aspartate and alanine aminotransferases, markers of hepatic damage, and lipid peroxidation in a rat model of acute ethanol intoxication.{37096} Administration of benfotiamine reduces the number of amyloid plaques and amount of phosphorylated tau in a transgenic mouse model of Alzheimer’s disease.{37097} It also improves spatial memory performance in the Morris water maze.
Brand:CaymanSKU:22192 -Out of stock
Benidipine is an orally bioavailable blocker of L-, T-, and N-type calcium channels.{34214} In guinea pig ventricular cells benidipine has an IC50 of 2.7 nM for calcium currents, determined using whole cell voltage clamp electrophysiology.{34216} It prevents oxidative stress dose-dependently in vitro, decreases blood pressure in spontaneously hypertensive rats (at 3 and 10 mg/kg), and is neuroprotective for neural stem cells after oxidative stress-induced injury.{34213,34215,34211} Benidipine is also a competitive antagonist at mineralocorticoid receptors.{34214}
Brand:CaymanSKU:21607 -Out of stock
Benidipine is an orally bioavailable blocker of L-, T-, and N-type calcium channels.{34214} In guinea pig ventricular cells benidipine has an IC50 of 2.7 nM for calcium currents, determined using whole cell voltage clamp electrophysiology.{34216} It prevents oxidative stress dose-dependently in vitro, decreases blood pressure in spontaneously hypertensive rats (at 3 and 10 mg/kg), and is neuroprotective for neural stem cells after oxidative stress-induced injury.{34213,34215,34211} Benidipine is also a competitive antagonist at mineralocorticoid receptors.{34214}
Brand:CaymanSKU:21607 -Out of stock
Benidipine is an orally bioavailable blocker of L-, T-, and N-type calcium channels.{34214} In guinea pig ventricular cells benidipine has an IC50 of 2.7 nM for calcium currents, determined using whole cell voltage clamp electrophysiology.{34216} It prevents oxidative stress dose-dependently in vitro, decreases blood pressure in spontaneously hypertensive rats (at 3 and 10 mg/kg), and is neuroprotective for neural stem cells after oxidative stress-induced injury.{34213,34215,34211} Benidipine is also a competitive antagonist at mineralocorticoid receptors.{34214}
Brand:CaymanSKU:21607 -Out of stock
Benidipine is an orally bioavailable blocker of L-, T-, and N-type calcium channels.{34214} In guinea pig ventricular cells benidipine has an IC50 of 2.7 nM for calcium currents, determined using whole cell voltage clamp electrophysiology.{34216} It prevents oxidative stress dose-dependently in vitro, decreases blood pressure in spontaneously hypertensive rats (at 3 and 10 mg/kg), and is neuroprotective for neural stem cells after oxidative stress-induced injury.{34213,34215,34211} Benidipine is also a competitive antagonist at mineralocorticoid receptors.{34214}
Brand:CaymanSKU:21607 -Out of stock
Benzocyclidine (BCP) is a derivative of phencyclidine with a benzothiophenyl group instead of a phenyl ring. It acts as a potent and selective dopamine reuptake inhibitor (IC50 = 8 nM) with negligible affinity for the NMDA receptor-linked phencyclidine receptor (K0.5 = 6 μM).{22336,22337} BCP has been used to label the dopamine transporter in the mouse brain.{22338} This product is intended for forensic and research applications.
Brand:CaymanSKU:11737 - 10 mgAvailable on backorder
Benzocyclidine (BCP) is a derivative of phencyclidine with a benzothiophenyl group instead of a phenyl ring. It acts as a potent and selective dopamine reuptake inhibitor (IC50 = 8 nM) with negligible affinity for the NMDA receptor-linked phencyclidine receptor (K0.5 = 6 μM).{22336,22337} BCP has been used to label the dopamine transporter in the mouse brain.{22338} This product is intended for forensic and research applications.
Brand:CaymanSKU:11737 - 5 mgAvailable on backorder
Benzocyclidine (BCP) is a derivative of phencyclidine with a benzothiophenyl group instead of a phenyl ring. It acts as a potent and selective dopamine reuptake inhibitor (IC50 = 8 nM) with negligible affinity for the NMDA receptor-linked phencyclidine receptor (K0.5 = 6 μM).{22336,22337} BCP has been used to label the dopamine transporter in the mouse brain.{22338} This product is intended for forensic and research applications.
Brand:CaymanSKU:11737 - 50 mgAvailable on backorder
Benserazide is an inhibitor of aromatic L-amino acid decarboxylase (AADC), an enzyme that has dopamine decarboxylase activity.{32006,32007} It is also unable to cross the blood-brain barrier. As a result, benserazide blocks the conversion of L-DOPA (Item No. 13248) to dopamine by AADC in the peripheral circulatory system. Benserazide is often combined with L-DOPA in patients with Parkinson’s disease.{32008}
Brand:CaymanSKU:20298 -Available on backorder
Benserazide is an inhibitor of aromatic L-amino acid decarboxylase (AADC), an enzyme that has dopamine decarboxylase activity.{32006,32007} It is also unable to cross the blood-brain barrier. As a result, benserazide blocks the conversion of L-DOPA (Item No. 13248) to dopamine by AADC in the peripheral circulatory system. Benserazide is often combined with L-DOPA in patients with Parkinson’s disease.{32008}
Brand:CaymanSKU:20298 -Available on backorder
Benserazide is an inhibitor of aromatic L-amino acid decarboxylase (AADC), an enzyme that has dopamine decarboxylase activity.{32006,32007} It is also unable to cross the blood-brain barrier. As a result, benserazide blocks the conversion of L-DOPA (Item No. 13248) to dopamine by AADC in the peripheral circulatory system. Benserazide is often combined with L-DOPA in patients with Parkinson’s disease.{32008}
Brand:CaymanSKU:20298 -Available on backorder
Benserazide is an inhibitor of aromatic L-amino acid decarboxylase (AADC), an enzyme that has dopamine decarboxylase activity.{32006,32007} It is also unable to cross the blood-brain barrier. As a result, benserazide blocks the conversion of L-DOPA (Item No. 13248) to dopamine by AADC in the peripheral circulatory system. Benserazide is often combined with L-DOPA in patients with Parkinson’s disease.{32008}
Brand:CaymanSKU:20298 -Available on backorder
Bentamapimod is an orally bioavailable inhibitor of Jun kinases (JNKs), with IC50 values for JNK1, JNK2, and JNK3 of 80, 90, and 230 nM, respectively.{33921,33920} It is selective for JNKs over a panel of 25 related kinases.{33921} Bentamapimod induces regression of endometriotic lesions without suppressing estrogen action in animal models of endometriosis.{33922,33924} It blocks proliferation and induces apoptosis of T cells in vitro and inhibits cancer stem cell survival, self-renewal, and tumor-initiating capacity in vitro and in mice.{33920,33923}
Brand:CaymanSKU:21482 -Out of stock
Bentamapimod is an orally bioavailable inhibitor of Jun kinases (JNKs), with IC50 values for JNK1, JNK2, and JNK3 of 80, 90, and 230 nM, respectively.{33921,33920} It is selective for JNKs over a panel of 25 related kinases.{33921} Bentamapimod induces regression of endometriotic lesions without suppressing estrogen action in animal models of endometriosis.{33922,33924} It blocks proliferation and induces apoptosis of T cells in vitro and inhibits cancer stem cell survival, self-renewal, and tumor-initiating capacity in vitro and in mice.{33920,33923}
Brand:CaymanSKU:21482 -Out of stock
Bentamapimod is an orally bioavailable inhibitor of Jun kinases (JNKs), with IC50 values for JNK1, JNK2, and JNK3 of 80, 90, and 230 nM, respectively.{33921,33920} It is selective for JNKs over a panel of 25 related kinases.{33921} Bentamapimod induces regression of endometriotic lesions without suppressing estrogen action in animal models of endometriosis.{33922,33924} It blocks proliferation and induces apoptosis of T cells in vitro and inhibits cancer stem cell survival, self-renewal, and tumor-initiating capacity in vitro and in mice.{33920,33923}
Brand:CaymanSKU:21482 -Out of stock
Bentamapimod is an orally bioavailable inhibitor of Jun kinases (JNKs), with IC50 values for JNK1, JNK2, and JNK3 of 80, 90, and 230 nM, respectively.{33921,33920} It is selective for JNKs over a panel of 25 related kinases.{33921} Bentamapimod induces regression of endometriotic lesions without suppressing estrogen action in animal models of endometriosis.{33922,33924} It blocks proliferation and induces apoptosis of T cells in vitro and inhibits cancer stem cell survival, self-renewal, and tumor-initiating capacity in vitro and in mice.{33920,33923}
Brand:CaymanSKU:21482 -Out of stock
Bentazepam (Item No. 27748) is an analytical reference standard categorized as a benzodiazepine.{46401} This product is intended for research and forensic applications.
Brand:CaymanSKU:27748 - 1 mgAvailable on backorder
Bentazepam (Item No. 27748) is an analytical reference standard categorized as a benzodiazepine.{46401} This product is intended for research and forensic applications.
Brand:CaymanSKU:27748 - 5 mgAvailable on backorder
Benzamidine is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Kis = 35, 350, and 220 µM, respectively).{33232,33233,33235} In addition to its use as a general serine protease inhibitor, benzamidine is used, when immobilized, to purify novel proteases.{33234,33236}
Brand:CaymanSKU:20651 -Available on backorder
Benzamidine is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Kis = 35, 350, and 220 µM, respectively).{33232,33233,33235} In addition to its use as a general serine protease inhibitor, benzamidine is used, when immobilized, to purify novel proteases.{33234,33236}
Brand:CaymanSKU:20651 -Available on backorder
Benzamidine is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Kis = 35, 350, and 220 µM, respectively).{33232,33233,33235} In addition to its use as a general serine protease inhibitor, benzamidine is used, when immobilized, to purify novel proteases.{33234,33236}
Brand:CaymanSKU:20651 -Available on backorder
Benzamidine is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Kis = 35, 350, and 220 µM, respectively).{33232,33233,33235} In addition to its use as a general serine protease inhibitor, benzamidine is used, when immobilized, to purify novel proteases.{33234,33236}
Brand:CaymanSKU:20651 -Available on backorder
Benzamil is a derivative of amiloride (Item No. 14409).{48507} Benzamil is an epithelial sodium channel (ENaC) blocker that inhibits sodium transport from (IC50 = 4 nM) and binds to (Kd = 5 nM) bovine kidney cortex membrane vesicles. It is also an inhibitor of the Na+/Ca2+ exchanger (NCX) that inhibits the cytosolic calcium response to extracellular sodium depletion in mouse podocytes (IC50 = ~100 nM).{48508} Benzamil inhibits transient receptor potential polycystin-L (TRPP3; IC50 = 1.1 μM), a member of the TRP superfamily of cation channels.{24798}
Brand:CaymanSKU:- Benzamil is a derivative of amiloride (Item No. 14409).{48507} Benzamil is an epithelial sodium channel (ENaC) blocker that inhibits sodium transport from (IC50 = 4 nM) and binds to (Kd = 5 nM) bovine kidney cortex membrane vesicles. It is also an inhibitor of the Na+/Ca2+ exchanger (NCX) that inhibits the cytosolic calcium response to extracellular sodium depletion in mouse podocytes (IC50 = ~100 nM).{48508} Benzamil inhibits transient receptor potential polycystin-L (TRPP3; IC50 = 1.1 μM), a member of the TRP superfamily of cation channels.{24798}
Brand:CaymanSKU:-
Benzbromarone is an inhibitor of the urate anion transporter (IC50 = 0.3 µM for hURAT1) that prevents renal urate resorption.{31716} It also potently inhibits CYP2C9 (Ki = 20 nM), a major cytochrome P450 enzyme involved in the metabolic clearance of a wide range of therapeutic agents.{24422} Several analogs of benzabromarone have been developed with varying binding affinities to CYP2C9 in order to study adverse drug-drug interactions.{24411}
Brand:CaymanSKU:19768 -Available on backorder
Benzbromarone is an inhibitor of the urate anion transporter (IC50 = 0.3 µM for hURAT1) that prevents renal urate resorption.{31716} It also potently inhibits CYP2C9 (Ki = 20 nM), a major cytochrome P450 enzyme involved in the metabolic clearance of a wide range of therapeutic agents.{24422} Several analogs of benzabromarone have been developed with varying binding affinities to CYP2C9 in order to study adverse drug-drug interactions.{24411}
Brand:CaymanSKU:19768 -Available on backorder
Benzbromarone is an inhibitor of the urate anion transporter (IC50 = 0.3 µM for hURAT1) that prevents renal urate resorption.{31716} It also potently inhibits CYP2C9 (Ki = 20 nM), a major cytochrome P450 enzyme involved in the metabolic clearance of a wide range of therapeutic agents.{24422} Several analogs of benzabromarone have been developed with varying binding affinities to CYP2C9 in order to study adverse drug-drug interactions.{24411}
Brand:CaymanSKU:19768 -Available on backorder
4-Methylmethcathinone (also known as Mephedrone) is a stimulatory designer drug found in bath salts and similar products.{19193,19508,20369} Benzedrone is an analog of mephedrone characterized by the replacement of the amino methyl group with a benzyl moiety. The physiological and toxicological properties of this compound are unknown. This product is intended for forensic and research applications.
Brand:CaymanSKU:11915 - 10 mgAvailable on backorder
4-Methylmethcathinone (also known as Mephedrone) is a stimulatory designer drug found in bath salts and similar products.{19193,19508,20369} Benzedrone is an analog of mephedrone characterized by the replacement of the amino methyl group with a benzyl moiety. The physiological and toxicological properties of this compound are unknown. This product is intended for forensic and research applications.
Brand:CaymanSKU:11915 - 5 mgAvailable on backorder
4-Methylmethcathinone (also known as Mephedrone) is a stimulatory designer drug found in bath salts and similar products.{19193,19508,20369} Benzedrone is an analog of mephedrone characterized by the replacement of the amino methyl group with a benzyl moiety. The physiological and toxicological properties of this compound are unknown. This product is intended for forensic and research applications.
Brand:CaymanSKU:11915 - 50 mgAvailable on backorder
Benzisoxazole Hsp90 inhibitor is an inhibitor of heat shock protein 90 (Hsp90; IC50 = 30 nM in a fluorescence polarization assay).{15810} It is selective for Hsp90 over a panel of kinases (IC50s = >20 µM). Benzisoxazole Hsp90 inhibitor inhibits the proliferation of HCT116, SK-BR-3, LNCaP, DU145, and H157 cancer cells (IC50s = 0.28, 0.37, 0.17, 0.29, and 0.23 µM, respectively). It also induces degradation of the Hsp90 targets HER2 and the androgen receptor in SK-BR-3 and LNCaP cells, respectively, with an IC50 value of 0.33 µM for both.
Brand:CaymanSKU:10012694 - 1 mgAvailable on backorder
Benzisoxazole Hsp90 inhibitor is an inhibitor of heat shock protein 90 (Hsp90; IC50 = 30 nM in a fluorescence polarization assay).{15810} It is selective for Hsp90 over a panel of kinases (IC50s = >20 µM). Benzisoxazole Hsp90 inhibitor inhibits the proliferation of HCT116, SK-BR-3, LNCaP, DU145, and H157 cancer cells (IC50s = 0.28, 0.37, 0.17, 0.29, and 0.23 µM, respectively). It also induces degradation of the Hsp90 targets HER2 and the androgen receptor in SK-BR-3 and LNCaP cells, respectively, with an IC50 value of 0.33 µM for both.
Brand:CaymanSKU:10012694 - 10 mgAvailable on backorder
Benzisoxazole Hsp90 inhibitor is an inhibitor of heat shock protein 90 (Hsp90; IC50 = 30 nM in a fluorescence polarization assay).{15810} It is selective for Hsp90 over a panel of kinases (IC50s = >20 µM). Benzisoxazole Hsp90 inhibitor inhibits the proliferation of HCT116, SK-BR-3, LNCaP, DU145, and H157 cancer cells (IC50s = 0.28, 0.37, 0.17, 0.29, and 0.23 µM, respectively). It also induces degradation of the Hsp90 targets HER2 and the androgen receptor in SK-BR-3 and LNCaP cells, respectively, with an IC50 value of 0.33 µM for both.
Brand:CaymanSKU:10012694 - 5 mgAvailable on backorder
Benznidazole is an orally bioavailable antiprotozoal agent.{48626} It is a 2-nitroimidazole prodrug that becomes active when the nitro group is reduced within the parasite.{48630} It inhibits the growth of the parasites T. cruzi, T. vaginalis, G. lamblia, and E. histolytica (IC50s = 8.1, 18.62, 22.58, and 4.27 μM, respectively).{48627,48628} It also inhibits clonogenic growth of human C33A cervical and KNS42 glioblastoma cancer cells under hypoxic, but not normoxic, conditions when used at a concentration of 100 μM.{48629} Benznidazole (100 mg/kg per day) decreases T. cruzi blood parasitemia to below detectable levels in a mouse model of chronic stable Chagas disease.{48626} Formulations containing benznidazole have been used in the treatment of Chagas disease caused by T. cruzi.
Brand:CaymanSKU:29090 - 100 mgAvailable on backorder
Benznidazole is an orally bioavailable antiprotozoal agent.{48626} It is a 2-nitroimidazole prodrug that becomes active when the nitro group is reduced within the parasite.{48630} It inhibits the growth of the parasites T. cruzi, T. vaginalis, G. lamblia, and E. histolytica (IC50s = 8.1, 18.62, 22.58, and 4.27 μM, respectively).{48627,48628} It also inhibits clonogenic growth of human C33A cervical and KNS42 glioblastoma cancer cells under hypoxic, but not normoxic, conditions when used at a concentration of 100 μM.{48629} Benznidazole (100 mg/kg per day) decreases T. cruzi blood parasitemia to below detectable levels in a mouse model of chronic stable Chagas disease.{48626} Formulations containing benznidazole have been used in the treatment of Chagas disease caused by T. cruzi.
Brand:CaymanSKU:29090 - 25 mgAvailable on backorder
Benznidazole is an orally bioavailable antiprotozoal agent.{48626} It is a 2-nitroimidazole prodrug that becomes active when the nitro group is reduced within the parasite.{48630} It inhibits the growth of the parasites T. cruzi, T. vaginalis, G. lamblia, and E. histolytica (IC50s = 8.1, 18.62, 22.58, and 4.27 μM, respectively).{48627,48628} It also inhibits clonogenic growth of human C33A cervical and KNS42 glioblastoma cancer cells under hypoxic, but not normoxic, conditions when used at a concentration of 100 μM.{48629} Benznidazole (100 mg/kg per day) decreases T. cruzi blood parasitemia to below detectable levels in a mouse model of chronic stable Chagas disease.{48626} Formulations containing benznidazole have been used in the treatment of Chagas disease caused by T. cruzi.
Brand:CaymanSKU:29090 - 250 mgAvailable on backorder
Benznidazole is an orally bioavailable antiprotozoal agent.{48626} It is a 2-nitroimidazole prodrug that becomes active when the nitro group is reduced within the parasite.{48630} It inhibits the growth of the parasites T. cruzi, T. vaginalis, G. lamblia, and E. histolytica (IC50s = 8.1, 18.62, 22.58, and 4.27 μM, respectively).{48627,48628} It also inhibits clonogenic growth of human C33A cervical and KNS42 glioblastoma cancer cells under hypoxic, but not normoxic, conditions when used at a concentration of 100 μM.{48629} Benznidazole (100 mg/kg per day) decreases T. cruzi blood parasitemia to below detectable levels in a mouse model of chronic stable Chagas disease.{48626} Formulations containing benznidazole have been used in the treatment of Chagas disease caused by T. cruzi.
Brand:CaymanSKU:29090 - 50 mgAvailable on backorder
Benzocaine (Item No. 20132) is an analytical reference standard that is categorized as an adulterant. It is commonly used as a topical anesthetic.{31800} Benzocaine is also found as an adulterant in cocaine (Item Nos. 16186 | ISO60176).{31797,31798,31799,31801} This product is intended for research and forensic applications.
Brand:CaymanSKU:20132 -Available on backorder
Benzocaine (Item No. 20132) is an analytical reference standard that is categorized as an adulterant. It is commonly used as a topical anesthetic.{31800} Benzocaine is also found as an adulterant in cocaine (Item Nos. 16186 | ISO60176).{31797,31798,31799,31801} This product is intended for research and forensic applications.
Brand:CaymanSKU:20132 -Available on backorder
Benzomalvin A is a fungal metabolite produced by Penicillium.{43022,38039} It inhibits yeast α-glucosidase in vitro (IC50 = 383.2 μM).{43022} In vivo, benzomalvin A (3.1-31.6 mg/kg) decreases plasma glucose levels in mice following administration of sucrose. It also decreases the plasma glucose postprandial peak in nicotinamide-streptozotocin-induced hyperglycemic mice when administered at a dose of 10 mg/kg. Benzomalvin A also acts as an antagonist of neurokinin-1 (NK1) receptors, inhibiting binding of substance P (Item No. 24035) to guinea pig, rat, and human NK1 (Kis = 12, 42, and 43 μM, respectively).{38039}
Brand:CaymanSKU:25016 - 1 mgAvailable on backorder