Chemicals
Showing 9601–9750 of 41137 results
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Apigenin-d5 is an internal standard for the quantificaiton of apigenin (Item No. 10010275) by GC- or LC-MS. Apigenin is a flavonoid compound found in many fruits and vegetables that selectively inhibits casein kinase 2 (CK2). Apigenin inhibits CK2 activity in the renal cortex with an IC50 value of 30 µM to improve renal function in a rat model of glomerulonephritis.{15364} CK2 inhibition by 20 µM apigenin decreases the degradation of IκBα and down-regulates NF-κB levels in WEHI-231 cells.{15361} Apigenin, at 5 µM, is a potent inhibitor of the synthesis of the inflammatory mediators nitric oxide and prostaglandin E2, reducing inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression by 56% and 64%, respectively, in the macrophage cell line J774A.1.{15362}
Brand:CaymanSKU:22106 -Out of stock
Apigeninidin is a natural 3-deoxyanthocyanidin that can be isolated from leaves of sorghum.{33556} The synthesis of apigeninidin is increased, particularly in leaves of S. bicolor, after wounding or pathogen invasion, resulting in purple coloration.{33554} Apigeninidin has antibiotic and antifungal properties.{33555,33557} It can be used to stain collagen fibers, muscles, and red blood cells in animal tissue sections.{33553}
Brand:CaymanSKU:19756 -Available on backorder
Apigeninidin is a natural 3-deoxyanthocyanidin that can be isolated from leaves of sorghum.{33556} The synthesis of apigeninidin is increased, particularly in leaves of S. bicolor, after wounding or pathogen invasion, resulting in purple coloration.{33554} Apigeninidin has antibiotic and antifungal properties.{33555,33557} It can be used to stain collagen fibers, muscles, and red blood cells in animal tissue sections.{33553}
Brand:CaymanSKU:19756 -Available on backorder
Apixaban is an orally bioavailable, selective inhibitor of both free and prothrombinase-bound factor Xa (Kis = 0.8 nM).{25094} In vivo, apixaban has antithrombotic effects in a rabbit model of venous thrombosis. Apixaban (357.5 mg) also prevents thrombus formation without inducing adverse bleeding events in a porcine model of aortic heterotopic valve replacement.{36697} Formulations containing apixaban have been used to prevent blood clot formation in patients with atrial fibrillation.
Brand:CaymanSKU:- Apixaban is an orally bioavailable, selective inhibitor of both free and prothrombinase-bound factor Xa (Kis = 0.8 nM).{25094} In vivo, apixaban has antithrombotic effects in a rabbit model of venous thrombosis. Apixaban (357.5 mg) also prevents thrombus formation without inducing adverse bleeding events in a porcine model of aortic heterotopic valve replacement.{36697} Formulations containing apixaban have been used to prevent blood clot formation in patients with atrial fibrillation.
Brand:CaymanSKU:- Apixaban is an orally bioavailable, selective inhibitor of both free and prothrombinase-bound factor Xa (Kis = 0.8 nM).{25094} In vivo, apixaban has antithrombotic effects in a rabbit model of venous thrombosis. Apixaban (357.5 mg) also prevents thrombus formation without inducing adverse bleeding events in a porcine model of aortic heterotopic valve replacement.{36697} Formulations containing apixaban have been used to prevent blood clot formation in patients with atrial fibrillation.
Brand:CaymanSKU:- Apixaban is an orally bioavailable, selective inhibitor of both free and prothrombinase-bound factor Xa (Kis = 0.8 nM).{25094} In vivo, apixaban has antithrombotic effects in a rabbit model of venous thrombosis. Apixaban (357.5 mg) also prevents thrombus formation without inducing adverse bleeding events in a porcine model of aortic heterotopic valve replacement.{36697} Formulations containing apixaban have been used to prevent blood clot formation in patients with atrial fibrillation.
Brand:CaymanSKU:-
Apixaban-13C-d3 is intended for use as an internal standard for the quantification of apixaban (Item No. 15427) by GC- or LC-MS. Apixaban is an orally bioavailable, selective inhibitor of both free and prothrombinase-bound factor Xa (Kis = 0.8 nM).{25094} In vivo, apixaban has antithrombotic effects in a rabbit model of venous thrombosis.
Brand:CaymanSKU:25034 - 1 mgAvailable on backorder
Apixaban-13C-d3 is intended for use as an internal standard for the quantification of apixaban (Item No. 15427) by GC- or LC-MS. Apixaban is an orally bioavailable, selective inhibitor of both free and prothrombinase-bound factor Xa (Kis = 0.8 nM).{25094} In vivo, apixaban has antithrombotic effects in a rabbit model of venous thrombosis.
Brand:CaymanSKU:25034 - 5 mgAvailable on backorder
Apixaban-13C-d3 is intended for use as an internal standard for the quantification of apixaban (Item No. 15427) by GC- or LC-MS. Apixaban is an orally bioavailable, selective inhibitor of both free and prothrombinase-bound factor Xa (Kis = 0.8 nM).{25094} In vivo, apixaban has antithrombotic effects in a rabbit model of venous thrombosis.
Brand:CaymanSKU:25034 - 500 µgAvailable on backorder
Apocynin is a compound isolated from the traditional medicinal plant P. kurroa and structurally related to vanillin that acts as an inhibitor of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity.{22116} Upon oxidation by myeloperoxidase, apocynin inhibits the assembly of a functional NADPH-oxidase complex that is responsible for reactive oxygen species production.{22114,22115} At 300 μM it is effective in preventing the production of superoxide in human white blood cells or neutrophilic granulocytes, but does not however obstruct the phagocytic or other defense roles of granulocytes.{22116,22114,22115,22117} Due to the selectivity of its inhibition, apocynin can be widely used as an inhibitor of NADPH oxidase without interfering in other aspects of the immune system. It has been used in the treatment of arthritis, bowel disease, asthma, atherosclerosis, and familial amyotrophic lateral sclerosis.{22116}
Brand:CaymanSKU:11976 - 1 gAvailable on backorder
Apocynin is a compound isolated from the traditional medicinal plant P. kurroa and structurally related to vanillin that acts as an inhibitor of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity.{22116} Upon oxidation by myeloperoxidase, apocynin inhibits the assembly of a functional NADPH-oxidase complex that is responsible for reactive oxygen species production.{22114,22115} At 300 μM it is effective in preventing the production of superoxide in human white blood cells or neutrophilic granulocytes, but does not however obstruct the phagocytic or other defense roles of granulocytes.{22116,22114,22115,22117} Due to the selectivity of its inhibition, apocynin can be widely used as an inhibitor of NADPH oxidase without interfering in other aspects of the immune system. It has been used in the treatment of arthritis, bowel disease, asthma, atherosclerosis, and familial amyotrophic lateral sclerosis.{22116}
Brand:CaymanSKU:11976 - 10 gAvailable on backorder
Apocynin is a compound isolated from the traditional medicinal plant P. kurroa and structurally related to vanillin that acts as an inhibitor of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity.{22116} Upon oxidation by myeloperoxidase, apocynin inhibits the assembly of a functional NADPH-oxidase complex that is responsible for reactive oxygen species production.{22114,22115} At 300 μM it is effective in preventing the production of superoxide in human white blood cells or neutrophilic granulocytes, but does not however obstruct the phagocytic or other defense roles of granulocytes.{22116,22114,22115,22117} Due to the selectivity of its inhibition, apocynin can be widely used as an inhibitor of NADPH oxidase without interfering in other aspects of the immune system. It has been used in the treatment of arthritis, bowel disease, asthma, atherosclerosis, and familial amyotrophic lateral sclerosis.{22116}
Brand:CaymanSKU:11976 - 5 gAvailable on backorder
Apoptolidin is an apoptosis inducer originally isolated from Nocardiopsis bacteria.{31038} It inhibits the mitochondrial F1FO ATPase (Ki = 4-5 µM).{31039,20629} Apoptolidin selectively kills transformed glial cells without significantly affecting untransformed cells.{20629} It also has antibiotic and antifungal actions.{31038,20629}
Brand:CaymanSKU:-Available on backorder
Apoptolidin is an apoptosis inducer originally isolated from Nocardiopsis bacteria.{31038} It inhibits the mitochondrial F1FO ATPase (Ki = 4-5 µM).{31039,20629} Apoptolidin selectively kills transformed glial cells without significantly affecting untransformed cells.{20629} It also has antibiotic and antifungal actions.{31038,20629}
Brand:CaymanSKU:-Available on backorder
Apoptosis activator 2 promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome, thus increasing procaspase-9 processing and subsequent caspase-3 activation.{11535} This compound has been shown to induce apoptosis in leukemia cells (IC50 = 4-9 μM) with weak or no effect on normal cell lines or those lacking Apaf-1, caspase-9, or caspase-3 activity (IC50s > 40 μM).{11535}
Brand:CaymanSKU:10004176 - 10 mgAvailable on backorder
Apoptosis activator 2 promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome, thus increasing procaspase-9 processing and subsequent caspase-3 activation.{11535} This compound has been shown to induce apoptosis in leukemia cells (IC50 = 4-9 μM) with weak or no effect on normal cell lines or those lacking Apaf-1, caspase-9, or caspase-3 activity (IC50s > 40 μM).{11535}
Brand:CaymanSKU:10004176 - 25 mgAvailable on backorder
Apoptosis activator 2 promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome, thus increasing procaspase-9 processing and subsequent caspase-3 activation.{11535} This compound has been shown to induce apoptosis in leukemia cells (IC50 = 4-9 μM) with weak or no effect on normal cell lines or those lacking Apaf-1, caspase-9, or caspase-3 activity (IC50s > 40 μM).{11535}
Brand:CaymanSKU:10004176 - 5 mgAvailable on backorder
Apoptosis activator 2 promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome, thus increasing procaspase-9 processing and subsequent caspase-3 activation.{11535} This compound has been shown to induce apoptosis in leukemia cells (IC50 = 4-9 μM) with weak or no effect on normal cell lines or those lacking Apaf-1, caspase-9, or caspase-3 activity (IC50s > 40 μM).{11535}
Brand:CaymanSKU:10004176 - 50 mgAvailable on backorder
Apoptozole is an inhibitor of heat shock protein 70 (Hsp70; 65% inhibition at 200 µM) that acts by blocking its ATPase activity.{28548} It does not act on Hsp40, Hsp60, or Hsp90. Apoptozole dose-dependently induces apoptosis in cancer cells (IC50 = 5-7 µM).{28548} It prevents the association of Hsp70 with apoptotic protease-activating factor 1 and triggers caspase activation in HeLa cells.{28548} Apoptozole (10 mg/kg, i.p.) prevents the growth of A549, RKO, and HeLa cell xenografts in mice without significant loss of body weight.{28545}
Brand:CaymanSKU:-Available on backorder
Apoptozole is an inhibitor of heat shock protein 70 (Hsp70; 65% inhibition at 200 µM) that acts by blocking its ATPase activity.{28548} It does not act on Hsp40, Hsp60, or Hsp90. Apoptozole dose-dependently induces apoptosis in cancer cells (IC50 = 5-7 µM).{28548} It prevents the association of Hsp70 with apoptotic protease-activating factor 1 and triggers caspase activation in HeLa cells.{28548} Apoptozole (10 mg/kg, i.p.) prevents the growth of A549, RKO, and HeLa cell xenografts in mice without significant loss of body weight.{28545}
Brand:CaymanSKU:-Available on backorder
Apoptozole is an inhibitor of heat shock protein 70 (Hsp70; 65% inhibition at 200 µM) that acts by blocking its ATPase activity.{28548} It does not act on Hsp40, Hsp60, or Hsp90. Apoptozole dose-dependently induces apoptosis in cancer cells (IC50 = 5-7 µM).{28548} It prevents the association of Hsp70 with apoptotic protease-activating factor 1 and triggers caspase activation in HeLa cells.{28548} Apoptozole (10 mg/kg, i.p.) prevents the growth of A549, RKO, and HeLa cell xenografts in mice without significant loss of body weight.{28545}
Brand:CaymanSKU:-Available on backorder
Apoptozole is an inhibitor of heat shock protein 70 (Hsp70; 65% inhibition at 200 µM) that acts by blocking its ATPase activity.{28548} It does not act on Hsp40, Hsp60, or Hsp90. Apoptozole dose-dependently induces apoptosis in cancer cells (IC50 = 5-7 µM).{28548} It prevents the association of Hsp70 with apoptotic protease-activating factor 1 and triggers caspase activation in HeLa cells.{28548} Apoptozole (10 mg/kg, i.p.) prevents the growth of A549, RKO, and HeLa cell xenografts in mice without significant loss of body weight.{28545}
Brand:CaymanSKU:-Available on backorder
Apraclonidine is an α2-adrenergic receptor (α2-AR) agonist and structural analog of clonidine (Item No. 15949).{40474} It binds to α2-ARs in calf cortex, rat kidney, and rat spleen with IC50 values of 0.9, 4.3, and 4.2 nM, respectively. Apraclonidine also binds to α2-ARs in rat cerebral cortex, pig submandibular gland and lung tissue, and in dog kidney membrane (Kds = 0.87, 5.28, 1.30, and 5.25 nM, respectively).{40475,40476} It inhibits noradrenaline-stimulated contraction in guinea pig ileum and rabbit vas deferens (EC50s = 7.59 and 6.76 nM, respectively).{40477} Opthalmic formulations containing apraclonidine have been used to treat elevated intraocular pressure.
Brand:CaymanSKU:23904 - 1 mgAvailable on backorder
Apraclonidine is an α2-adrenergic receptor (α2-AR) agonist and structural analog of clonidine (Item No. 15949).{40474} It binds to α2-ARs in calf cortex, rat kidney, and rat spleen with IC50 values of 0.9, 4.3, and 4.2 nM, respectively. Apraclonidine also binds to α2-ARs in rat cerebral cortex, pig submandibular gland and lung tissue, and in dog kidney membrane (Kds = 0.87, 5.28, 1.30, and 5.25 nM, respectively).{40475,40476} It inhibits noradrenaline-stimulated contraction in guinea pig ileum and rabbit vas deferens (EC50s = 7.59 and 6.76 nM, respectively).{40477} Opthalmic formulations containing apraclonidine have been used to treat elevated intraocular pressure.
Brand:CaymanSKU:23904 - 10 mgAvailable on backorder
Apraclonidine is an α2-adrenergic receptor (α2-AR) agonist and structural analog of clonidine (Item No. 15949).{40474} It binds to α2-ARs in calf cortex, rat kidney, and rat spleen with IC50 values of 0.9, 4.3, and 4.2 nM, respectively. Apraclonidine also binds to α2-ARs in rat cerebral cortex, pig submandibular gland and lung tissue, and in dog kidney membrane (Kds = 0.87, 5.28, 1.30, and 5.25 nM, respectively).{40475,40476} It inhibits noradrenaline-stimulated contraction in guinea pig ileum and rabbit vas deferens (EC50s = 7.59 and 6.76 nM, respectively).{40477} Opthalmic formulations containing apraclonidine have been used to treat elevated intraocular pressure.
Brand:CaymanSKU:23904 - 5 mgAvailable on backorder
Apramycin is an aminoglycoside antibiotic first isolated from S. tenebrarius.{32374} It is active against a variety of Gram-positive and Gram-negative bacteria, including strains which produce aminoglycoside-modifying enzymes.{32373} Apramycin inhibits protein synthesis in bacteria both in vivo and in vitro.{32374}
Brand:CaymanSKU:19688 -Available on backorder
Apramycin is an aminoglycoside antibiotic first isolated from S. tenebrarius.{32374} It is active against a variety of Gram-positive and Gram-negative bacteria, including strains which produce aminoglycoside-modifying enzymes.{32373} Apramycin inhibits protein synthesis in bacteria both in vivo and in vitro.{32374}
Brand:CaymanSKU:19688 -Available on backorder
Apramycin is an aminoglycoside antibiotic first isolated from S. tenebrarius.{32374} It is active against a variety of Gram-positive and Gram-negative bacteria, including strains which produce aminoglycoside-modifying enzymes.{32373} Apramycin inhibits protein synthesis in bacteria both in vivo and in vitro.{32374}
Brand:CaymanSKU:19688 -Available on backorder
Apremilast is an inhibitor of phosphodiesterase 4 (PDE4) with an IC50 value of 74 nM when tested in U937 cell lysates with 1 mM cAMP.{29958,29960} It is orally active, significantly decreasing epidermal thickness and epithelial cell proliferation index in a mouse model of psoriasis.{29960} Apremilast reduces both TNF-α and matrix metalloproteinase-3 production in gut lamina propria mononuclear cells from patients with inflammatory bowel disease.{29957} It also blocks spontaneous production of TNF-α from human rheumatoid synovial cells and improves clinical score in mouse models of arthritis.{29959}
Brand:CaymanSKU:-Available on backorder
Apremilast is an inhibitor of phosphodiesterase 4 (PDE4) with an IC50 value of 74 nM when tested in U937 cell lysates with 1 mM cAMP.{29958,29960} It is orally active, significantly decreasing epidermal thickness and epithelial cell proliferation index in a mouse model of psoriasis.{29960} Apremilast reduces both TNF-α and matrix metalloproteinase-3 production in gut lamina propria mononuclear cells from patients with inflammatory bowel disease.{29957} It also blocks spontaneous production of TNF-α from human rheumatoid synovial cells and improves clinical score in mouse models of arthritis.{29959}
Brand:CaymanSKU:-Available on backorder
Apremilast is an inhibitor of phosphodiesterase 4 (PDE4) with an IC50 value of 74 nM when tested in U937 cell lysates with 1 mM cAMP.{29958,29960} It is orally active, significantly decreasing epidermal thickness and epithelial cell proliferation index in a mouse model of psoriasis.{29960} Apremilast reduces both TNF-α and matrix metalloproteinase-3 production in gut lamina propria mononuclear cells from patients with inflammatory bowel disease.{29957} It also blocks spontaneous production of TNF-α from human rheumatoid synovial cells and improves clinical score in mouse models of arthritis.{29959}
Brand:CaymanSKU:-Available on backorder
Apremilast is an inhibitor of phosphodiesterase 4 (PDE4) with an IC50 value of 74 nM when tested in U937 cell lysates with 1 mM cAMP.{29958,29960} It is orally active, significantly decreasing epidermal thickness and epithelial cell proliferation index in a mouse model of psoriasis.{29960} Apremilast reduces both TNF-α and matrix metalloproteinase-3 production in gut lamina propria mononuclear cells from patients with inflammatory bowel disease.{29957} It also blocks spontaneous production of TNF-α from human rheumatoid synovial cells and improves clinical score in mouse models of arthritis.{29959}
Brand:CaymanSKU:-Available on backorder
Apremilast-d5 is intended for use as an internal standard for the quantification of apremilast (Item No. 18502) by GC- or LC-MS. Apremilast is an inhibitor of phosphodiesterase 4 (PDE4) with an IC50 value of 74 nM when tested in U937 cell lysates with 1 mM cAMP.{29958,29960} It is orally active, significantly decreasing epidermal thickness and the epithelial cell proliferation index in a mouse model of psoriasis.{29960} Apremilast reduces both TNF-α and matrix metalloproteinase-3 production in gut lamina propria mononuclear cells from patients with inflammatory bowel disease.{29957} It also blocks spontaneous production of TNF-α from human rheumatoid synovial cells and improves the clinical score in mouse models of arthritis.{29959}
Brand:CaymanSKU:22553 -Out of stock
Apremilast-d5 is intended for use as an internal standard for the quantification of apremilast (Item No. 18502) by GC- or LC-MS. Apremilast is an inhibitor of phosphodiesterase 4 (PDE4) with an IC50 value of 74 nM when tested in U937 cell lysates with 1 mM cAMP.{29958,29960} It is orally active, significantly decreasing epidermal thickness and the epithelial cell proliferation index in a mouse model of psoriasis.{29960} Apremilast reduces both TNF-α and matrix metalloproteinase-3 production in gut lamina propria mononuclear cells from patients with inflammatory bowel disease.{29957} It also blocks spontaneous production of TNF-α from human rheumatoid synovial cells and improves the clinical score in mouse models of arthritis.{29959}
Brand:CaymanSKU:22553 -Out of stock
Aprepitant an antiemetic and antagonist of the neurokinin-1 (NK1) receptor (Ki = 3 nM; IC50 = 0.09 nM for the human receptor).{24162,24160} It is selective for NK1 over NK3 receptors (Ki = 454.1 nM for human NK3).{24162} In vivo, aprepitant (1 mg/kg) prevents plasma extravasation into the esophagus of guinea pigs induced by substance P (Item No. 24035).{24161} It also reduces NK1-agonist-induced foot tapping in gerbils. Formulations containing aprepitant have been used to prevent chemotherapy-induced nausea and vomiting.
Brand:CaymanSKU:- Aprepitant an antiemetic and antagonist of the neurokinin-1 (NK1) receptor (Ki = 3 nM; IC50 = 0.09 nM for the human receptor).{24162,24160} It is selective for NK1 over NK3 receptors (Ki = 454.1 nM for human NK3).{24162} In vivo, aprepitant (1 mg/kg) prevents plasma extravasation into the esophagus of guinea pigs induced by substance P (Item No. 24035).{24161} It also reduces NK1-agonist-induced foot tapping in gerbils. Formulations containing aprepitant have been used to prevent chemotherapy-induced nausea and vomiting.
Brand:CaymanSKU:- Aprepitant an antiemetic and antagonist of the neurokinin-1 (NK1) receptor (Ki = 3 nM; IC50 = 0.09 nM for the human receptor).{24162,24160} It is selective for NK1 over NK3 receptors (Ki = 454.1 nM for human NK3).{24162} In vivo, aprepitant (1 mg/kg) prevents plasma extravasation into the esophagus of guinea pigs induced by substance P (Item No. 24035).{24161} It also reduces NK1-agonist-induced foot tapping in gerbils. Formulations containing aprepitant have been used to prevent chemotherapy-induced nausea and vomiting.
Brand:CaymanSKU:- Aprepitant an antiemetic and antagonist of the neurokinin-1 (NK1) receptor (Ki = 3 nM; IC50 = 0.09 nM for the human receptor).{24162,24160} It is selective for NK1 over NK3 receptors (Ki = 454.1 nM for human NK3).{24162} In vivo, aprepitant (1 mg/kg) prevents plasma extravasation into the esophagus of guinea pigs induced by substance P (Item No. 24035).{24161} It also reduces NK1-agonist-induced foot tapping in gerbils. Formulations containing aprepitant have been used to prevent chemotherapy-induced nausea and vomiting.
Brand:CaymanSKU:-
Aprepitant-d4 is intended for use as an internal standard for the quantification of aprepitant (Item No. 14867) by GC- or LC-MS. Aprepitant an antiemetic compound and antagonist of the neurokinin-1 (NK1) receptor (Ki = 3 nM; IC50 = 0.09 nM for the human receptor).{24162,24160} It is selective for NK1 over NK3 receptors (Ki = 454.1 nM for human NK3).{24162} In vivo, aprepitant (1 mg/kg) prevents plasma extravasation into the esophagus of guinea pigs induced by substance P (Item No. 24035).{24161} It also reduces NK1-agonist-induced foot tapping in gerbils. Formulations containing aprepitant have been used to prevent chemotherapy-induced nausea and vomiting.
Brand:CaymanSKU:25232 - 1 mgAvailable on backorder
Aprepitant-d4 is intended for use as an internal standard for the quantification of aprepitant (Item No. 14867) by GC- or LC-MS. Aprepitant an antiemetic compound and antagonist of the neurokinin-1 (NK1) receptor (Ki = 3 nM; IC50 = 0.09 nM for the human receptor).{24162,24160} It is selective for NK1 over NK3 receptors (Ki = 454.1 nM for human NK3).{24162} In vivo, aprepitant (1 mg/kg) prevents plasma extravasation into the esophagus of guinea pigs induced by substance P (Item No. 24035).{24161} It also reduces NK1-agonist-induced foot tapping in gerbils. Formulations containing aprepitant have been used to prevent chemotherapy-induced nausea and vomiting.
Brand:CaymanSKU:25232 - 500 µgAvailable on backorder
Aprotinin is a reversible inhibitor of serine proteases such as trypsin (Ki = 0.06 pM), chymotrypsin (Ki = 9.5 nM), and kallikrein (Ki = 0.8 nM).{23496} It is a much weaker inhibitor of thrombin (Ki = 0.1-0.8 mM) and trypsinogen (Ki = 2 µM).{23496} Aprotinin also competitively inhibits nNOS and iNOS with Ki values of 50 and 78 µM, respectively.{9516} Aprotinin is widely used as a protein purification tool to prevent proteases present in tissue samples from degrading the protein of interest.
Brand:CaymanSKU:- Aprotinin is a reversible inhibitor of serine proteases such as trypsin (Ki = 0.06 pM), chymotrypsin (Ki = 9.5 nM), and kallikrein (Ki = 0.8 nM).{23496} It is a much weaker inhibitor of thrombin (Ki = 0.1-0.8 mM) and trypsinogen (Ki = 2 µM).{23496} Aprotinin also competitively inhibits nNOS and iNOS with Ki values of 50 and 78 µM, respectively.{9516} Aprotinin is widely used as a protein purification tool to prevent proteases present in tissue samples from degrading the protein of interest.
Brand:CaymanSKU:- Aprotinin is a reversible inhibitor of serine proteases such as trypsin (Ki = 0.06 pM), chymotrypsin (Ki = 9.5 nM), and kallikrein (Ki = 0.8 nM).{23496} It is a much weaker inhibitor of thrombin (Ki = 0.1-0.8 mM) and trypsinogen (Ki = 2 µM).{23496} Aprotinin also competitively inhibits nNOS and iNOS with Ki values of 50 and 78 µM, respectively.{9516} Aprotinin is widely used as a protein purification tool to prevent proteases present in tissue samples from degrading the protein of interest.
Brand:CaymanSKU:- Aprotinin is a reversible inhibitor of serine proteases such as trypsin (Ki = 0.06 pM), chymotrypsin (Ki = 9.5 nM), and kallikrein (Ki = 0.8 nM).{23496} It is a much weaker inhibitor of thrombin (Ki = 0.1-0.8 mM) and trypsinogen (Ki = 2 µM).{23496} Aprotinin also competitively inhibits nNOS and iNOS with Ki values of 50 and 78 µM, respectively.{9516} Aprotinin is widely used as a protein purification tool to prevent proteases present in tissue samples from degrading the protein of interest.
Brand:CaymanSKU:-
APS-2-79 is an inhibitor of MAPK signaling dependent on kinase suppressor of Ras (KSR).{45098} It inhibits ATPbiotin binding to KSR2 in KSR2-MEK1 complexes (IC50 = 120 nM), stabilizes KSR2 in an inactive state, and reduces interactions between B-RAF and KSR2-MEK1 complexes.{45098,45099} APS-2-79 (5 μM) inhibits KSR-stimulated phosphorylation of MEK and ERK in HEK293H cells.{45098} It enhances the efficacy of the MEK inhibitor trametinib (Item No. 16292), further reducing cell viability in HCT116 and A549 cell lines containing K-Ras mutations, but not B-RAF mutant SK-MEL-239 and A375 cell lines, when used at a concentration of 1 μM.
Brand:CaymanSKU:22137 -Out of stock
APS-2-79 is an inhibitor of MAPK signaling dependent on kinase suppressor of Ras (KSR).{45098} It inhibits ATPbiotin binding to KSR2 in KSR2-MEK1 complexes (IC50 = 120 nM), stabilizes KSR2 in an inactive state, and reduces interactions between B-RAF and KSR2-MEK1 complexes.{45098,45099} APS-2-79 (5 μM) inhibits KSR-stimulated phosphorylation of MEK and ERK in HEK293H cells.{45098} It enhances the efficacy of the MEK inhibitor trametinib (Item No. 16292), further reducing cell viability in HCT116 and A549 cell lines containing K-Ras mutations, but not B-RAF mutant SK-MEL-239 and A375 cell lines, when used at a concentration of 1 μM.
Brand:CaymanSKU:22137 -Out of stock
APS-2-79 is an inhibitor of MAPK signaling dependent on kinase suppressor of Ras (KSR).{45098} It inhibits ATPbiotin binding to KSR2 in KSR2-MEK1 complexes (IC50 = 120 nM), stabilizes KSR2 in an inactive state, and reduces interactions between B-RAF and KSR2-MEK1 complexes.{45098,45099} APS-2-79 (5 μM) inhibits KSR-stimulated phosphorylation of MEK and ERK in HEK293H cells.{45098} It enhances the efficacy of the MEK inhibitor trametinib (Item No. 16292), further reducing cell viability in HCT116 and A549 cell lines containing K-Ras mutations, but not B-RAF mutant SK-MEL-239 and A375 cell lines, when used at a concentration of 1 μM.
Brand:CaymanSKU:22137 -Out of stock
APS-2-79 is an inhibitor of MAPK signaling dependent on kinase suppressor of Ras (KSR).{45098} It inhibits ATPbiotin binding to KSR2 in KSR2-MEK1 complexes (IC50 = 120 nM), stabilizes KSR2 in an inactive state, and reduces interactions between B-RAF and KSR2-MEK1 complexes.{45098,45099} APS-2-79 (5 μM) inhibits KSR-stimulated phosphorylation of MEK and ERK in HEK293H cells.{45098} It enhances the efficacy of the MEK inhibitor trametinib (Item No. 16292), further reducing cell viability in HCT116 and A549 cell lines containing K-Ras mutations, but not B-RAF mutant SK-MEL-239 and A375 cell lines, when used at a concentration of 1 μM.
Brand:CaymanSKU:22137 -Out of stock
APY-29 is a modulator of inositol requiring enzyme 1 α (IRE1α), which is a protein located in the endoplasmic reticulum (ER) membrane that has kinase and RNase activities triggered by ER stress.{36117} It binds to the ATP-binding site on IRE1α, where it inhibits its autophosphorylation (IC50 = 280 nM) and enhances its RNase function (EC50 = 460 nM). In vitro, it restores the ability of dephosphoylated IRE1α to cleave XBP1 mRNA in a dose-dependent manner. It also enhances IRE1α oligomerization in a crosslinking assay.
Brand:CaymanSKU:22913 - 10 mgAvailable on backorder
APY-29 is a modulator of inositol requiring enzyme 1 α (IRE1α), which is a protein located in the endoplasmic reticulum (ER) membrane that has kinase and RNase activities triggered by ER stress.{36117} It binds to the ATP-binding site on IRE1α, where it inhibits its autophosphorylation (IC50 = 280 nM) and enhances its RNase function (EC50 = 460 nM). In vitro, it restores the ability of dephosphoylated IRE1α to cleave XBP1 mRNA in a dose-dependent manner. It also enhances IRE1α oligomerization in a crosslinking assay.
Brand:CaymanSKU:22913 - 25 mgAvailable on backorder
APY-29 is a modulator of inositol requiring enzyme 1 α (IRE1α), which is a protein located in the endoplasmic reticulum (ER) membrane that has kinase and RNase activities triggered by ER stress.{36117} It binds to the ATP-binding site on IRE1α, where it inhibits its autophosphorylation (IC50 = 280 nM) and enhances its RNase function (EC50 = 460 nM). In vitro, it restores the ability of dephosphoylated IRE1α to cleave XBP1 mRNA in a dose-dependent manner. It also enhances IRE1α oligomerization in a crosslinking assay.
Brand:CaymanSKU:22913 - 5 mgAvailable on backorder
APY-29 is a modulator of inositol requiring enzyme 1 α (IRE1α), which is a protein located in the endoplasmic reticulum (ER) membrane that has kinase and RNase activities triggered by ER stress.{36117} It binds to the ATP-binding site on IRE1α, where it inhibits its autophosphorylation (IC50 = 280 nM) and enhances its RNase function (EC50 = 460 nM). In vitro, it restores the ability of dephosphoylated IRE1α to cleave XBP1 mRNA in a dose-dependent manner. It also enhances IRE1α oligomerization in a crosslinking assay.
Brand:CaymanSKU:22913 - 50 mgAvailable on backorder
APY0201 is an inhibitor of FYVE finger-containing phosphoinositide kinase (PIKFYVE; IC50 = 5.2 nM) that selectively inhibits interleukin-12 (IL-12) family inflammatory cytokine production (IC50s = 8, 99, and >10,000 nM for IL-12p70, IL-12p40, and TNF-α in stimulated human peripheral blood mononuclear cells (PBMCs)).{40423} It is selective for PIKFYVE over a panel of 137 G protein-coupled receptors, enzymes, ion channels, transporters, and other kinases only exhibiting >50% inhibition at lymphocyte-oriented kinase (LOK) and inositol-tetrakisphosphate 1 kinase (ITPK1) at a concentration of 300 nM. APY0201 inhibits Il-12p70 production ex vivo in murine plasma and reduces colonic inflammation in a mouse Il-10-/- cell transfer model of inflammatory bowel disease in a dose-dependent manner.
Brand:CaymanSKU:9001589 - 1 mgAvailable on backorder
APY0201 is an inhibitor of FYVE finger-containing phosphoinositide kinase (PIKFYVE; IC50 = 5.2 nM) that selectively inhibits interleukin-12 (IL-12) family inflammatory cytokine production (IC50s = 8, 99, and >10,000 nM for IL-12p70, IL-12p40, and TNF-α in stimulated human peripheral blood mononuclear cells (PBMCs)).{40423} It is selective for PIKFYVE over a panel of 137 G protein-coupled receptors, enzymes, ion channels, transporters, and other kinases only exhibiting >50% inhibition at lymphocyte-oriented kinase (LOK) and inositol-tetrakisphosphate 1 kinase (ITPK1) at a concentration of 300 nM. APY0201 inhibits Il-12p70 production ex vivo in murine plasma and reduces colonic inflammation in a mouse Il-10-/- cell transfer model of inflammatory bowel disease in a dose-dependent manner.
Brand:CaymanSKU:9001589 - 10 mgAvailable on backorder
APY0201 is an inhibitor of FYVE finger-containing phosphoinositide kinase (PIKFYVE; IC50 = 5.2 nM) that selectively inhibits interleukin-12 (IL-12) family inflammatory cytokine production (IC50s = 8, 99, and >10,000 nM for IL-12p70, IL-12p40, and TNF-α in stimulated human peripheral blood mononuclear cells (PBMCs)).{40423} It is selective for PIKFYVE over a panel of 137 G protein-coupled receptors, enzymes, ion channels, transporters, and other kinases only exhibiting >50% inhibition at lymphocyte-oriented kinase (LOK) and inositol-tetrakisphosphate 1 kinase (ITPK1) at a concentration of 300 nM. APY0201 inhibits Il-12p70 production ex vivo in murine plasma and reduces colonic inflammation in a mouse Il-10-/- cell transfer model of inflammatory bowel disease in a dose-dependent manner.
Brand:CaymanSKU:9001589 - 25 mgAvailable on backorder
APY0201 is an inhibitor of FYVE finger-containing phosphoinositide kinase (PIKFYVE; IC50 = 5.2 nM) that selectively inhibits interleukin-12 (IL-12) family inflammatory cytokine production (IC50s = 8, 99, and >10,000 nM for IL-12p70, IL-12p40, and TNF-α in stimulated human peripheral blood mononuclear cells (PBMCs)).{40423} It is selective for PIKFYVE over a panel of 137 G protein-coupled receptors, enzymes, ion channels, transporters, and other kinases only exhibiting >50% inhibition at lymphocyte-oriented kinase (LOK) and inositol-tetrakisphosphate 1 kinase (ITPK1) at a concentration of 300 nM. APY0201 inhibits Il-12p70 production ex vivo in murine plasma and reduces colonic inflammation in a mouse Il-10-/- cell transfer model of inflammatory bowel disease in a dose-dependent manner.
Brand:CaymanSKU:9001589 - 5 mgAvailable on backorder
AQC is a reactive probe for the pre-column derivatization of primary and secondary amines, including those found in amino acids, peptides, proteins, and polyamines.{53979,53980} It forms stable and highly fluorescent derivatives and has been used for chromatographic separation and analysis of derivatized amino acids and polyamines.{53979,53980,53981} AQC-derivatized polyamines display excitation/emission maxima of 248/398 nm, respectively.{53980}
Brand:CaymanSKU:30877 - 100 mgAvailable on backorder
AQC is a reactive probe for the pre-column derivatization of primary and secondary amines, including those found in amino acids, peptides, proteins, and polyamines.{53979,53980} It forms stable and highly fluorescent derivatives and has been used for chromatographic separation and analysis of derivatized amino acids and polyamines.{53979,53980,53981} AQC-derivatized polyamines display excitation/emission maxima of 248/398 nm, respectively.{53980}
Brand:CaymanSKU:30877 - 25 mgAvailable on backorder
AQC is a reactive probe for the pre-column derivatization of primary and secondary amines, including those found in amino acids, peptides, proteins, and polyamines.{53979,53980} It forms stable and highly fluorescent derivatives and has been used for chromatographic separation and analysis of derivatized amino acids and polyamines.{53979,53980,53981} AQC-derivatized polyamines display excitation/emission maxima of 248/398 nm, respectively.{53980}
Brand:CaymanSKU:30877 - 250 mgAvailable on backorder
AQC is a reactive probe for the pre-column derivatization of primary and secondary amines, including those found in amino acids, peptides, proteins, and polyamines.{53979,53980} It forms stable and highly fluorescent derivatives and has been used for chromatographic separation and analysis of derivatized amino acids and polyamines.{53979,53980,53981} AQC-derivatized polyamines display excitation/emission maxima of 248/398 nm, respectively.{53980}
Brand:CaymanSKU:30877 - 50 mgAvailable on backorder
AR-7 is a retinoic acid receptor α (RARα) antagonist.{45302} In mouse fibroblasts, AR-7 (20 μM) increases chaperone-mediated autophagy in an RARα-dependent manner, increases LAMP-2A expression, and inhibits paraquat-induced decreases in cell viability. AR-7 is also selectively cytotoxic to HepG2 cells grown under hypoxic over normoxic conditions (IC50s = 10 and >1,000 μM, respectively).{45303}
Brand:CaymanSKU:22946 - 1 mgAvailable on backorder
AR-7 is a retinoic acid receptor α (RARα) antagonist.{45302} In mouse fibroblasts, AR-7 (20 μM) increases chaperone-mediated autophagy in an RARα-dependent manner, increases LAMP-2A expression, and inhibits paraquat-induced decreases in cell viability. AR-7 is also selectively cytotoxic to HepG2 cells grown under hypoxic over normoxic conditions (IC50s = 10 and >1,000 μM, respectively).{45303}
Brand:CaymanSKU:22946 - 10 mgAvailable on backorder
AR-7 is a retinoic acid receptor α (RARα) antagonist.{45302} In mouse fibroblasts, AR-7 (20 μM) increases chaperone-mediated autophagy in an RARα-dependent manner, increases LAMP-2A expression, and inhibits paraquat-induced decreases in cell viability. AR-7 is also selectively cytotoxic to HepG2 cells grown under hypoxic over normoxic conditions (IC50s = 10 and >1,000 μM, respectively).{45303}
Brand:CaymanSKU:22946 - 25 mgAvailable on backorder
AR-7 is a retinoic acid receptor α (RARα) antagonist.{45302} In mouse fibroblasts, AR-7 (20 μM) increases chaperone-mediated autophagy in an RARα-dependent manner, increases LAMP-2A expression, and inhibits paraquat-induced decreases in cell viability. AR-7 is also selectively cytotoxic to HepG2 cells grown under hypoxic over normoxic conditions (IC50s = 10 and >1,000 μM, respectively).{45303}
Brand:CaymanSKU:22946 - 5 mgAvailable on backorder
AR-C 155858 is an inhibitor of monocarboxylate transporter 1 (MCT1) and MCT2 (Kis = 2.3 and Xenopus oocytes expressing the human receptors).{48632} It is selective for MCT1 and MCT2 over MCT4 (Ki = >10 μM). AR-C 155858 inhibits L-lactate uptake in and proliferation of murine 4T1 breast cancer cells (IC50s = 25 and 20.2 nM, respectively).{48633}
Brand:CaymanSKU:-
Free fatty acid receptor 3 (FFAR3; GPR41) is a G protein-coupled receptor activated by short chain fatty acids (SCFAs). It is expressed in adipose tissue, the gastrointestinal tract, and the peripheral nervous system, and it is involved in SCFA-dependent energy regulation.{28496} AR420626 is a selective agonist of FFAR3 (GPR41; IC50 = 117 nM) that does not activate the related receptor FFAR2 (GPR43) at concentrations up to 100 µM.{27420} At 10 µM, it can stimulate a 1.26-fold increased release of glucagon-like peptide-1 from colonic crypt cultures.{28497}
Brand:CaymanSKU:-Available on backorder
Free fatty acid receptor 3 (FFAR3; GPR41) is a G protein-coupled receptor activated by short chain fatty acids (SCFAs). It is expressed in adipose tissue, the gastrointestinal tract, and the peripheral nervous system, and it is involved in SCFA-dependent energy regulation.{28496} AR420626 is a selective agonist of FFAR3 (GPR41; IC50 = 117 nM) that does not activate the related receptor FFAR2 (GPR43) at concentrations up to 100 µM.{27420} At 10 µM, it can stimulate a 1.26-fold increased release of glucagon-like peptide-1 from colonic crypt cultures.{28497}
Brand:CaymanSKU:-Available on backorder
Free fatty acid receptor 3 (FFAR3; GPR41) is a G protein-coupled receptor activated by short chain fatty acids (SCFAs). It is expressed in adipose tissue, the gastrointestinal tract, and the peripheral nervous system, and it is involved in SCFA-dependent energy regulation.{28496} AR420626 is a selective agonist of FFAR3 (GPR41; IC50 = 117 nM) that does not activate the related receptor FFAR2 (GPR43) at concentrations up to 100 µM.{27420} At 10 µM, it can stimulate a 1.26-fold increased release of glucagon-like peptide-1 from colonic crypt cultures.{28497}
Brand:CaymanSKU:-Available on backorder
Free fatty acid receptor 3 (FFAR3; GPR41) is a G protein-coupled receptor activated by short chain fatty acids (SCFAs). It is expressed in adipose tissue, the gastrointestinal tract, and the peripheral nervous system, and it is involved in SCFA-dependent energy regulation.{28496} AR420626 is a selective agonist of FFAR3 (GPR41; IC50 = 117 nM) that does not activate the related receptor FFAR2 (GPR43) at concentrations up to 100 µM.{27420} At 10 µM, it can stimulate a 1.26-fold increased release of glucagon-like peptide-1 from colonic crypt cultures.{28497}
Brand:CaymanSKU:-Available on backorder
Ara-G is an analog of the nucleoside guanosine and an active metabolite of nelarabine (Item No. 20248).{47551,47552} Ara-G accumulates in T lymphoblasts and malignant T-lymphoid cells, where it is phosphorylated to produce ara-GTP and incorporated into the DNA.{32256,47551} Ara-G inhibits DNA replication by 92% after 30 minutes when used at a concentration of 50 µM in CEM cells, which are used as a model for human T lymphoblasts.{47551} It also halts the cell cycle at the sub-G1 phase and induces apoptosis in CEM cells.{32256} Syngeneic bone marrow containing 6C3HED tumor cells treated with ara-G (100 mM) ex vivo prior to transplantation increases survival of lethally irradiated mice and induces reconstitution of lymphoid, myeloid, and erythroid cell linages.{47553}
Brand:CaymanSKU:27984 - 100 mgAvailable on backorder
Ara-G is an analog of the nucleoside guanosine and an active metabolite of nelarabine (Item No. 20248).{47551,47552} Ara-G accumulates in T lymphoblasts and malignant T-lymphoid cells, where it is phosphorylated to produce ara-GTP and incorporated into the DNA.{32256,47551} Ara-G inhibits DNA replication by 92% after 30 minutes when used at a concentration of 50 µM in CEM cells, which are used as a model for human T lymphoblasts.{47551} It also halts the cell cycle at the sub-G1 phase and induces apoptosis in CEM cells.{32256} Syngeneic bone marrow containing 6C3HED tumor cells treated with ara-G (100 mM) ex vivo prior to transplantation increases survival of lethally irradiated mice and induces reconstitution of lymphoid, myeloid, and erythroid cell linages.{47553}
Brand:CaymanSKU:27984 - 250 mgAvailable on backorder
Ara-G is an analog of the nucleoside guanosine and an active metabolite of nelarabine (Item No. 20248).{47551,47552} Ara-G accumulates in T lymphoblasts and malignant T-lymphoid cells, where it is phosphorylated to produce ara-GTP and incorporated into the DNA.{32256,47551} Ara-G inhibits DNA replication by 92% after 30 minutes when used at a concentration of 50 µM in CEM cells, which are used as a model for human T lymphoblasts.{47551} It also halts the cell cycle at the sub-G1 phase and induces apoptosis in CEM cells.{32256} Syngeneic bone marrow containing 6C3HED tumor cells treated with ara-G (100 mM) ex vivo prior to transplantation increases survival of lethally irradiated mice and induces reconstitution of lymphoid, myeloid, and erythroid cell linages.{47553}
Brand:CaymanSKU:27984 - 50 mgAvailable on backorder
Arachidic acid is a long-chain saturated fatty acid that has been found in peanut butter and anaerobic fungi.{48209,32736} It inhibits rabbit neutrophil aggregation induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP; Item No. 21495) when used at a concentration of 5 μM.{2095} Formulations containing arachidic acid have been used as surfactants in the manufacture of soaps and cosmetics.
Brand:CaymanSKU:9000339 - 100 mgAvailable on backorder
Arachidic acid is a long-chain saturated fatty acid that has been found in peanut butter and anaerobic fungi.{48209,32736} It inhibits rabbit neutrophil aggregation induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP; Item No. 21495) when used at a concentration of 5 μM.{2095} Formulations containing arachidic acid have been used as surfactants in the manufacture of soaps and cosmetics.
Brand:CaymanSKU:9000339 - 50 mgAvailable on backorder
Arachidic acid is a long-chain saturated fatty acid that has been found in peanut butter and anaerobic fungi.{48209,32736} It inhibits rabbit neutrophil aggregation induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP; Item No. 21495) when used at a concentration of 5 μM.{2095} Formulations containing arachidic acid have been used as surfactants in the manufacture of soaps and cosmetics.
Brand:CaymanSKU:21906 -Out of stock
Arachidic acid is a long-chain saturated fatty acid that has been found in peanut butter and anaerobic fungi.{48209,32736} It inhibits rabbit neutrophil aggregation induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP; Item No. 21495) when used at a concentration of 5 μM.{2095} Formulations containing arachidic acid have been used as surfactants in the manufacture of soaps and cosmetics.
Brand:CaymanSKU:21906 -Out of stock
Arachidic acid methyl ester is an esterified form of arachidic acid (Item Nos. 9000339 | 21906). It is a minor constituent of biodiesel generated from acid-catalyzed or subcritical water-subcritical methanol (SCW-SCM) in situ transesterification of dry activated sludge or sludge oil, respectively.{46211}
Brand:CaymanSKU:26724 - 1 gAvailable on backorder
Arachidic acid methyl ester is an esterified form of arachidic acid (Item Nos. 9000339 | 21906). It is a minor constituent of biodiesel generated from acid-catalyzed or subcritical water-subcritical methanol (SCW-SCM) in situ transesterification of dry activated sludge or sludge oil, respectively.{46211}
Brand:CaymanSKU:26724 - 10 gAvailable on backorder
Arachidic acid methyl ester is an esterified form of arachidic acid (Item Nos. 9000339 | 21906). It is a minor constituent of biodiesel generated from acid-catalyzed or subcritical water-subcritical methanol (SCW-SCM) in situ transesterification of dry activated sludge or sludge oil, respectively.{46211}
Brand:CaymanSKU:26724 - 25 gAvailable on backorder
Arachidic acid methyl ester is an esterified form of arachidic acid (Item Nos. 9000339 | 21906). It is a minor constituent of biodiesel generated from acid-catalyzed or subcritical water-subcritical methanol (SCW-SCM) in situ transesterification of dry activated sludge or sludge oil, respectively.{46211}
Brand:CaymanSKU:26724 - 5 gAvailable on backorder