Chemicals
Showing 8851–9000 of 41137 results
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all-cis-1,2,3-Docosahexaenoyl glycerol is a polyunsaturated triacylglycerol that contains all-cis docosahexaenoic acid (DHA; Item No. 90310) at the sn-1, sn-2, and sn-3 positions.
Brand:CaymanSKU:10009667 - 1 mgAvailable on backorder
all-cis-1,2,3-Docosahexaenoyl glycerol is a polyunsaturated triacylglycerol that contains all-cis docosahexaenoic acid (DHA; Item No. 90310) at the sn-1, sn-2, and sn-3 positions.
Brand:CaymanSKU:10009667 - 10 mgAvailable on backorder
all-cis-1,2,3-Docosahexaenoyl glycerol is a polyunsaturated triacylglycerol that contains all-cis docosahexaenoic acid (DHA; Item No. 90310) at the sn-1, sn-2, and sn-3 positions.
Brand:CaymanSKU:10009667 - 25 mgAvailable on backorder
all-cis-1,2,3-Docosahexaenoyl glycerol is a polyunsaturated triacylglycerol that contains all-cis docosahexaenoic acid (DHA; Item No. 90310) at the sn-1, sn-2, and sn-3 positions.
Brand:CaymanSKU:10009667 - 5 mgAvailable on backorder
Docosapentaenoic acid (DPA) (Item No. 90165) is a 22-carbon fatty acid found in fish oils. It is a minor constituent of the total serum unsaturated fatty acids in humans, ranging from 0.1 to 1%, and increases on dietary supplementation.{1936} all-cis-4,7,10,13,16-DPA, also known as osbond acid, is an isomer of DPA. It is an ω-6 fatty acid formed by the elongation and desaturation of arachidonic acid (Item No. 90010). Levels of this fatty acid may be diminished during fatty acid desaturase syndrome and this may affect development.{27613} Upregulated expression of hepatic elongation of very long fatty acids protein 6 and increased levels of very long chain fatty acids, including all-cis-4,7,10,13,16-DPA, are characteristic of non-alcoholic steatohepatitis, a preneoplastic condition of hepatocellular carcinoma.{27614}
Brand:CaymanSKU:10008335 - 1 mgAvailable on backorder
Docosapentaenoic acid (DPA) (Item No. 90165) is a 22-carbon fatty acid found in fish oils. It is a minor constituent of the total serum unsaturated fatty acids in humans, ranging from 0.1 to 1%, and increases on dietary supplementation.{1936} all-cis-4,7,10,13,16-DPA, also known as osbond acid, is an isomer of DPA. It is an ω-6 fatty acid formed by the elongation and desaturation of arachidonic acid (Item No. 90010). Levels of this fatty acid may be diminished during fatty acid desaturase syndrome and this may affect development.{27613} Upregulated expression of hepatic elongation of very long fatty acids protein 6 and increased levels of very long chain fatty acids, including all-cis-4,7,10,13,16-DPA, are characteristic of non-alcoholic steatohepatitis, a preneoplastic condition of hepatocellular carcinoma.{27614}
Brand:CaymanSKU:10008335 - 10 mgAvailable on backorder
Docosapentaenoic acid (DPA) (Item No. 90165) is a 22-carbon fatty acid found in fish oils. It is a minor constituent of the total serum unsaturated fatty acids in humans, ranging from 0.1 to 1%, and increases on dietary supplementation.{1936} all-cis-4,7,10,13,16-DPA, also known as osbond acid, is an isomer of DPA. It is an ω-6 fatty acid formed by the elongation and desaturation of arachidonic acid (Item No. 90010). Levels of this fatty acid may be diminished during fatty acid desaturase syndrome and this may affect development.{27613} Upregulated expression of hepatic elongation of very long fatty acids protein 6 and increased levels of very long chain fatty acids, including all-cis-4,7,10,13,16-DPA, are characteristic of non-alcoholic steatohepatitis, a preneoplastic condition of hepatocellular carcinoma.{27614}
Brand:CaymanSKU:10008335 - 25 mgAvailable on backorder
Docosapentaenoic acid (DPA) (Item No. 90165) is a 22-carbon fatty acid found in fish oils. It is a minor constituent of the total serum unsaturated fatty acids in humans, ranging from 0.1 to 1%, and increases on dietary supplementation.{1936} all-cis-4,7,10,13,16-DPA, also known as osbond acid, is an isomer of DPA. It is an ω-6 fatty acid formed by the elongation and desaturation of arachidonic acid (Item No. 90010). Levels of this fatty acid may be diminished during fatty acid desaturase syndrome and this may affect development.{27613} Upregulated expression of hepatic elongation of very long fatty acids protein 6 and increased levels of very long chain fatty acids, including all-cis-4,7,10,13,16-DPA, are characteristic of non-alcoholic steatohepatitis, a preneoplastic condition of hepatocellular carcinoma.{27614}
Brand:CaymanSKU:10008335 - 5 mgAvailable on backorder
all-cis-4,7,10,13,16-Docosapentaenoic acid ethyl ester (all-cis-4,7,10,13,16-DPA ethyl ester) is a derivative of DPA (Item No. 90165), an ω-3 fatty acid found in fish oils. Ethyl ester derivatives of fatty acids, including DPA, are often used in formulations designed as dietary supplements.{16505,33057,33058}
Brand:CaymanSKU:23607 - 100 mgAvailable on backorder
all-cis-4,7,10,13,16-Docosapentaenoic acid ethyl ester (all-cis-4,7,10,13,16-DPA ethyl ester) is a derivative of DPA (Item No. 90165), an ω-3 fatty acid found in fish oils. Ethyl ester derivatives of fatty acids, including DPA, are often used in formulations designed as dietary supplements.{16505,33057,33058}
Brand:CaymanSKU:23607 - 25 mgAvailable on backorder
all-cis-4,7,10,13,16-Docosapentaenoic acid ethyl ester (all-cis-4,7,10,13,16-DPA ethyl ester) is a derivative of DPA (Item No. 90165), an ω-3 fatty acid found in fish oils. Ethyl ester derivatives of fatty acids, including DPA, are often used in formulations designed as dietary supplements.{16505,33057,33058}
Brand:CaymanSKU:23607 - 250 mgAvailable on backorder
all-cis-4,7,10,13,16-Docosapentaenoic acid ethyl ester (all-cis-4,7,10,13,16-DPA ethyl ester) is a derivative of DPA (Item No. 90165), an ω-3 fatty acid found in fish oils. Ethyl ester derivatives of fatty acids, including DPA, are often used in formulations designed as dietary supplements.{16505,33057,33058}
Brand:CaymanSKU:23607 - 5 mgAvailable on backorder
all-cis-4,7,10,13,16-Docosapentaenoic acid (all-cis-4,7,10,13,16-DPA) methyl ester is a more lipid-soluble form of the free acid (Item No. 10008335). all-cis-4,7,10,13,16-DPA, also known as osbond acid, is an isomer of DPA (Item No. 90165) an ω-3, 22-carbon fatty acid found in fish oils. It is an ω-6 fatty acid formed by the elongation and desaturation of arachidonic acid (Item No. 90010). Levels of all-cis-4,7,10,13,16-DPA fatty acid may be diminished during fatty acid desaturase syndrome and this may affect development.{27613} Upregulated expression of hepatic elongation of very long fatty acids protein 6 and increased levels of very long chain fatty acids, including all-cis-4,7,10,13,16-DPA, are characteristic of nonalcoholic steatohepatitis, a preneoplastic condition of hepatocellular carcinoma.{27614}
Brand:CaymanSKU:21124 -Out of stock
all-cis-4,7,10,13,16-Docosapentaenoic acid (all-cis-4,7,10,13,16-DPA) methyl ester is a more lipid-soluble form of the free acid (Item No. 10008335). all-cis-4,7,10,13,16-DPA, also known as osbond acid, is an isomer of DPA (Item No. 90165) an ω-3, 22-carbon fatty acid found in fish oils. It is an ω-6 fatty acid formed by the elongation and desaturation of arachidonic acid (Item No. 90010). Levels of all-cis-4,7,10,13,16-DPA fatty acid may be diminished during fatty acid desaturase syndrome and this may affect development.{27613} Upregulated expression of hepatic elongation of very long fatty acids protein 6 and increased levels of very long chain fatty acids, including all-cis-4,7,10,13,16-DPA, are characteristic of nonalcoholic steatohepatitis, a preneoplastic condition of hepatocellular carcinoma.{27614}
Brand:CaymanSKU:21124 -Out of stock
all-cis-4,7,10,13,16-Docosapentaenoic acid (all-cis-4,7,10,13,16-DPA) methyl ester is a more lipid-soluble form of the free acid (Item No. 10008335). all-cis-4,7,10,13,16-DPA, also known as osbond acid, is an isomer of DPA (Item No. 90165) an ω-3, 22-carbon fatty acid found in fish oils. It is an ω-6 fatty acid formed by the elongation and desaturation of arachidonic acid (Item No. 90010). Levels of all-cis-4,7,10,13,16-DPA fatty acid may be diminished during fatty acid desaturase syndrome and this may affect development.{27613} Upregulated expression of hepatic elongation of very long fatty acids protein 6 and increased levels of very long chain fatty acids, including all-cis-4,7,10,13,16-DPA, are characteristic of nonalcoholic steatohepatitis, a preneoplastic condition of hepatocellular carcinoma.{27614}
Brand:CaymanSKU:21124 -Out of stock
all-cis-4,7,10,13,16-Docosapentaenoic acid (all-cis-4,7,10,13,16-DPA) methyl ester is a more lipid-soluble form of the free acid (Item No. 10008335). all-cis-4,7,10,13,16-DPA, also known as osbond acid, is an isomer of DPA (Item No. 90165) an ω-3, 22-carbon fatty acid found in fish oils. It is an ω-6 fatty acid formed by the elongation and desaturation of arachidonic acid (Item No. 90010). Levels of all-cis-4,7,10,13,16-DPA fatty acid may be diminished during fatty acid desaturase syndrome and this may affect development.{27613} Upregulated expression of hepatic elongation of very long fatty acids protein 6 and increased levels of very long chain fatty acids, including all-cis-4,7,10,13,16-DPA, are characteristic of nonalcoholic steatohepatitis, a preneoplastic condition of hepatocellular carcinoma.{27614}
Brand:CaymanSKU:21124 -Out of stock
all-trans Retinoic acid is a metabolite of vitamin A and a ligand for retinoic acid receptors (RARs) with IC50 values of 9, 3, and 10 nM for RARα, RARβ, and RARγ, respectively, in radioligand binding assays.{34779} It induces expression of a luciferase reporter in COS-7 cells expressing RARα, RARβ, or RARγ (EC50s = 169, 9, and 2 nM, respectively). all-trans Retinoic acid (17 nmol) reduces papilloma formation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice.{36738} It reduces bile duct proliferation, hydroxyproline levels, and liver inflammation in a rat model of α-naphthylisothiocyanate-induced chronic cholestasis and reduces plasma levels of alkaline phosphatase and bile salts in the Mdr2-/- mouse model of cholestasis.{36739} all-trans Retinoic acid also reduces hepatic fat accumulation, triglycerides, body weight, and serum glucose levels in mice with Western diet-induced obesity.{36740}
Brand:CaymanSKU:11017 - 1 gAvailable on backorder
all-trans Retinoic acid is a metabolite of vitamin A and a ligand for retinoic acid receptors (RARs) with IC50 values of 9, 3, and 10 nM for RARα, RARβ, and RARγ, respectively, in radioligand binding assays.{34779} It induces expression of a luciferase reporter in COS-7 cells expressing RARα, RARβ, or RARγ (EC50s = 169, 9, and 2 nM, respectively). all-trans Retinoic acid (17 nmol) reduces papilloma formation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice.{36738} It reduces bile duct proliferation, hydroxyproline levels, and liver inflammation in a rat model of α-naphthylisothiocyanate-induced chronic cholestasis and reduces plasma levels of alkaline phosphatase and bile salts in the Mdr2-/- mouse model of cholestasis.{36739} all-trans Retinoic acid also reduces hepatic fat accumulation, triglycerides, body weight, and serum glucose levels in mice with Western diet-induced obesity.{36740}
Brand:CaymanSKU:11017 - 5 gAvailable on backorder
all-trans Retinoic acid is a metabolite of vitamin A and a ligand for retinoic acid receptors (RARs) with IC50 values of 9, 3, and 10 nM for RARα, RARβ, and RARγ, respectively, in radioligand binding assays.{34779} It induces expression of a luciferase reporter in COS-7 cells expressing RARα, RARβ, or RARγ (EC50s = 169, 9, and 2 nM, respectively). all-trans Retinoic acid (17 nmol) reduces papilloma formation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice.{36738} It reduces bile duct proliferation, hydroxyproline levels, and liver inflammation in a rat model of α-naphthylisothiocyanate-induced chronic cholestasis and reduces plasma levels of alkaline phosphatase and bile salts in the Mdr2-/- mouse model of cholestasis.{36739} all-trans Retinoic acid also reduces hepatic fat accumulation, triglycerides, body weight, and serum glucose levels in mice with Western diet-induced obesity.{36740}
Brand:CaymanSKU:11017 - 50 mgAvailable on backorder
all-trans Retinoic acid is a metabolite of vitamin A and a ligand for retinoic acid receptors (RARs) with IC50 values of 9, 3, and 10 nM for RARα, RARβ, and RARγ, respectively, in radioligand binding assays.{34779} It induces expression of a luciferase reporter in COS-7 cells expressing RARα, RARβ, or RARγ (EC50s = 169, 9, and 2 nM, respectively). all-trans Retinoic acid (17 nmol) reduces papilloma formation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice.{36738} It reduces bile duct proliferation, hydroxyproline levels, and liver inflammation in a rat model of α-naphthylisothiocyanate-induced chronic cholestasis and reduces plasma levels of alkaline phosphatase and bile salts in the Mdr2-/- mouse model of cholestasis.{36739} all-trans Retinoic acid also reduces hepatic fat accumulation, triglycerides, body weight, and serum glucose levels in mice with Western diet-induced obesity.{36740}
Brand:CaymanSKU:11017 - 500 mgAvailable on backorder
all-trans Retinoyl β-D-glucuronide is a metabolite of all-trans retinoic acid (Item No. 11017) formed by the UDP-glucuronosyltransferase (UGT) system.{51003} It is rapidly converted to all-trans retinoic acid following in vitro or in vivo administration.{51004,51005}
Brand:CaymanSKU:28057 - 2 mgAvailable on backorder
all-trans-4-hydroxy Retinoic acid is a metabolite of all-trans retinoic acid (Item No. 11017) formed by the cytochrome P450 (CYP) isoforms CYP26A1, B1, and C1.{34779,38575} It binds to retinoic acid receptors (RARs) with a lower affinity than other all-trans retinoic acid metabolites (IC50s = 606, 298, and 892 nM for RARα, RARβ, and RARγ, respectively, in a radioligand binding assay). It also transactivates RARs with a lower efficacy than other metabolites (EC50s = 791, 64, and 94 nM for RARα, RARβ, and RARγ, respectively) but induces transcription of a reporter plasmid equipotently. all-trans-4-hydroxy Retinoic acid inhibits cell growth, halts the cell cycle in the G1 phase, and induces differentiation of NB4 acute promyelocytic leukemia cells (EC50 = 79.8 nM).{34781}
Brand:CaymanSKU:21378 -Out of stock
all-trans-5,6-epoxy Retinoic acid (5,6-epoxy RA) is an agonist of all isoforms of the retinoic acid receptor (RAR; EC50s = 77, 35, and 4 nM for RARα, RARβ, and RARγ, respectively).{34779} 5,6-epoxy RA (1 µM) also induces growth arrest of MCF-7 and NB4 cells in vitro.{34780, 34781} It is a natural metabolite of all-trans retinoic acid (Item No. 11017), which is a metabolite of vitamin A.{34778}
Brand:CaymanSKU:22124 -Out of stock
all-trans-5,6-epoxy Retinoic acid (5,6-epoxy RA) is an agonist of all isoforms of the retinoic acid receptor (RAR; EC50s = 77, 35, and 4 nM for RARα, RARβ, and RARγ, respectively).{34779} 5,6-epoxy RA (1 µM) also induces growth arrest of MCF-7 and NB4 cells in vitro.{34780, 34781} It is a natural metabolite of all-trans retinoic acid (Item No. 11017), which is a metabolite of vitamin A.{34778}
Brand:CaymanSKU:22124 -Out of stock
all-trans-Retinal is a natural retinoid that is derived from vitamin A. It is the oxidation product of all-trans-retinol and associates with cellular retinol-binding protein-I (CRBP-I) and CRBP-II (Kds = 50 and 90 nM, respectively), which are involved in the intracellular transport of retinol.{14372} all-trans-Retinal is also an intermediate of the phototransduction pathway of photoreceptors, including rhodopsin and bacterial opsins.{29923} As a chemically reactive aldehyde, all-trans-retinal can form toxic conjugates with proteins and lipids, leading to degeneration of the retina.{29923}
Brand:CaymanSKU:-Available on backorder
all-trans-Retinal is a natural retinoid that is derived from vitamin A. It is the oxidation product of all-trans-retinol and associates with cellular retinol-binding protein-I (CRBP-I) and CRBP-II (Kds = 50 and 90 nM, respectively), which are involved in the intracellular transport of retinol.{14372} all-trans-Retinal is also an intermediate of the phototransduction pathway of photoreceptors, including rhodopsin and bacterial opsins.{29923} As a chemically reactive aldehyde, all-trans-retinal can form toxic conjugates with proteins and lipids, leading to degeneration of the retina.{29923}
Brand:CaymanSKU:-Available on backorder
all-trans-Retinal is a natural retinoid that is derived from vitamin A. It is the oxidation product of all-trans-retinol and associates with cellular retinol-binding protein-I (CRBP-I) and CRBP-II (Kds = 50 and 90 nM, respectively), which are involved in the intracellular transport of retinol.{14372} all-trans-Retinal is also an intermediate of the phototransduction pathway of photoreceptors, including rhodopsin and bacterial opsins.{29923} As a chemically reactive aldehyde, all-trans-retinal can form toxic conjugates with proteins and lipids, leading to degeneration of the retina.{29923}
Brand:CaymanSKU:-Available on backorder
all-trans-Retinal is a natural retinoid that is derived from vitamin A. It is the oxidation product of all-trans-retinol and associates with cellular retinol-binding protein-I (CRBP-I) and CRBP-II (Kds = 50 and 90 nM, respectively), which are involved in the intracellular transport of retinol.{14372} all-trans-Retinal is also an intermediate of the phototransduction pathway of photoreceptors, including rhodopsin and bacterial opsins.{29923} As a chemically reactive aldehyde, all-trans-retinal can form toxic conjugates with proteins and lipids, leading to degeneration of the retina.{29923}
Brand:CaymanSKU:-Available on backorder
Allantoin is a product of purine and uric acid metabolism.{45992} It is formed through oxidation of uric acid by urate oxidase in most mammals but is formed only through non-enzymatic oxidation by free radicals in humans. Urinary levels of allantoin are increased prior to the onset of Alzheimer’s disease symptoms in mice expressing mutations in amyloid precursor protein and tau (APP/tau) but not during the early/middle stage of the disease, indicating its potential use as a biomarker for predicting Alzheimer’s disease onset.{45993} Due to the formation of allantoin by free radicals in humans, increased urinary levels are a potential biomarker for oxidative stress status.{45992}
Brand:CaymanSKU:30204 - 100 gAvailable on backorder
Allantoin is a product of purine and uric acid metabolism.{45992} It is formed through oxidation of uric acid by urate oxidase in most mammals but is formed only through non-enzymatic oxidation by free radicals in humans. Urinary levels of allantoin are increased prior to the onset of Alzheimer’s disease symptoms in mice expressing mutations in amyloid precursor protein and tau (APP/tau) but not during the early/middle stage of the disease, indicating its potential use as a biomarker for predicting Alzheimer’s disease onset.{45993} Due to the formation of allantoin by free radicals in humans, increased urinary levels are a potential biomarker for oxidative stress status.{45992}
Brand:CaymanSKU:30204 - 25 gAvailable on backorder
Allethrin is a pyrethroid insecticide and modulator of voltage-gated sodium channels (NaV).{39796} It delays channel deactivation in cockroach giant axons when used at a concentration of 1 μM. Allethrin is 100-fold more potent at insect than rat NaV1.8 channels expressed in Xenopus oocytes.{36375} It decreases egg production by and is lethal to mosquitoes (LC50 = 0.01%).{39797} Allethrin induces production of reactive oxygen species (ROS), lipid peroxidation, and apoptosis in rat primary Leydig cells.{39798} In vivo, the smoke of an allethrin-based mosquito coil increases levels of the hepatic enzymes ALT and AST and induces hepatocyte apoptosis as well as emphysema and lung hyperplasia in mice.{39799}
Brand:CaymanSKU:24132 - 100 mgAvailable on backorder
Allethrin is a pyrethroid insecticide and modulator of voltage-gated sodium channels (NaV).{39796} It delays channel deactivation in cockroach giant axons when used at a concentration of 1 μM. Allethrin is 100-fold more potent at insect than rat NaV1.8 channels expressed in Xenopus oocytes.{36375} It decreases egg production by and is lethal to mosquitoes (LC50 = 0.01%).{39797} Allethrin induces production of reactive oxygen species (ROS), lipid peroxidation, and apoptosis in rat primary Leydig cells.{39798} In vivo, the smoke of an allethrin-based mosquito coil increases levels of the hepatic enzymes ALT and AST and induces hepatocyte apoptosis as well as emphysema and lung hyperplasia in mice.{39799}
Brand:CaymanSKU:24132 - 50 mgAvailable on backorder
Allicin is a natural product originally isolated from A. sativum that has wide-ranging biological effects including antioxidative, anticancer, antimicrobial, and antifungal activities.{25626,36056,36054,36055} It inhibits the cysteine proteases cathepsin B and L, facipain 2, and rhodesain with Ki values of 8.6 and 9.3, 1.04, and 5.31 µM, respectively.{25625} It shows antiparasitic activity against P. falciparum (IC50 = 5.2 µM) and T. b. brucei (IC50 = 13.8 µM), the parasites that cause malaria and African sleeping sickness, respectively. Allicin (5-10 µM) dose-dependently inhibits cell adhesion, invasion, and migration in various lung adenocarcinoma cell lines.{36056} It also alters the balance of tissue inhibitors of matrix metalloproteinases (TIMPs) and matrix metalloproteinases (MMPs), decreases phosphorylation of Akt, and decreases PI3K/Akt signaling.
Brand:CaymanSKU:- Allicin is a natural product originally isolated from A. sativum that has wide-ranging biological effects including antioxidative, anticancer, antimicrobial, and antifungal activities.{25626,36056,36054,36055} It inhibits the cysteine proteases cathepsin B and L, facipain 2, and rhodesain with Ki values of 8.6 and 9.3, 1.04, and 5.31 µM, respectively.{25625} It shows antiparasitic activity against P. falciparum (IC50 = 5.2 µM) and T. b. brucei (IC50 = 13.8 µM), the parasites that cause malaria and African sleeping sickness, respectively. Allicin (5-10 µM) dose-dependently inhibits cell adhesion, invasion, and migration in various lung adenocarcinoma cell lines.{36056} It also alters the balance of tissue inhibitors of matrix metalloproteinases (TIMPs) and matrix metalloproteinases (MMPs), decreases phosphorylation of Akt, and decreases PI3K/Akt signaling.
Brand:CaymanSKU:-
Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of the GPCR-like receptor, Smoothened (SMO).{21774} In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the Gli family. Overactivation of this pathway contributes to certain cancers.{27050} ALLO-1 is a SMO antagonist that inhibits both wild-type (IC50 = 50 nM) and mutant SMO, including the D473H SMO mutant (IC50s = 300-1000 nM).{29056} This compound binds to the SMO cysteine-rich domain, which is a different mechanism of interaction compared to other known SMO ligands that bind the transmembrane pocket.{29056,28806}
Brand:CaymanSKU:-Available on backorder
Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of the GPCR-like receptor, Smoothened (SMO).{21774} In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the Gli family. Overactivation of this pathway contributes to certain cancers.{27050} ALLO-1 is a SMO antagonist that inhibits both wild-type (IC50 = 50 nM) and mutant SMO, including the D473H SMO mutant (IC50s = 300-1000 nM).{29056} This compound binds to the SMO cysteine-rich domain, which is a different mechanism of interaction compared to other known SMO ligands that bind the transmembrane pocket.{29056,28806}
Brand:CaymanSKU:-Available on backorder
Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of the GPCR-like receptor, Smoothened (SMO).{21774} In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the Gli family. Overactivation of this pathway contributes to certain cancers.{27050} ALLO-1 is a SMO antagonist that inhibits both wild-type (IC50 = 50 nM) and mutant SMO, including the D473H SMO mutant (IC50s = 300-1000 nM).{29056} This compound binds to the SMO cysteine-rich domain, which is a different mechanism of interaction compared to other known SMO ligands that bind the transmembrane pocket.{29056,28806}
Brand:CaymanSKU:-Available on backorder
Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of the GPCR-like receptor, Smoothened (SMO).{21774} In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the Gli family. Overactivation of this pathway contributes to certain cancers.{27050} ALLO-1 is a SMO antagonist that inhibits both wild-type (IC50 = 50 nM) and mutant SMO, including the D473H SMO mutant (IC50s = 300-1000 nM).{29056} This compound binds to the SMO cysteine-rich domain, which is a different mechanism of interaction compared to other known SMO ligands that bind the transmembrane pocket.{29056,28806}
Brand:CaymanSKU:-Available on backorder
Allocholic acid is a bile acid and an isomer of cholic acid (Item No. 20250).{53996} It is typically produced in the fetal or larval stages of development but has been found in adult mammals in the context of cancer or during liver regeneration in rats.{53996,53997} Allocholic acid is a precursor to petromyzonol (Item No. 98250), a bile acid of larval sea lamprey that acts as a migratory pheromone.{55234} The levels of allocholic acid are elevated in the plasma of mdr2-/- mice, a model of bile duct inflammation leading to hepatocellular carcinoma.{53998}
Brand:CaymanSKU:30415 - 1 mgAvailable on backorder
Allocholic acid is a bile acid and an isomer of cholic acid (Item No. 20250).{53996} It is typically produced in the fetal or larval stages of development but has been found in adult mammals in the context of cancer or during liver regeneration in rats.{53996,53997} Allocholic acid is a precursor to petromyzonol (Item No. 98250), a bile acid of larval sea lamprey that acts as a migratory pheromone.{55234} The levels of allocholic acid are elevated in the plasma of mdr2-/- mice, a model of bile duct inflammation leading to hepatocellular carcinoma.{53998}
Brand:CaymanSKU:30415 - 10 mgAvailable on backorder
Allocholic acid is a bile acid and an isomer of cholic acid (Item No. 20250).{53996} It is typically produced in the fetal or larval stages of development but has been found in adult mammals in the context of cancer or during liver regeneration in rats.{53996,53997} Allocholic acid is a precursor to petromyzonol (Item No. 98250), a bile acid of larval sea lamprey that acts as a migratory pheromone.{55234} The levels of allocholic acid are elevated in the plasma of mdr2-/- mice, a model of bile duct inflammation leading to hepatocellular carcinoma.{53998}
Brand:CaymanSKU:30415 - 5 mgAvailable on backorder
Alloisolithocholic acid (AILCA) is an allomonohydroxy bile acid.{53938,53939} It activates large-conductance calcium-activated potassium channels (BKCas; EC50 = 44.21 µM in Xenopus oocytes expressing human channels).{53938} AILCA (6 mg/kg) reduces hepatic bile flow and bile salt, cholesterol, and phospholipid secretion, as well as induces loss of microvilli and dilation of canaliculi in hepatocytes, markers of cholestasis, in rats.{53939}
Brand:CaymanSKU:29542 - 10 mgAvailable on backorder
Alloisolithocholic acid (AILCA) is an allomonohydroxy bile acid.{53938,53939} It activates large-conductance calcium-activated potassium channels (BKCas; EC50 = 44.21 µM in Xenopus oocytes expressing human channels).{53938} AILCA (6 mg/kg) reduces hepatic bile flow and bile salt, cholesterol, and phospholipid secretion, as well as induces loss of microvilli and dilation of canaliculi in hepatocytes, markers of cholestasis, in rats.{53939}
Brand:CaymanSKU:29542 - 25 mgAvailable on backorder
Alloisolithocholic acid (AILCA) is an allomonohydroxy bile acid.{53938,53939} It activates large-conductance calcium-activated potassium channels (BKCas; EC50 = 44.21 µM in Xenopus oocytes expressing human channels).{53938} AILCA (6 mg/kg) reduces hepatic bile flow and bile salt, cholesterol, and phospholipid secretion, as well as induces loss of microvilli and dilation of canaliculi in hepatocytes, markers of cholestasis, in rats.{53939}
Brand:CaymanSKU:29542 - 5 mgAvailable on backorder
Xanthine oxidoreductase mediates the successive oxidation of hypoxanthine and xanthine to produce uric acid. The enzyme can interconvert between xanthine dehydrogenase and xanthine oxidase activities through reversible sulfhydryl oxidation on specific cysteine residues. Both forms oxidize hypoxanthine and xanthine to uric acid. However the dehydrogenase simultaneously reduces nicotinamide adenine dinucleotide while the oxidase reduces oxygen to superoxide. Allopurinol is an isomer of hypoxanthine that inhibits xanthine oxidoreductase (IC50 values between 0.2 and 50 μM, depending on assay and cell type).{17631,17630} In vivo, allopurinol has been reported to effectively and safely lower serum and urinary uric acid levels and is also reported to be effective in the treatment of gout and hyperuricemia. Allopurinol is rapidly metabolized in vivo to the xanthine analog oxypurinol, which is a metabolite that clearly augments the therapeutic effect of allopurinol.{17632}
Brand:CaymanSKU:10012597 - 100 gAvailable on backorder
Xanthine oxidoreductase mediates the successive oxidation of hypoxanthine and xanthine to produce uric acid. The enzyme can interconvert between xanthine dehydrogenase and xanthine oxidase activities through reversible sulfhydryl oxidation on specific cysteine residues. Both forms oxidize hypoxanthine and xanthine to uric acid. However the dehydrogenase simultaneously reduces nicotinamide adenine dinucleotide while the oxidase reduces oxygen to superoxide. Allopurinol is an isomer of hypoxanthine that inhibits xanthine oxidoreductase (IC50 values between 0.2 and 50 μM, depending on assay and cell type).{17631,17630} In vivo, allopurinol has been reported to effectively and safely lower serum and urinary uric acid levels and is also reported to be effective in the treatment of gout and hyperuricemia. Allopurinol is rapidly metabolized in vivo to the xanthine analog oxypurinol, which is a metabolite that clearly augments the therapeutic effect of allopurinol.{17632}
Brand:CaymanSKU:10012597 - 25 gAvailable on backorder
Xanthine oxidoreductase mediates the successive oxidation of hypoxanthine and xanthine to produce uric acid. The enzyme can interconvert between xanthine dehydrogenase and xanthine oxidase activities through reversible sulfhydryl oxidation on specific cysteine residues. Both forms oxidize hypoxanthine and xanthine to uric acid. However the dehydrogenase simultaneously reduces nicotinamide adenine dinucleotide while the oxidase reduces oxygen to superoxide. Allopurinol is an isomer of hypoxanthine that inhibits xanthine oxidoreductase (IC50 values between 0.2 and 50 μM, depending on assay and cell type).{17631,17630} In vivo, allopurinol has been reported to effectively and safely lower serum and urinary uric acid levels and is also reported to be effective in the treatment of gout and hyperuricemia. Allopurinol is rapidly metabolized in vivo to the xanthine analog oxypurinol, which is a metabolite that clearly augments the therapeutic effect of allopurinol.{17632}
Brand:CaymanSKU:10012597 - 50 gAvailable on backorder
Allylescaline is a derivative of the phenethylamine escaline (Item No. 14107) in which an allyl group replaces the ethyl group. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research purposes.
Brand:CaymanSKU:9001982 - 1 mgAvailable on backorder
Allylescaline is a derivative of the phenethylamine escaline (Item No. 14107) in which an allyl group replaces the ethyl group. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research purposes.
Brand:CaymanSKU:9001982 - 10 mgAvailable on backorder
Allylescaline is a derivative of the phenethylamine escaline (Item No. 14107) in which an allyl group replaces the ethyl group. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research purposes.
Brand:CaymanSKU:9001982 - 5 mgAvailable on backorder
Almorexant is a dual antagonist of orexin 1 receptor (OX1R) and OX2R (Kis = 4.7 and 0.9 nM, respectively, in a radioligand binding assay).{28150} It decreases the latency to persistent non-rapid eye movement (NREM) sleep and increases the duration of NREM and REM sleep in male rats when administered at a dose of 100 mg/kg.{49493} Almorexant (300 mg/kg) does not impair spatial learning and memory in the Morris water maze and does not reverse spatial memory impairments induced by scopolamine in rats.{49494}
Brand:CaymanSKU:- Almorexant is a dual antagonist of orexin 1 receptor (OX1R) and OX2R (Kis = 4.7 and 0.9 nM, respectively, in a radioligand binding assay).{28150} It decreases the latency to persistent non-rapid eye movement (NREM) sleep and increases the duration of NREM and REM sleep in male rats when administered at a dose of 100 mg/kg.{49493} Almorexant (300 mg/kg) does not impair spatial learning and memory in the Morris water maze and does not reverse spatial memory impairments induced by scopolamine in rats.{49494}
Brand:CaymanSKU:- Almorexant is a dual antagonist of orexin 1 receptor (OX1R) and OX2R (Kis = 4.7 and 0.9 nM, respectively, in a radioligand binding assay).{28150} It decreases the latency to persistent non-rapid eye movement (NREM) sleep and increases the duration of NREM and REM sleep in male rats when administered at a dose of 100 mg/kg.{49493} Almorexant (300 mg/kg) does not impair spatial learning and memory in the Morris water maze and does not reverse spatial memory impairments induced by scopolamine in rats.{49494}
Brand:CaymanSKU:-
Almotriptan is an agonist of the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D (IC50s = 12 and 13 nM, respectively, in a radioligand binding assay).{47183} It is selective for human 5-HT1B and 5-HT1D receptors over rat 5-HT1A and human 5-HT2A and 5-HT4 receptors (IC50s = 0.85, 25.1, and 140 μM, respectively). Almotriptan induces contractions in isolated canine saphenous veins (EC50 = 394 nM) but not isolated rabbit renal or mesenteric arteries. It increases carotid vascular resistance in anesthetized cats (ED100 = 11 μg/kg, i.v.) without increasing blood pressure or heart rate.{47184} Formulations containing almotriptan have been used in the treatment of migraine headaches.
Brand:CaymanSKU:25646 - 10 mgAvailable on backorder
Almotriptan is an agonist of the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D (IC50s = 12 and 13 nM, respectively, in a radioligand binding assay).{47183} It is selective for human 5-HT1B and 5-HT1D receptors over rat 5-HT1A and human 5-HT2A and 5-HT4 receptors (IC50s = 0.85, 25.1, and 140 μM, respectively). Almotriptan induces contractions in isolated canine saphenous veins (EC50 = 394 nM) but not isolated rabbit renal or mesenteric arteries. It increases carotid vascular resistance in anesthetized cats (ED100 = 11 μg/kg, i.v.) without increasing blood pressure or heart rate.{47184} Formulations containing almotriptan have been used in the treatment of migraine headaches.
Brand:CaymanSKU:25646 - 25 mgAvailable on backorder
Almotriptan is an agonist of the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D (IC50s = 12 and 13 nM, respectively, in a radioligand binding assay).{47183} It is selective for human 5-HT1B and 5-HT1D receptors over rat 5-HT1A and human 5-HT2A and 5-HT4 receptors (IC50s = 0.85, 25.1, and 140 μM, respectively). Almotriptan induces contractions in isolated canine saphenous veins (EC50 = 394 nM) but not isolated rabbit renal or mesenteric arteries. It increases carotid vascular resistance in anesthetized cats (ED100 = 11 μg/kg, i.v.) without increasing blood pressure or heart rate.{47184} Formulations containing almotriptan have been used in the treatment of migraine headaches.
Brand:CaymanSKU:25646 - 5 mgAvailable on backorder
Almotriptan is an agonist of the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D (IC50s = 12 and 13 nM, respectively, in a radioligand binding assay).{47183} It is selective for human 5-HT1B and 5-HT1D receptors over rat 5-HT1A and human 5-HT2A and 5-HT4 receptors (IC50s = 0.85, 25.1, and 140 μM, respectively). Almotriptan induces contractions in isolated canine saphenous veins (EC50 = 394 nM) but not isolated rabbit renal or mesenteric arteries. It increases carotid vascular resistance in anesthetized cats (ED100 = 11 μg/kg, i.v.) without increasing blood pressure or heart rate.{47184} Formulations containing almotriptan have been used in the treatment of migraine headaches.
Brand:CaymanSKU:25646 - 50 mgAvailable on backorder
Aloe-emodin is a hydroxyanthraquinone found in Aloe vera leaves that has potent laxative action by inducing chloride secretion in colonic mucosa and releasing acetylcholine, which stimulates contraction of intestinal smooth muscle.{28847} It also demonstrates anti-tumor activity (ED50s = 1-13 µM), inducing apoptosis in various cancer cells by increasing the production of reactive oxygen species.{28848,28849} Aloe-emodin is reported to have estrogenic activity as a phytoestrogen and has been shown to inhibit breast cancer cell proliferation by downregulating ERα protein levels, and thus, suppressing transcriptional activation of the receptor.{21490,28850}
Brand:CaymanSKU:11677 - 10 mgAvailable on backorder
Aloe-emodin is a hydroxyanthraquinone found in Aloe vera leaves that has potent laxative action by inducing chloride secretion in colonic mucosa and releasing acetylcholine, which stimulates contraction of intestinal smooth muscle.{28847} It also demonstrates anti-tumor activity (ED50s = 1-13 µM), inducing apoptosis in various cancer cells by increasing the production of reactive oxygen species.{28848,28849} Aloe-emodin is reported to have estrogenic activity as a phytoestrogen and has been shown to inhibit breast cancer cell proliferation by downregulating ERα protein levels, and thus, suppressing transcriptional activation of the receptor.{21490,28850}
Brand:CaymanSKU:11677 - 100 mgAvailable on backorder
Aloe-emodin is a hydroxyanthraquinone found in Aloe vera leaves that has potent laxative action by inducing chloride secretion in colonic mucosa and releasing acetylcholine, which stimulates contraction of intestinal smooth muscle.{28847} It also demonstrates anti-tumor activity (ED50s = 1-13 µM), inducing apoptosis in various cancer cells by increasing the production of reactive oxygen species.{28848,28849} Aloe-emodin is reported to have estrogenic activity as a phytoestrogen and has been shown to inhibit breast cancer cell proliferation by downregulating ERα protein levels, and thus, suppressing transcriptional activation of the receptor.{21490,28850}
Brand:CaymanSKU:11677 - 25 mgAvailable on backorder
Aloe-emodin is a hydroxyanthraquinone found in Aloe vera leaves that has potent laxative action by inducing chloride secretion in colonic mucosa and releasing acetylcholine, which stimulates contraction of intestinal smooth muscle.{28847} It also demonstrates anti-tumor activity (ED50s = 1-13 µM), inducing apoptosis in various cancer cells by increasing the production of reactive oxygen species.{28848,28849} Aloe-emodin is reported to have estrogenic activity as a phytoestrogen and has been shown to inhibit breast cancer cell proliferation by downregulating ERα protein levels, and thus, suppressing transcriptional activation of the receptor.{21490,28850}
Brand:CaymanSKU:11677 - 50 mgAvailable on backorder
Aloesin is a C-glycosylated chromone compound found in aloe (Liliaceae) that inhibits tyrosinase (IC50 = 0.9 mM), an enzyme responsible for catalyzing the first step of the conversion of tyrosine to melanin.{23238} Derivatives of aloesin have been shown to exhibit free radical scavenging and anti-inflammatory activity.{23236} The antihyperpigmenting effects of aloesin have been explored in melanocytes.{23237}
Brand:CaymanSKU:- Aloesin is a C-glycosylated chromone compound found in aloe (Liliaceae) that inhibits tyrosinase (IC50 = 0.9 mM), an enzyme responsible for catalyzing the first step of the conversion of tyrosine to melanin.{23238} Derivatives of aloesin have been shown to exhibit free radical scavenging and anti-inflammatory activity.{23236} The antihyperpigmenting effects of aloesin have been explored in melanocytes.{23237}
Brand:CaymanSKU:- Aloesin is a C-glycosylated chromone compound found in aloe (Liliaceae) that inhibits tyrosinase (IC50 = 0.9 mM), an enzyme responsible for catalyzing the first step of the conversion of tyrosine to melanin.{23238} Derivatives of aloesin have been shown to exhibit free radical scavenging and anti-inflammatory activity.{23236} The antihyperpigmenting effects of aloesin have been explored in melanocytes.{23237}
Brand:CaymanSKU:-
Alofanib is an allosteric inhibitor of FGFR2.{58160,58161} It inhibits FGF2-induced phosphorylation of FGFR substrate 2 (FRS2α) in KATO III gastric carcinoma cells (IC50 = 50s = 370 and 210 nM, respectively). It inhibits proliferation of human umbilical vein endothelial cells (HUVECs) induced by basic FGF (bFGF; IC50 = 11 nM) and tube formation of SVEC4-10 endothelial cells when used at a concentration of 50 nM.{58160} It also inhibits migration of SVEC4-10 cells in a wound healing assay. Alofanib (50 mg/kg) decreases the number of microvessels in tumor tissue by 50% in a SKOV3 ovarian serous carcinoma mouse model. It reduces tumor growth in mouse xenograft models when administered at a dose of 30 mg/kg per day, and the degree of tumor volume reduction positively correlates with the expression level of FGFR2{58161}
Brand:CaymanSKU:31754 - 100 mgAvailable on backorder
Alofanib is an allosteric inhibitor of FGFR2.{58160,58161} It inhibits FGF2-induced phosphorylation of FGFR substrate 2 (FRS2α) in KATO III gastric carcinoma cells (IC50 = 50s = 370 and 210 nM, respectively). It inhibits proliferation of human umbilical vein endothelial cells (HUVECs) induced by basic FGF (bFGF; IC50 = 11 nM) and tube formation of SVEC4-10 endothelial cells when used at a concentration of 50 nM.{58160} It also inhibits migration of SVEC4-10 cells in a wound healing assay. Alofanib (50 mg/kg) decreases the number of microvessels in tumor tissue by 50% in a SKOV3 ovarian serous carcinoma mouse model. It reduces tumor growth in mouse xenograft models when administered at a dose of 30 mg/kg per day, and the degree of tumor volume reduction positively correlates with the expression level of FGFR2{58161}
Brand:CaymanSKU:31754 - 25 mgAvailable on backorder
Alofanib is an allosteric inhibitor of FGFR2.{58160,58161} It inhibits FGF2-induced phosphorylation of FGFR substrate 2 (FRS2α) in KATO III gastric carcinoma cells (IC50 = 50s = 370 and 210 nM, respectively). It inhibits proliferation of human umbilical vein endothelial cells (HUVECs) induced by basic FGF (bFGF; IC50 = 11 nM) and tube formation of SVEC4-10 endothelial cells when used at a concentration of 50 nM.{58160} It also inhibits migration of SVEC4-10 cells in a wound healing assay. Alofanib (50 mg/kg) decreases the number of microvessels in tumor tissue by 50% in a SKOV3 ovarian serous carcinoma mouse model. It reduces tumor growth in mouse xenograft models when administered at a dose of 30 mg/kg per day, and the degree of tumor volume reduction positively correlates with the expression level of FGFR2{58161}
Brand:CaymanSKU:31754 - 5 mgAvailable on backorder
Alofanib is an allosteric inhibitor of FGFR2.{58160,58161} It inhibits FGF2-induced phosphorylation of FGFR substrate 2 (FRS2α) in KATO III gastric carcinoma cells (IC50 = 50s = 370 and 210 nM, respectively). It inhibits proliferation of human umbilical vein endothelial cells (HUVECs) induced by basic FGF (bFGF; IC50 = 11 nM) and tube formation of SVEC4-10 endothelial cells when used at a concentration of 50 nM.{58160} It also inhibits migration of SVEC4-10 cells in a wound healing assay. Alofanib (50 mg/kg) decreases the number of microvessels in tumor tissue by 50% in a SKOV3 ovarian serous carcinoma mouse model. It reduces tumor growth in mouse xenograft models when administered at a dose of 30 mg/kg per day, and the degree of tumor volume reduction positively correlates with the expression level of FGFR2{58161}
Brand:CaymanSKU:31754 - 50 mgAvailable on backorder
Alogliptin is an orally bioavailable dipeptidyl peptidase 4 (DPP-4) inhibitor (IC50 = 6.9 nM) that is selective for DPP-4 over DPP-2, DPP-8, DPP-9, prolyl endopeptidase, fibroblast activation protein (FAP), and tryptase (IC50s = >100,000 nM).{36524} It does not inhibit cytochrome P450 enzymes and does not block the human ether-a-go-go-related gene (hERG) channel when used at concentrations up to 30 μM.{36525} Alogliptin inhibits DPP-4 activity in vivo in rats, dogs, and cynomolgus monkeys (EC50s = 3.4, 4.9, and 5.6 ng/ml, respectively, in plasma).{36524} It increases plasma glucagon-like peptide-1 (GLP-1; Item No. 24460) and insulin levels and decreases blood glucose levels during an oral glucose challenge in Zucker fa/fa rats when administered at a dose of 10 mg/kg. Alogliptin (2.8 mg/kg per day) decreases plasma DPP-4 activity and increases GLP-1 levels in diabetic ob/ob mice when administered for 29 days.{36526} Formulations containing alogliptin have been used as an adjunct treatment for type 2 diabetes mellitus.
Brand:CaymanSKU:23768 - 100 mgAvailable on backorder
Alogliptin is an orally bioavailable dipeptidyl peptidase 4 (DPP-4) inhibitor (IC50 = 6.9 nM) that is selective for DPP-4 over DPP-2, DPP-8, DPP-9, prolyl endopeptidase, fibroblast activation protein (FAP), and tryptase (IC50s = >100,000 nM).{36524} It does not inhibit cytochrome P450 enzymes and does not block the human ether-a-go-go-related gene (hERG) channel when used at concentrations up to 30 μM.{36525} Alogliptin inhibits DPP-4 activity in vivo in rats, dogs, and cynomolgus monkeys (EC50s = 3.4, 4.9, and 5.6 ng/ml, respectively, in plasma).{36524} It increases plasma glucagon-like peptide-1 (GLP-1; Item No. 24460) and insulin levels and decreases blood glucose levels during an oral glucose challenge in Zucker fa/fa rats when administered at a dose of 10 mg/kg. Alogliptin (2.8 mg/kg per day) decreases plasma DPP-4 activity and increases GLP-1 levels in diabetic ob/ob mice when administered for 29 days.{36526} Formulations containing alogliptin have been used as an adjunct treatment for type 2 diabetes mellitus.
Brand:CaymanSKU:23768 - 25 mgAvailable on backorder
Alogliptin is an orally bioavailable dipeptidyl peptidase 4 (DPP-4) inhibitor (IC50 = 6.9 nM) that is selective for DPP-4 over DPP-2, DPP-8, DPP-9, prolyl endopeptidase, fibroblast activation protein (FAP), and tryptase (IC50s = >100,000 nM).{36524} It does not inhibit cytochrome P450 enzymes and does not block the human ether-a-go-go-related gene (hERG) channel when used at concentrations up to 30 μM.{36525} Alogliptin inhibits DPP-4 activity in vivo in rats, dogs, and cynomolgus monkeys (EC50s = 3.4, 4.9, and 5.6 ng/ml, respectively, in plasma).{36524} It increases plasma glucagon-like peptide-1 (GLP-1; Item No. 24460) and insulin levels and decreases blood glucose levels during an oral glucose challenge in Zucker fa/fa rats when administered at a dose of 10 mg/kg. Alogliptin (2.8 mg/kg per day) decreases plasma DPP-4 activity and increases GLP-1 levels in diabetic ob/ob mice when administered for 29 days.{36526} Formulations containing alogliptin have been used as an adjunct treatment for type 2 diabetes mellitus.
Brand:CaymanSKU:23768 - 250 mgAvailable on backorder
Alogliptin is an orally bioavailable dipeptidyl peptidase 4 (DPP-4) inhibitor (IC50 = 6.9 nM) that is selective for DPP-4 over DPP-2, DPP-8, DPP-9, prolyl endopeptidase, fibroblast activation protein (FAP), and tryptase (IC50s = >100,000 nM).{36524} It does not inhibit cytochrome P450 enzymes and does not block the human ether-a-go-go-related gene (hERG) channel when used at concentrations up to 30 μM.{36525} Alogliptin inhibits DPP-4 activity in vivo in rats, dogs, and cynomolgus monkeys (EC50s = 3.4, 4.9, and 5.6 ng/ml, respectively, in plasma).{36524} It increases plasma glucagon-like peptide-1 (GLP-1; Item No. 24460) and insulin levels and decreases blood glucose levels during an oral glucose challenge in Zucker fa/fa rats when administered at a dose of 10 mg/kg. Alogliptin (2.8 mg/kg per day) decreases plasma DPP-4 activity and increases GLP-1 levels in diabetic ob/ob mice when administered for 29 days.{36526} Formulations containing alogliptin have been used as an adjunct treatment for type 2 diabetes mellitus.
Brand:CaymanSKU:23768 - 50 mgAvailable on backorder
Aloin is a mixture of aloin A and aloin B (Item No. 23321), anthraquinones found in Aloe vera, and has diverse biological activities.{36960,36961,36962} It reduces IL-6 and TNF-α expression as well as nitric oxide (NO) production and COX-2 and inducible NO synthase (iNOS) expression in LPS-stimulated RAW 264.7 cells when used at concentrations ranging from 100 to 400 mM.{36960} Aloin inhibits LPS-induced p65 acetylation, nuclear translocation of NF-kB, and apoptosis in RAW 264.7 cells. It reduces motility of T. congolense in vitro and reduces the number of parasites in T. congolense-infected mice when administered at a dose of 400 mg/kg.{36961} Aloin (50 and 100 mg/kg) also reduces activity of glutathione peroxidase (GPX), glutathione-S-transferase (GST), and glutathione reductase (GR), the level of colonic malondialdehyde (MDA), and the number of aberrant crypt foci and mucin-depleted foci in a rat model of 1,2-dimethylhydrazine-induced colon cancer.{36962}
Brand:CaymanSKU:22435 -Out of stock
Aloin is a mixture of aloin A and aloin B (Item No. 23321), anthraquinones found in Aloe vera, and has diverse biological activities.{36960,36961,36962} It reduces IL-6 and TNF-α expression as well as nitric oxide (NO) production and COX-2 and inducible NO synthase (iNOS) expression in LPS-stimulated RAW 264.7 cells when used at concentrations ranging from 100 to 400 mM.{36960} Aloin inhibits LPS-induced p65 acetylation, nuclear translocation of NF-kB, and apoptosis in RAW 264.7 cells. It reduces motility of T. congolense in vitro and reduces the number of parasites in T. congolense-infected mice when administered at a dose of 400 mg/kg.{36961} Aloin (50 and 100 mg/kg) also reduces activity of glutathione peroxidase (GPX), glutathione-S-transferase (GST), and glutathione reductase (GR), the level of colonic malondialdehyde (MDA), and the number of aberrant crypt foci and mucin-depleted foci in a rat model of 1,2-dimethylhydrazine-induced colon cancer.{36962}
Brand:CaymanSKU:22435 -Out of stock
Aloin is a mixture of aloin A and aloin B (Item No. 23321), anthraquinones found in Aloe vera, and has diverse biological activities.{36960,36961,36962} It reduces IL-6 and TNF-α expression as well as nitric oxide (NO) production and COX-2 and inducible NO synthase (iNOS) expression in LPS-stimulated RAW 264.7 cells when used at concentrations ranging from 100 to 400 mM.{36960} Aloin inhibits LPS-induced p65 acetylation, nuclear translocation of NF-kB, and apoptosis in RAW 264.7 cells. It reduces motility of T. congolense in vitro and reduces the number of parasites in T. congolense-infected mice when administered at a dose of 400 mg/kg.{36961} Aloin (50 and 100 mg/kg) also reduces activity of glutathione peroxidase (GPX), glutathione-S-transferase (GST), and glutathione reductase (GR), the level of colonic malondialdehyde (MDA), and the number of aberrant crypt foci and mucin-depleted foci in a rat model of 1,2-dimethylhydrazine-induced colon cancer.{36962}
Brand:CaymanSKU:22435 -Out of stock
Aloin B is an anthraquinone found in Aloe vera and a component of racemic aloin (Item No. 22435).{47080}
Brand:CaymanSKU:23321 - 1 mgAvailable on backorder
Aloin B is an anthraquinone found in Aloe vera and a component of racemic aloin (Item No. 22435).{47080}
Brand:CaymanSKU:23321 - 10 mgAvailable on backorder
Aloin B is an anthraquinone found in Aloe vera and a component of racemic aloin (Item No. 22435).{47080}
Brand:CaymanSKU:23321 - 25 mgAvailable on backorder
Aloin B is an anthraquinone found in Aloe vera and a component of racemic aloin (Item No. 22435).{47080}
Brand:CaymanSKU:23321 - 5 mgAvailable on backorder
Aloisine is an inhibitor of Cdk1/cyclin B, Cdk5/p25, and GSK3 (IC50s = 0.70, 1.5, and 0.92 µM, respectively).{38576} It is a derivative of the aloisines A and B, which competitively inhibit ATP binding to the catalytic subunit of CDKs and GSKs.
Brand:CaymanSKU:21873 -Out of stock
Aloisine is an inhibitor of Cdk1/cyclin B, Cdk5/p25, and GSK3 (IC50s = 0.70, 1.5, and 0.92 µM, respectively).{38576} It is a derivative of the aloisines A and B, which competitively inhibit ATP binding to the catalytic subunit of CDKs and GSKs.
Brand:CaymanSKU:21873 -Out of stock