Chemicals
Showing 8251–8400 of 41137 results
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ACPT-II is a general competitive antagonist of metabotropic glutamate (mGlu) receptors. The KB values for mGlu1a, mGlu2, and mGlu4a receptors are 115, 88, and 77 µM, respectively.{5944} It binds to the large extracellular domain called a Venus flytrap module, where agonists bind.{30235} ACPT-II is a stereoisomer of the group III mGlu receptor-selective antagonist, ACPT-I.{5944}
Brand:CaymanSKU:78020 - 50 mgAvailable on backorder
Acremine I is a fungal metabolite originally isolated from Acremonium byssoides.{53576} It inhibits germination of P. viticola sporangia by 23.2 and 32.8% when used at concentrations of 0.5 and 1 mM, respectively.
Brand:CaymanSKU:29771 - 1 mgAvailable on backorder
Acridine orange is a cell-permeable, nucleic acid-selective fluorescent cationic dye useful for cell cycle determination and detection of cellular autophagy.{22781,22782,41255} It exhibits excitation/emission spectra of 502/525, 460/650, and 475/590 nm when bound to dsDNA, bound to ssDNA or RNA, and under acidic conditions, respectively.{22781,22782} The ratio of acridine orange emission at 590 to emission at 525 nm can be used to quantify the increase in the number of acidic vesicular organelles observed during cellular autophagy.
Brand:CaymanSKU:- Acridine orange is a cell-permeable, nucleic acid-selective fluorescent cationic dye useful for cell cycle determination and detection of cellular autophagy.{22781,22782,41255} It exhibits excitation/emission spectra of 502/525, 460/650, and 475/590 nm when bound to dsDNA, bound to ssDNA or RNA, and under acidic conditions, respectively.{22781,22782} The ratio of acridine orange emission at 590 to emission at 525 nm can be used to quantify the increase in the number of acidic vesicular organelles observed during cellular autophagy.
Brand:CaymanSKU:- Acridine orange is a cell-permeable, nucleic acid-selective fluorescent cationic dye useful for cell cycle determination and detection of cellular autophagy.{22781,22782,41255} It exhibits excitation/emission spectra of 502/525, 460/650, and 475/590 nm when bound to dsDNA, bound to ssDNA or RNA, and under acidic conditions, respectively.{22781,22782} The ratio of acridine orange emission at 590 to emission at 525 nm can be used to quantify the increase in the number of acidic vesicular organelles observed during cellular autophagy.
Brand:CaymanSKU:-
Acridine orange 10-nonyl is a mitochondrial dye and derivative of acridine orange (Item No. 14338) that incorporates into the cardiolipin-rich inner mitochondrial membrane.{36790} It selectively binds to cardiolipin-containing liposomes over phosphatidylserine- and phosphatidylinositol-containing liposomes in vitro (Kas = 0.002, 7,000, and 7,000 mM, respectively). Acridine orange 10-nonyl binding to mitochondria is abolished by the mitochondrial uncoupler FCCP (Item No. 15218) in rat cortical astrocytes, neonatal cardiomyocytes, and isolated brain mitochondria, indicating dependence on mitochondrial membrane potential.{36791} Acridine orange 10-nonyl displays excitation/emission maxima of 490/510 nm, respectively, and has been used to quantify cardiolipin content and mitochondrial mass in isolated mitochondria and cellular systems.
Brand:CaymanSKU:25545 - 10 mgAvailable on backorder
Acridine orange 10-nonyl is a mitochondrial dye and derivative of acridine orange (Item No. 14338) that incorporates into the cardiolipin-rich inner mitochondrial membrane.{36790} It selectively binds to cardiolipin-containing liposomes over phosphatidylserine- and phosphatidylinositol-containing liposomes in vitro (Kas = 0.002, 7,000, and 7,000 mM, respectively). Acridine orange 10-nonyl binding to mitochondria is abolished by the mitochondrial uncoupler FCCP (Item No. 15218) in rat cortical astrocytes, neonatal cardiomyocytes, and isolated brain mitochondria, indicating dependence on mitochondrial membrane potential.{36791} Acridine orange 10-nonyl displays excitation/emission maxima of 490/510 nm, respectively, and has been used to quantify cardiolipin content and mitochondrial mass in isolated mitochondria and cellular systems.
Brand:CaymanSKU:25545 - 25 mgAvailable on backorder
Acridine orange 10-nonyl is a mitochondrial dye and derivative of acridine orange (Item No. 14338) that incorporates into the cardiolipin-rich inner mitochondrial membrane.{36790} It selectively binds to cardiolipin-containing liposomes over phosphatidylserine- and phosphatidylinositol-containing liposomes in vitro (Kas = 0.002, 7,000, and 7,000 mM, respectively). Acridine orange 10-nonyl binding to mitochondria is abolished by the mitochondrial uncoupler FCCP (Item No. 15218) in rat cortical astrocytes, neonatal cardiomyocytes, and isolated brain mitochondria, indicating dependence on mitochondrial membrane potential.{36791} Acridine orange 10-nonyl displays excitation/emission maxima of 490/510 nm, respectively, and has been used to quantify cardiolipin content and mitochondrial mass in isolated mitochondria and cellular systems.
Brand:CaymanSKU:25545 - 5 mgAvailable on backorder
Acridine orange 10-nonyl is a mitochondrial dye and derivative of acridine orange (Item No. 14338) that incorporates into the cardiolipin-rich inner mitochondrial membrane.{36790} It selectively binds to cardiolipin-containing liposomes over phosphatidylserine- and phosphatidylinositol-containing liposomes in vitro (Kas = 0.002, 7,000, and 7,000 mM, respectively). Acridine orange 10-nonyl binding to mitochondria is abolished by the mitochondrial uncoupler FCCP (Item No. 15218) in rat cortical astrocytes, neonatal cardiomyocytes, and isolated brain mitochondria, indicating dependence on mitochondrial membrane potential.{36791} Acridine orange 10-nonyl displays excitation/emission maxima of 490/510 nm, respectively, and has been used to quantify cardiolipin content and mitochondrial mass in isolated mitochondria and cellular systems.
Brand:CaymanSKU:25545 - 50 mgAvailable on backorder
The acridinium NHS ester can be used to label proteins and nucleic acids. The covalently bound acridinium NHS ester will produce chemiluminescence in the presence of hydrogen peroxide. Acridinium-labeled proteins can be used as a detection method in immunoassays.{2437,2438}
Brand:CaymanSKU:200200 -Available on backorder
The acridinium NHS ester can be used to label proteins and nucleic acids. The covalently bound acridinium NHS ester will produce chemiluminescence in the presence of hydrogen peroxide. Acridinium-labeled proteins can be used as a detection method in immunoassays.{2437,2438}
Brand:CaymanSKU:200200 -Available on backorder
The acridinium NHS ester can be used to label proteins and nucleic acids. The covalently bound acridinium NHS ester will produce chemiluminescence in the presence of hydrogen peroxide. Acridinium-labeled proteins can be used as a detection method in immunoassays.{2437,2438}
Brand:CaymanSKU:200200 -Available on backorder
The acridinium NHS ester can be used to label proteins and nucleic acids. The covalently bound acridinium NHS ester will produce chemiluminescence in the presence of hydrogen peroxide. Acridinium-labeled proteins can be used as a detection method in immunoassays.{2437,2438}
Brand:CaymanSKU:200200 -Available on backorder
Acrivastine is a histamine H1 receptor antagonist with a Ki value of 10 nM in COS-7 cells expressing the human receptor.{39413} In vivo, acrivastine (1 mg/kg) completely inhibits response to histamine in guinea pigs.{39412} Formulations containing acrivastine have been used for the treatment of seasonal allergies and hay fever.
Brand:CaymanSKU:24021 - 10 mgAvailable on backorder
Acrivastine is a histamine H1 receptor antagonist with a Ki value of 10 nM in COS-7 cells expressing the human receptor.{39413} In vivo, acrivastine (1 mg/kg) completely inhibits response to histamine in guinea pigs.{39412} Formulations containing acrivastine have been used for the treatment of seasonal allergies and hay fever.
Brand:CaymanSKU:24021 - 25 mgAvailable on backorder
Acrivastine is a histamine H1 receptor antagonist with a Ki value of 10 nM in COS-7 cells expressing the human receptor.{39413} In vivo, acrivastine (1 mg/kg) completely inhibits response to histamine in guinea pigs.{39412} Formulations containing acrivastine have been used for the treatment of seasonal allergies and hay fever.
Brand:CaymanSKU:24021 - 5 mgAvailable on backorder
Acrivastine is a histamine H1 receptor antagonist with a Ki value of 10 nM in COS-7 cells expressing the human receptor.{39413} In vivo, acrivastine (1 mg/kg) completely inhibits response to histamine in guinea pigs.{39412} Formulations containing acrivastine have been used for the treatment of seasonal allergies and hay fever.
Brand:CaymanSKU:24021 - 50 mgAvailable on backorder
Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug for the treatment of glaucoma.{1107} Latanoprost is an isopropyl ester, a prodrug form which is converted to latanoprost (free acid) by endogenous esterase enzymes. The free acid form is 200 times more potent than latanoprost as an FP receptor ligand for the human recombinant FP receptor.{8322} ACS 67 is an analog of latanoprost (free acid) that contains a hydrogen sulfide releasing component conjugated to the latanoprost carboxyl group.{17577} In glaucomatous pigmented rabbits, ACS 67 reduced intra-ocular pressure (IOP) more rapidly and to a greater extent than latanoprost (15 versus 25.5 mm Hg at four hours) at a dose of 0.005% for each compound.{17577} ACS 67 also increased the levels of reduced glutathione and cGMP in the aqueous humor of glaucomatous pigmented rabbits better than latanoprost.{17577}
Brand:CaymanSKU:- Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug for the treatment of glaucoma.{1107} Latanoprost is an isopropyl ester, a prodrug form which is converted to latanoprost (free acid) by endogenous esterase enzymes. The free acid form is 200 times more potent than latanoprost as an FP receptor ligand for the human recombinant FP receptor.{8322} ACS 67 is an analog of latanoprost (free acid) that contains a hydrogen sulfide releasing component conjugated to the latanoprost carboxyl group.{17577} In glaucomatous pigmented rabbits, ACS 67 reduced intra-ocular pressure (IOP) more rapidly and to a greater extent than latanoprost (15 versus 25.5 mm Hg at four hours) at a dose of 0.005% for each compound.{17577} ACS 67 also increased the levels of reduced glutathione and cGMP in the aqueous humor of glaucomatous pigmented rabbits better than latanoprost.{17577}
Brand:CaymanSKU:- Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug for the treatment of glaucoma.{1107} Latanoprost is an isopropyl ester, a prodrug form which is converted to latanoprost (free acid) by endogenous esterase enzymes. The free acid form is 200 times more potent than latanoprost as an FP receptor ligand for the human recombinant FP receptor.{8322} ACS 67 is an analog of latanoprost (free acid) that contains a hydrogen sulfide releasing component conjugated to the latanoprost carboxyl group.{17577} In glaucomatous pigmented rabbits, ACS 67 reduced intra-ocular pressure (IOP) more rapidly and to a greater extent than latanoprost (15 versus 25.5 mm Hg at four hours) at a dose of 0.005% for each compound.{17577} ACS 67 also increased the levels of reduced glutathione and cGMP in the aqueous humor of glaucomatous pigmented rabbits better than latanoprost.{17577}
Brand:CaymanSKU:- Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug for the treatment of glaucoma.{1107} Latanoprost is an isopropyl ester, a prodrug form which is converted to latanoprost (free acid) by endogenous esterase enzymes. The free acid form is 200 times more potent than latanoprost as an FP receptor ligand for the human recombinant FP receptor.{8322} ACS 67 is an analog of latanoprost (free acid) that contains a hydrogen sulfide releasing component conjugated to the latanoprost carboxyl group.{17577} In glaucomatous pigmented rabbits, ACS 67 reduced intra-ocular pressure (IOP) more rapidly and to a greater extent than latanoprost (15 versus 25.5 mm Hg at four hours) at a dose of 0.005% for each compound.{17577} ACS 67 also increased the levels of reduced glutathione and cGMP in the aqueous humor of glaucomatous pigmented rabbits better than latanoprost.{17577}
Brand:CaymanSKU:-
Actagardin is a tetracyclic lantibiotic produced by several species of Actinoplanes.{27114} It is composed of macrocyclic rings formed by thioether bridges.{27114} Actagardin preferably targets Gram-positive bacteria, inhibiting the synthesis of peptidoglycan.{27114}
Brand:CaymanSKU:19940 -Available on backorder
Actagardin is a tetracyclic lantibiotic produced by several species of Actinoplanes.{27114} It is composed of macrocyclic rings formed by thioether bridges.{27114} Actagardin preferably targets Gram-positive bacteria, inhibiting the synthesis of peptidoglycan.{27114}
Brand:CaymanSKU:19940 -Available on backorder
Actarit is an orally active immunomodulator that reduces symptoms in animal models and clinical trials of rheumatoid arthritis.{32948,32949,32951} It suppresses inflammation and nitric oxide production, particularly in early stages of disease development.{32948,32949,32952} Actarit also alters immunological signaling and symptoms in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis.{32950}
Brand:CaymanSKU:20852 -Out of stock
Actarit is an orally active immunomodulator that reduces symptoms in animal models and clinical trials of rheumatoid arthritis.{32948,32949,32951} It suppresses inflammation and nitric oxide production, particularly in early stages of disease development.{32948,32949,32952} Actarit also alters immunological signaling and symptoms in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis.{32950}
Brand:CaymanSKU:20852 -Out of stock
Actarit is an orally active immunomodulator that reduces symptoms in animal models and clinical trials of rheumatoid arthritis.{32948,32949,32951} It suppresses inflammation and nitric oxide production, particularly in early stages of disease development.{32948,32949,32952} Actarit also alters immunological signaling and symptoms in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis.{32950}
Brand:CaymanSKU:20852 -Out of stock
Actarit is an orally active immunomodulator that reduces symptoms in animal models and clinical trials of rheumatoid arthritis.{32948,32949,32951} It suppresses inflammation and nitric oxide production, particularly in early stages of disease development.{32948,32949,32952} Actarit also alters immunological signaling and symptoms in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis.{32950}
Brand:CaymanSKU:20852 -Out of stock
ACTB-1003 is a multi-kinase inhibitor (IC50s = 6, 2, 4, 5, and 32 nM for FGFR1, VEGFR2, Tie-2, RSK, and p70S6K, respectively).{49609} It inhibits growth of OPM2 human multiple myeloma and murine Ba/F3-TEL-FGFR1 leukemia cells in vitro. ACTB-1003 inhibits tumor angiogenesis in an H460 mouse xenograft model. It also reduces tumor growth in an HCT116 mouse xenograft model when administered in combination with 5-fluorouracil (5-FU; Item No. 14416) or paclitaxel (Item No. 10461).
Brand:CaymanSKU:30069 - 1 mgAvailable on backorder
ACTB-1003 is a multi-kinase inhibitor (IC50s = 6, 2, 4, 5, and 32 nM for FGFR1, VEGFR2, Tie-2, RSK, and p70S6K, respectively).{49609} It inhibits growth of OPM2 human multiple myeloma and murine Ba/F3-TEL-FGFR1 leukemia cells in vitro. ACTB-1003 inhibits tumor angiogenesis in an H460 mouse xenograft model. It also reduces tumor growth in an HCT116 mouse xenograft model when administered in combination with 5-fluorouracil (5-FU; Item No. 14416) or paclitaxel (Item No. 10461).
Brand:CaymanSKU:30069 - 10 mgAvailable on backorder
ACTB-1003 is a multi-kinase inhibitor (IC50s = 6, 2, 4, 5, and 32 nM for FGFR1, VEGFR2, Tie-2, RSK, and p70S6K, respectively).{49609} It inhibits growth of OPM2 human multiple myeloma and murine Ba/F3-TEL-FGFR1 leukemia cells in vitro. ACTB-1003 inhibits tumor angiogenesis in an H460 mouse xenograft model. It also reduces tumor growth in an HCT116 mouse xenograft model when administered in combination with 5-fluorouracil (5-FU; Item No. 14416) or paclitaxel (Item No. 10461).
Brand:CaymanSKU:30069 - 5 mgAvailable on backorder
Adrenocorticotropic hormone (ACTH) (18-39) is a C-terminal peptide fragment of ACTH, a peptide hormone found in the brain that is involved in the biological stress response.{45140} It is produced via processing of ACTH in the intermediate lobe of the pituitary gland.{45140,45275} ACTH (18-39) increases cumulative food intake in fasted, but not fed, rats when administered intracerebroventricularly at a dose of 2.5 nmol/animal.{45275}
Brand:CaymanSKU:27274 - 1 mgAvailable on backorder
Adrenocorticotropic hormone (ACTH) (18-39) is a C-terminal peptide fragment of ACTH, a peptide hormone found in the brain that is involved in the biological stress response.{45140} It is produced via processing of ACTH in the intermediate lobe of the pituitary gland.{45140,45275} ACTH (18-39) increases cumulative food intake in fasted, but not fed, rats when administered intracerebroventricularly at a dose of 2.5 nmol/animal.{45275}
Brand:CaymanSKU:27274 - 2.5 mgAvailable on backorder
Adrenocorticotropic hormone (ACTH) (18-39) is a C-terminal peptide fragment of ACTH, a peptide hormone found in the brain that is involved in the biological stress response.{45140} It is produced via processing of ACTH in the intermediate lobe of the pituitary gland.{45140,45275} ACTH (18-39) increases cumulative food intake in fasted, but not fed, rats when administered intracerebroventricularly at a dose of 2.5 nmol/animal.{45275}
Brand:CaymanSKU:27274 - 500 µgAvailable on backorder
ACTH (4-11) is a peptide fragment of adrenocorticotropic hormone (ACTH; Item No. 24257), a peptide hormone found in the brain that is involved in the biological stress response.{45140} ACTH (4-11) induces differentiation of melanocytes when used at a concentration of 1,000 nM.{48409} It inhibits angiotensin converting enzyme (ACE) activity in homogenized canine lung with an IC50 value of 24 µM.{45300} ACTH (4-11) has been used to determine substrate specificity of recombinant H. zea carboxypeptidase B enzyme (CPBHz).{45301}
Brand:CaymanSKU:27430 - 1 mgAvailable on backorder
ACTH (4-11) is a peptide fragment of adrenocorticotropic hormone (ACTH; Item No. 24257), a peptide hormone found in the brain that is involved in the biological stress response.{45140} ACTH (4-11) induces differentiation of melanocytes when used at a concentration of 1,000 nM.{48409} It inhibits angiotensin converting enzyme (ACE) activity in homogenized canine lung with an IC50 value of 24 µM.{45300} ACTH (4-11) has been used to determine substrate specificity of recombinant H. zea carboxypeptidase B enzyme (CPBHz).{45301}
Brand:CaymanSKU:27430 - 10 mgAvailable on backorder
ACTH (4-11) is a peptide fragment of adrenocorticotropic hormone (ACTH; Item No. 24257), a peptide hormone found in the brain that is involved in the biological stress response.{45140} ACTH (4-11) induces differentiation of melanocytes when used at a concentration of 1,000 nM.{48409} It inhibits angiotensin converting enzyme (ACE) activity in homogenized canine lung with an IC50 value of 24 µM.{45300} ACTH (4-11) has been used to determine substrate specificity of recombinant H. zea carboxypeptidase B enzyme (CPBHz).{45301}
Brand:CaymanSKU:27430 - 5 mgAvailable on backorder
Actinomycin D is a cyclic polypeptide-containing antibiotic that binds to DNA and blocks transcription. It binds to pre-melted double-stranded DNA in transcription bubbles and once bound is slow to dissociate.{21521,21519} DNA in transcriptionally hyperactive cancer cells efficiently and rapidly bind actinomycin D at low concentrations (~10 nM), which interferes with RNA synthesis and ultimately leads to cell death.{21521,21520} Actinomycin D is widely used as an anticancer agent for treating a variety of tumors and along with its fluorescent derivative, 7-aminoactinomycin D (Item No. 11397) has become a useful tool in biochemistry and molecular biology research as a marker for DNA.
Brand:CaymanSKU:11421 - 10 mgAvailable on backorder
Actinomycin D is a cyclic polypeptide-containing antibiotic that binds to DNA and blocks transcription. It binds to pre-melted double-stranded DNA in transcription bubbles and once bound is slow to dissociate.{21521,21519} DNA in transcriptionally hyperactive cancer cells efficiently and rapidly bind actinomycin D at low concentrations (~10 nM), which interferes with RNA synthesis and ultimately leads to cell death.{21521,21520} Actinomycin D is widely used as an anticancer agent for treating a variety of tumors and along with its fluorescent derivative, 7-aminoactinomycin D (Item No. 11397) has become a useful tool in biochemistry and molecular biology research as a marker for DNA.
Brand:CaymanSKU:11421 - 25 mgAvailable on backorder
Actinomycin D is a cyclic polypeptide-containing antibiotic that binds to DNA and blocks transcription. It binds to pre-melted double-stranded DNA in transcription bubbles and once bound is slow to dissociate.{21521,21519} DNA in transcriptionally hyperactive cancer cells efficiently and rapidly bind actinomycin D at low concentrations (~10 nM), which interferes with RNA synthesis and ultimately leads to cell death.{21521,21520} Actinomycin D is widely used as an anticancer agent for treating a variety of tumors and along with its fluorescent derivative, 7-aminoactinomycin D (Item No. 11397) has become a useful tool in biochemistry and molecular biology research as a marker for DNA.
Brand:CaymanSKU:11421 - 5 mgAvailable on backorder
Actinomycin D is a cyclic polypeptide-containing antibiotic that binds to DNA and blocks transcription. It binds to pre-melted double-stranded DNA in transcription bubbles and once bound is slow to dissociate.{21521,21519} DNA in transcriptionally hyperactive cancer cells efficiently and rapidly bind actinomycin D at low concentrations (~10 nM), which interferes with RNA synthesis and ultimately leads to cell death.{21521,21520} Actinomycin D is widely used as an anticancer agent for treating a variety of tumors and along with its fluorescent derivative, 7-aminoactinomycin D (Item No. 11397) has become a useful tool in biochemistry and molecular biology research as a marker for DNA.
Brand:CaymanSKU:11421 - 50 mgAvailable on backorder
Actinonin is a peptidomimetic antibiotic produced by Actinomyces that inhibits aminopeptidases. It inhibits the following matrix metalloproteinases (MMPs): MMP-1 (Ki = 300 nM), MMP-3 (Ki = 1,700 nM), MMP-8 (Ki = 130 nM), and MMP-9 (Ki = 330 nM).{27523}} Actinonin acts as an herbicide by targeting plastid peptide deformylase, an enzyme required for N-terminal processing of plastid-encoded proteins.{27463} Actinonin has also been identified as an effective inhibitor of human meprin α (Ki = 20 nM), a zinc endopeptidase that cleaves matrix proteins.{24095} More recently actinonin has been shown to inhibit tumor cell invasion and matrix degradation and to induce apoptosis in animal models by targeting human mitochondrial peptide deformylase.{27522}
Brand:CaymanSKU:-Out of stock
Actinonin is a peptidomimetic antibiotic produced by Actinomyces that inhibits aminopeptidases. It inhibits the following matrix metalloproteinases (MMPs): MMP-1 (Ki = 300 nM), MMP-3 (Ki = 1,700 nM), MMP-8 (Ki = 130 nM), and MMP-9 (Ki = 330 nM).{27523}} Actinonin acts as an herbicide by targeting plastid peptide deformylase, an enzyme required for N-terminal processing of plastid-encoded proteins.{27463} Actinonin has also been identified as an effective inhibitor of human meprin α (Ki = 20 nM), a zinc endopeptidase that cleaves matrix proteins.{24095} More recently actinonin has been shown to inhibit tumor cell invasion and matrix degradation and to induce apoptosis in animal models by targeting human mitochondrial peptide deformylase.{27522}
Brand:CaymanSKU:-Out of stock
Actinopyrone A is a pyrone isolated from S. pactum with diverse biological activities.{41117} It has selective and potent antimicrobial activity against H. pylori (MIC = 0.1 ng/mL) with no activity against other Gram-negative bacteria including E. coli, K. pneumoniae, P. aeruginosa, and B. fragilis.{41117,41118} Actinopyrone A also mildly inhibits growth of Gram-positive bacteria and dermatophytes with MIC values ranging from <6.25 to 25 μg/mL.{41117} Intravenous administration of actinopyrone A (30 μg/kg) increases coronary blood flow in dogs by 196.2%.
Brand:CaymanSKU:23140 - 2.5 mgAvailable on backorder
Actinopyrone A is a pyrone isolated from S. pactum with diverse biological activities.{41117} It has selective and potent antimicrobial activity against H. pylori (MIC = 0.1 ng/mL) with no activity against other Gram-negative bacteria including E. coli, K. pneumoniae, P. aeruginosa, and B. fragilis.{41117,41118} Actinopyrone A also mildly inhibits growth of Gram-positive bacteria and dermatophytes with MIC values ranging from <6.25 to 25 μg/mL.{41117} Intravenous administration of actinopyrone A (30 μg/kg) increases coronary blood flow in dogs by 196.2%.
Brand:CaymanSKU:23140 - 500 µgAvailable on backorder
Actinotetraose hexatiglate is a unique tetrasaccharide with six tiglate esters that was isolated from an Amycolatopsis culture.{31053} The sugar is distinguished by a two-fold axis of symmetry and is a co-metabolite of quinaldopeptin, a cytotoxic antibiotic with anthelmintic activity.{31053} The biological role of this metabolite is not known but is suspected to lack antimicrobial activity.{31053}
Brand:CaymanSKU:-Available on backorder
Actinotetraose hexatiglate is a unique tetrasaccharide with six tiglate esters that was isolated from an Amycolatopsis culture.{31053} The sugar is distinguished by a two-fold axis of symmetry and is a co-metabolite of quinaldopeptin, a cytotoxic antibiotic with anthelmintic activity.{31053} The biological role of this metabolite is not known but is suspected to lack antimicrobial activity.{31053}
Brand:CaymanSKU:-Available on backorder
Brand:CaymanSKU:25832 - 1 mgAvailable on backorder
Brand:CaymanSKU:25832 - 10 mgAvailable on backorder
Brand:CaymanSKU:25832 - 25 mgAvailable on backorder
Brand:CaymanSKU:25832 - 5 mgAvailable on backorder
ACY-1215 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 5 nM).{33843} It is at least 10-fold less active against other HDACs in enzymatic assays. ACY-1215 shows synergistic activity with the proteasome inhibitor bortezomib (Item No. 10008822) against multiple myeloma (MM) cells, inducing protracted endoplasmic reticulum stress and apoptosis.{33843,33840} ACY-1215 combined with proteasome inhibitors suppresses tumor growth and increases survival in mice with MM and mantle cell lymphoma xenografts.{33840,33843,33842} A multicenter phase I trial examining ACY-1215 combined with the E3 ligase inhibitor lenalidomide (Item No. 14643) and dexamethasone (Item No. 11015) in multiple myeloma found inhibition of HDAC6 in vivo.{33845} ACY-1215 also diminishes liver cyst development and fibrosis in a rat model of polycystic liver disease.{33841}
Brand:CaymanSKU:21531 -Out of stock
ACY-1215 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 5 nM).{33843} It is at least 10-fold less active against other HDACs in enzymatic assays. ACY-1215 shows synergistic activity with the proteasome inhibitor bortezomib (Item No. 10008822) against multiple myeloma (MM) cells, inducing protracted endoplasmic reticulum stress and apoptosis.{33843,33840} ACY-1215 combined with proteasome inhibitors suppresses tumor growth and increases survival in mice with MM and mantle cell lymphoma xenografts.{33840,33843,33842} A multicenter phase I trial examining ACY-1215 combined with the E3 ligase inhibitor lenalidomide (Item No. 14643) and dexamethasone (Item No. 11015) in multiple myeloma found inhibition of HDAC6 in vivo.{33845} ACY-1215 also diminishes liver cyst development and fibrosis in a rat model of polycystic liver disease.{33841}
Brand:CaymanSKU:21531 -Out of stock
ACY-1215 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 5 nM).{33843} It is at least 10-fold less active against other HDACs in enzymatic assays. ACY-1215 shows synergistic activity with the proteasome inhibitor bortezomib (Item No. 10008822) against multiple myeloma (MM) cells, inducing protracted endoplasmic reticulum stress and apoptosis.{33843,33840} ACY-1215 combined with proteasome inhibitors suppresses tumor growth and increases survival in mice with MM and mantle cell lymphoma xenografts.{33840,33843,33842} A multicenter phase I trial examining ACY-1215 combined with the E3 ligase inhibitor lenalidomide (Item No. 14643) and dexamethasone (Item No. 11015) in multiple myeloma found inhibition of HDAC6 in vivo.{33845} ACY-1215 also diminishes liver cyst development and fibrosis in a rat model of polycystic liver disease.{33841}
Brand:CaymanSKU:21531 -Out of stock
ACY-1215 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 5 nM).{33843} It is at least 10-fold less active against other HDACs in enzymatic assays. ACY-1215 shows synergistic activity with the proteasome inhibitor bortezomib (Item No. 10008822) against multiple myeloma (MM) cells, inducing protracted endoplasmic reticulum stress and apoptosis.{33843,33840} ACY-1215 combined with proteasome inhibitors suppresses tumor growth and increases survival in mice with MM and mantle cell lymphoma xenografts.{33840,33843,33842} A multicenter phase I trial examining ACY-1215 combined with the E3 ligase inhibitor lenalidomide (Item No. 14643) and dexamethasone (Item No. 11015) in multiple myeloma found inhibition of HDAC6 in vivo.{33845} ACY-1215 also diminishes liver cyst development and fibrosis in a rat model of polycystic liver disease.{33841}
Brand:CaymanSKU:21531 -Out of stock
ACY-241 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 2.6 nM).{47143} It is selective for HDAC6 over HDAC1-3, HDAC7, and HDAC9 (IC50s = 35, 45, 46, 7,300, and 137 nM, respectively), as well as HDAC4, HDAC5, and HDAC9 (IC50 = >20,000 nM for all). It reduces proliferation of A2780, TOV-21G, and MDA-MB-231 cells when used at a concentration of 3 µM and completely inhibits it and induces apoptosis at a concentration of 10 µM. ACY-241, when used in combination with paclitaxel (Item No. 10461), inhibits proliferation in MiaPaCa-2, TOV-21G, and T47D cells. It also reduces tumor growth in a MiaPaCa-2 mouse xenograft model when administered at a dose of 50 mg/kg in combination with paclitaxel. ACY-241, in combination with the somatostatin receptor agonist pasireotide (Item No. 24092), reduces hepatorenal cystogenesis in a rat model of polycystic liver disease.{47144}
Brand:CaymanSKU:26173 - 10 mgAvailable on backorder
ACY-241 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 2.6 nM).{47143} It is selective for HDAC6 over HDAC1-3, HDAC7, and HDAC9 (IC50s = 35, 45, 46, 7,300, and 137 nM, respectively), as well as HDAC4, HDAC5, and HDAC9 (IC50 = >20,000 nM for all). It reduces proliferation of A2780, TOV-21G, and MDA-MB-231 cells when used at a concentration of 3 µM and completely inhibits it and induces apoptosis at a concentration of 10 µM. ACY-241, when used in combination with paclitaxel (Item No. 10461), inhibits proliferation in MiaPaCa-2, TOV-21G, and T47D cells. It also reduces tumor growth in a MiaPaCa-2 mouse xenograft model when administered at a dose of 50 mg/kg in combination with paclitaxel. ACY-241, in combination with the somatostatin receptor agonist pasireotide (Item No. 24092), reduces hepatorenal cystogenesis in a rat model of polycystic liver disease.{47144}
Brand:CaymanSKU:26173 - 25 mgAvailable on backorder
ACY-241 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 2.6 nM).{47143} It is selective for HDAC6 over HDAC1-3, HDAC7, and HDAC9 (IC50s = 35, 45, 46, 7,300, and 137 nM, respectively), as well as HDAC4, HDAC5, and HDAC9 (IC50 = >20,000 nM for all). It reduces proliferation of A2780, TOV-21G, and MDA-MB-231 cells when used at a concentration of 3 µM and completely inhibits it and induces apoptosis at a concentration of 10 µM. ACY-241, when used in combination with paclitaxel (Item No. 10461), inhibits proliferation in MiaPaCa-2, TOV-21G, and T47D cells. It also reduces tumor growth in a MiaPaCa-2 mouse xenograft model when administered at a dose of 50 mg/kg in combination with paclitaxel. ACY-241, in combination with the somatostatin receptor agonist pasireotide (Item No. 24092), reduces hepatorenal cystogenesis in a rat model of polycystic liver disease.{47144}
Brand:CaymanSKU:26173 - 5 mgAvailable on backorder
ACY-738 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 1.7 nM).{47573} It is selective for HDAC6 over HDAC1-3 (IC50s = 94, 128, and 218 nM, respectively). ACY-738 (5 mg/kg) increases acetylation of α-tubulin in mouse brain. It increases exploratory activity in a novel open-field test and reduces immobility time in a tail suspension test in wild-type, but not neural cell-selective HDAC6 knockout, mice when administered at a dose of 50 mg/kg, indicating anxiolytic and antidepressant-like activity, respectively. ACY-738 (100 mg/kg in the diet) attenuates decreases in caudal nerve sensory nerve action potential (SNAP) amplitude and increases in hind paw mechanical hypersensitivity in a mouse model of peripheral neuropathy induced by vincristine (Item No. 11764).{47574} It decreases hepatorenal cystogenesis in a rat model of polycystic liver disease when administered at a dose of 30 mg/kg.{47144}
Brand:CaymanSKU:28282 - 1 mgAvailable on backorder
ACY-738 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 1.7 nM).{47573} It is selective for HDAC6 over HDAC1-3 (IC50s = 94, 128, and 218 nM, respectively). ACY-738 (5 mg/kg) increases acetylation of α-tubulin in mouse brain. It increases exploratory activity in a novel open-field test and reduces immobility time in a tail suspension test in wild-type, but not neural cell-selective HDAC6 knockout, mice when administered at a dose of 50 mg/kg, indicating anxiolytic and antidepressant-like activity, respectively. ACY-738 (100 mg/kg in the diet) attenuates decreases in caudal nerve sensory nerve action potential (SNAP) amplitude and increases in hind paw mechanical hypersensitivity in a mouse model of peripheral neuropathy induced by vincristine (Item No. 11764).{47574} It decreases hepatorenal cystogenesis in a rat model of polycystic liver disease when administered at a dose of 30 mg/kg.{47144}
Brand:CaymanSKU:28282 - 10 mgAvailable on backorder
ACY-738 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 1.7 nM).{47573} It is selective for HDAC6 over HDAC1-3 (IC50s = 94, 128, and 218 nM, respectively). ACY-738 (5 mg/kg) increases acetylation of α-tubulin in mouse brain. It increases exploratory activity in a novel open-field test and reduces immobility time in a tail suspension test in wild-type, but not neural cell-selective HDAC6 knockout, mice when administered at a dose of 50 mg/kg, indicating anxiolytic and antidepressant-like activity, respectively. ACY-738 (100 mg/kg in the diet) attenuates decreases in caudal nerve sensory nerve action potential (SNAP) amplitude and increases in hind paw mechanical hypersensitivity in a mouse model of peripheral neuropathy induced by vincristine (Item No. 11764).{47574} It decreases hepatorenal cystogenesis in a rat model of polycystic liver disease when administered at a dose of 30 mg/kg.{47144}
Brand:CaymanSKU:28282 - 25 mgAvailable on backorder
ACY-738 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 1.7 nM).{47573} It is selective for HDAC6 over HDAC1-3 (IC50s = 94, 128, and 218 nM, respectively). ACY-738 (5 mg/kg) increases acetylation of α-tubulin in mouse brain. It increases exploratory activity in a novel open-field test and reduces immobility time in a tail suspension test in wild-type, but not neural cell-selective HDAC6 knockout, mice when administered at a dose of 50 mg/kg, indicating anxiolytic and antidepressant-like activity, respectively. ACY-738 (100 mg/kg in the diet) attenuates decreases in caudal nerve sensory nerve action potential (SNAP) amplitude and increases in hind paw mechanical hypersensitivity in a mouse model of peripheral neuropathy induced by vincristine (Item No. 11764).{47574} It decreases hepatorenal cystogenesis in a rat model of polycystic liver disease when administered at a dose of 30 mg/kg.{47144}
Brand:CaymanSKU:28282 - 5 mgAvailable on backorder
ACY-775 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 0.0075 µM).{47573} It is selective for HDAC6 over HDAC1, HDAC2, and HDAC3 (IC50s = 2.1, 2.5, and 11.2 µM, respectively). ACY-775 (2.5 µM) increases α-tubulin acetylation at lysine 40 in RN46A-B14 serotonergic cells. It increases the distance traveled in the center of the open field test and decreases immobility time in the tail suspension test, indicating anxiolytic- and antidepressant-like activities, respectively, in mice when administered at a dose of 50 mg/kg.
Brand:CaymanSKU:29198 - 1 mgAvailable on backorder
ACY-775 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 0.0075 µM).{47573} It is selective for HDAC6 over HDAC1, HDAC2, and HDAC3 (IC50s = 2.1, 2.5, and 11.2 µM, respectively). ACY-775 (2.5 µM) increases α-tubulin acetylation at lysine 40 in RN46A-B14 serotonergic cells. It increases the distance traveled in the center of the open field test and decreases immobility time in the tail suspension test, indicating anxiolytic- and antidepressant-like activities, respectively, in mice when administered at a dose of 50 mg/kg.
Brand:CaymanSKU:29198 - 10 mgAvailable on backorder
ACY-775 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 0.0075 µM).{47573} It is selective for HDAC6 over HDAC1, HDAC2, and HDAC3 (IC50s = 2.1, 2.5, and 11.2 µM, respectively). ACY-775 (2.5 µM) increases α-tubulin acetylation at lysine 40 in RN46A-B14 serotonergic cells. It increases the distance traveled in the center of the open field test and decreases immobility time in the tail suspension test, indicating anxiolytic- and antidepressant-like activities, respectively, in mice when administered at a dose of 50 mg/kg.
Brand:CaymanSKU:29198 - 25 mgAvailable on backorder
ACY-775 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 0.0075 µM).{47573} It is selective for HDAC6 over HDAC1, HDAC2, and HDAC3 (IC50s = 2.1, 2.5, and 11.2 µM, respectively). ACY-775 (2.5 µM) increases α-tubulin acetylation at lysine 40 in RN46A-B14 serotonergic cells. It increases the distance traveled in the center of the open field test and decreases immobility time in the tail suspension test, indicating anxiolytic- and antidepressant-like activities, respectively, in mice when administered at a dose of 50 mg/kg.
Brand:CaymanSKU:29198 - 5 mgAvailable on backorder
Acyclovir is a guanosine analog that has antiviral activity in vitro against the herpes simplex viruses, varicella zoster virus, Epstein-Barr virus, cytomegalovirus, and human herpes virus 6 (ID50s = 0.1-63.1 μM).{22178} It diffuses freely into cells and is selectively converted into acyclo-guanosine monophosphate by a virus-specific thymidine kinase. During DNA replication, the phosphorylated form of acyclovir is preferentially incorporated into viral DNA, resulting in premature chain termination and inhibition of further DNA polymerase activity.{22179} Acyclovir (5 mg/kg) reduces viral titers in mice infected with the herpes simplex virus-1 (HSV-1) strain SC16.{48054}
Brand:CaymanSKU:- Acyclovir is a guanosine analog that has antiviral activity in vitro against the herpes simplex viruses, varicella zoster virus, Epstein-Barr virus, cytomegalovirus, and human herpes virus 6 (ID50s = 0.1-63.1 μM).{22178} It diffuses freely into cells and is selectively converted into acyclo-guanosine monophosphate by a virus-specific thymidine kinase. During DNA replication, the phosphorylated form of acyclovir is preferentially incorporated into viral DNA, resulting in premature chain termination and inhibition of further DNA polymerase activity.{22179} Acyclovir (5 mg/kg) reduces viral titers in mice infected with the herpes simplex virus-1 (HSV-1) strain SC16.{48054}
Brand:CaymanSKU:- Acyclovir is a guanosine analog that has antiviral activity in vitro against the herpes simplex viruses, varicella zoster virus, Epstein-Barr virus, cytomegalovirus, and human herpes virus 6 (ID50s = 0.1-63.1 μM).{22178} It diffuses freely into cells and is selectively converted into acyclo-guanosine monophosphate by a virus-specific thymidine kinase. During DNA replication, the phosphorylated form of acyclovir is preferentially incorporated into viral DNA, resulting in premature chain termination and inhibition of further DNA polymerase activity.{22179} Acyclovir (5 mg/kg) reduces viral titers in mice infected with the herpes simplex virus-1 (HSV-1) strain SC16.{48054}
Brand:CaymanSKU:- Acyclovir is a guanosine analog that has antiviral activity in vitro against the herpes simplex viruses, varicella zoster virus, Epstein-Barr virus, cytomegalovirus, and human herpes virus 6 (ID50s = 0.1-63.1 μM).{22178} It diffuses freely into cells and is selectively converted into acyclo-guanosine monophosphate by a virus-specific thymidine kinase. During DNA replication, the phosphorylated form of acyclovir is preferentially incorporated into viral DNA, resulting in premature chain termination and inhibition of further DNA polymerase activity.{22179} Acyclovir (5 mg/kg) reduces viral titers in mice infected with the herpes simplex virus-1 (HSV-1) strain SC16.{48054}
Brand:CaymanSKU:-
Acyclovir-d4 is intended for use as an internal standard for the quantification of acyclovir (Item No. 14160) by GC- or LC-MS. Acyclovir is a guanosine analog that has antiviral activity in vitro against the herpes simplex viruses, varicella zoster virus, Epstein-Barr virus, cytomegalovirus, and human herpes virus 6 (ID50s = 0.1-63.1 μM).{22178} It diffuses freely into cells and is selectively converted into acyclo-guanosine monophosphate by a virus-specific thymidine kinase. During DNA replication, the phosphorylated form of acyclovir is preferentially incorporated into viral DNA, resulting in premature chain termination and inhibition of further DNA polymerase activity.{22179} Acyclovir (5 mg/kg) reduces viral titers in mice infected with the herpes simplex virus-1 (HSV-1) strain SC16.{48054}
Brand:CaymanSKU:26272 - 1 mgAvailable on backorder
Complex diseases, like cancer, may best be countered by compounds that affect multiple targets. AD57 is a polypharmacological cancer therapeutic, in that it is designed to modulate multiple targets related to cancer.{21665} In Drosophila, it potently inhibits the receptor tyrosine kinase RET (IC50 = 2 nM) and reduces the activity of numerous other kinases by more than 80% when given at 1 μM.{21665} Most notably, AD57 interferes with kinases downstream of RET, including Src, Raf, and S6K, providing further efficacy in preventing signaling leading to invasion, proliferation, and metabolism relevant to cancer.{21665}
Brand:CaymanSKU:- Complex diseases, like cancer, may best be countered by compounds that affect multiple targets. AD57 is a polypharmacological cancer therapeutic, in that it is designed to modulate multiple targets related to cancer.{21665} In Drosophila, it potently inhibits the receptor tyrosine kinase RET (IC50 = 2 nM) and reduces the activity of numerous other kinases by more than 80% when given at 1 μM.{21665} Most notably, AD57 interferes with kinases downstream of RET, including Src, Raf, and S6K, providing further efficacy in preventing signaling leading to invasion, proliferation, and metabolism relevant to cancer.{21665}
Brand:CaymanSKU:- Complex diseases, like cancer, may best be countered by compounds that affect multiple targets. AD57 is a polypharmacological cancer therapeutic, in that it is designed to modulate multiple targets related to cancer.{21665} In Drosophila, it potently inhibits the receptor tyrosine kinase RET (IC50 = 2 nM) and reduces the activity of numerous other kinases by more than 80% when given at 1 μM.{21665} Most notably, AD57 interferes with kinases downstream of RET, including Src, Raf, and S6K, providing further efficacy in preventing signaling leading to invasion, proliferation, and metabolism relevant to cancer.{21665}
Brand:CaymanSKU:-
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) is an aggrecanase in that it cleaves aggrecan, a major proteoglycan in cartilage. While it has key roles in cartilage destruction associated with osteoarthritis, ADAMTS-5 is also involved in other pathways, including neurological processes.{28337,28336} ADAMTS-5 Inhibitor is an inhibitor of ADAMTS-5 (aggrecanase-2; IC50 = 1.1 µM) with 40-fold selectivity over ADAMTS-4 (aggrecanase-1).{28335,28334}
Brand:CaymanSKU:-Out of stock
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) is an aggrecanase in that it cleaves aggrecan, a major proteoglycan in cartilage. While it has key roles in cartilage destruction associated with osteoarthritis, ADAMTS-5 is also involved in other pathways, including neurological processes.{28337,28336} ADAMTS-5 Inhibitor is an inhibitor of ADAMTS-5 (aggrecanase-2; IC50 = 1.1 µM) with 40-fold selectivity over ADAMTS-4 (aggrecanase-1).{28335,28334}
Brand:CaymanSKU:-Out of stock
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) is an aggrecanase in that it cleaves aggrecan, a major proteoglycan in cartilage. While it has key roles in cartilage destruction associated with osteoarthritis, ADAMTS-5 is also involved in other pathways, including neurological processes.{28337,28336} ADAMTS-5 Inhibitor is an inhibitor of ADAMTS-5 (aggrecanase-2; IC50 = 1.1 µM) with 40-fold selectivity over ADAMTS-4 (aggrecanase-1).{28335,28334}
Brand:CaymanSKU:-Out of stock
Adapalene is a synthetic retinoid and an agonist of retinoic acid receptors (RARs; Kds = 1,100, 34, and 130 nM for RARα, RARβ, and RARγ, respectively).{18516,37761,37762,37763,37764} It inhibits growth and differentiation of sebocytes in a concentration-dependent manner in primary rat preputial cell culture. Adapalene (10 μM) completely inhibits the activity of soybean 15-lipoxygenase (15-LOX) in an enzyme assay and inhibits the 5- and 15-LOX pathways in human blood polymorphonuclear leukocytes (PMNs).{37761} It reduces the protein levels of toll-like receptor 2 (TLR2) and IL-10 in skin explants isolated from patients with acne and healthy controls in a concentration-dependent manner but increases the expression of the antigen-presenting protein CD1d in acne skin explants while decreasing it in control explants.{37762} It inhibits inflammation in rodent models of ear edema induced by arachidonic acid and carrageenan-induced paw edema.{37761} Adapalene (100 μM) also induces apoptosis and inhibits proliferation of CC-531, HT-29, and LoVo colon cancer cells and reduces tumor growth in a DLD-1 colon cancer nude mouse xenograft model in a dose-dependent manner.{37764,37763} Formulations containing adapalene have been used in the treatment of acne vulgaris.
Brand:CaymanSKU:- Adapalene is a synthetic retinoid and an agonist of retinoic acid receptors (RARs; Kds = 1,100, 34, and 130 nM for RARα, RARβ, and RARγ, respectively).{18516,37761,37762,37763,37764} It inhibits growth and differentiation of sebocytes in a concentration-dependent manner in primary rat preputial cell culture. Adapalene (10 μM) completely inhibits the activity of soybean 15-lipoxygenase (15-LOX) in an enzyme assay and inhibits the 5- and 15-LOX pathways in human blood polymorphonuclear leukocytes (PMNs).{37761} It reduces the protein levels of toll-like receptor 2 (TLR2) and IL-10 in skin explants isolated from patients with acne and healthy controls in a concentration-dependent manner but increases the expression of the antigen-presenting protein CD1d in acne skin explants while decreasing it in control explants.{37762} It inhibits inflammation in rodent models of ear edema induced by arachidonic acid and carrageenan-induced paw edema.{37761} Adapalene (100 μM) also induces apoptosis and inhibits proliferation of CC-531, HT-29, and LoVo colon cancer cells and reduces tumor growth in a DLD-1 colon cancer nude mouse xenograft model in a dose-dependent manner.{37764,37763} Formulations containing adapalene have been used in the treatment of acne vulgaris.
Brand:CaymanSKU:- Adapalene is a synthetic retinoid and an agonist of retinoic acid receptors (RARs; Kds = 1,100, 34, and 130 nM for RARα, RARβ, and RARγ, respectively).{18516,37761,37762,37763,37764} It inhibits growth and differentiation of sebocytes in a concentration-dependent manner in primary rat preputial cell culture. Adapalene (10 μM) completely inhibits the activity of soybean 15-lipoxygenase (15-LOX) in an enzyme assay and inhibits the 5- and 15-LOX pathways in human blood polymorphonuclear leukocytes (PMNs).{37761} It reduces the protein levels of toll-like receptor 2 (TLR2) and IL-10 in skin explants isolated from patients with acne and healthy controls in a concentration-dependent manner but increases the expression of the antigen-presenting protein CD1d in acne skin explants while decreasing it in control explants.{37762} It inhibits inflammation in rodent models of ear edema induced by arachidonic acid and carrageenan-induced paw edema.{37761} Adapalene (100 μM) also induces apoptosis and inhibits proliferation of CC-531, HT-29, and LoVo colon cancer cells and reduces tumor growth in a DLD-1 colon cancer nude mouse xenograft model in a dose-dependent manner.{37764,37763} Formulations containing adapalene have been used in the treatment of acne vulgaris.
Brand:CaymanSKU:- Adapalene is a synthetic retinoid and an agonist of retinoic acid receptors (RARs; Kds = 1,100, 34, and 130 nM for RARα, RARβ, and RARγ, respectively).{18516,37761,37762,37763,37764} It inhibits growth and differentiation of sebocytes in a concentration-dependent manner in primary rat preputial cell culture. Adapalene (10 μM) completely inhibits the activity of soybean 15-lipoxygenase (15-LOX) in an enzyme assay and inhibits the 5- and 15-LOX pathways in human blood polymorphonuclear leukocytes (PMNs).{37761} It reduces the protein levels of toll-like receptor 2 (TLR2) and IL-10 in skin explants isolated from patients with acne and healthy controls in a concentration-dependent manner but increases the expression of the antigen-presenting protein CD1d in acne skin explants while decreasing it in control explants.{37762} It inhibits inflammation in rodent models of ear edema induced by arachidonic acid and carrageenan-induced paw edema.{37761} Adapalene (100 μM) also induces apoptosis and inhibits proliferation of CC-531, HT-29, and LoVo colon cancer cells and reduces tumor growth in a DLD-1 colon cancer nude mouse xenograft model in a dose-dependent manner.{37764,37763} Formulations containing adapalene have been used in the treatment of acne vulgaris.
Brand:CaymanSKU:-
Adapalene-d3 is intended for use as an internal standard for the quantification of adapalene (Item No. 13655) by GC- or LC-MS. Adapalene is a synthetic retinoid and an agonist of retinoic acid receptors (RARs; Kds = 1,100, 34, and 130 nM for RARα, RARβ, and RARγ, respectively).{18516,37761,37762,37763,37764} It inhibits growth and differentiation of sebocytes in a concentration-dependent manner in primary rat preputial cell culture. Adapalene (10 μM) completely inhibits the activity of soybean 15-lipoxygenase (15-LOX) in an enzyme assay and inhibits the 5- and 15-LOX pathways in human blood polymorphonuclear leukocytes (PMNs).{37761} It reduces the protein levels of toll-like receptor 2 (TLR2) and IL-10 in skin explants isolated from patients with acne and healthy controls in a concentration-dependent manner but increases the expression of the antigen-presenting protein CD1d in acne skin explants while decreasing it in control explants.{37762} It inhibits inflammation in rodent models of ear edema induced by arachidonic acid and carrageenan-induced paw edema.{37761} Adapalene (100 μM) also induces apoptosis and inhibits proliferation of CC-531, HT-29, and LoVo colon cancer cells and reduces tumor growth in a DLD-1 colon cancer nude mouse xenograft model in a dose-dependent manner.{37764,37763} Formulations containing adapalene have been used in the treatment of acne vulgaris.
Brand:CaymanSKU:25758 - 1 mgAvailable on backorder