Chemicals
Showing 7801–7950 of 41137 results
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A-971432 is a sphingosine-1-phosphate receptor 5 (S1P5) agonist that is selective for S1P5 over S1P1 and S1P3 (IC50s = 0.006, 0.362, and >10 µM, respectively).{42320} It inhibits forskolin-induced cAMP production in CHO cells expressing S1P5 (EC50 = 4.1 nM). A-971432 (1 µM) increases electrical resistance of hCMEC/D3 cells in an in vitro blood-brain barrier model, indicating enhanced barrier integrity, and attenuates blood-brain barrier leakage in an R6/2 transgenic mouse model of Huntington’s disease when administered at a dose of 0.1 mg/kg.{42320,42321} A-971432 (0.1 mg/kg per day, i.p.) decreases the number of errors made in a horizontal ladder task and increases latency to fall in the rotarod test in R6/2 mice. It also increases spontaneous alternation in the t-maze in aged mice when administered at a dose of 0.1 mg/kg.{42320}
Brand:CaymanSKU:25326 - 10 mgAvailable on backorder
A-971432 is a sphingosine-1-phosphate receptor 5 (S1P5) agonist that is selective for S1P5 over S1P1 and S1P3 (IC50s = 0.006, 0.362, and >10 µM, respectively).{42320} It inhibits forskolin-induced cAMP production in CHO cells expressing S1P5 (EC50 = 4.1 nM). A-971432 (1 µM) increases electrical resistance of hCMEC/D3 cells in an in vitro blood-brain barrier model, indicating enhanced barrier integrity, and attenuates blood-brain barrier leakage in an R6/2 transgenic mouse model of Huntington’s disease when administered at a dose of 0.1 mg/kg.{42320,42321} A-971432 (0.1 mg/kg per day, i.p.) decreases the number of errors made in a horizontal ladder task and increases latency to fall in the rotarod test in R6/2 mice. It also increases spontaneous alternation in the t-maze in aged mice when administered at a dose of 0.1 mg/kg.{42320}
Brand:CaymanSKU:25326 - 25 mgAvailable on backorder
A-971432 is a sphingosine-1-phosphate receptor 5 (S1P5) agonist that is selective for S1P5 over S1P1 and S1P3 (IC50s = 0.006, 0.362, and >10 µM, respectively).{42320} It inhibits forskolin-induced cAMP production in CHO cells expressing S1P5 (EC50 = 4.1 nM). A-971432 (1 µM) increases electrical resistance of hCMEC/D3 cells in an in vitro blood-brain barrier model, indicating enhanced barrier integrity, and attenuates blood-brain barrier leakage in an R6/2 transgenic mouse model of Huntington’s disease when administered at a dose of 0.1 mg/kg.{42320,42321} A-971432 (0.1 mg/kg per day, i.p.) decreases the number of errors made in a horizontal ladder task and increases latency to fall in the rotarod test in R6/2 mice. It also increases spontaneous alternation in the t-maze in aged mice when administered at a dose of 0.1 mg/kg.{42320}
Brand:CaymanSKU:25326 - 5 mgAvailable on backorder
A01 is an inhibitor of Smad ubiquitination regulatory factor 1 (Smurf1) ubiquitin ligase (Kd = 3.67 nM).{47561} It inhibits Smurf1-mediated ubiquitination of Smad1/5 and increases Smad1/5 protein levels in C2C12 cells stimulated with bone morphogenic protein 2 (BMP2) in a concentration-dependent manner. A01 (2 μM) increases BMP2-induced mRNA expression of alkaline phosphatase (ALP), osteocalcin, and type-1 collagen in MC3T3-E1 mouse pre-osteoblasts.
Brand:CaymanSKU:26137 - 10 mgAvailable on backorder
A01 is an inhibitor of Smad ubiquitination regulatory factor 1 (Smurf1) ubiquitin ligase (Kd = 3.67 nM).{47561} It inhibits Smurf1-mediated ubiquitination of Smad1/5 and increases Smad1/5 protein levels in C2C12 cells stimulated with bone morphogenic protein 2 (BMP2) in a concentration-dependent manner. A01 (2 μM) increases BMP2-induced mRNA expression of alkaline phosphatase (ALP), osteocalcin, and type-1 collagen in MC3T3-E1 mouse pre-osteoblasts.
Brand:CaymanSKU:26137 - 25 mgAvailable on backorder
A01 is an inhibitor of Smad ubiquitination regulatory factor 1 (Smurf1) ubiquitin ligase (Kd = 3.67 nM).{47561} It inhibits Smurf1-mediated ubiquitination of Smad1/5 and increases Smad1/5 protein levels in C2C12 cells stimulated with bone morphogenic protein 2 (BMP2) in a concentration-dependent manner. A01 (2 μM) increases BMP2-induced mRNA expression of alkaline phosphatase (ALP), osteocalcin, and type-1 collagen in MC3T3-E1 mouse pre-osteoblasts.
Brand:CaymanSKU:26137 - 5 mgAvailable on backorder
A01 is an inhibitor of Smad ubiquitination regulatory factor 1 (Smurf1) ubiquitin ligase (Kd = 3.67 nM).{47561} It inhibits Smurf1-mediated ubiquitination of Smad1/5 and increases Smad1/5 protein levels in C2C12 cells stimulated with bone morphogenic protein 2 (BMP2) in a concentration-dependent manner. A01 (2 μM) increases BMP2-induced mRNA expression of alkaline phosphatase (ALP), osteocalcin, and type-1 collagen in MC3T3-E1 mouse pre-osteoblasts.
Brand:CaymanSKU:26137 - 50 mgAvailable on backorder
A1-Phytoprostane-I is a cyclopentenone isoprostane produced by the action of reactive oxygen species on α-linolenic acid in plants.{11938,17890,17915} There are two A1-phytoprostanes, both having the single ketone group on the ring structure. This isoform results from cyclization between carbons 9 and 13 of linolenic acid, as opposed to carbons 3 and 7 in A1-phytoprostane-II. A1-Phytoprostanes induce the expression of glutathione-S-transferase, increase phytoalexin biosynthesis, and trigger the expression of several genes involved in primary and secondary metabolism in plants.{11938,20855,17915}
Brand:CaymanSKU:9000593 - 1 mgAvailable on backorder
A1-Phytoprostane-I is a cyclopentenone isoprostane produced by the action of reactive oxygen species on α-linolenic acid in plants.{11938,17890,17915} There are two A1-phytoprostanes, both having the single ketone group on the ring structure. This isoform results from cyclization between carbons 9 and 13 of linolenic acid, as opposed to carbons 3 and 7 in A1-phytoprostane-II. A1-Phytoprostanes induce the expression of glutathione-S-transferase, increase phytoalexin biosynthesis, and trigger the expression of several genes involved in primary and secondary metabolism in plants.{11938,20855,17915}
Brand:CaymanSKU:9000593 - 100 µgAvailable on backorder
A1-Phytoprostane-I is a cyclopentenone isoprostane produced by the action of reactive oxygen species on α-linolenic acid in plants.{11938,17890,17915} There are two A1-phytoprostanes, both having the single ketone group on the ring structure. This isoform results from cyclization between carbons 9 and 13 of linolenic acid, as opposed to carbons 3 and 7 in A1-phytoprostane-II. A1-Phytoprostanes induce the expression of glutathione-S-transferase, increase phytoalexin biosynthesis, and trigger the expression of several genes involved in primary and secondary metabolism in plants.{11938,20855,17915}
Brand:CaymanSKU:9000593 - 500 µgAvailable on backorder
A23187 is a divalent cation ionophore. While more selective for Mn2+, it is commonly used to facilitate the movement of Ca2+ into cells, triggering the activation of intracellular calcium-dependent pathways.{20154} A23187 is also used to produce apoptosis through calcium overload, as occurs during hypoxic or oxidative stress.{20153,20152}
Brand:CaymanSKU:11016 - 1 mgAvailable on backorder
A23187 is a divalent cation ionophore. While more selective for Mn2+, it is commonly used to facilitate the movement of Ca2+ into cells, triggering the activation of intracellular calcium-dependent pathways.{20154} A23187 is also used to produce apoptosis through calcium overload, as occurs during hypoxic or oxidative stress.{20153,20152}
Brand:CaymanSKU:11016 - 10 mgAvailable on backorder
A23187 is a divalent cation ionophore. While more selective for Mn2+, it is commonly used to facilitate the movement of Ca2+ into cells, triggering the activation of intracellular calcium-dependent pathways.{20154} A23187 is also used to produce apoptosis through calcium overload, as occurs during hypoxic or oxidative stress.{20153,20152}
Brand:CaymanSKU:11016 - 25 mgAvailable on backorder
A23187 is a divalent cation ionophore. While more selective for Mn2+, it is commonly used to facilitate the movement of Ca2+ into cells, triggering the activation of intracellular calcium-dependent pathways.{20154} A23187 is also used to produce apoptosis through calcium overload, as occurs during hypoxic or oxidative stress.{20153,20152}
Brand:CaymanSKU:11016 - 5 mgAvailable on backorder
A286982 is an inhibitor that blocks the integrin-ligand interaction between leukocyte function-associated antigen-1 (LFA-1) and intercellular adhesion molecule-1 (ICAM-1; IC50 = 35 nM).{46441} It inhibits adhesion of JY-8 cells to ICAM-1-coated microtiter plates (IC50 = 44 nM).
Brand:CaymanSKU:27646 - 10 mgAvailable on backorder
A286982 is an inhibitor that blocks the integrin-ligand interaction between leukocyte function-associated antigen-1 (LFA-1) and intercellular adhesion molecule-1 (ICAM-1; IC50 = 35 nM).{46441} It inhibits adhesion of JY-8 cells to ICAM-1-coated microtiter plates (IC50 = 44 nM).
Brand:CaymanSKU:27646 - 25 mgAvailable on backorder
A286982 is an inhibitor that blocks the integrin-ligand interaction between leukocyte function-associated antigen-1 (LFA-1) and intercellular adhesion molecule-1 (ICAM-1; IC50 = 35 nM).{46441} It inhibits adhesion of JY-8 cells to ICAM-1-coated microtiter plates (IC50 = 44 nM).
Brand:CaymanSKU:27646 - 5 mgAvailable on backorder
A286982 is an inhibitor that blocks the integrin-ligand interaction between leukocyte function-associated antigen-1 (LFA-1) and intercellular adhesion molecule-1 (ICAM-1; IC50 = 35 nM).{46441} It inhibits adhesion of JY-8 cells to ICAM-1-coated microtiter plates (IC50 = 44 nM).
Brand:CaymanSKU:27646 - 50 mgAvailable on backorder
A2AR agonist-1 is an agonist of the adenosine A2A receptor and an inhibitor of equilibrative nucleoside transporter 1 (ENT1; Kis = 4.39 and 3.47 µM for the human receptor and guinea pig transporter, respectively).{50081} It decreases adenosine uptake by 80% in PC12 cells when used at a concentration of 61 µM and increases brain levels of adenosine in a transgenic mouse model of Huntington’s disease when administered at a dose of 20 mg/kg.{47653} A2AR agonist-1 (0.11 mg/kg) also rescues motor performance and increases survival in a transgenic mouse model of Huntington’s disease.
Brand:CaymanSKU:28414 - 1 mgAvailable on backorder
A2AR agonist-1 is an agonist of the adenosine A2A receptor and an inhibitor of equilibrative nucleoside transporter 1 (ENT1; Kis = 4.39 and 3.47 µM for the human receptor and guinea pig transporter, respectively).{50081} It decreases adenosine uptake by 80% in PC12 cells when used at a concentration of 61 µM and increases brain levels of adenosine in a transgenic mouse model of Huntington’s disease when administered at a dose of 20 mg/kg.{47653} A2AR agonist-1 (0.11 mg/kg) also rescues motor performance and increases survival in a transgenic mouse model of Huntington’s disease.
Brand:CaymanSKU:28414 - 5 mgAvailable on backorder
A2AR agonist-1 is an agonist of the adenosine A2A receptor and an inhibitor of equilibrative nucleoside transporter 1 (ENT1; Kis = 4.39 and 3.47 µM for the human receptor and guinea pig transporter, respectively).{50081} It decreases adenosine uptake by 80% in PC12 cells when used at a concentration of 61 µM and increases brain levels of adenosine in a transgenic mouse model of Huntington’s disease when administered at a dose of 20 mg/kg.{47653} A2AR agonist-1 (0.11 mg/kg) also rescues motor performance and increases survival in a transgenic mouse model of Huntington’s disease.
Brand:CaymanSKU:28414 - 500 µgAvailable on backorder
![An inhibitor of S1P lyase; induces accumulation of [3H]dhS1P in IT-79MTNC3 cells (EC50 = 6 (EC50 =](https://interpriseusa.com/wp-content/uploads/2021/06/29972.png)
A6770 is an inhibitor of sphingosine-1-phosphate (S1P) lyase.{50834} It induces accumulation of [3H]sphinganine-1-phosphate ([3H]dhS1P), an S1P lyase substrate, in IT-79MTNC3 cells that endogenously express high levels of S1P lyase (EC50 = 6 (EC50 = <100 µM).
Brand:CaymanSKU:29972 - 1 mgAvailable on backorder
A6770 is an inhibitor of sphingosine-1-phosphate (S1P) lyase.{50834} It induces accumulation of [3H]sphinganine-1-phosphate ([3H]dhS1P), an S1P lyase substrate, in IT-79MTNC3 cells that endogenously express high levels of S1P lyase (EC50 = 6 (EC50 = <100 µM).
Brand:CaymanSKU:29972 - 10 mgAvailable on backorder
A6770 is an inhibitor of sphingosine-1-phosphate (S1P) lyase.{50834} It induces accumulation of [3H]sphinganine-1-phosphate ([3H]dhS1P), an S1P lyase substrate, in IT-79MTNC3 cells that endogenously express high levels of S1P lyase (EC50 = 6 (EC50 = <100 µM).
Brand:CaymanSKU:29972 - 5 mgAvailable on backorder
A6770 is an inhibitor of sphingosine-1-phosphate (S1P) lyase.{50834} It induces accumulation of [3H]sphinganine-1-phosphate ([3H]dhS1P), an S1P lyase substrate, in IT-79MTNC3 cells that endogenously express high levels of S1P lyase (EC50 = 6 (EC50 = <100 µM).
Brand:CaymanSKU:29972 - 500 µgAvailable on backorder
Tripeptidyl peptidase II (TPPII) is a serine peptidase of the subtilisin-type which removes tripeptides from the free NH2 terminus of oligopeptides.{22987} AAF-CMK is an irreversible inhibitor of TPPII commonly used at 10-100 µM.{22991,22989,22990} It does not significantly interfere with the chymotrypsin-like activity of the proteasome. AAF-CMK also inhibits bleomycin hydrolase and puromycin-sensitive aminopeptidase when used at 50 µM.{22988}
Brand:CaymanSKU:- Tripeptidyl peptidase II (TPPII) is a serine peptidase of the subtilisin-type which removes tripeptides from the free NH2 terminus of oligopeptides.{22987} AAF-CMK is an irreversible inhibitor of TPPII commonly used at 10-100 µM.{22991,22989,22990} It does not significantly interfere with the chymotrypsin-like activity of the proteasome. AAF-CMK also inhibits bleomycin hydrolase and puromycin-sensitive aminopeptidase when used at 50 µM.{22988}
Brand:CaymanSKU:- Tripeptidyl peptidase II (TPPII) is a serine peptidase of the subtilisin-type which removes tripeptides from the free NH2 terminus of oligopeptides.{22987} AAF-CMK is an irreversible inhibitor of TPPII commonly used at 10-100 µM.{22991,22989,22990} It does not significantly interfere with the chymotrypsin-like activity of the proteasome. AAF-CMK also inhibits bleomycin hydrolase and puromycin-sensitive aminopeptidase when used at 50 µM.{22988}
Brand:CaymanSKU:-
AAL-993 is a potent inhibitor of VEGF receptors, inhibiting VEGFR1, 2, and 3 with IC50 values of 130, 23, and 18 nM, respectively.{26698,26700} It less potently inhibits c-Kit, colony stimulating factor 1 receptor, PGDF receptor β, and EGF receptor (IC50s = 236, 380, 640, and 1,040 nM, respectively) and is without effect on a number of other tyrosine kinases.{26698} AAL-993 is orally bioavailable in vivo, blocks VEGF-induced angiogenesis, and prevents the growth of primary tumors and spontaneous peripheral metastases in mice.{26698,26699} It also inhibits hypoxia-mediated increase in hypoxia-inducible factor-1 transcriptional activity in an ERK-dependent manner (IC50 = ~5 µM).{26701}
Brand:CaymanSKU:-Out of stock
AAL-993 is a potent inhibitor of VEGF receptors, inhibiting VEGFR1, 2, and 3 with IC50 values of 130, 23, and 18 nM, respectively.{26698,26700} It less potently inhibits c-Kit, colony stimulating factor 1 receptor, PGDF receptor β, and EGF receptor (IC50s = 236, 380, 640, and 1,040 nM, respectively) and is without effect on a number of other tyrosine kinases.{26698} AAL-993 is orally bioavailable in vivo, blocks VEGF-induced angiogenesis, and prevents the growth of primary tumors and spontaneous peripheral metastases in mice.{26698,26699} It also inhibits hypoxia-mediated increase in hypoxia-inducible factor-1 transcriptional activity in an ERK-dependent manner (IC50 = ~5 µM).{26701}
Brand:CaymanSKU:-Out of stock
AAPH is a water-soluble azo compound which is used extensively as a free radical generator, often in the study of lipid peroxidation and the characterization of antioxidants.{6422,7745,9407,9459} Decomposition of AAPH produces molecular nitrogen and 2 carbon radicals. The carbon radicals may combine to produce stable products or react with molecular oxygen to give peroxyl radicals. The half-life of AAPH is about 175 hours (37°C at neutral pH), making the rate of free radical generation essentially constant during the first several hours in solution.{9745} While AAPH may be used effectively for lipid peroxidation in aqueous dispersions of fatty acids, other radical generators may be better suited for peroxidation studies in lipid micelles or membranes.{9746,8841}
Brand:CaymanSKU:82235 - 10 gAvailable on backorder
AAPH is a water-soluble azo compound which is used extensively as a free radical generator, often in the study of lipid peroxidation and the characterization of antioxidants.{6422,7745,9407,9459} Decomposition of AAPH produces molecular nitrogen and 2 carbon radicals. The carbon radicals may combine to produce stable products or react with molecular oxygen to give peroxyl radicals. The half-life of AAPH is about 175 hours (37°C at neutral pH), making the rate of free radical generation essentially constant during the first several hours in solution.{9745} While AAPH may be used effectively for lipid peroxidation in aqueous dispersions of fatty acids, other radical generators may be better suited for peroxidation studies in lipid micelles or membranes.{9746,8841}
Brand:CaymanSKU:82235 - 5 gAvailable on backorder
Aaptamine is a marine sponge alkaloid originally isolated from A. aaptos with diverse biological activities, including antiproliferative and antidepressant properties.{47125,47126,47127,47128} It is an agonist of δ- and μ-opioid receptors (EC50s = 5.1 and 10.1 μM, respectively, in HEK293 cells expressing human recombinant receptors) and a competitive antagonist of α-adrenergic receptors (α-ARs; pA2s = 4.88 and 5.43, respectively, in isolated rabbit aorta and renal artery).{47125,47128} Aaptamine inhibits growth of HeLa cervical cancer (IC50 = 15 μg/ml) and K562 leukemia (GI50 = 10 μM) cells and induces cell cycle arrest in the G2/M phase in K562 leukemia and MG63 osteosarcoma cells.{47126,47127,47129} It is a proteasome inhibitor that inhibits chymotrypsin-, caspase-, and trypsin-like activity in a partially purified rat liver proteasome preparation (IC50s = 1.6, 2.7, and 18 μg/ml, respectively) and dose-dependently activates p21 independent of p53 in MG63 cells when used at concentrations ranging from 20 to 50 μM.{47126,47129} Aaptamine (40 mg/kg, i.p.) decreases immobility time in the forced swim test in mice, indicating antidepressant-like activity.{47128}
Brand:CaymanSKU:24297 - 1 mgAvailable on backorder
Aaptamine is a marine sponge alkaloid originally isolated from A. aaptos with diverse biological activities, including antiproliferative and antidepressant properties.{47125,47126,47127,47128} It is an agonist of δ- and μ-opioid receptors (EC50s = 5.1 and 10.1 μM, respectively, in HEK293 cells expressing human recombinant receptors) and a competitive antagonist of α-adrenergic receptors (α-ARs; pA2s = 4.88 and 5.43, respectively, in isolated rabbit aorta and renal artery).{47125,47128} Aaptamine inhibits growth of HeLa cervical cancer (IC50 = 15 μg/ml) and K562 leukemia (GI50 = 10 μM) cells and induces cell cycle arrest in the G2/M phase in K562 leukemia and MG63 osteosarcoma cells.{47126,47127,47129} It is a proteasome inhibitor that inhibits chymotrypsin-, caspase-, and trypsin-like activity in a partially purified rat liver proteasome preparation (IC50s = 1.6, 2.7, and 18 μg/ml, respectively) and dose-dependently activates p21 independent of p53 in MG63 cells when used at concentrations ranging from 20 to 50 μM.{47126,47129} Aaptamine (40 mg/kg, i.p.) decreases immobility time in the forced swim test in mice, indicating antidepressant-like activity.{47128}
Brand:CaymanSKU:24297 - 500 µgAvailable on backorder
AAT-008 is an orally bioavailable and potent antagonist of the prostaglandin E2 (PGE2) receptor subtype 4 (EP4; IC50 = 16.3 nM in a human EP4 functional assay).{33448} It is selective for EP4 with IC50 values of 2.4, 1,890, >20,000, and >20,000 nM for binding to human recombinant EP4, EP2, EP1, and EP3, respectively. AAT-008 has potent binding affinity for human, rat, and dog EP4 (Kis = 0.97, 6.1, and 38 nM, respectively) and suppresses PGE2-induced elevation of intracellular cAMP with an antagonistic potency (pA2) of 1.1 nM in vitro. Oral administration of AAT-008 reduces carrageenan-induced mechanical hyperalgesia in rats in a dose-dependent manner.
Brand:CaymanSKU:21810 -Out of stock
AAT-008 is an orally bioavailable and potent antagonist of the prostaglandin E2 (PGE2) receptor subtype 4 (EP4; IC50 = 16.3 nM in a human EP4 functional assay).{33448} It is selective for EP4 with IC50 values of 2.4, 1,890, >20,000, and >20,000 nM for binding to human recombinant EP4, EP2, EP1, and EP3, respectively. AAT-008 has potent binding affinity for human, rat, and dog EP4 (Kis = 0.97, 6.1, and 38 nM, respectively) and suppresses PGE2-induced elevation of intracellular cAMP with an antagonistic potency (pA2) of 1.1 nM in vitro. Oral administration of AAT-008 reduces carrageenan-induced mechanical hyperalgesia in rats in a dose-dependent manner.
Brand:CaymanSKU:21810 -Out of stock
AAT-008 is an orally bioavailable and potent antagonist of the prostaglandin E2 (PGE2) receptor subtype 4 (EP4; IC50 = 16.3 nM in a human EP4 functional assay).{33448} It is selective for EP4 with IC50 values of 2.4, 1,890, >20,000, and >20,000 nM for binding to human recombinant EP4, EP2, EP1, and EP3, respectively. AAT-008 has potent binding affinity for human, rat, and dog EP4 (Kis = 0.97, 6.1, and 38 nM, respectively) and suppresses PGE2-induced elevation of intracellular cAMP with an antagonistic potency (pA2) of 1.1 nM in vitro. Oral administration of AAT-008 reduces carrageenan-induced mechanical hyperalgesia in rats in a dose-dependent manner.
Brand:CaymanSKU:21810 -Out of stock
AAT-008 is an orally bioavailable and potent antagonist of the prostaglandin E2 (PGE2) receptor subtype 4 (EP4; IC50 = 16.3 nM in a human EP4 functional assay).{33448} It is selective for EP4 with IC50 values of 2.4, 1,890, >20,000, and >20,000 nM for binding to human recombinant EP4, EP2, EP1, and EP3, respectively. AAT-008 has potent binding affinity for human, rat, and dog EP4 (Kis = 0.97, 6.1, and 38 nM, respectively) and suppresses PGE2-induced elevation of intracellular cAMP with an antagonistic potency (pA2) of 1.1 nM in vitro. Oral administration of AAT-008 reduces carrageenan-induced mechanical hyperalgesia in rats in a dose-dependent manner.
Brand:CaymanSKU:21810 -Out of stock
![A synthetic CB built on a 1-[(1-methylpiperidin-2-yl)methyl]-indole base that is characteristic of a series of potent CBs; may have selectivity for the CB2 receptor; intended for forensic and research applications](https://interpriseusa.com/wp-content/uploads/2021/06/11766.png)
AB-005 is a synthetic cannabinoid (CB) built on a 1-[(1-methylpiperidin-2-yl)methyl]-indole base that is characteristic of a series of potent CBs, including AM1220 (Item No. 9001055), AM1241 (Item No. 10010118), and AM1248 (Item No. 11282).{20430} The addition of a tetramethylcyclopropyl group has, in some cases, increased selectivity of synthetic CBs for the peripheral CB2 receptor.{21031} The physiological and toxicological properties of this compound have not been established. This product is intended for forensic and research applications.
Brand:CaymanSKU:11766 - 1 mgAvailable on backorder
AB-005 is a synthetic cannabinoid (CB) built on a 1-[(1-methylpiperidin-2-yl)methyl]-indole base that is characteristic of a series of potent CBs, including AM1220 (Item No. 9001055), AM1241 (Item No. 10010118), and AM1248 (Item No. 11282).{20430} The addition of a tetramethylcyclopropyl group has, in some cases, increased selectivity of synthetic CBs for the peripheral CB2 receptor.{21031} The physiological and toxicological properties of this compound have not been established. This product is intended for forensic and research applications.
Brand:CaymanSKU:11766 - 10 mgAvailable on backorder
AB-005 is a synthetic cannabinoid (CB) built on a 1-[(1-methylpiperidin-2-yl)methyl]-indole base that is characteristic of a series of potent CBs, including AM1220 (Item No. 9001055), AM1241 (Item No. 10010118), and AM1248 (Item No. 11282).{20430} The addition of a tetramethylcyclopropyl group has, in some cases, increased selectivity of synthetic CBs for the peripheral CB2 receptor.{21031} The physiological and toxicological properties of this compound have not been established. This product is intended for forensic and research applications.
Brand:CaymanSKU:11766 - 5 mgAvailable on backorder
AB-005 (Item No. 11766) is a synthetic cannabinoid (CB) built on a 1-[(1-methylpiperidin-2-yl)methyl]-indole base that is characteristic of a series of potent CBs, including AM1220 (Item No. 9001055), AM1241 (Item No. 10010118), and AM1248 (Item No. 11282).{20430} AB-005 azepane isomer is a variant of AB-005 in which the methylpiperidine group has been replaced with methylazepane. The physiological and toxicological properties of this compound have not been established. This product is intended for forensic and research applications.
Brand:CaymanSKU:11877 - 1 mgAvailable on backorder
AB-005 (Item No. 11766) is a synthetic cannabinoid (CB) built on a 1-[(1-methylpiperidin-2-yl)methyl]-indole base that is characteristic of a series of potent CBs, including AM1220 (Item No. 9001055), AM1241 (Item No. 10010118), and AM1248 (Item No. 11282).{20430} AB-005 azepane isomer is a variant of AB-005 in which the methylpiperidine group has been replaced with methylazepane. The physiological and toxicological properties of this compound have not been established. This product is intended for forensic and research applications.
Brand:CaymanSKU:11877 - 10 mgAvailable on backorder
AB-005 (Item No. 11766) is a synthetic cannabinoid (CB) built on a 1-[(1-methylpiperidin-2-yl)methyl]-indole base that is characteristic of a series of potent CBs, including AM1220 (Item No. 9001055), AM1241 (Item No. 10010118), and AM1248 (Item No. 11282).{20430} AB-005 azepane isomer is a variant of AB-005 in which the methylpiperidine group has been replaced with methylazepane. The physiological and toxicological properties of this compound have not been established. This product is intended for forensic and research applications.
Brand:CaymanSKU:11877 - 5 mgAvailable on backorder
AB-928 is an adenosine A2A and A2B receptor dual antagonist.{58116} It inhibits the ability of adenosine (Item No. 21232) to suppress activation of human CD4 or CD8 T cells, as well as monocyte-derived dendritic cells, in vitro.{58117,58118} AB-928, alone or in combination with doxorubicin (Item No. 15007), reduces tumor growth in an AT3-OVA syngeneic mouse model. It also acts synergistically with an anti-PD-1 antibody to reduce tumor growth in a B16/F10 syngeneic mouse model.
Brand:CaymanSKU:31444 - 10 mgAvailable on backorder
AB-928 is an adenosine A2A and A2B receptor dual antagonist.{58116} It inhibits the ability of adenosine (Item No. 21232) to suppress activation of human CD4 or CD8 T cells, as well as monocyte-derived dendritic cells, in vitro.{58117,58118} AB-928, alone or in combination with doxorubicin (Item No. 15007), reduces tumor growth in an AT3-OVA syngeneic mouse model. It also acts synergistically with an anti-PD-1 antibody to reduce tumor growth in a B16/F10 syngeneic mouse model.
Brand:CaymanSKU:31444 - 25 mgAvailable on backorder
AB-928 is an adenosine A2A and A2B receptor dual antagonist.{58116} It inhibits the ability of adenosine (Item No. 21232) to suppress activation of human CD4 or CD8 T cells, as well as monocyte-derived dendritic cells, in vitro.{58117,58118} AB-928, alone or in combination with doxorubicin (Item No. 15007), reduces tumor growth in an AT3-OVA syngeneic mouse model. It also acts synergistically with an anti-PD-1 antibody to reduce tumor growth in a B16/F10 syngeneic mouse model.
Brand:CaymanSKU:31444 - 5 mgAvailable on backorder
AB-928 is an adenosine A2A and A2B receptor dual antagonist.{58116} It inhibits the ability of adenosine (Item No. 21232) to suppress activation of human CD4 or CD8 T cells, as well as monocyte-derived dendritic cells, in vitro.{58117,58118} AB-928, alone or in combination with doxorubicin (Item No. 15007), reduces tumor growth in an AT3-OVA syngeneic mouse model. It also acts synergistically with an anti-PD-1 antibody to reduce tumor growth in a B16/F10 syngeneic mouse model.
Brand:CaymanSKU:31444 - 50 mgAvailable on backorder
AB-BICA (Item No. 18759) is an analytical reference standard that is structurally classified as a synthetic cannabinoid.{31681} The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications
Brand:CaymanSKU:-Available on backorder
AB-BICA (Item No. 18759) is an analytical reference standard that is structurally classified as a synthetic cannabinoid.{31681} The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications
Brand:CaymanSKU:-Available on backorder
AB-CHMINACA (Item No. 15434) is an indazole-based synthetic cannabinoid (CB) that is structurally related to AB-FUBINACA (Item No. 14039), a high affinity ligand of the central CB1 receptor (Ki = 0.9 nM).{22006,22072} AB-CHMINACA metabolite M2 is a metabolite of AB-CHMINACA that can be detected in the urine.{29562} The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:-Out of stock
AB-CHMINACA (Item No. 15434) is an indazole-based synthetic cannabinoid (CB) that is structurally related to AB-FUBINACA (Item No. 14039), a high affinity ligand of the central CB1 receptor (Ki = 0.9 nM).{22006,22072} AB-CHMINACA metabolite M2 is a metabolite of AB-CHMINACA that can be detected in the urine.{29562} The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:-Out of stock
AB-CHMINACA (Item No. 15434) is an indazole-based synthetic cannabinoid (CB) that is structurally related to AB-FUBINACA (Item No. 14039), a high affinity ligand of the central CB1 receptor (Ki = 0.9 nM).{22006,22072} AB-CHMINACA metabolite M2 is a metabolite of AB-CHMINACA that can be detected in the urine.{29562} The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:-Out of stock
AB-CHMINACA metabolite M4 RM (Item No. 16393) is an analytical reference standard that is structurally categorized as a synthetic cannabinoid. It is an expected metabolite of AB-CHMINACA (Item No. 15434) in which the carboxamide-linked aminocarbonyl-2-methylpropyl side chain associated with both AB-CHMINACA and AB-FUBINACA has been replaced with a carboxyl group. The physiological and toxicological properties of this compound have not been determined. This product is intended for research and forensic applications.
Brand:CaymanSKU:-Out of stock
AB-CHMINACA metabolite M4 RM (Item No. 16393) is an analytical reference standard that is structurally categorized as a synthetic cannabinoid. It is an expected metabolite of AB-CHMINACA (Item No. 15434) in which the carboxamide-linked aminocarbonyl-2-methylpropyl side chain associated with both AB-CHMINACA and AB-FUBINACA has been replaced with a carboxyl group. The physiological and toxicological properties of this compound have not been determined. This product is intended for research and forensic applications.
Brand:CaymanSKU:-Out of stock
AB-CHMINACA metabolite M4 RM (Item No. 16393) is an analytical reference standard that is structurally categorized as a synthetic cannabinoid. It is an expected metabolite of AB-CHMINACA (Item No. 15434) in which the carboxamide-linked aminocarbonyl-2-methylpropyl side chain associated with both AB-CHMINACA and AB-FUBINACA has been replaced with a carboxyl group. The physiological and toxicological properties of this compound have not been determined. This product is intended for research and forensic applications.
Brand:CaymanSKU:-Out of stock
AB-FUBINACA (Item No. 14039) is an indazole-based synthetic cannabinoid (CB) that potently binds the central CB1 receptor (Ki = 0.9 nM).{22006,22072} This compound has been identified along with AB-PINACA (Item No. 14038) in illegal herbal products.{22006,22072} AB-FUBINACA 3-fluorobenzyl isomer is an isomer of AB-FUBINACA that differs by having the fluoro group at the three, rather than four, position on the benzyl group. This compound binds CB1 with a Ki value of 51.1 nM.{22072} This product is intended for research and forensic applications.
Brand:CaymanSKU:9001523 - 1 mgAvailable on backorder
AB-FUBINACA (Item No. 14039) is an indazole-based synthetic cannabinoid (CB) that potently binds the central CB1 receptor (Ki = 0.9 nM).{22006,22072} This compound has been identified along with AB-PINACA (Item No. 14038) in illegal herbal products.{22006,22072} AB-FUBINACA 3-fluorobenzyl isomer is an isomer of AB-FUBINACA that differs by having the fluoro group at the three, rather than four, position on the benzyl group. This compound binds CB1 with a Ki value of 51.1 nM.{22072} This product is intended for research and forensic applications.
Brand:CaymanSKU:9001523 - 10 mgAvailable on backorder
AB-FUBINACA (Item No. 14039) is an indazole-based synthetic cannabinoid (CB) that potently binds the central CB1 receptor (Ki = 0.9 nM).{22006,22072} This compound has been identified along with AB-PINACA (Item No. 14038) in illegal herbal products.{22006,22072} AB-FUBINACA 3-fluorobenzyl isomer is an isomer of AB-FUBINACA that differs by having the fluoro group at the three, rather than four, position on the benzyl group. This compound binds CB1 with a Ki value of 51.1 nM.{22072} This product is intended for research and forensic applications.
Brand:CaymanSKU:9001523 - 5 mgAvailable on backorder
AB-FUBINACA (Item No. 14039) is an adamantylindole-based synthetic cannabinoid (CB) with 10-fold greater affinity for the central CB1 receptor (Ki = 0.9 nM) than that of JWH 018 (Item No. 10900).{22006,22072} AB-FUBINACA was first synthesized by Pfizer as a potent CB1 receptor modulator for potential therapeutic use, but recently was identified along with AB-PINACA (Item No. 14038) in illegal herbal products.{22006,22072} AB-FUBINACA isomer 2 is a regioisomer of AB-FUBINACA. The physiological and toxicological properties of this compound have not been determined. This product is intended for research and forensic applications.
Brand:CaymanSKU:9001529 - 1 mgAvailable on backorder
AB-FUBINACA (Item No. 14039) is an adamantylindole-based synthetic cannabinoid (CB) with 10-fold greater affinity for the central CB1 receptor (Ki = 0.9 nM) than that of JWH 018 (Item No. 10900).{22006,22072} AB-FUBINACA was first synthesized by Pfizer as a potent CB1 receptor modulator for potential therapeutic use, but recently was identified along with AB-PINACA (Item No. 14038) in illegal herbal products.{22006,22072} AB-FUBINACA isomer 2 is a regioisomer of AB-FUBINACA. The physiological and toxicological properties of this compound have not been determined. This product is intended for research and forensic applications.
Brand:CaymanSKU:9001529 - 10 mgAvailable on backorder
AB-FUBINACA (Item No. 14039) is an adamantylindole-based synthetic cannabinoid (CB) with 10-fold greater affinity for the central CB1 receptor (Ki = 0.9 nM) than that of JWH 018 (Item No. 10900).{22006,22072} AB-FUBINACA was first synthesized by Pfizer as a potent CB1 receptor modulator for potential therapeutic use, but recently was identified along with AB-PINACA (Item No. 14038) in illegal herbal products.{22006,22072} AB-FUBINACA isomer 2 is a regioisomer of AB-FUBINACA. The physiological and toxicological properties of this compound have not been determined. This product is intended for research and forensic applications.
Brand:CaymanSKU:9001529 - 5 mgAvailable on backorder
AB-FUBINACA metabolite 4 (Item No. 20179) is an analytical reference standard that is structurally classified as a synthetic cannabinoid. It is the carboxylic acid indazole 4-fluorobenzyl metabolite of AB-FUBINACA (Item Nos. 14039 | ISO60211).{30114} The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:20179 -Available on backorder
AB-FUBINACA metabolite 4 (Item No. 20179) is an analytical reference standard that is structurally classified as a synthetic cannabinoid. It is the carboxylic acid indazole 4-fluorobenzyl metabolite of AB-FUBINACA (Item Nos. 14039 | ISO60211).{30114} The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:20179 -Available on backorder
AB-MECA is an adenosine A3 receptor agonist (Ki = 430.5 nM for the human receptor expressed in CHO cells).{45426} It inhibits LPS-induced TNF-α production in primary cultured human lung macrophages (pD2 = 6.9).{45427} AB-MECA increases contraction of isolated guinea pig trachea ex vivo when used at a concentration of 0.1 μM and increases bronchoconstriction in vivo when administered at a dose of 3 μg/kg in a guinea pig model of ovalbumin-sensitized asthma.{45428} A radiolabeled form of AB-MECA has been used for radioligand binding assays and binds to rat adenosine A1 and A3 receptors (Kds = 3.42 and 1.48 nM in COS-7 and CHO cells, respectively) and canine adenosine A2a receptors (Kd = 25.1 nM in COS-7 cells).{45429}
Brand:CaymanSKU:28415 - 1 mgAvailable on backorder
AB-MECA is an adenosine A3 receptor agonist (Ki = 430.5 nM for the human receptor expressed in CHO cells).{45426} It inhibits LPS-induced TNF-α production in primary cultured human lung macrophages (pD2 = 6.9).{45427} AB-MECA increases contraction of isolated guinea pig trachea ex vivo when used at a concentration of 0.1 μM and increases bronchoconstriction in vivo when administered at a dose of 3 μg/kg in a guinea pig model of ovalbumin-sensitized asthma.{45428} A radiolabeled form of AB-MECA has been used for radioligand binding assays and binds to rat adenosine A1 and A3 receptors (Kds = 3.42 and 1.48 nM in COS-7 and CHO cells, respectively) and canine adenosine A2a receptors (Kd = 25.1 nM in COS-7 cells).{45429}
Brand:CaymanSKU:28415 - 10 mgAvailable on backorder
AB-MECA is an adenosine A3 receptor agonist (Ki = 430.5 nM for the human receptor expressed in CHO cells).{45426} It inhibits LPS-induced TNF-α production in primary cultured human lung macrophages (pD2 = 6.9).{45427} AB-MECA increases contraction of isolated guinea pig trachea ex vivo when used at a concentration of 0.1 μM and increases bronchoconstriction in vivo when administered at a dose of 3 μg/kg in a guinea pig model of ovalbumin-sensitized asthma.{45428} A radiolabeled form of AB-MECA has been used for radioligand binding assays and binds to rat adenosine A1 and A3 receptors (Kds = 3.42 and 1.48 nM in COS-7 and CHO cells, respectively) and canine adenosine A2a receptors (Kd = 25.1 nM in COS-7 cells).{45429}
Brand:CaymanSKU:28415 - 5 mgAvailable on backorder
AB-PINACA 3-carboxyindazole metabolite (Item No. 27732) is an analytical reference standard that is structurally similar to known synthetic cannabinoid metabolites. This product is intended for research and forensic applications.
Brand:CaymanSKU:27732 - 1 mgAvailable on backorder
AB-PINACA 3-carboxyindazole metabolite (Item No. 27732) is an analytical reference standard that is structurally similar to known synthetic cannabinoid metabolites. This product is intended for research and forensic applications.
Brand:CaymanSKU:27732 - 5 mgAvailable on backorder
AB-PINACA (Item No. 14038) is a synthetic cannabinoid (CB) that has been identified in illegal herbal products.{22006} AB-PINACA pentanoic acid metabolite is an expected compound produced by phase I metabolism of AB-PINACA in vivo, based on the metabolism of comparable alkylindole CBs.{18291,20170} The physiological and toxicological properties of this compound have not been determined. This product is intended for research and forensic applications.
Brand:CaymanSKU:- AB-PINACA (Item No. 14038) is a synthetic cannabinoid (CB) that has been identified in illegal herbal products.{22006} AB-PINACA pentanoic acid metabolite is an expected compound produced by phase I metabolism of AB-PINACA in vivo, based on the metabolism of comparable alkylindole CBs.{18291,20170} The physiological and toxicological properties of this compound have not been determined. This product is intended for research and forensic applications.
Brand:CaymanSKU:- AB-PINACA (Item No. 14038) is a synthetic cannabinoid (CB) that has been identified in illegal herbal products.{22006} AB-PINACA pentanoic acid metabolite is an expected compound produced by phase I metabolism of AB-PINACA in vivo, based on the metabolism of comparable alkylindole CBs.{18291,20170} The physiological and toxicological properties of this compound have not been determined. This product is intended for research and forensic applications.
Brand:CaymanSKU:-
Abacavir is a nucleoside analog and an inhibitor of HIV-1 reverse transcriptase (Ki = 2.1 µM for the wild-type enzyme).{18404} It inhibits replication of a variety of HIV-1 and HIV-2 strains, including strains resistant to 3′-azido-3′-deoxythymidine (zidovudine; Item No. 15492) or 2′,3′-dideoxyinosine (didanosine; Item No. 23715), in HeLa cells stably expressing CD4 (IC50s = 5.8-21 µM). Abacavir inhibits replication of eight HIV-1 clinical isolates in phytohemagglutinin-stimulated isolated human peripheral blood lymphocytes with a mean IC50 value of 0.26 µM. It inhibits hepatitis B virus (HBV) DNA synthesis in HepG2 cells (IC50 = 7 µM) and is also active against human cytomegalovirus (CMV) strain AD169 and the Petaluma strain of feline immunodeficiency virus (FIV) in plaque reduction assays (IC50s = 32 and 0.4 µM, respectively). Formulations containing abacavir have been used in the treatment of HIV infection.
Brand:CaymanSKU:- Abacavir is a nucleoside analog and an inhibitor of HIV-1 reverse transcriptase (Ki = 2.1 µM for the wild-type enzyme).{18404} It inhibits replication of a variety of HIV-1 and HIV-2 strains, including strains resistant to 3′-azido-3′-deoxythymidine (zidovudine; Item No. 15492) or 2′,3′-dideoxyinosine (didanosine; Item No. 23715), in HeLa cells stably expressing CD4 (IC50s = 5.8-21 µM). Abacavir inhibits replication of eight HIV-1 clinical isolates in phytohemagglutinin-stimulated isolated human peripheral blood lymphocytes with a mean IC50 value of 0.26 µM. It inhibits hepatitis B virus (HBV) DNA synthesis in HepG2 cells (IC50 = 7 µM) and is also active against human cytomegalovirus (CMV) strain AD169 and the Petaluma strain of feline immunodeficiency virus (FIV) in plaque reduction assays (IC50s = 32 and 0.4 µM, respectively). Formulations containing abacavir have been used in the treatment of HIV infection.
Brand:CaymanSKU:- Abacavir is a nucleoside analog and an inhibitor of HIV-1 reverse transcriptase (Ki = 2.1 µM for the wild-type enzyme).{18404} It inhibits replication of a variety of HIV-1 and HIV-2 strains, including strains resistant to 3′-azido-3′-deoxythymidine (zidovudine; Item No. 15492) or 2′,3′-dideoxyinosine (didanosine; Item No. 23715), in HeLa cells stably expressing CD4 (IC50s = 5.8-21 µM). Abacavir inhibits replication of eight HIV-1 clinical isolates in phytohemagglutinin-stimulated isolated human peripheral blood lymphocytes with a mean IC50 value of 0.26 µM. It inhibits hepatitis B virus (HBV) DNA synthesis in HepG2 cells (IC50 = 7 µM) and is also active against human cytomegalovirus (CMV) strain AD169 and the Petaluma strain of feline immunodeficiency virus (FIV) in plaque reduction assays (IC50s = 32 and 0.4 µM, respectively). Formulations containing abacavir have been used in the treatment of HIV infection.
Brand:CaymanSKU:- Abacavir is a nucleoside analog and an inhibitor of HIV-1 reverse transcriptase (Ki = 2.1 µM for the wild-type enzyme).{18404} It inhibits replication of a variety of HIV-1 and HIV-2 strains, including strains resistant to 3′-azido-3′-deoxythymidine (zidovudine; Item No. 15492) or 2′,3′-dideoxyinosine (didanosine; Item No. 23715), in HeLa cells stably expressing CD4 (IC50s = 5.8-21 µM). Abacavir inhibits replication of eight HIV-1 clinical isolates in phytohemagglutinin-stimulated isolated human peripheral blood lymphocytes with a mean IC50 value of 0.26 µM. It inhibits hepatitis B virus (HBV) DNA synthesis in HepG2 cells (IC50 = 7 µM) and is also active against human cytomegalovirus (CMV) strain AD169 and the Petaluma strain of feline immunodeficiency virus (FIV) in plaque reduction assays (IC50s = 32 and 0.4 µM, respectively). Formulations containing abacavir have been used in the treatment of HIV infection.
Brand:CaymanSKU:-
Abacavir carboxylate is an inactive metabolite of the HIV-1 reverse transcriptase inhibitor abacavir (Item No. 14746).{43845,43846} It is formed from abacavir via reactive aldehyde intermediates that can form adducts with proteins on valine residues.{43846}
Brand:CaymanSKU:27777 - 1 mgAvailable on backorder
Abacavir-d4 is intended for use as an internal standard for the quantification of abacavir (Item No. 14746) by GC- or LC-MS. Abacavir is a nucleoside analog and an inhibitor of HIV-1 reverse transcriptase (Ki = 2.1 µM for the wild-type enzyme).{18404} It inhibits replication of a variety of HIV-1 and HIV-2 strains, including strains resistant to 3′-azido-3′-deoxythymidine (zidovudine; Item No. 15492) or 2′,3′-dideoxyinosine (didanosine; Item No. 23715), in HeLa cells stably expressing CD4 (IC50s = 5.8-21 µM). Abacavir inhibits replication of eight HIV-1 clinical isolates in phytohemagglutinin-stimulated isolated human peripheral blood lymphocytes with a mean IC50 value of 0.26 µM. It inhibits hepatitis B virus (HBV) DNA synthesis in HepG2 cells (IC50 = 7 µM) and is also active against human cytomegalovirus (CMV) strain AD169 and the Petaluma strain of feline immunodeficiency virus (FIV) in plaque reduction assays (IC50s = 32 and 0.4 µM, respectively). Formulations containing abacavir have been used in the treatment of HIV infection.
Brand:CaymanSKU:30076 - 1 mgAvailable on backorder
Abacavir-d4 is intended for use as an internal standard for the quantification of abacavir (Item No. 14746) by GC- or LC-MS. Abacavir is a nucleoside analog and an inhibitor of HIV-1 reverse transcriptase (Ki = 2.1 µM for the wild-type enzyme).{18404} It inhibits replication of a variety of HIV-1 and HIV-2 strains, including strains resistant to 3′-azido-3′-deoxythymidine (zidovudine; Item No. 15492) or 2′,3′-dideoxyinosine (didanosine; Item No. 23715), in HeLa cells stably expressing CD4 (IC50s = 5.8-21 µM). Abacavir inhibits replication of eight HIV-1 clinical isolates in phytohemagglutinin-stimulated isolated human peripheral blood lymphocytes with a mean IC50 value of 0.26 µM. It inhibits hepatitis B virus (HBV) DNA synthesis in HepG2 cells (IC50 = 7 µM) and is also active against human cytomegalovirus (CMV) strain AD169 and the Petaluma strain of feline immunodeficiency virus (FIV) in plaque reduction assays (IC50s = 32 and 0.4 µM, respectively). Formulations containing abacavir have been used in the treatment of HIV infection.
Brand:CaymanSKU:30076 - 500 µgAvailable on backorder
Abamectin is a mixture of the natural macrocyclic lactones avermectin B1a and avermectin B1b (Item No. 17453). It has both insecticidal and anthelmintic actions and is used in both agriculture and veterinary medicine.{31111,31112,31113,31114} Abamectin can inhibit nicotinic acetylcholine receptors of worms.{31083} It can also inhibit chikungunya virus (EC50 = 1.5 µM) and yellow fever virus.{31115}
Brand:CaymanSKU:-Available on backorder
Abamectin is a mixture of the natural macrocyclic lactones avermectin B1a and avermectin B1b (Item No. 17453). It has both insecticidal and anthelmintic actions and is used in both agriculture and veterinary medicine.{31111,31112,31113,31114} Abamectin can inhibit nicotinic acetylcholine receptors of worms.{31083} It can also inhibit chikungunya virus (EC50 = 1.5 µM) and yellow fever virus.{31115}
Brand:CaymanSKU:-Available on backorder