Chemicals
Showing 6901–7050 of 41137 results
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6-Formylindolo[3,2-b]carbazole (FICZ) is a degradation product of tryptophan upon exposure to visible light that activates the aryl hydrocarbon receptor (AhR; Kd = 70 pM).{31887} This endogenous AhR ligand is also a good substrate for cytochromes P450 (CYP) 1A1, 1A2, and 1B1 (Kis = 15.4, 3.9, and 13.3 µM, respectively).{31888} When activated by either environmental toxins or endogenous ligands, the AhR induces detoxifying enzymes and modulates immune cell differentiation. FICZ has been used to study the immunomodulatory and host defense mechanisms of AhR signaling pathways.{27028}
Brand:CaymanSKU:-Available on backorder
6-Formylindolo[3,2-b]carbazole (FICZ) is a degradation product of tryptophan upon exposure to visible light that activates the aryl hydrocarbon receptor (AhR; Kd = 70 pM).{31887} This endogenous AhR ligand is also a good substrate for cytochromes P450 (CYP) 1A1, 1A2, and 1B1 (Kis = 15.4, 3.9, and 13.3 µM, respectively).{31888} When activated by either environmental toxins or endogenous ligands, the AhR induces detoxifying enzymes and modulates immune cell differentiation. FICZ has been used to study the immunomodulatory and host defense mechanisms of AhR signaling pathways.{27028}
Brand:CaymanSKU:-Available on backorder
6-Formylindolo[3,2-b]carbazole (FICZ) is a degradation product of tryptophan upon exposure to visible light that activates the aryl hydrocarbon receptor (AhR; Kd = 70 pM).{31887} This endogenous AhR ligand is also a good substrate for cytochromes P450 (CYP) 1A1, 1A2, and 1B1 (Kis = 15.4, 3.9, and 13.3 µM, respectively).{31888} When activated by either environmental toxins or endogenous ligands, the AhR induces detoxifying enzymes and modulates immune cell differentiation. FICZ has been used to study the immunomodulatory and host defense mechanisms of AhR signaling pathways.{27028}
Brand:CaymanSKU:-Available on backorder
6-Formylindolo[3,2-b]carbazole (FICZ) is a degradation product of tryptophan upon exposure to visible light that activates the aryl hydrocarbon receptor (AhR; Kd = 70 pM).{31887} This endogenous AhR ligand is also a good substrate for cytochromes P450 (CYP) 1A1, 1A2, and 1B1 (Kis = 15.4, 3.9, and 13.3 µM, respectively).{31888} When activated by either environmental toxins or endogenous ligands, the AhR induces detoxifying enzymes and modulates immune cell differentiation. FICZ has been used to study the immunomodulatory and host defense mechanisms of AhR signaling pathways.{27028}
Brand:CaymanSKU:-Available on backorder
Xanthine oxidase (XO) generates reactive oxygen species, including hydrogen peroxide (H2O2), as it oxidizes specific substrates in the presence of water and oxygen.{15324} 6-Formylpterin is an oxidized pterin produced by photolytic breakdown of folic acid.{24043} It binds to one of two active sites on XO nearly quantitatively and irreversibly and prevents the metabolism of other substrates at the second site, resulting in “hetero-substrate” inhibition at nanomolar concentrations.{24043,24041} However, 6-formylpterin itself is converted by XO to 6-carboxylpterin and H2O2 and the turnover rate of this reaction can actually be accelerated by prior binding of a hetero-substrate to XO.{24041} In this way, 6-formylpterin acts as an intracellular generator of H2O2 in cells expressing XO, altering cellular function.{24042,24039}
Brand:CaymanSKU:- Xanthine oxidase (XO) generates reactive oxygen species, including hydrogen peroxide (H2O2), as it oxidizes specific substrates in the presence of water and oxygen.{15324} 6-Formylpterin is an oxidized pterin produced by photolytic breakdown of folic acid.{24043} It binds to one of two active sites on XO nearly quantitatively and irreversibly and prevents the metabolism of other substrates at the second site, resulting in “hetero-substrate” inhibition at nanomolar concentrations.{24043,24041} However, 6-formylpterin itself is converted by XO to 6-carboxylpterin and H2O2 and the turnover rate of this reaction can actually be accelerated by prior binding of a hetero-substrate to XO.{24041} In this way, 6-formylpterin acts as an intracellular generator of H2O2 in cells expressing XO, altering cellular function.{24042,24039}
Brand:CaymanSKU:- Xanthine oxidase (XO) generates reactive oxygen species, including hydrogen peroxide (H2O2), as it oxidizes specific substrates in the presence of water and oxygen.{15324} 6-Formylpterin is an oxidized pterin produced by photolytic breakdown of folic acid.{24043} It binds to one of two active sites on XO nearly quantitatively and irreversibly and prevents the metabolism of other substrates at the second site, resulting in “hetero-substrate” inhibition at nanomolar concentrations.{24043,24041} However, 6-formylpterin itself is converted by XO to 6-carboxylpterin and H2O2 and the turnover rate of this reaction can actually be accelerated by prior binding of a hetero-substrate to XO.{24041} In this way, 6-formylpterin acts as an intracellular generator of H2O2 in cells expressing XO, altering cellular function.{24042,24039}
Brand:CaymanSKU:- Xanthine oxidase (XO) generates reactive oxygen species, including hydrogen peroxide (H2O2), as it oxidizes specific substrates in the presence of water and oxygen.{15324} 6-Formylpterin is an oxidized pterin produced by photolytic breakdown of folic acid.{24043} It binds to one of two active sites on XO nearly quantitatively and irreversibly and prevents the metabolism of other substrates at the second site, resulting in “hetero-substrate” inhibition at nanomolar concentrations.{24043,24041} However, 6-formylpterin itself is converted by XO to 6-carboxylpterin and H2O2 and the turnover rate of this reaction can actually be accelerated by prior binding of a hetero-substrate to XO.{24041} In this way, 6-formylpterin acts as an intracellular generator of H2O2 in cells expressing XO, altering cellular function.{24042,24039}
Brand:CaymanSKU:- Xanthine oxidase (XO) generates reactive oxygen species, including hydrogen peroxide (H2O2), as it oxidizes specific substrates in the presence of water and oxygen.{15324} 6-Formylpterin is an oxidized pterin produced by photolytic breakdown of folic acid.{24043} It binds to one of two active sites on XO nearly quantitatively and irreversibly and prevents the metabolism of other substrates at the second site, resulting in “hetero-substrate” inhibition at nanomolar concentrations.{24043,24041} However, 6-formylpterin itself is converted by XO to 6-carboxylpterin and H2O2 and the turnover rate of this reaction can actually be accelerated by prior binding of a hetero-substrate to XO.{24041} In this way, 6-formylpterin acts as an intracellular generator of H2O2 in cells expressing XO, altering cellular function.{24042,24039}
Brand:CaymanSKU:-
6-Gingerol is a natural chemical found in the rhizomes of ginger (Z. officinale). It shares the vanillyl group found on capsaicin (Item No. 92350) and, like capsaicin, activates the transient receptor potential vanilloid receptor TRPV1 (EC50 = 3.3 µM) as well as the TRP ankyrin receptor TRPA1 (EC50 = 10.4 µM).{25921} 6-Gingerol also non-competitively inhibits serotonin currents (IC50 = 30.3 µM) and weakly inhibits the cyclooxygenases COX-1 and COX-2 (IC50s = 129 and 125 µM).{25920,25922}
Brand:CaymanSKU:11707 - 1 mgAvailable on backorder
6-Gingerol is a natural chemical found in the rhizomes of ginger (Z. officinale). It shares the vanillyl group found on capsaicin (Item No. 92350) and, like capsaicin, activates the transient receptor potential vanilloid receptor TRPV1 (EC50 = 3.3 µM) as well as the TRP ankyrin receptor TRPA1 (EC50 = 10.4 µM).{25921} 6-Gingerol also non-competitively inhibits serotonin currents (IC50 = 30.3 µM) and weakly inhibits the cyclooxygenases COX-1 and COX-2 (IC50s = 129 and 125 µM).{25920,25922}
Brand:CaymanSKU:11707 - 10 mgAvailable on backorder
6-Gingerol is a natural chemical found in the rhizomes of ginger (Z. officinale). It shares the vanillyl group found on capsaicin (Item No. 92350) and, like capsaicin, activates the transient receptor potential vanilloid receptor TRPV1 (EC50 = 3.3 µM) as well as the TRP ankyrin receptor TRPA1 (EC50 = 10.4 µM).{25921} 6-Gingerol also non-competitively inhibits serotonin currents (IC50 = 30.3 µM) and weakly inhibits the cyclooxygenases COX-1 and COX-2 (IC50s = 129 and 125 µM).{25920,25922}
Brand:CaymanSKU:11707 - 25 mgAvailable on backorder
6-Gingerol is a natural chemical found in the rhizomes of ginger (Z. officinale). It shares the vanillyl group found on capsaicin (Item No. 92350) and, like capsaicin, activates the transient receptor potential vanilloid receptor TRPV1 (EC50 = 3.3 µM) as well as the TRP ankyrin receptor TRPA1 (EC50 = 10.4 µM).{25921} 6-Gingerol also non-competitively inhibits serotonin currents (IC50 = 30.3 µM) and weakly inhibits the cyclooxygenases COX-1 and COX-2 (IC50s = 129 and 125 µM).{25920,25922}
Brand:CaymanSKU:11707 - 5 mgAvailable on backorder
6-hydroxy Bexarotene is an oxidative metabolite of bexarotene (Item No. 11571), a high-affinity ligand for retinoid X receptors (RXRs).{35324} 6-hydroxy Bexarotene binds to RXRα, RXRβ, and RXRγ as well as retinoic acid receptor α (RARα; Kds = 3.46, 4.21, 4.83, and 8.17 μM, respectively). It selectively activates RXRα, RXRβ, and RXRγ over RARα, RARβ, and RARγ in vitro (EC50s = 398, 356, 420, 4,414, 2,121, and 2,043 nM, respectively).
Brand:CaymanSKU:22098 -Out of stock
6-hydroxy Bexarotene is an oxidative metabolite of bexarotene (Item No. 11571), a high-affinity ligand for retinoid X receptors (RXRs).{35324} 6-hydroxy Bexarotene binds to RXRα, RXRβ, and RXRγ as well as retinoic acid receptor α (RARα; Kds = 3.46, 4.21, 4.83, and 8.17 μM, respectively). It selectively activates RXRα, RXRβ, and RXRγ over RARα, RARβ, and RARγ in vitro (EC50s = 398, 356, 420, 4,414, 2,121, and 2,043 nM, respectively).
Brand:CaymanSKU:22098 -Out of stock
6-hydroxy Bexarotene is an oxidative metabolite of bexarotene (Item No. 11571), a high-affinity ligand for retinoid X receptors (RXRs).{35324} 6-hydroxy Bexarotene binds to RXRα, RXRβ, and RXRγ as well as retinoic acid receptor α (RARα; Kds = 3.46, 4.21, 4.83, and 8.17 μM, respectively). It selectively activates RXRα, RXRβ, and RXRγ over RARα, RARβ, and RARγ in vitro (EC50s = 398, 356, 420, 4,414, 2,121, and 2,043 nM, respectively).
Brand:CaymanSKU:22098 -Out of stock
6-hydroxy Chlorzoxazone is a metabolite of chlorzoxazone (Item No. 18869).{14227} It is formed by metabolism of chlorzoxazone by the cytochrome P450 (CYP) isoform CYP2E1 in human hepatic microsomes.
Brand:CaymanSKU:10009029 - 1 mgAvailable on backorder
6-hydroxy Chlorzoxazone is a metabolite of chlorzoxazone (Item No. 18869).{14227} It is formed by metabolism of chlorzoxazone by the cytochrome P450 (CYP) isoform CYP2E1 in human hepatic microsomes.
Brand:CaymanSKU:10009029 - 10 mgAvailable on backorder
6-hydroxy Chlorzoxazone is a metabolite of chlorzoxazone (Item No. 18869).{14227} It is formed by metabolism of chlorzoxazone by the cytochrome P450 (CYP) isoform CYP2E1 in human hepatic microsomes.
Brand:CaymanSKU:10009029 - 5 mgAvailable on backorder
6-hydroxy Melatonin is the primary active metabolite of melatonin (Item No. 14427). 6-hydroxy Melatonin acts as an agonist at the melatonin 1 (MT1) and MT2 receptors, with approximately the same potency as melatonin in a competition assay using [3H]-melatonin and human recombinant receptors (pKi = 9.23 and 9.93, respectively for MT1; 8.79 and 9.65, respectively for MT2).{34286} Melatonin is an indoleamine neurohormone whose levels vary in a daily cycle, thereby allowing the entrainment of the circadian rhythms of several biological functions in animals, plants, and microbes.{22956} Melatonin also has antioxidative properties, but 6-hydroxy melatonin is a better scavenger of reactive oxygen species than melatonin in rat brain homogenates.{34285,34287}
Brand:CaymanSKU:21857 -Out of stock
6-hydroxy Melatonin is the primary active metabolite of melatonin (Item No. 14427). 6-hydroxy Melatonin acts as an agonist at the melatonin 1 (MT1) and MT2 receptors, with approximately the same potency as melatonin in a competition assay using [3H]-melatonin and human recombinant receptors (pKi = 9.23 and 9.93, respectively for MT1; 8.79 and 9.65, respectively for MT2).{34286} Melatonin is an indoleamine neurohormone whose levels vary in a daily cycle, thereby allowing the entrainment of the circadian rhythms of several biological functions in animals, plants, and microbes.{22956} Melatonin also has antioxidative properties, but 6-hydroxy melatonin is a better scavenger of reactive oxygen species than melatonin in rat brain homogenates.{34285,34287}
Brand:CaymanSKU:21857 -Out of stock
6-hydroxy Melatonin is the primary active metabolite of melatonin (Item No. 14427). 6-hydroxy Melatonin acts as an agonist at the melatonin 1 (MT1) and MT2 receptors, with approximately the same potency as melatonin in a competition assay using [3H]-melatonin and human recombinant receptors (pKi = 9.23 and 9.93, respectively for MT1; 8.79 and 9.65, respectively for MT2).{34286} Melatonin is an indoleamine neurohormone whose levels vary in a daily cycle, thereby allowing the entrainment of the circadian rhythms of several biological functions in animals, plants, and microbes.{22956} Melatonin also has antioxidative properties, but 6-hydroxy melatonin is a better scavenger of reactive oxygen species than melatonin in rat brain homogenates.{34285,34287}
Brand:CaymanSKU:21857 -Out of stock
Brand:CaymanSKU:28587 - 1 mgAvailable on backorder
6-hydroxy Warfarin is a metabolite of (+)-warfarin (Item No. 13526), which is a weaker vitamin K antagonist than (-)-warfarin (Item No. 13531).{34754, 34753,17423} Both isomers of warfarin are metabolized by the cytochrome P450 isoform 2C9 (CYP2C9); however, stereoselective metabolism also occurs, with CYP1A1 and CYP1A2 primarily responsible for metabolism of (+)-warfarin to 6-hydroxy warfarin.{34754,34753}
Brand:CaymanSKU:9000632 - 1 mgAvailable on backorder
6-hydroxy Warfarin is a metabolite of (+)-warfarin (Item No. 13526), which is a weaker vitamin K antagonist than (-)-warfarin (Item No. 13531).{34754, 34753,17423} Both isomers of warfarin are metabolized by the cytochrome P450 isoform 2C9 (CYP2C9); however, stereoselective metabolism also occurs, with CYP1A1 and CYP1A2 primarily responsible for metabolism of (+)-warfarin to 6-hydroxy warfarin.{34754,34753}
Brand:CaymanSKU:9000632 - 10 mgAvailable on backorder
6-hydroxy Warfarin is a metabolite of (+)-warfarin (Item No. 13526), which is a weaker vitamin K antagonist than (-)-warfarin (Item No. 13531).{34754, 34753,17423} Both isomers of warfarin are metabolized by the cytochrome P450 isoform 2C9 (CYP2C9); however, stereoselective metabolism also occurs, with CYP1A1 and CYP1A2 primarily responsible for metabolism of (+)-warfarin to 6-hydroxy warfarin.{34754,34753}
Brand:CaymanSKU:9000632 - 5 mgAvailable on backorder
6-hydroxy Warfarin is a metabolite of (+)-warfarin (Item No. 13526), which is a weaker vitamin K antagonist than (-)-warfarin (Item No. 13531).{34754, 34753,17423} Both isomers of warfarin are metabolized by the cytochrome P450 isoform 2C9 (CYP2C9); however, stereoselective metabolism also occurs, with CYP1A1 and CYP1A2 primarily responsible for metabolism of (+)-warfarin to 6-hydroxy warfarin.{34754,34753}
Brand:CaymanSKU:9000632 - 500 µgAvailable on backorder
6-Hydroxypyridin-3-ylboronic acid is a heterocyclic building block.{52494,52495} It has been used in the synthesis of non-nucleoside inhibitors of hepatitis C virus (HCV) RNA-dependent RNA polymerase nonstructural protein 5B (NS5B).{52494} 6-Hydroxypyridin-3-ylboronic acid has also been used in the synthesis of mammalian target of rapamycin (mTOR) inhibitors.{52495}
Brand:CaymanSKU:30492 - 100 mgAvailable on backorder
6-Hydroxypyridin-3-ylboronic acid is a heterocyclic building block.{52494,52495} It has been used in the synthesis of non-nucleoside inhibitors of hepatitis C virus (HCV) RNA-dependent RNA polymerase nonstructural protein 5B (NS5B).{52494} 6-Hydroxypyridin-3-ylboronic acid has also been used in the synthesis of mammalian target of rapamycin (mTOR) inhibitors.{52495}
Brand:CaymanSKU:30492 - 250 mgAvailable on backorder
6-Hydroxypyridin-3-ylboronic acid is a heterocyclic building block.{52494,52495} It has been used in the synthesis of non-nucleoside inhibitors of hepatitis C virus (HCV) RNA-dependent RNA polymerase nonstructural protein 5B (NS5B).{52494} 6-Hydroxypyridin-3-ylboronic acid has also been used in the synthesis of mammalian target of rapamycin (mTOR) inhibitors.{52495}
Brand:CaymanSKU:30492 - 500 mgAvailable on backorder
6-IT (Item No. 13938) is an analytical reference standard that is structurally categorized as an amphetamine. The resolution of 6-IT and its (2-aminopropyl) indole positional isomers has been reported.{30151} This product is intended for forensic and research applications.
Brand:CaymanSKU:- 6-IT (Item No. 13938) is an analytical reference standard that is structurally categorized as an amphetamine. The resolution of 6-IT and its (2-aminopropyl) indole positional isomers has been reported.{30151} This product is intended for forensic and research applications.
Brand:CaymanSKU:- 6-IT (Item No. 13938) is an analytical reference standard that is structurally categorized as an amphetamine. The resolution of 6-IT and its (2-aminopropyl) indole positional isomers has been reported.{30151} This product is intended for forensic and research applications.
Brand:CaymanSKU:-
6-keto PGE1 is a metabolite isolated after the incubation of PGI2 with rabbit liver microsomes.{6609} However, it is not produced in appreciable amounts following IV infusion of PGI2 in humans.{6610} 6-keto PGE1 is equipotent with PGI2 as a vasodilator; in most other aspects its activity resembles PGE1.{423}
Brand:CaymanSKU:- 6-keto PGE1 is a metabolite isolated after the incubation of PGI2 with rabbit liver microsomes.{6609} However, it is not produced in appreciable amounts following IV infusion of PGI2 in humans.{6610} 6-keto PGE1 is equipotent with PGI2 as a vasodilator; in most other aspects its activity resembles PGE1.{423}
Brand:CaymanSKU:- 6-keto PGE1 is a metabolite isolated after the incubation of PGI2 with rabbit liver microsomes.{6609} However, it is not produced in appreciable amounts following IV infusion of PGI2 in humans.{6610} 6-keto PGE1 is equipotent with PGI2 as a vasodilator; in most other aspects its activity resembles PGE1.{423}
Brand:CaymanSKU:-
6-keto Prostaglandin E1 (6-keto PGE1) is a stable non-enzymatic hydrolysis product of prostacyclin (PGI2; Item No. 18220). 6-keto PGE1 is a metabolite isolated after the incubation of PGI2 with rabbit liver microsomes.{6609} However, it is not produced in appreciable amounts following IV infusion of PGI2 in humans.{6610} 6-keto PGE1 is equipotent with PGI2 as a vasodilator; in most other aspects its activity resembles PGE1 (Item No. 13010).{423} 6-keto PGE1 MaxSpec® standard is a quantitative grade standard of 6-keto PGE1 (Item No. 13260) that has been prepared specifically for mass spectrometry or any application where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This 6-keto PGE1 MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.
Brand:CaymanSKU:10007210 - 100 µgAvailable on backorder
6-keto prostaglandin F1α (6-keto PGF1α) is the inactive, non-enzymatic hydrolysis product of PGI2.{441,443} 6-keto PGF1α serves as a useful marker of PGI2 biosynthesis in vivo.{439} When [3H]-PGI2 is injected into healthy human males, 6.6% of the radioactivity is recovered from urine as [3H]-6-keto PGF1α.{439}
Brand:CaymanSKU:- 6-keto prostaglandin F1α (6-keto PGF1α) is the inactive, non-enzymatic hydrolysis product of PGI2.{441,443} 6-keto PGF1α serves as a useful marker of PGI2 biosynthesis in vivo.{439} When [3H]-PGI2 is injected into healthy human males, 6.6% of the radioactivity is recovered from urine as [3H]-6-keto PGF1α.{439}
Brand:CaymanSKU:- 6-keto prostaglandin F1α (6-keto PGF1α) is the inactive, non-enzymatic hydrolysis product of PGI2.{441,443} 6-keto PGF1α serves as a useful marker of PGI2 biosynthesis in vivo.{439} When [3H]-PGI2 is injected into healthy human males, 6.6% of the radioactivity is recovered from urine as [3H]-6-keto PGF1α.{439}
Brand:CaymanSKU:-
6-keto Prostaglandin F1α (6-keto PGF1α) is the inactive, non-enzymatic hydrolysis product of PGI2 (Item No. 18220).{441,443} 6-keto PGF1α serves as a useful marker of PGI2 biosynthesis in vivo.{439} When [3H]-PGI2 is injected into healthy human males, 6.6% of the radioactivity is recovered from urine as [3H]-6-keto PGF1α.{439} 6-keto PGF1α MaxSpec® standard is a quantitative grade standard of 6-keto PGF1α (Item No. 15210) that has been prepared specifically for mass spectrometry or any application where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This 6-keto PGF1α MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.
Brand:CaymanSKU:10007219 - 100 µgAvailable on backorder
6-keto Prostaglandin F1α-d4 (6-keto PGF1α-d4) contains four deuterium atoms at the 3, 3′, 4, and 4′ positions. It is intended for use as an internal standard for the quantification of 6-keto PGF1α (Item No. 15210) by GC- or LC-MS. 6-keto PGF1α is the inactive, non-enzymatic hydrolysis product of PGI2.{441,443} 6-keto PGF1α serves as a useful marker of PGI2 biosynthesis in vivo.{439} When [3H]-PGI2 is injected into healthy human males, 6.6% of the radioactivity is recovered from urine as [3H]-6-keto PGF1α.{439}
Brand:CaymanSKU:315210 - 1 mgAvailable on backorder
6-keto Prostaglandin F1α-d4 (6-keto PGF1α-d4) contains four deuterium atoms at the 3, 3′, 4, and 4′ positions. It is intended for use as an internal standard for the quantification of 6-keto PGF1α (Item No. 15210) by GC- or LC-MS. 6-keto PGF1α is the inactive, non-enzymatic hydrolysis product of PGI2.{441,443} 6-keto PGF1α serves as a useful marker of PGI2 biosynthesis in vivo.{439} When [3H]-PGI2 is injected into healthy human males, 6.6% of the radioactivity is recovered from urine as [3H]-6-keto PGF1α.{439}
Brand:CaymanSKU:315210 - 100 µgAvailable on backorder
6-keto Prostaglandin F1α-d4 (6-keto PGF1α-d4) contains four deuterium atoms at the 3, 3′, 4, and 4′ positions. It is intended for use as an internal standard for the quantification of 6-keto PGF1α (Item No. 15210) by GC- or LC-MS. 6-keto PGF1α is the inactive, non-enzymatic hydrolysis product of PGI2.{441,443} 6-keto PGF1α serves as a useful marker of PGI2 biosynthesis in vivo.{439} When [3H]-PGI2 is injected into healthy human males, 6.6% of the radioactivity is recovered from urine as [3H]-6-keto PGF1α.{439}
Brand:CaymanSKU:315210 - 25 µgAvailable on backorder
6-keto Prostaglandin F1α-d4 (6-keto PGF1α-d4) contains four deuterium atoms at the 3, 3′, 4, and 4′ positions. It is intended for use as an internal standard for the quantification of 6-keto PGF1α (Item No. 15210) by GC- or LC-MS. 6-keto PGF1α is the inactive, non-enzymatic hydrolysis product of PGI2.{441,443} 6-keto PGF1α serves as a useful marker of PGI2 biosynthesis in vivo.{439} When [3H]-PGI2 is injected into healthy human males, 6.6% of the radioactivity is recovered from urine as [3H]-6-keto PGF1α.{439}
Brand:CaymanSKU:315210 - 50 µgAvailable on backorder
6-Mercaptopurine (6-MP) is an inhibitor of purine synthesis and interconversion.{36297} It is rapidly converted to 6-mercaptopurine ribonucleoside-5′-monophosphate, which inhibits phosphoribosyl pyrophosphate (PRPP) amidotransferase, the rate-limiting enzyme in purine synthesis. It also inhibits the conversion of IMP to adenylosuccinic acid and xanthylic acid and blocks AMP formation in vitro. 6-MP (30 mg/kg) inhibits growth of sarcoma 180, adenocarcinoma E 0771, and adenocarcinoma 755 tumors and reduces the size of leukemia L1210 subcutaneous growths in mice.{36298} It also decreases delayed-type hypersensitivity and thyroid inflammation in a guinea pig model of thyroiditis when administered pre- or post-disease onset.{36299} Formulations containing mercaptopurine have been used for maintenance therapy in patients with acute lymphoblastic leukemia.{36300}
Brand:CaymanSKU:23675 - 10 gAvailable on backorder
6-Mercaptopurine (6-MP) is an inhibitor of purine synthesis and interconversion.{36297} It is rapidly converted to 6-mercaptopurine ribonucleoside-5′-monophosphate, which inhibits phosphoribosyl pyrophosphate (PRPP) amidotransferase, the rate-limiting enzyme in purine synthesis. It also inhibits the conversion of IMP to adenylosuccinic acid and xanthylic acid and blocks AMP formation in vitro. 6-MP (30 mg/kg) inhibits growth of sarcoma 180, adenocarcinoma E 0771, and adenocarcinoma 755 tumors and reduces the size of leukemia L1210 subcutaneous growths in mice.{36298} It also decreases delayed-type hypersensitivity and thyroid inflammation in a guinea pig model of thyroiditis when administered pre- or post-disease onset.{36299} Formulations containing mercaptopurine have been used for maintenance therapy in patients with acute lymphoblastic leukemia.{36300}
Brand:CaymanSKU:23675 - 25 gAvailable on backorder
6-Mercaptopurine (6-MP) is an inhibitor of purine synthesis and interconversion.{36297} It is rapidly converted to 6-mercaptopurine ribonucleoside-5′-monophosphate, which inhibits phosphoribosyl pyrophosphate (PRPP) amidotransferase, the rate-limiting enzyme in purine synthesis. It also inhibits the conversion of IMP to adenylosuccinic acid and xanthylic acid and blocks AMP formation in vitro. 6-MP (30 mg/kg) inhibits growth of sarcoma 180, adenocarcinoma E 0771, and adenocarcinoma 755 tumors and reduces the size of leukemia L1210 subcutaneous growths in mice.{36298} It also decreases delayed-type hypersensitivity and thyroid inflammation in a guinea pig model of thyroiditis when administered pre- or post-disease onset.{36299} Formulations containing mercaptopurine have been used for maintenance therapy in patients with acute lymphoblastic leukemia.{36300}
Brand:CaymanSKU:23675 - 5 gAvailable on backorder
6-MNA is a competitive, non-selective COX inhibitor.{1286,1364,1791} The Ki values for ovine COX-1 and -2 are 21 and 19 µM, respectively.{1364} The IC50 values are 70 and 20 µM for human recombinant COX-1 and -2, respectively.{1286}
Brand:CaymanSKU:70620 - 10 mgAvailable on backorder
6-MNA is a competitive, non-selective COX inhibitor.{1286,1364,1791} The Ki values for ovine COX-1 and -2 are 21 and 19 µM, respectively.{1364} The IC50 values are 70 and 20 µM for human recombinant COX-1 and -2, respectively.{1286}
Brand:CaymanSKU:70620 - 100 mgAvailable on backorder
6-MNA is a competitive, non-selective COX inhibitor.{1286,1364,1791} The Ki values for ovine COX-1 and -2 are 21 and 19 µM, respectively.{1364} The IC50 values are 70 and 20 µM for human recombinant COX-1 and -2, respectively.{1286}
Brand:CaymanSKU:70620 - 5 mgAvailable on backorder
6-MNA is a competitive, non-selective COX inhibitor.{1286,1364,1791} The Ki values for ovine COX-1 and -2 are 21 and 19 µM, respectively.{1364} The IC50 values are 70 and 20 µM for human recombinant COX-1 and -2, respectively.{1286}
Brand:CaymanSKU:70620 - 50 mgAvailable on backorder
6-Methylsulfinylhexyl isothiocyanate (6-MSITC) is an isothiocyanate that has been found in wasabi (W. japonica) and has diverse biological activities.{31411,31409,54330,31410,54331} It inhibits nitric oxide (NO) production in mouse peritoneal exudate macrophages when used at a concentration of 5 µM.{31411} It inhibits aggregation of isolated human platelets induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607; IC50 = 21.9 µM).{31409} 6-MSITC reduces cell survival in a panel of breast, brain, colon, lung, ovarian, renal, and prostate cancer cell lines (mean IC50 = 43.7 µM).{54330} In vivo, 6-MSITC (5 mg/kg twice weekly) reduces apoptosis of substantia nigral dopaminergic neurons and motor dysfunction in a mouse model of Parkinson’s disease induced by 6-OHDA (Item No. 25330).{31410} 6-MSITC also reduces the number of lung metastases in a B16/F10 murine melanoma model.{54331}
Brand:CaymanSKU:19638 -Available on backorder
6-Methylsulfinylhexyl isothiocyanate (6-MSITC) is an isothiocyanate that has been found in wasabi (W. japonica) and has diverse biological activities.{31411,31409,54330,31410,54331} It inhibits nitric oxide (NO) production in mouse peritoneal exudate macrophages when used at a concentration of 5 µM.{31411} It inhibits aggregation of isolated human platelets induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607; IC50 = 21.9 µM).{31409} 6-MSITC reduces cell survival in a panel of breast, brain, colon, lung, ovarian, renal, and prostate cancer cell lines (mean IC50 = 43.7 µM).{54330} In vivo, 6-MSITC (5 mg/kg twice weekly) reduces apoptosis of substantia nigral dopaminergic neurons and motor dysfunction in a mouse model of Parkinson’s disease induced by 6-OHDA (Item No. 25330).{31410} 6-MSITC also reduces the number of lung metastases in a B16/F10 murine melanoma model.{54331}
Brand:CaymanSKU:19638 -Available on backorder
6-Methylsulfinylhexyl isothiocyanate (6-MSITC) is an isothiocyanate that has been found in wasabi (W. japonica) and has diverse biological activities.{31411,31409,54330,31410,54331} It inhibits nitric oxide (NO) production in mouse peritoneal exudate macrophages when used at a concentration of 5 µM.{31411} It inhibits aggregation of isolated human platelets induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607; IC50 = 21.9 µM).{31409} 6-MSITC reduces cell survival in a panel of breast, brain, colon, lung, ovarian, renal, and prostate cancer cell lines (mean IC50 = 43.7 µM).{54330} In vivo, 6-MSITC (5 mg/kg twice weekly) reduces apoptosis of substantia nigral dopaminergic neurons and motor dysfunction in a mouse model of Parkinson’s disease induced by 6-OHDA (Item No. 25330).{31410} 6-MSITC also reduces the number of lung metastases in a B16/F10 murine melanoma model.{54331}
Brand:CaymanSKU:19638 -Available on backorder
6-Methylsulfinylhexyl isothiocyanate (6-MSITC) is an isothiocyanate that has been found in wasabi (W. japonica) and has diverse biological activities.{31411,31409,54330,31410,54331} It inhibits nitric oxide (NO) production in mouse peritoneal exudate macrophages when used at a concentration of 5 µM.{31411} It inhibits aggregation of isolated human platelets induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607; IC50 = 21.9 µM).{31409} 6-MSITC reduces cell survival in a panel of breast, brain, colon, lung, ovarian, renal, and prostate cancer cell lines (mean IC50 = 43.7 µM).{54330} In vivo, 6-MSITC (5 mg/kg twice weekly) reduces apoptosis of substantia nigral dopaminergic neurons and motor dysfunction in a mouse model of Parkinson’s disease induced by 6-OHDA (Item No. 25330).{31410} 6-MSITC also reduces the number of lung metastases in a B16/F10 murine melanoma model.{54331}
Brand:CaymanSKU:19638 -Available on backorder
6-NBDG is a non-hydrolyzable fluorescent glucose analog that is used to monitor glucose uptake and transport in living cells.{33229,33230,33231} 6-NBDG has been validated as a probe for the glucose transporter GLUT1 in cells.{33228} The fluorophore NBD displays excitation/emission maxima of 465/535 nm.
Brand:CaymanSKU:- 6-NBDG is a non-hydrolyzable fluorescent glucose analog that is used to monitor glucose uptake and transport in living cells.{33229,33230,33231} 6-NBDG has been validated as a probe for the glucose transporter GLUT1 in cells.{33228} The fluorophore NBD displays excitation/emission maxima of 465/535 nm.
Brand:CaymanSKU:- 6-NBDG is a non-hydrolyzable fluorescent glucose analog that is used to monitor glucose uptake and transport in living cells.{33229,33230,33231} 6-NBDG has been validated as a probe for the glucose transporter GLUT1 in cells.{33228} The fluorophore NBD displays excitation/emission maxima of 465/535 nm.
Brand:CaymanSKU:-
6-Nitroveratraldehyde is a photolabile H+-donor that releases acid when excited at 405 nm.{36196} It has been used for fluorescence imaging, in conjunction with the pH sensitive fluorescent probe cSNARF1, to study nuclear proton dynamics, acid venting from cancer cells, and hemoglobin-restricted diffusion in the cytoplasm of red blood cells.{36196,36197,36198} 6-Nitroveratraldehyde has also been used as a precursor for [18F]fluoride displacement reactions in the synthesis of NCA 6-[18F]fluoro-L-dopa that is used in positron emission tomography (PET) studies of dopaminergic systems.{36199}
Brand:CaymanSKU:23364 - 10 gAvailable on backorder
6-Nitroveratraldehyde is a photolabile H+-donor that releases acid when excited at 405 nm.{36196} It has been used for fluorescence imaging, in conjunction with the pH sensitive fluorescent probe cSNARF1, to study nuclear proton dynamics, acid venting from cancer cells, and hemoglobin-restricted diffusion in the cytoplasm of red blood cells.{36196,36197,36198} 6-Nitroveratraldehyde has also been used as a precursor for [18F]fluoride displacement reactions in the synthesis of NCA 6-[18F]fluoro-L-dopa that is used in positron emission tomography (PET) studies of dopaminergic systems.{36199}
Brand:CaymanSKU:23364 - 25 gAvailable on backorder
6-Nitroveratraldehyde is a photolabile H+-donor that releases acid when excited at 405 nm.{36196} It has been used for fluorescence imaging, in conjunction with the pH sensitive fluorescent probe cSNARF1, to study nuclear proton dynamics, acid venting from cancer cells, and hemoglobin-restricted diffusion in the cytoplasm of red blood cells.{36196,36197,36198} 6-Nitroveratraldehyde has also been used as a precursor for [18F]fluoride displacement reactions in the synthesis of NCA 6-[18F]fluoro-L-dopa that is used in positron emission tomography (PET) studies of dopaminergic systems.{36199}
Brand:CaymanSKU:23364 - 5 gAvailable on backorder
6-Nitroveratraldehyde is a photolabile H+-donor that releases acid when excited at 405 nm.{36196} It has been used for fluorescence imaging, in conjunction with the pH sensitive fluorescent probe cSNARF1, to study nuclear proton dynamics, acid venting from cancer cells, and hemoglobin-restricted diffusion in the cytoplasm of red blood cells.{36196,36197,36198} 6-Nitroveratraldehyde has also been used as a precursor for [18F]fluoride displacement reactions in the synthesis of NCA 6-[18F]fluoro-L-dopa that is used in positron emission tomography (PET) studies of dopaminergic systems.{36199}
Brand:CaymanSKU:23364 - 50 gAvailable on backorder
6-O-desmethyl Donepezil is an active metabolite of the acetylcholinesterase inhibitor donepezil (Item No. 13245).{42676} It is formed through dealkylation by the cytochrome P450 (CYP) isoform CYP2D6.{42677} It inhibits human ether a go-go (hERG) channels (IC50 = 1.5 µM in HEK293 cells expressing hERG).{42676}
Brand:CaymanSKU:27175 - 1 mgAvailable on backorder
6-O-desmethyl Donepezil is an active metabolite of the acetylcholinesterase inhibitor donepezil (Item No. 13245).{42676} It is formed through dealkylation by the cytochrome P450 (CYP) isoform CYP2D6.{42677} It inhibits human ether a go-go (hERG) channels (IC50 = 1.5 µM in HEK293 cells expressing hERG).{42676}
Brand:CaymanSKU:27175 - 5 mgAvailable on backorder
6-O-desmethyl Donepezil is an active metabolite of the acetylcholinesterase inhibitor donepezil (Item No. 13245).{42676} It is formed through dealkylation by the cytochrome P450 (CYP) isoform CYP2D6.{42677} It inhibits human ether a go-go (hERG) channels (IC50 = 1.5 µM in HEK293 cells expressing hERG).{42676}
Brand:CaymanSKU:27175 - 500 µgAvailable on backorder
6-O-Sulfo-β-cyclodextrin is a sulfated cyclodextrin.{56041} It has been used for the chiral separation of nadolol racemates by capillary electrophoresis.
Brand:CaymanSKU:30168 - 100 mgAvailable on backorder
6-O-Sulfo-β-cyclodextrin is a sulfated cyclodextrin.{56041} It has been used for the chiral separation of nadolol racemates by capillary electrophoresis.
Brand:CaymanSKU:30168 - 250 mgAvailable on backorder
6-O-Sulfo-β-cyclodextrin is a sulfated cyclodextrin.{56041} It has been used for the chiral separation of nadolol racemates by capillary electrophoresis.
Brand:CaymanSKU:30168 - 50 mgAvailable on backorder
GPR84 is a Gαi protein-coupled receptor that is activated by medium-chain free fatty acids, but only at micromolar concentrations.{27421} GPR84 is expressed in leukocytes and its expression is further induced by LPS.{27421,29190} 6-OAU is a synthetic agonist for GPR84 (EC50 = 512 nM).{29190} It has insignificant actions at a panel of 69 other receptors, channels, or transporters.{29190} 6-OAU promotes chemotaxis in human neutrophils (EC50 = 318 nM) and amplifies TNF-α production by LPS-treated U937 macrophages.{29190} In rats, 6-OAU (1 mg/ml) drives the recruitment of neutrophils and macrophages when injected into a subcutaneous air pouch and raises serum levels of CXCL1 (growth-regulated α protein) when delivered intravenously.{29190}
Brand:CaymanSKU:-Available on backorder
GPR84 is a Gαi protein-coupled receptor that is activated by medium-chain free fatty acids, but only at micromolar concentrations.{27421} GPR84 is expressed in leukocytes and its expression is further induced by LPS.{27421,29190} 6-OAU is a synthetic agonist for GPR84 (EC50 = 512 nM).{29190} It has insignificant actions at a panel of 69 other receptors, channels, or transporters.{29190} 6-OAU promotes chemotaxis in human neutrophils (EC50 = 318 nM) and amplifies TNF-α production by LPS-treated U937 macrophages.{29190} In rats, 6-OAU (1 mg/ml) drives the recruitment of neutrophils and macrophages when injected into a subcutaneous air pouch and raises serum levels of CXCL1 (growth-regulated α protein) when delivered intravenously.{29190}
Brand:CaymanSKU:-Available on backorder
GPR84 is a Gαi protein-coupled receptor that is activated by medium-chain free fatty acids, but only at micromolar concentrations.{27421} GPR84 is expressed in leukocytes and its expression is further induced by LPS.{27421,29190} 6-OAU is a synthetic agonist for GPR84 (EC50 = 512 nM).{29190} It has insignificant actions at a panel of 69 other receptors, channels, or transporters.{29190} 6-OAU promotes chemotaxis in human neutrophils (EC50 = 318 nM) and amplifies TNF-α production by LPS-treated U937 macrophages.{29190} In rats, 6-OAU (1 mg/ml) drives the recruitment of neutrophils and macrophages when injected into a subcutaneous air pouch and raises serum levels of CXCL1 (growth-regulated α protein) when delivered intravenously.{29190}
Brand:CaymanSKU:-Available on backorder
6-OHDA is a catecholaminergic neurotoxin that has been used to induce dopaminergic lesions and parkinsonian symptoms as a model of Parkinson’s disease in rodents.{37722} It induces locomotor impairment in mice and loss of tyrosine hydroxylase-reactive neurons in mouse brain when administered into the substantia nigra, medial forebrain bundle (MFB), or striatum at doses of 9, 6, and 18 μg, respectively.{37727} Intracisternal administration of 6-OHDA (200 μg) decreases dopamine (Item No. 21992) and norepinephrine (Item No. 16673) levels in rat brain.{37726} It induces apoptosis in primary rat cortical cells and PC12 rat adrenal cells when used at a concentration of 50 μM.{37723,37724} 6-OHDA (75 μM) activates caspase-3, -8, and -9 in a time-dependent manner and increases the level of intracellular reactive oxygen species (ROS) in PC12 cells and induces apoptosis in rat substantia nigra when stereotaxically injected into the right MFB.{37724,37725}
Brand:CaymanSKU:25330 - 1 gAvailable on backorder
6-OHDA is a catecholaminergic neurotoxin that has been used to induce dopaminergic lesions and parkinsonian symptoms as a model of Parkinson’s disease in rodents.{37722} It induces locomotor impairment in mice and loss of tyrosine hydroxylase-reactive neurons in mouse brain when administered into the substantia nigra, medial forebrain bundle (MFB), or striatum at doses of 9, 6, and 18 μg, respectively.{37727} Intracisternal administration of 6-OHDA (200 μg) decreases dopamine (Item No. 21992) and norepinephrine (Item No. 16673) levels in rat brain.{37726} It induces apoptosis in primary rat cortical cells and PC12 rat adrenal cells when used at a concentration of 50 μM.{37723,37724} 6-OHDA (75 μM) activates caspase-3, -8, and -9 in a time-dependent manner and increases the level of intracellular reactive oxygen species (ROS) in PC12 cells and induces apoptosis in rat substantia nigra when stereotaxically injected into the right MFB.{37724,37725}
Brand:CaymanSKU:25330 - 250 mgAvailable on backorder
6-OHDA is a catecholaminergic neurotoxin that has been used to induce dopaminergic lesions and parkinsonian symptoms as a model of Parkinson’s disease in rodents.{37722} It induces locomotor impairment in mice and loss of tyrosine hydroxylase-reactive neurons in mouse brain when administered into the substantia nigra, medial forebrain bundle (MFB), or striatum at doses of 9, 6, and 18 μg, respectively.{37727} Intracisternal administration of 6-OHDA (200 μg) decreases dopamine (Item No. 21992) and norepinephrine (Item No. 16673) levels in rat brain.{37726} It induces apoptosis in primary rat cortical cells and PC12 rat adrenal cells when used at a concentration of 50 μM.{37723,37724} 6-OHDA (75 μM) activates caspase-3, -8, and -9 in a time-dependent manner and increases the level of intracellular reactive oxygen species (ROS) in PC12 cells and induces apoptosis in rat substantia nigra when stereotaxically injected into the right MFB.{37724,37725}
Brand:CaymanSKU:25330 - 50 mgAvailable on backorder
6-Paradol is a phenolic ketone that has been found in ginger (Z. officinale) and has diverse biological activities, including antioxidant, anti-inflammatory, and anti-hyperglycemic properties.{50301,50302,50303} It inhibits hydrogen peroxide-induced oxidation of cell-free calf thymus DNA when used at a concentration of 100 μM.{50301} In vitro, 6-paradol (10 μg/ml) inhibits LPS-induced nitric oxide (NO), IL-6, and TNF-α production by mouse BV-2 microglia.{50302} In vivo, 6-paradol (6.75 mg/kg per day) lowers blood glucose levels in an oral glucose tolerance test (OGTT) and inhibits weight-gain in a mouse model of high-fat diet-induced obesity.{50303}
Brand:CaymanSKU:27554 - 100 mgAvailable on backorder
6-Paradol is a phenolic ketone that has been found in ginger (Z. officinale) and has diverse biological activities, including antioxidant, anti-inflammatory, and anti-hyperglycemic properties.{50301,50302,50303} It inhibits hydrogen peroxide-induced oxidation of cell-free calf thymus DNA when used at a concentration of 100 μM.{50301} In vitro, 6-paradol (10 μg/ml) inhibits LPS-induced nitric oxide (NO), IL-6, and TNF-α production by mouse BV-2 microglia.{50302} In vivo, 6-paradol (6.75 mg/kg per day) lowers blood glucose levels in an oral glucose tolerance test (OGTT) and inhibits weight-gain in a mouse model of high-fat diet-induced obesity.{50303}
Brand:CaymanSKU:27554 - 25 mgAvailable on backorder
6-Paradol is a phenolic ketone that has been found in ginger (Z. officinale) and has diverse biological activities, including antioxidant, anti-inflammatory, and anti-hyperglycemic properties.{50301,50302,50303} It inhibits hydrogen peroxide-induced oxidation of cell-free calf thymus DNA when used at a concentration of 100 μM.{50301} In vitro, 6-paradol (10 μg/ml) inhibits LPS-induced nitric oxide (NO), IL-6, and TNF-α production by mouse BV-2 microglia.{50302} In vivo, 6-paradol (6.75 mg/kg per day) lowers blood glucose levels in an oral glucose tolerance test (OGTT) and inhibits weight-gain in a mouse model of high-fat diet-induced obesity.{50303}
Brand:CaymanSKU:27554 - 250 mgAvailable on backorder
6-Paradol is a phenolic ketone that has been found in ginger (Z. officinale) and has diverse biological activities, including antioxidant, anti-inflammatory, and anti-hyperglycemic properties.{50301,50302,50303} It inhibits hydrogen peroxide-induced oxidation of cell-free calf thymus DNA when used at a concentration of 100 μM.{50301} In vitro, 6-paradol (10 μg/ml) inhibits LPS-induced nitric oxide (NO), IL-6, and TNF-α production by mouse BV-2 microglia.{50302} In vivo, 6-paradol (6.75 mg/kg per day) lowers blood glucose levels in an oral glucose tolerance test (OGTT) and inhibits weight-gain in a mouse model of high-fat diet-induced obesity.{50303}
Brand:CaymanSKU:27554 - 50 mgAvailable on backorder
6-piperazin-1-yl-Isoquinoline (hydrochloride) is a synthetic intermediate useful for pharmaceutical synthesis.
Brand:CaymanSKU:10007148 - 1 gAvailable on backorder
6-piperazin-1-yl-Isoquinoline (hydrochloride) is a synthetic intermediate useful for pharmaceutical synthesis.
Brand:CaymanSKU:10007148 - 100 mgAvailable on backorder