Chemicals
Showing 6301–6450 of 41137 results
-
4µ8C is an inhibitor of inositol requiring enzyme 1 α (IRE1α), which is a protein located in the endoplasmic reticulum (ER) membrane that has kinase and RNase activities triggered by ER stress.{39181} 4µ8C inhibits IRE1α splicing of Xbp1 mRNA (IC50 = 6.8 µM) and reduces subsequent gene expression of Erdj4 (IC50 = 3.4 µM) in stress-cultured MEF cells but does not block IRE1α autophosphorylation. It reduces IL-4 production in CD4+ T cells isolated from murine spleen and LPS-stimulated increases in TNF-α and IL-6 mRNA expression and protein secretion in isolated alveolar macrophages from patients with cystic fibrosis.{39182,39183}
Brand:CaymanSKU:22110 -Out of stock
4µ8C is an inhibitor of inositol requiring enzyme 1 α (IRE1α), which is a protein located in the endoplasmic reticulum (ER) membrane that has kinase and RNase activities triggered by ER stress.{39181} 4µ8C inhibits IRE1α splicing of Xbp1 mRNA (IC50 = 6.8 µM) and reduces subsequent gene expression of Erdj4 (IC50 = 3.4 µM) in stress-cultured MEF cells but does not block IRE1α autophosphorylation. It reduces IL-4 production in CD4+ T cells isolated from murine spleen and LPS-stimulated increases in TNF-α and IL-6 mRNA expression and protein secretion in isolated alveolar macrophages from patients with cystic fibrosis.{39182,39183}
Brand:CaymanSKU:22110 -Out of stock
4µ8C is an inhibitor of inositol requiring enzyme 1 α (IRE1α), which is a protein located in the endoplasmic reticulum (ER) membrane that has kinase and RNase activities triggered by ER stress.{39181} 4µ8C inhibits IRE1α splicing of Xbp1 mRNA (IC50 = 6.8 µM) and reduces subsequent gene expression of Erdj4 (IC50 = 3.4 µM) in stress-cultured MEF cells but does not block IRE1α autophosphorylation. It reduces IL-4 production in CD4+ T cells isolated from murine spleen and LPS-stimulated increases in TNF-α and IL-6 mRNA expression and protein secretion in isolated alveolar macrophages from patients with cystic fibrosis.{39182,39183}
Brand:CaymanSKU:22110 -Out of stock
Brand:CaymanSKU:- Brand:CaymanSKU:- Brand:CaymanSKU:- Brand:CaymanSKU:-
DNA methylation occurs mainly at the 5’-position of cytosine rings (5-methylcytosine) and occurs almost exclusively in CpG islands. Another epigenetic modification in DNA has been recently identified that involves hydroxymethylation of this same base (5-hydroxymethylcytosine), which potentially offers another level of transcriptional control.{20327} 5-(Hydroxymethyl)-2’-deoxycytidine is a modified pyrimidine that is capable of producing interstrand cross-links in double-stranded DNA and has been used to quantify DNA hydroxymethylation levels in biological samples.{29256,29258,29257}
Brand:CaymanSKU:-Available on backorder
DNA methylation occurs mainly at the 5’-position of cytosine rings (5-methylcytosine) and occurs almost exclusively in CpG islands. Another epigenetic modification in DNA has been recently identified that involves hydroxymethylation of this same base (5-hydroxymethylcytosine), which potentially offers another level of transcriptional control.{20327} 5-(Hydroxymethyl)-2’-deoxycytidine is a modified pyrimidine that is capable of producing interstrand cross-links in double-stranded DNA and has been used to quantify DNA hydroxymethylation levels in biological samples.{29256,29258,29257}
Brand:CaymanSKU:-Available on backorder
DNA methylation occurs mainly at the 5’-position of cytosine rings (5-methylcytosine) and occurs almost exclusively in CpG islands. Another epigenetic modification in DNA has been recently identified that involves hydroxymethylation of this same base (5-hydroxymethylcytosine), which potentially offers another level of transcriptional control.{20327} 5-(Hydroxymethyl)-2’-deoxycytidine is a modified pyrimidine that is capable of producing interstrand cross-links in double-stranded DNA and has been used to quantify DNA hydroxymethylation levels in biological samples.{29256,29258,29257}
Brand:CaymanSKU:-Available on backorder
DNA methylation occurs mainly at the 5’-position of cytosine rings (5-methylcytosine) and occurs almost exclusively in CpG islands. Another epigenetic modification in DNA has been recently identified that involves hydroxymethylation of this same base (5-hydroxymethylcytosine), which potentially offers another level of transcriptional control.{20327} 5-(Hydroxymethyl)-2’-deoxycytidine is a modified pyrimidine that is capable of producing interstrand cross-links in double-stranded DNA and has been used to quantify DNA hydroxymethylation levels in biological samples.{29256,29258,29257}
Brand:CaymanSKU:-Available on backorder
5-(Hydroxymethyl)-2’-deoxyuridine is a nucleoside analog with anticancer and antiviral activities.{38403} It inhibits the replication of murine S180 lung carcinoma cells and Ehrlich ascites mammary carcinoma cells (ED50s = 8.5 and 4 μM, respectively) and multiple human leukemia cell lines (IC50s = 1.7-5.8 μM).{38403,38404} 5-(Hydroxymethyl)-2’-deoxyuridine acts synergistically with 5-fluorouracil (5-FU; Item No. 14416) against HT-29, HCT116, PANC-1, and EKVX cancer cells with no effect on WI38 embryonic lung fibroblasts.{38405} It inhibits herpes simplex virus type 1 (HSV-1) pyrimidine 2’-deoxyribonucleoside kinase (Ki = 3.5 μM) and reduces HSV-1 viral titer to 0.05% of the control at a concentration of 200 μM.{38403} 5-(Hydroxymethyl)-2’-deoxyuridine is also a DNA adduct, formed in response to oxidative stress, that is found in hepatic DNA of rats treated with gamma irradiation, diethylnitrosamine, 2-acetylaminofluorene, and ciprofibrate (Item No. 18515).{38406}
Brand:CaymanSKU:23381 - 10 mgAvailable on backorder
5-(Hydroxymethyl)-2’-deoxyuridine is a nucleoside analog with anticancer and antiviral activities.{38403} It inhibits the replication of murine S180 lung carcinoma cells and Ehrlich ascites mammary carcinoma cells (ED50s = 8.5 and 4 μM, respectively) and multiple human leukemia cell lines (IC50s = 1.7-5.8 μM).{38403,38404} 5-(Hydroxymethyl)-2’-deoxyuridine acts synergistically with 5-fluorouracil (5-FU; Item No. 14416) against HT-29, HCT116, PANC-1, and EKVX cancer cells with no effect on WI38 embryonic lung fibroblasts.{38405} It inhibits herpes simplex virus type 1 (HSV-1) pyrimidine 2’-deoxyribonucleoside kinase (Ki = 3.5 μM) and reduces HSV-1 viral titer to 0.05% of the control at a concentration of 200 μM.{38403} 5-(Hydroxymethyl)-2’-deoxyuridine is also a DNA adduct, formed in response to oxidative stress, that is found in hepatic DNA of rats treated with gamma irradiation, diethylnitrosamine, 2-acetylaminofluorene, and ciprofibrate (Item No. 18515).{38406}
Brand:CaymanSKU:23381 - 100 mgAvailable on backorder
5-(Hydroxymethyl)-2’-deoxyuridine is a nucleoside analog with anticancer and antiviral activities.{38403} It inhibits the replication of murine S180 lung carcinoma cells and Ehrlich ascites mammary carcinoma cells (ED50s = 8.5 and 4 μM, respectively) and multiple human leukemia cell lines (IC50s = 1.7-5.8 μM).{38403,38404} 5-(Hydroxymethyl)-2’-deoxyuridine acts synergistically with 5-fluorouracil (5-FU; Item No. 14416) against HT-29, HCT116, PANC-1, and EKVX cancer cells with no effect on WI38 embryonic lung fibroblasts.{38405} It inhibits herpes simplex virus type 1 (HSV-1) pyrimidine 2’-deoxyribonucleoside kinase (Ki = 3.5 μM) and reduces HSV-1 viral titer to 0.05% of the control at a concentration of 200 μM.{38403} 5-(Hydroxymethyl)-2’-deoxyuridine is also a DNA adduct, formed in response to oxidative stress, that is found in hepatic DNA of rats treated with gamma irradiation, diethylnitrosamine, 2-acetylaminofluorene, and ciprofibrate (Item No. 18515).{38406}
Brand:CaymanSKU:23381 - 25 mgAvailable on backorder
5-(Hydroxymethyl)-2’-deoxyuridine is a nucleoside analog with anticancer and antiviral activities.{38403} It inhibits the replication of murine S180 lung carcinoma cells and Ehrlich ascites mammary carcinoma cells (ED50s = 8.5 and 4 μM, respectively) and multiple human leukemia cell lines (IC50s = 1.7-5.8 μM).{38403,38404} 5-(Hydroxymethyl)-2’-deoxyuridine acts synergistically with 5-fluorouracil (5-FU; Item No. 14416) against HT-29, HCT116, PANC-1, and EKVX cancer cells with no effect on WI38 embryonic lung fibroblasts.{38405} It inhibits herpes simplex virus type 1 (HSV-1) pyrimidine 2’-deoxyribonucleoside kinase (Ki = 3.5 μM) and reduces HSV-1 viral titer to 0.05% of the control at a concentration of 200 μM.{38403} 5-(Hydroxymethyl)-2’-deoxyuridine is also a DNA adduct, formed in response to oxidative stress, that is found in hepatic DNA of rats treated with gamma irradiation, diethylnitrosamine, 2-acetylaminofluorene, and ciprofibrate (Item No. 18515).{38406}
Brand:CaymanSKU:23381 - 50 mgAvailable on backorder
5-(Hydroxymethyl)furfuryl alcohol is a heterocyclic organic compound that is naturally produced by certain wood-inhabiting fungi.{32788} It can be derived by the reduction of the formyl group of 5-hydroxymethylfurfural.{32787,32789} 5-(Hydroxymethyl)furfuryl alcohol can be used as a building block in the enzymatic synthesis of biobased polyesters.{32786}
Brand:CaymanSKU:20658 -Available on backorder
5-(Hydroxymethyl)furfuryl alcohol is a heterocyclic organic compound that is naturally produced by certain wood-inhabiting fungi.{32788} It can be derived by the reduction of the formyl group of 5-hydroxymethylfurfural.{32787,32789} 5-(Hydroxymethyl)furfuryl alcohol can be used as a building block in the enzymatic synthesis of biobased polyesters.{32786}
Brand:CaymanSKU:20658 -Available on backorder
5-(Hydroxymethyl)furfuryl alcohol is a heterocyclic organic compound that is naturally produced by certain wood-inhabiting fungi.{32788} It can be derived by the reduction of the formyl group of 5-hydroxymethylfurfural.{32787,32789} 5-(Hydroxymethyl)furfuryl alcohol can be used as a building block in the enzymatic synthesis of biobased polyesters.{32786}
Brand:CaymanSKU:20658 -Available on backorder
5-(Hydroxymethyl)furfuryl alcohol is a heterocyclic organic compound that is naturally produced by certain wood-inhabiting fungi.{32788} It can be derived by the reduction of the formyl group of 5-hydroxymethylfurfural.{32787,32789} 5-(Hydroxymethyl)furfuryl alcohol can be used as a building block in the enzymatic synthesis of biobased polyesters.{32786}
Brand:CaymanSKU:20658 -Available on backorder
Sodium-hydrogen exchangers (NHE) are involved in maintaining sodium and pH balance in a variety of tissues. They are also known as sodium-hydrogen antiporters and solute carrier family 9 members. 5-(N-ethyl-N-isopropyl)-Amiloride (EIPA) is a potent inhibitor of several NHE isoforms, inhibiting NHE1, NHE2, NHE3, and NHE5 with Ki values of 0.02, 0.5, 2.4, and 0.42 μM, respectively.{22706,22708} It less effectively inhibits NHE4 (IC50 ≥10 μM).{22706} EIPA is commonly used at a concentration of 5-10 μM to inhibit cellular HNE activity.{22705,22707}
Brand:CaymanSKU:- Sodium-hydrogen exchangers (NHE) are involved in maintaining sodium and pH balance in a variety of tissues. They are also known as sodium-hydrogen antiporters and solute carrier family 9 members. 5-(N-ethyl-N-isopropyl)-Amiloride (EIPA) is a potent inhibitor of several NHE isoforms, inhibiting NHE1, NHE2, NHE3, and NHE5 with Ki values of 0.02, 0.5, 2.4, and 0.42 μM, respectively.{22706,22708} It less effectively inhibits NHE4 (IC50 ≥10 μM).{22706} EIPA is commonly used at a concentration of 5-10 μM to inhibit cellular HNE activity.{22705,22707}
Brand:CaymanSKU:- Sodium-hydrogen exchangers (NHE) are involved in maintaining sodium and pH balance in a variety of tissues. They are also known as sodium-hydrogen antiporters and solute carrier family 9 members. 5-(N-ethyl-N-isopropyl)-Amiloride (EIPA) is a potent inhibitor of several NHE isoforms, inhibiting NHE1, NHE2, NHE3, and NHE5 with Ki values of 0.02, 0.5, 2.4, and 0.42 μM, respectively.{22706,22708} It less effectively inhibits NHE4 (IC50 ≥10 μM).{22706} EIPA is commonly used at a concentration of 5-10 μM to inhibit cellular HNE activity.{22705,22707}
Brand:CaymanSKU:-
Sodium-hydrogen exchangers (NHE) are involved in maintaining sodium and pH balance in a variety of tissues. They are also known as sodium-hydrogen antiporters and solute carrier family 9 members. 5-(N,N-dimethyl)-Amiloride (DMA) inhibits NHE1, NHE2, and NHE3 with Ki values of 0.02, 0.25, and 14 μM, respectively.{22706} Because NHE1 is present in dorsal root ganglion and spinal cord, DMA was investigated for its ability to reduce inflammatory pain in rat nociception behavior tests.{30630}
Brand:CaymanSKU:-Available on backorder
Sodium-hydrogen exchangers (NHE) are involved in maintaining sodium and pH balance in a variety of tissues. They are also known as sodium-hydrogen antiporters and solute carrier family 9 members. 5-(N,N-dimethyl)-Amiloride (DMA) inhibits NHE1, NHE2, and NHE3 with Ki values of 0.02, 0.25, and 14 μM, respectively.{22706} Because NHE1 is present in dorsal root ganglion and spinal cord, DMA was investigated for its ability to reduce inflammatory pain in rat nociception behavior tests.{30630}
Brand:CaymanSKU:-Available on backorder
5-(N,N-hexamethylene)-Amiloride (HMA) is a derivative of amiloride (Item No. 14409) with diverse biological activities.{53366,53368,53367,53369,53370} It is an allosteric antagonist of adenosine A2A receptors (Ki = 3.3 µM).{53368} HMA inhibits the cation-selective ion channel formed by the HIV-1 viral protein Vpu when used at a concentration of 50 µM, as well as budding of virus-like particles in HeLa cells expressing the HIV-1 proteins Gag and Vpu when used at a concentration of 10 µM.{53366} It also blocks the cation-selective ion channels formed by the hepatitis C virus (HCV) protein p7.{53367} HMA (40 µM) induces necrosis in and reduces the viability of MCF-7, MDA-MB-231, T47D, SK-BR-3, Met-1, and NDL breast cancer cells but not cardiomyocytes or uterine, pulmonary, and renal epithelial cells.{53369} HMA protects against post-ischemic contractile dysfunction and reduces coronary effluent creatine phosphokinase activity in a model of ischemia-reperfusion injury using isolated rat right ventricular free walls.{53370}
Brand:CaymanSKU:29788 - 10 mgAvailable on backorder
5-(N,N-hexamethylene)-Amiloride (HMA) is a derivative of amiloride (Item No. 14409) with diverse biological activities.{53366,53368,53367,53369,53370} It is an allosteric antagonist of adenosine A2A receptors (Ki = 3.3 µM).{53368} HMA inhibits the cation-selective ion channel formed by the HIV-1 viral protein Vpu when used at a concentration of 50 µM, as well as budding of virus-like particles in HeLa cells expressing the HIV-1 proteins Gag and Vpu when used at a concentration of 10 µM.{53366} It also blocks the cation-selective ion channels formed by the hepatitis C virus (HCV) protein p7.{53367} HMA (40 µM) induces necrosis in and reduces the viability of MCF-7, MDA-MB-231, T47D, SK-BR-3, Met-1, and NDL breast cancer cells but not cardiomyocytes or uterine, pulmonary, and renal epithelial cells.{53369} HMA protects against post-ischemic contractile dysfunction and reduces coronary effluent creatine phosphokinase activity in a model of ischemia-reperfusion injury using isolated rat right ventricular free walls.{53370}
Brand:CaymanSKU:29788 - 25 mgAvailable on backorder
5-(N,N-hexamethylene)-Amiloride (HMA) is a derivative of amiloride (Item No. 14409) with diverse biological activities.{53366,53368,53367,53369,53370} It is an allosteric antagonist of adenosine A2A receptors (Ki = 3.3 µM).{53368} HMA inhibits the cation-selective ion channel formed by the HIV-1 viral protein Vpu when used at a concentration of 50 µM, as well as budding of virus-like particles in HeLa cells expressing the HIV-1 proteins Gag and Vpu when used at a concentration of 10 µM.{53366} It also blocks the cation-selective ion channels formed by the hepatitis C virus (HCV) protein p7.{53367} HMA (40 µM) induces necrosis in and reduces the viability of MCF-7, MDA-MB-231, T47D, SK-BR-3, Met-1, and NDL breast cancer cells but not cardiomyocytes or uterine, pulmonary, and renal epithelial cells.{53369} HMA protects against post-ischemic contractile dysfunction and reduces coronary effluent creatine phosphokinase activity in a model of ischemia-reperfusion injury using isolated rat right ventricular free walls.{53370}
Brand:CaymanSKU:29788 - 5 mgAvailable on backorder
5-(N,N-hexamethylene)-Amiloride (HMA) is a derivative of amiloride (Item No. 14409) with diverse biological activities.{53366,53368,53367,53369,53370} It is an allosteric antagonist of adenosine A2A receptors (Ki = 3.3 µM).{53368} HMA inhibits the cation-selective ion channel formed by the HIV-1 viral protein Vpu when used at a concentration of 50 µM, as well as budding of virus-like particles in HeLa cells expressing the HIV-1 proteins Gag and Vpu when used at a concentration of 10 µM.{53366} It also blocks the cation-selective ion channels formed by the hepatitis C virus (HCV) protein p7.{53367} HMA (40 µM) induces necrosis in and reduces the viability of MCF-7, MDA-MB-231, T47D, SK-BR-3, Met-1, and NDL breast cancer cells but not cardiomyocytes or uterine, pulmonary, and renal epithelial cells.{53369} HMA protects against post-ischemic contractile dysfunction and reduces coronary effluent creatine phosphokinase activity in a model of ischemia-reperfusion injury using isolated rat right ventricular free walls.{53370}
Brand:CaymanSKU:29788 - 50 mgAvailable on backorder
5-AEDB (hydrochloride) (Item No. 18351) is an analytical reference standard that is structurally categorized as a phenethylamine. The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications.
Brand:CaymanSKU:-Available on backorder
5-AEDB (hydrochloride) (Item No. 18351) is an analytical reference standard that is structurally categorized as a phenethylamine. The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications.
Brand:CaymanSKU:-Available on backorder
5-AEDB (hydrochloride) (Item No. 18351) is an analytical reference standard that is structurally categorized as a phenethylamine. The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications.
Brand:CaymanSKU:-Available on backorder
5-Aminosalicylic acid (5-ASA) is a metabolite and potential pharmacologically active component of sulphasalazine, a drug used in the treatment of Crohn’s disease and ulcerative colitis. However, the mechanism by which this drug works has not been established. In whole blood assays, 5-ASA proves to be a weak, non-selective inhibitor of both COX-1 and COX-2 with IC50 values of 410 and 61 µM, respectively.{8427} In ionophore-stimulated colonic mucosal cells, 1 mM 5-ASA does not inhibit prostaglandin E2 (PGE2) production, but does reduce leukotriene B4 (LTB4) synthesis approx. 50%.{8429} In ionophore-stimulated human leukocytes, 400 µM 5-ASA reduces LTB4 production approximately 20%.{8435} 5-ASA does not inhibit 15-hydroxy PGDH at concentrations up to 50 µM.{8455}
Brand:CaymanSKU:70265 - 10 gAvailable on backorder
5-Aminosalicylic acid (5-ASA) is a metabolite and potential pharmacologically active component of sulphasalazine, a drug used in the treatment of Crohn’s disease and ulcerative colitis. However, the mechanism by which this drug works has not been established. In whole blood assays, 5-ASA proves to be a weak, non-selective inhibitor of both COX-1 and COX-2 with IC50 values of 410 and 61 µM, respectively.{8427} In ionophore-stimulated colonic mucosal cells, 1 mM 5-ASA does not inhibit prostaglandin E2 (PGE2) production, but does reduce leukotriene B4 (LTB4) synthesis approx. 50%.{8429} In ionophore-stimulated human leukocytes, 400 µM 5-ASA reduces LTB4 production approximately 20%.{8435} 5-ASA does not inhibit 15-hydroxy PGDH at concentrations up to 50 µM.{8455}
Brand:CaymanSKU:70265 - 100 gAvailable on backorder
5-Aminosalicylic acid (5-ASA) is a metabolite and potential pharmacologically active component of sulphasalazine, a drug used in the treatment of Crohn’s disease and ulcerative colitis. However, the mechanism by which this drug works has not been established. In whole blood assays, 5-ASA proves to be a weak, non-selective inhibitor of both COX-1 and COX-2 with IC50 values of 410 and 61 µM, respectively.{8427} In ionophore-stimulated colonic mucosal cells, 1 mM 5-ASA does not inhibit prostaglandin E2 (PGE2) production, but does reduce leukotriene B4 (LTB4) synthesis approx. 50%.{8429} In ionophore-stimulated human leukocytes, 400 µM 5-ASA reduces LTB4 production approximately 20%.{8435} 5-ASA does not inhibit 15-hydroxy PGDH at concentrations up to 50 µM.{8455}
Brand:CaymanSKU:70265 - 25 gAvailable on backorder
5-Aminosalicylic acid (5-ASA) is a metabolite and potential pharmacologically active component of sulphasalazine, a drug used in the treatment of Crohn’s disease and ulcerative colitis. However, the mechanism by which this drug works has not been established. In whole blood assays, 5-ASA proves to be a weak, non-selective inhibitor of both COX-1 and COX-2 with IC50 values of 410 and 61 µM, respectively.{8427} In ionophore-stimulated colonic mucosal cells, 1 mM 5-ASA does not inhibit prostaglandin E2 (PGE2) production, but does reduce leukotriene B4 (LTB4) synthesis approx. 50%.{8429} In ionophore-stimulated human leukocytes, 400 µM 5-ASA reduces LTB4 production approximately 20%.{8435} 5-ASA does not inhibit 15-hydroxy PGDH at concentrations up to 50 µM.{8455}
Brand:CaymanSKU:70265 - 50 gAvailable on backorder
5-APB is a derivative of the designer drug 6-APB, also known as benzo fury, and is a stimulant and entactogen belonging to the amphetamine and the phenethylamine classes.{22885} It is an analog of MDA where the 3,4-methylenedioxyphenyl ring system has been replaced with a benzofuran ring. 5-APB is also the unsaturated benzofuran derivative of 5-APDB. This product is intended for forensic purposes.
Brand:CaymanSKU:11134 - 1 mgAvailable on backorder
5-APB is a derivative of the designer drug 6-APB, also known as benzo fury, and is a stimulant and entactogen belonging to the amphetamine and the phenethylamine classes.{22885} It is an analog of MDA where the 3,4-methylenedioxyphenyl ring system has been replaced with a benzofuran ring. 5-APB is also the unsaturated benzofuran derivative of 5-APDB. This product is intended for forensic purposes.
Brand:CaymanSKU:11134 - 10 mgAvailable on backorder
5-APB is a derivative of the designer drug 6-APB, also known as benzo fury, and is a stimulant and entactogen belonging to the amphetamine and the phenethylamine classes.{22885} It is an analog of MDA where the 3,4-methylenedioxyphenyl ring system has been replaced with a benzofuran ring. 5-APB is also the unsaturated benzofuran derivative of 5-APDB. This product is intended for forensic purposes.
Brand:CaymanSKU:11134 - 5 mgAvailable on backorder
5-APDB is an entactogen belonging to the amphetamine and the phenethylamine classes. It is an analog of MDA where the heterocyclic 3-position oxygen from the 3,4-methylenedioxy ring has been replaced by a methylene group. 5-APDB can inhibit serotonin, dopamine and norepinephrine reuptake with IC50 values of 0.13, 7.1, and 3.2 µM, respectively, and generalizes closely to the non-stimulant MDMA analogs, MBDB and MMAI, in drug discrimination studies.{21930} This product is intended for forensic purposes.
Brand:CaymanSKU:11456 - 1 mgAvailable on backorder
5-APDB is an entactogen belonging to the amphetamine and the phenethylamine classes. It is an analog of MDA where the heterocyclic 3-position oxygen from the 3,4-methylenedioxy ring has been replaced by a methylene group. 5-APDB can inhibit serotonin, dopamine and norepinephrine reuptake with IC50 values of 0.13, 7.1, and 3.2 µM, respectively, and generalizes closely to the non-stimulant MDMA analogs, MBDB and MMAI, in drug discrimination studies.{21930} This product is intended for forensic purposes.
Brand:CaymanSKU:11456 - 10 mgAvailable on backorder
5-APDB is an entactogen belonging to the amphetamine and the phenethylamine classes. It is an analog of MDA where the heterocyclic 3-position oxygen from the 3,4-methylenedioxy ring has been replaced by a methylene group. 5-APDB can inhibit serotonin, dopamine and norepinephrine reuptake with IC50 values of 0.13, 7.1, and 3.2 µM, respectively, and generalizes closely to the non-stimulant MDMA analogs, MBDB and MMAI, in drug discrimination studies.{21930} This product is intended for forensic purposes.
Brand:CaymanSKU:11456 - 5 mgAvailable on backorder
5-APDI is an indane with an amphetamine-like aminopropane group. It inhibits the uptake of serotonin, dopamine, and norepinephrine by crude synaptosomes (IC50 = 82, 1,847, and 849 nM, respectively).{21930} In discrimination studies using rats, 5-APDI fully substitutes for the entactogen N-methyl-1,3-dioxolyl-N-methylbutanamine but does not substitute for amphetamine.{21930} This product is intended for forensic and research applications.
Brand:CaymanSKU:- 5-APDI is an indane with an amphetamine-like aminopropane group. It inhibits the uptake of serotonin, dopamine, and norepinephrine by crude synaptosomes (IC50 = 82, 1,847, and 849 nM, respectively).{21930} In discrimination studies using rats, 5-APDI fully substitutes for the entactogen N-methyl-1,3-dioxolyl-N-methylbutanamine but does not substitute for amphetamine.{21930} This product is intended for forensic and research applications.
Brand:CaymanSKU:- 5-APDI is an indane with an amphetamine-like aminopropane group. It inhibits the uptake of serotonin, dopamine, and norepinephrine by crude synaptosomes (IC50 = 82, 1,847, and 849 nM, respectively).{21930} In discrimination studies using rats, 5-APDI fully substitutes for the entactogen N-methyl-1,3-dioxolyl-N-methylbutanamine but does not substitute for amphetamine.{21930} This product is intended for forensic and research applications.
Brand:CaymanSKU:-
5-Azacytidine, a chemical analogue of the DNA and RNA nucleoside cytidine, is an inhibitor of DNA methyltransferases, potentially serving to reverse epigenetic changes.{17258} It reduces hypermethylation associated with certain diseases, including myelodysplastic syndromes (IC50s = 2.4 and 2.6 μM for in vitro anti-myeloma activity) and cancer (IC50s ~ 0.4 μM for inhibiting proliferation of various cancer cell lines).{18356,18373,17257} 5-Azacytidine has a reported half-life of 17 hours and is considerably cytotoxic; it must be incorporated into DNA to covalently trap DNA methyltransferases.{17258}
Brand:CaymanSKU:11164 - 100 mgAvailable on backorder
5-Azacytidine, a chemical analogue of the DNA and RNA nucleoside cytidine, is an inhibitor of DNA methyltransferases, potentially serving to reverse epigenetic changes.{17258} It reduces hypermethylation associated with certain diseases, including myelodysplastic syndromes (IC50s = 2.4 and 2.6 μM for in vitro anti-myeloma activity) and cancer (IC50s ~ 0.4 μM for inhibiting proliferation of various cancer cell lines).{18356,18373,17257} 5-Azacytidine has a reported half-life of 17 hours and is considerably cytotoxic; it must be incorporated into DNA to covalently trap DNA methyltransferases.{17258}
Brand:CaymanSKU:11164 - 250 mgAvailable on backorder
5-Azacytidine, a chemical analogue of the DNA and RNA nucleoside cytidine, is an inhibitor of DNA methyltransferases, potentially serving to reverse epigenetic changes.{17258} It reduces hypermethylation associated with certain diseases, including myelodysplastic syndromes (IC50s = 2.4 and 2.6 μM for in vitro anti-myeloma activity) and cancer (IC50s ~ 0.4 μM for inhibiting proliferation of various cancer cell lines).{18356,18373,17257} 5-Azacytidine has a reported half-life of 17 hours and is considerably cytotoxic; it must be incorporated into DNA to covalently trap DNA methyltransferases.{17258}
Brand:CaymanSKU:11164 - 50 mgAvailable on backorder
5-Azidopentanoic acid is a building block for use in click chemistry reactions that enables selective conjugation of peptides with various molecules and can be used for the cyclization of peptides.{17992,27060} The azido moiety reacts with acetylenes in the presence of copper yielding triazoles that can function as versatile linkers.{27061}
Brand:CaymanSKU:-Out of stock
5-Azidopentanoic acid is a building block for use in click chemistry reactions that enables selective conjugation of peptides with various molecules and can be used for the cyclization of peptides.{17992,27060} The azido moiety reacts with acetylenes in the presence of copper yielding triazoles that can function as versatile linkers.{27061}
Brand:CaymanSKU:-Out of stock
5-Azidopentanoic acid is a building block for use in click chemistry reactions that enables selective conjugation of peptides with various molecules and can be used for the cyclization of peptides.{17992,27060} The azido moiety reacts with acetylenes in the presence of copper yielding triazoles that can function as versatile linkers.{27061}
Brand:CaymanSKU:-Out of stock
5-bromo APINACA (Item No. 25209) is an analytical reference standard that is structurally similar to known synthetic cannabinoids. This product is intended for research and forensic applications.
Brand:CaymanSKU:25209 - 1 mgAvailable on backorder
5-bromo APINACA (Item No. 25209) is an analytical reference standard that is structurally similar to known synthetic cannabinoids. This product is intended for research and forensic applications.
Brand:CaymanSKU:25209 - 5 mgAvailable on backorder
5-bromo-2-chloro-4-Methoxypyrimidine is a building block used in the chemical synthesis of halogenated heterocycles.
Brand:CaymanSKU:21862 -Out of stock
5-bromo-2-chloro-4-Methoxypyrimidine is a building block used in the chemical synthesis of halogenated heterocycles.
Brand:CaymanSKU:21862 -Out of stock
5-Bromo-2′-deoxyuridine (BrdU) is a thymidine analog used to label DNA. It is incorporated into newly synthesized DNA in place of thymidine during the S phase of the cell cycle.{25404} Cells that were actively proliferating can then be detected by denaturing the DNA and allowing specific antibodies to target the BrdU incorporation.{25404}
Brand:CaymanSKU:- 5-Bromo-2′-deoxyuridine (BrdU) is a thymidine analog used to label DNA. It is incorporated into newly synthesized DNA in place of thymidine during the S phase of the cell cycle.{25404} Cells that were actively proliferating can then be detected by denaturing the DNA and allowing specific antibodies to target the BrdU incorporation.{25404}
Brand:CaymanSKU:- 5-Bromo-2′-deoxyuridine (BrdU) is a thymidine analog used to label DNA. It is incorporated into newly synthesized DNA in place of thymidine during the S phase of the cell cycle.{25404} Cells that were actively proliferating can then be detected by denaturing the DNA and allowing specific antibodies to target the BrdU incorporation.{25404}
Brand:CaymanSKU:- 5-Bromo-2′-deoxyuridine (BrdU) is a thymidine analog used to label DNA. It is incorporated into newly synthesized DNA in place of thymidine during the S phase of the cell cycle.{25404} Cells that were actively proliferating can then be detected by denaturing the DNA and allowing specific antibodies to target the BrdU incorporation.{25404}
Brand:CaymanSKU:-
The aldo-keto reductase (AKR) enzymes constitute a family of related NADPH-dependent oxidoreductases. The 1C subfamily (AKR1C) includes four human hydroxysteroid dehydrogenases (HSDs), with AKR1C1 being a 20α-HSD and the other three being 3α-HSDs. AKR1C1 metabolizes progesterone to an inactive progestin, 20α-hydroxy progesterone.{17634} In addition, AKR1C1 actions have been implicated in cancer and in the processing of neuroactive steroids involved in brain function.{17637,17636,17638,17635} 5-bromo-3-phenyl Salicyclic acid selectively inhibits AKR1C1 (Ki = 140 nM) over AKR1C2 (K1 = 1.97 µM) and AKR1C3 (Ki = 21 µM).{17245} It does not inhibit AKR1C4 at 100 µM.{17245}
Brand:CaymanSKU:- The aldo-keto reductase (AKR) enzymes constitute a family of related NADPH-dependent oxidoreductases. The 1C subfamily (AKR1C) includes four human hydroxysteroid dehydrogenases (HSDs), with AKR1C1 being a 20α-HSD and the other three being 3α-HSDs. AKR1C1 metabolizes progesterone to an inactive progestin, 20α-hydroxy progesterone.{17634} In addition, AKR1C1 actions have been implicated in cancer and in the processing of neuroactive steroids involved in brain function.{17637,17636,17638,17635} 5-bromo-3-phenyl Salicyclic acid selectively inhibits AKR1C1 (Ki = 140 nM) over AKR1C2 (K1 = 1.97 µM) and AKR1C3 (Ki = 21 µM).{17245} It does not inhibit AKR1C4 at 100 µM.{17245}
Brand:CaymanSKU:- The aldo-keto reductase (AKR) enzymes constitute a family of related NADPH-dependent oxidoreductases. The 1C subfamily (AKR1C) includes four human hydroxysteroid dehydrogenases (HSDs), with AKR1C1 being a 20α-HSD and the other three being 3α-HSDs. AKR1C1 metabolizes progesterone to an inactive progestin, 20α-hydroxy progesterone.{17634} In addition, AKR1C1 actions have been implicated in cancer and in the processing of neuroactive steroids involved in brain function.{17637,17636,17638,17635} 5-bromo-3-phenyl Salicyclic acid selectively inhibits AKR1C1 (Ki = 140 nM) over AKR1C2 (K1 = 1.97 µM) and AKR1C3 (Ki = 21 µM).{17245} It does not inhibit AKR1C4 at 100 µM.{17245}
Brand:CaymanSKU:- The aldo-keto reductase (AKR) enzymes constitute a family of related NADPH-dependent oxidoreductases. The 1C subfamily (AKR1C) includes four human hydroxysteroid dehydrogenases (HSDs), with AKR1C1 being a 20α-HSD and the other three being 3α-HSDs. AKR1C1 metabolizes progesterone to an inactive progestin, 20α-hydroxy progesterone.{17634} In addition, AKR1C1 actions have been implicated in cancer and in the processing of neuroactive steroids involved in brain function.{17637,17636,17638,17635} 5-bromo-3-phenyl Salicyclic acid selectively inhibits AKR1C1 (Ki = 140 nM) over AKR1C2 (K1 = 1.97 µM) and AKR1C3 (Ki = 21 µM).{17245} It does not inhibit AKR1C4 at 100 µM.{17245}
Brand:CaymanSKU:-
5-bromo-5-nitro-1,3-Dioxane is an antimicrobial compound that is effective against Gram-positive and Gram-negative bacteria and fungi, including yeast.{33085} Its mode of action occurs via the oxidation of essential protein thiols causing inhibition of enzyme activity and subsequent inhibition of microbial growth.{33085} This compound has been used as a preservative for biological molecules and solutions such as antibodies and antisera.
Brand:CaymanSKU:20935 -Out of stock
5-bromo-5-nitro-1,3-Dioxane is an antimicrobial compound that is effective against Gram-positive and Gram-negative bacteria and fungi, including yeast.{33085} Its mode of action occurs via the oxidation of essential protein thiols causing inhibition of enzyme activity and subsequent inhibition of microbial growth.{33085} This compound has been used as a preservative for biological molecules and solutions such as antibodies and antisera.
Brand:CaymanSKU:20935 -Out of stock
5-bromo-5-nitro-1,3-Dioxane is an antimicrobial compound that is effective against Gram-positive and Gram-negative bacteria and fungi, including yeast.{33085} Its mode of action occurs via the oxidation of essential protein thiols causing inhibition of enzyme activity and subsequent inhibition of microbial growth.{33085} This compound has been used as a preservative for biological molecules and solutions such as antibodies and antisera.
Brand:CaymanSKU:20935 -Out of stock
5-bromo-5-nitro-1,3-Dioxane is an antimicrobial compound that is effective against Gram-positive and Gram-negative bacteria and fungi, including yeast.{33085} Its mode of action occurs via the oxidation of essential protein thiols causing inhibition of enzyme activity and subsequent inhibition of microbial growth.{33085} This compound has been used as a preservative for biological molecules and solutions such as antibodies and antisera.
Brand:CaymanSKU:20935 -Out of stock
Brand:CaymanSKU:10007079 - 1 gAvailable on backorder
Brand:CaymanSKU:10007079 - 5 gAvailable on backorder
Brand:CaymanSKU:10007079 - 500 mgAvailable on backorder
Brand:CaymanSKU:10007134 - 100 mgAvailable on backorder
Brand:CaymanSKU:10007134 - 250 mgAvailable on backorder
Brand:CaymanSKU:10007134 - 50 mgAvailable on backorder
Brand:CaymanSKU:10007134 - 500 mgAvailable on backorder
5-Bromouridine is a brominated analog of the nucleoside uridine (Item No. 20300).{46879} It can be incorporated into RNA and subsequently detected by antibodies against bromodeoxyuridine (Item No. 15580).{46880} 5-Bromouridine decreases the viability of HL-60 and MOLT-4 cells (LC50s = 10 and 20 μM, respectively). It induces apoptosis and halts the cell cycle at the S phase in HL-60 cells. It is photoreactive, and UV irradiation has been used to cross-link RNA containing 5-bromouridine to proteins in the study of of RNA-protein interactions.{46879,46881} 5-Bromouridine can also be incorporated into RNA using 5-bromouridine 5’-triphosphate (Item No. 18140).
Brand:CaymanSKU:30457 - 1 gAvailable on backorder
5-Bromouridine is a brominated analog of the nucleoside uridine (Item No. 20300).{46879} It can be incorporated into RNA and subsequently detected by antibodies against bromodeoxyuridine (Item No. 15580).{46880} 5-Bromouridine decreases the viability of HL-60 and MOLT-4 cells (LC50s = 10 and 20 μM, respectively). It induces apoptosis and halts the cell cycle at the S phase in HL-60 cells. It is photoreactive, and UV irradiation has been used to cross-link RNA containing 5-bromouridine to proteins in the study of of RNA-protein interactions.{46879,46881} 5-Bromouridine can also be incorporated into RNA using 5-bromouridine 5’-triphosphate (Item No. 18140).
Brand:CaymanSKU:30457 - 500 mgAvailable on backorder
5-Butyl-4-[2,3-difluoro-4-(phenylmethoxy)phenyl]-6-phenyl-2-pyrimidinamine is an inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1; IC50s = 66 and 2,730 nM for the human and mouse enzymes, respectively).{52747} It is selective for mPGES-1 over COX-1 but does inhibit COX-2 at 20 µM. It also inhibits LPS-induced prostaglandin E2 (PGE2; Item No. 14010) production in mouse peritoneal cells (IC50 = 12 nM). In vivo, 5-butyl-4-[2,3-difluoro-4-(phenylmethoxy)phenyl]-6-phenyl-2-pyrimidinamine (25 mg/kg) reduces carrageenan-induced paw edema in rats.
Brand:CaymanSKU:31338 - 1 mgAvailable on backorder
5-Butyl-4-[2,3-difluoro-4-(phenylmethoxy)phenyl]-6-phenyl-2-pyrimidinamine is an inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1; IC50s = 66 and 2,730 nM for the human and mouse enzymes, respectively).{52747} It is selective for mPGES-1 over COX-1 but does inhibit COX-2 at 20 µM. It also inhibits LPS-induced prostaglandin E2 (PGE2; Item No. 14010) production in mouse peritoneal cells (IC50 = 12 nM). In vivo, 5-butyl-4-[2,3-difluoro-4-(phenylmethoxy)phenyl]-6-phenyl-2-pyrimidinamine (25 mg/kg) reduces carrageenan-induced paw edema in rats.
Brand:CaymanSKU:31338 - 250 µgAvailable on backorder
5-Butyl-4-[2,3-difluoro-4-(phenylmethoxy)phenyl]-6-phenyl-2-pyrimidinamine is an inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1; IC50s = 66 and 2,730 nM for the human and mouse enzymes, respectively).{52747} It is selective for mPGES-1 over COX-1 but does inhibit COX-2 at 20 µM. It also inhibits LPS-induced prostaglandin E2 (PGE2; Item No. 14010) production in mouse peritoneal cells (IC50 = 12 nM). In vivo, 5-butyl-4-[2,3-difluoro-4-(phenylmethoxy)phenyl]-6-phenyl-2-pyrimidinamine (25 mg/kg) reduces carrageenan-induced paw edema in rats.
Brand:CaymanSKU:31338 - 500 µgAvailable on backorder
5-Butyl-4-phenyl-6-[4-(phenylmethoxy)phenyl]-2-pyrimidinamine is an inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1; IC50s = 117 and 60 nM for the human and mouse enzymes, respectively).{52747} It inhibits LPS-induced prostaglandin E2 (PGE2; Item No. 14010) production in mouse peritoneal cells (IC50 = 31 nM). In vivo, 5-Butyl-4-phenyl-6-[4-(phenylmethoxy)phenyl]-2-pyrimidinamine (25 mg/kg) reduces carrageenan-induced paw edema in rats.
Brand:CaymanSKU:31337 - 1 mgAvailable on backorder
5-Butyl-4-phenyl-6-[4-(phenylmethoxy)phenyl]-2-pyrimidinamine is an inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1; IC50s = 117 and 60 nM for the human and mouse enzymes, respectively).{52747} It inhibits LPS-induced prostaglandin E2 (PGE2; Item No. 14010) production in mouse peritoneal cells (IC50 = 31 nM). In vivo, 5-Butyl-4-phenyl-6-[4-(phenylmethoxy)phenyl]-2-pyrimidinamine (25 mg/kg) reduces carrageenan-induced paw edema in rats.
Brand:CaymanSKU:31337 - 250 µgAvailable on backorder
5-Butyl-4-phenyl-6-[4-(phenylmethoxy)phenyl]-2-pyrimidinamine is an inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1; IC50s = 117 and 60 nM for the human and mouse enzymes, respectively).{52747} It inhibits LPS-induced prostaglandin E2 (PGE2; Item No. 14010) production in mouse peritoneal cells (IC50 = 31 nM). In vivo, 5-Butyl-4-phenyl-6-[4-(phenylmethoxy)phenyl]-2-pyrimidinamine (25 mg/kg) reduces carrageenan-induced paw edema in rats.
Brand:CaymanSKU:31337 - 500 µgAvailable on backorder