Chemicals
Showing 6151–6300 of 41137 results
-
4-palmitamido TEMPO is a lipid-soluble spin label.{49152,49153} It incorporates into vesicles and cell membranes and has been used to study the entrapment of molecules within phosphatidylcholine vesicles.{49154}
Brand:CaymanSKU:25995 - 10 mgAvailable on backorder
4-palmitamido TEMPO is a lipid-soluble spin label.{49152,49153} It incorporates into vesicles and cell membranes and has been used to study the entrapment of molecules within phosphatidylcholine vesicles.{49154}
Brand:CaymanSKU:25995 - 5 mgAvailable on backorder
4-phenyl U-51754 (hydrochloride) (Item No. 24980) is an analytical reference standard that is structurally similar to known opioids. This product is intended for research and forensic applications.
Brand:CaymanSKU:24980 - 1 mgAvailable on backorder
4-phenyl U-51754 (hydrochloride) (Item No. 24980) is an analytical reference standard that is structurally similar to known opioids. This product is intended for research and forensic applications.
Brand:CaymanSKU:24980 - 5 mgAvailable on backorder
Cytochrome P450 (CYP450) enzymes are a superfamily of oxidative catalysts important in the biosynthesis and metabolism of a wide range of endogenous molecules as well as the metabolism of xenobiotics. For example, CYP2B4 metabolizes substituted amines, CYP2E1 metabolizes various alcohols and halogenated alkenes, and CYP1A2 catalyzes the oxygenation of aromatic compounds and polycyclic hydrocarbons. 4-phenyl-1,2,3-Thiadiazole is, at 100 µM, a selective inhibitor of certain CYP450 enzymes (CYP2B4, CYP2E1), but not others (CYP1A2), with inactivation occurring in a mechanism-based manner.{15950} 1,2,3-Thiadiazole compounds and their derivatives, including 4-phenyl-1,2,3-thiadiazole, are also commonly used as fungicides, herbicides, and plant growth regulators.
Brand:CaymanSKU:10011055 - 100 mgAvailable on backorder
4-Phenyl-2-pyrrolidinone is a precursor and synthetic intermediate.{52536,52537} It has been used as a precursor in the synthesis of compounds with anticonvulsant and nootropic activities and is an intermediate in the synthesis of bromodomain-containing protein 4 (BRD4) bromodomain 1 inhibitors.
Brand:CaymanSKU:30490 - 1 gAvailable on backorder
4-Phenyl-2-pyrrolidinone is a precursor and synthetic intermediate.{52536,52537} It has been used as a precursor in the synthesis of compounds with anticonvulsant and nootropic activities and is an intermediate in the synthesis of bromodomain-containing protein 4 (BRD4) bromodomain 1 inhibitors.
Brand:CaymanSKU:30490 - 500 mgAvailable on backorder
4-Piperidone (hydrochloride hydrate) (Item No. 21961) is an analytical reference standard categorized as a piperidine. It is a starting material in the synthesis of fentanyl (hydrochloride) (Item Nos. ISO60197 | 14719) with phenethylbromide (Item No. 20087). The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications.
Brand:CaymanSKU:21961 -Out of stock
4-Piperidone (hydrochloride hydrate) (Item No. 21961) is an analytical reference standard categorized as a piperidine. It is a starting material in the synthesis of fentanyl (hydrochloride) (Item Nos. ISO60197 | 14719) with phenethylbromide (Item No. 20087). The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications.
Brand:CaymanSKU:21961 -Out of stock
4-propanoyloxy DMT (Item No. 29951) is an analytical reference standard categorized as a tryptamine. This product is intended for research and forensic applications.
Brand:CaymanSKU:29951 - 1 mgAvailable on backorder
4-propanoyloxy DMT (Item No. 29951) is an analytical reference standard categorized as a tryptamine. This product is intended for research and forensic applications.
Brand:CaymanSKU:29951 - 5 mgAvailable on backorder
Brand:CaymanSKU:13005 - 1 gAvailable on backorder
Brand:CaymanSKU:13005 - 100 mgAvailable on backorder
Brand:CaymanSKU:13005 - 250 mgAvailable on backorder
Brand:CaymanSKU:13005 - 500 mgAvailable on backorder
Brand:CaymanSKU:13056 - 1 gAvailable on backorder
Brand:CaymanSKU:13056 - 10 gAvailable on backorder
Brand:CaymanSKU:13056 - 25 gAvailable on backorder
Brand:CaymanSKU:13056 - 5 gAvailable on backorder
4-Pyrimidine methanamine (hydrochloride) is a synthetic intermediate useful for pharmaceutical synthesis.
Brand:CaymanSKU:10007124 - 1 gAvailable on backorder
4-Pyrimidine methanamine (hydrochloride) is a synthetic intermediate useful for pharmaceutical synthesis.
Brand:CaymanSKU:10007124 - 100 mgAvailable on backorder
4-Pyrimidine methanamine (hydrochloride) is a synthetic intermediate useful for pharmaceutical synthesis.
Brand:CaymanSKU:10007124 - 50 mgAvailable on backorder
4-Pyrimidine methanamine (hydrochloride) is a synthetic intermediate useful for pharmaceutical synthesis.
Brand:CaymanSKU:10007124 - 500 mgAvailable on backorder
4-Pyrimidinecarboxaldehyde, dimethyl acetal is a synthetic intermediate useful for pharmaceutical synthesis.
Brand:CaymanSKU:10007120 - 1 gAvailable on backorder
4-Pyrimidinecarboxaldehyde, dimethyl acetal is a synthetic intermediate useful for pharmaceutical synthesis.
Brand:CaymanSKU:10007120 - 100 mgAvailable on backorder
4-Pyrimidinecarboxaldehyde, dimethyl acetal is a synthetic intermediate useful for pharmaceutical synthesis.
Brand:CaymanSKU:10007120 - 5 gAvailable on backorder
4-Pyrimidinecarboxaldehyde, dimethyl acetal is a synthetic intermediate useful for pharmaceutical synthesis.
Brand:CaymanSKU:10007120 - 500 mgAvailable on backorder
Cannabinoids (CBs) and their synthetic analogs produce biochemical and pharmacological effects by interacting with the central CB1 and peripheral CB2 receptors. The CB2 receptor has emerged as a pharmacotherapeutic target for treating osteoporosis, as well as for eliciting antinociceptive effects in various models of pain. 4-Quinolone-3-carboxamide CB2 ligand is a selective, high-affinity ligand of the CB2 receptor, displaying a Ki value of 0.6 nM (Ki >10,000 nM for CB1) in vitro. At a dose of 6 mg/kg, 4-quinolone-3-carboxamide CB2 ligand exhibits antinociceptive activity in a formalin test of nocifensive response in mice. This analgesic affect is not significantly reversed by the CB2 antagonist AM630 (Item No. 10006974), which suggests 4-quinolone-3-carboxamide CB2 ligand may behave as an inverse agonist.{20020}
Brand:CaymanSKU:11093 - 1 mgAvailable on backorder
Cannabinoids (CBs) and their synthetic analogs produce biochemical and pharmacological effects by interacting with the central CB1 and peripheral CB2 receptors. The CB2 receptor has emerged as a pharmacotherapeutic target for treating osteoporosis, as well as for eliciting antinociceptive effects in various models of pain. 4-Quinolone-3-carboxamide CB2 ligand is a selective, high-affinity ligand of the CB2 receptor, displaying a Ki value of 0.6 nM (Ki >10,000 nM for CB1) in vitro. At a dose of 6 mg/kg, 4-quinolone-3-carboxamide CB2 ligand exhibits antinociceptive activity in a formalin test of nocifensive response in mice. This analgesic affect is not significantly reversed by the CB2 antagonist AM630 (Item No. 10006974), which suggests 4-quinolone-3-carboxamide CB2 ligand may behave as an inverse agonist.{20020}
Brand:CaymanSKU:11093 - 10 mgAvailable on backorder
Cannabinoids (CBs) and their synthetic analogs produce biochemical and pharmacological effects by interacting with the central CB1 and peripheral CB2 receptors. The CB2 receptor has emerged as a pharmacotherapeutic target for treating osteoporosis, as well as for eliciting antinociceptive effects in various models of pain. 4-Quinolone-3-carboxamide CB2 ligand is a selective, high-affinity ligand of the CB2 receptor, displaying a Ki value of 0.6 nM (Ki >10,000 nM for CB1) in vitro. At a dose of 6 mg/kg, 4-quinolone-3-carboxamide CB2 ligand exhibits antinociceptive activity in a formalin test of nocifensive response in mice. This analgesic affect is not significantly reversed by the CB2 antagonist AM630 (Item No. 10006974), which suggests 4-quinolone-3-carboxamide CB2 ligand may behave as an inverse agonist.{20020}
Brand:CaymanSKU:11093 - 25 mgAvailable on backorder
Cannabinoids (CBs) and their synthetic analogs produce biochemical and pharmacological effects by interacting with the central CB1 and peripheral CB2 receptors. The CB2 receptor has emerged as a pharmacotherapeutic target for treating osteoporosis, as well as for eliciting antinociceptive effects in various models of pain. 4-Quinolone-3-carboxamide CB2 ligand is a selective, high-affinity ligand of the CB2 receptor, displaying a Ki value of 0.6 nM (Ki >10,000 nM for CB1) in vitro. At a dose of 6 mg/kg, 4-quinolone-3-carboxamide CB2 ligand exhibits antinociceptive activity in a formalin test of nocifensive response in mice. This analgesic affect is not significantly reversed by the CB2 antagonist AM630 (Item No. 10006974), which suggests 4-quinolone-3-carboxamide CB2 ligand may behave as an inverse agonist.{20020}
Brand:CaymanSKU:11093 - 5 mgAvailable on backorder
Agonists of the peripheral cannabinoid (CB) receptor CB2 may have antinociceptive and anti-inflammatory effects, as well as prevent osteoporosis.{16338,13862} 4-Quinolone-3-carboxamide Furan CB2 Agonist is a high-affinity ligand of CB2 (Ki = 8.5 nM) with little affinity for CB1 (Ki >10,000 nM).{20020} This compound demonstrates antinociceptive efficacy in the mouse formalin test at 1 mg/kg, an action which is blocked by a CB2-selective antagonist, AM630 (Item No. 10006974).{20020}
Brand:CaymanSKU:11094 - 1 mgAvailable on backorder
Agonists of the peripheral cannabinoid (CB) receptor CB2 may have antinociceptive and anti-inflammatory effects, as well as prevent osteoporosis.{16338,13862} 4-Quinolone-3-carboxamide Furan CB2 Agonist is a high-affinity ligand of CB2 (Ki = 8.5 nM) with little affinity for CB1 (Ki >10,000 nM).{20020} This compound demonstrates antinociceptive efficacy in the mouse formalin test at 1 mg/kg, an action which is blocked by a CB2-selective antagonist, AM630 (Item No. 10006974).{20020}
Brand:CaymanSKU:11094 - 10 mgAvailable on backorder
Agonists of the peripheral cannabinoid (CB) receptor CB2 may have antinociceptive and anti-inflammatory effects, as well as prevent osteoporosis.{16338,13862} 4-Quinolone-3-carboxamide Furan CB2 Agonist is a high-affinity ligand of CB2 (Ki = 8.5 nM) with little affinity for CB1 (Ki >10,000 nM).{20020} This compound demonstrates antinociceptive efficacy in the mouse formalin test at 1 mg/kg, an action which is blocked by a CB2-selective antagonist, AM630 (Item No. 10006974).{20020}
Brand:CaymanSKU:11094 - 25 mgAvailable on backorder
Agonists of the peripheral cannabinoid (CB) receptor CB2 may have antinociceptive and anti-inflammatory effects, as well as prevent osteoporosis.{16338,13862} 4-Quinolone-3-carboxamide Furan CB2 Agonist is a high-affinity ligand of CB2 (Ki = 8.5 nM) with little affinity for CB1 (Ki >10,000 nM).{20020} This compound demonstrates antinociceptive efficacy in the mouse formalin test at 1 mg/kg, an action which is blocked by a CB2-selective antagonist, AM630 (Item No. 10006974).{20020}
Brand:CaymanSKU:11094 - 5 mgAvailable on backorder
4-tert-Octylphenol diethoxylate is a degradation product of the multi-purpose surfactant, Triton X. A known environmental contaminant, 4-tert-octylphenol diethoxylate is reported to be an endocrine disruptor in animal and human research studies, producing weak estrogenic effects.{30154,30155,30156,30153}
Brand:CaymanSKU:-Available on backorder
4-tert-Octylphenol diethoxylate is a degradation product of the multi-purpose surfactant, Triton X. A known environmental contaminant, 4-tert-octylphenol diethoxylate is reported to be an endocrine disruptor in animal and human research studies, producing weak estrogenic effects.{30154,30155,30156,30153}
Brand:CaymanSKU:-Available on backorder
4-tert-Octylphenol diethoxylate is a degradation product of the multi-purpose surfactant, Triton X. A known environmental contaminant, 4-tert-octylphenol diethoxylate is reported to be an endocrine disruptor in animal and human research studies, producing weak estrogenic effects.{30154,30155,30156,30153}
Brand:CaymanSKU:-Available on backorder
4-tert-Octylphenol diethoxylate is a degradation product of the multi-purpose surfactant, Triton X. A known environmental contaminant, 4-tert-octylphenol diethoxylate is reported to be an endocrine disruptor in animal and human research studies, producing weak estrogenic effects.{30154,30155,30156,30153}
Brand:CaymanSKU:-Available on backorder
4-Thiouracil is a site-specific, photoactivatable probe used to detect RNA structures and nucleic acid-nucleic acid contacts.{29954} It absorbs ultraviolet light >300 nm and, in the presence of oxygen, acts as an energy donor to produce singlet oxygen by triplet-triplet energy transfer. The highly reactive oxygen species then reacts readily with 4-thiouracil, leading to the production of uracil and uracil-6-sulfonate, which is fluorescent at a wavelength of ~390 nm.{29955} 4-Thiouracil is used as a T. gondii uracil phosphoribosyltransferase substrate to produce 4-thiouridine monophosphate, which can ultimately be incorporated into RNA.{29956}
Brand:CaymanSKU:-Out of stock
4-Thiouracil is a site-specific, photoactivatable probe used to detect RNA structures and nucleic acid-nucleic acid contacts.{29954} It absorbs ultraviolet light >300 nm and, in the presence of oxygen, acts as an energy donor to produce singlet oxygen by triplet-triplet energy transfer. The highly reactive oxygen species then reacts readily with 4-thiouracil, leading to the production of uracil and uracil-6-sulfonate, which is fluorescent at a wavelength of ~390 nm.{29955} 4-Thiouracil is used as a T. gondii uracil phosphoribosyltransferase substrate to produce 4-thiouridine monophosphate, which can ultimately be incorporated into RNA.{29956}
Brand:CaymanSKU:-Out of stock
4-Thiouracil is a site-specific, photoactivatable probe used to detect RNA structures and nucleic acid-nucleic acid contacts.{29954} It absorbs ultraviolet light >300 nm and, in the presence of oxygen, acts as an energy donor to produce singlet oxygen by triplet-triplet energy transfer. The highly reactive oxygen species then reacts readily with 4-thiouracil, leading to the production of uracil and uracil-6-sulfonate, which is fluorescent at a wavelength of ~390 nm.{29955} 4-Thiouracil is used as a T. gondii uracil phosphoribosyltransferase substrate to produce 4-thiouridine monophosphate, which can ultimately be incorporated into RNA.{29956}
Brand:CaymanSKU:-Out of stock
4-Thiouridine (4-SU) is a photoactivatable ribonucleoside analog that is widely used for RNA analysis, including short-range RNA-RNA crosslinking and nascent RNA labeling.{26731,26729,26732} The crosslinking thio moiety is attached directly to the nucleotide base, thus 4-SU differs from uridine only by a single sulfur substitution. This offers the advantage of incorporating into an RNA chain with minimal structural perturbation and with similar base-pairing properties, reducing the likelihood that substitution will impair RNA interactions or activities.{26732}
Brand:CaymanSKU:-Out of stock
4-Thiouridine (4-SU) is a photoactivatable ribonucleoside analog that is widely used for RNA analysis, including short-range RNA-RNA crosslinking and nascent RNA labeling.{26731,26729,26732} The crosslinking thio moiety is attached directly to the nucleotide base, thus 4-SU differs from uridine only by a single sulfur substitution. This offers the advantage of incorporating into an RNA chain with minimal structural perturbation and with similar base-pairing properties, reducing the likelihood that substitution will impair RNA interactions or activities.{26732}
Brand:CaymanSKU:-Out of stock
4-Thiouridine (4-SU) is a photoactivatable ribonucleoside analog that is widely used for RNA analysis, including short-range RNA-RNA crosslinking and nascent RNA labeling.{26731,26729,26732} The crosslinking thio moiety is attached directly to the nucleotide base, thus 4-SU differs from uridine only by a single sulfur substitution. This offers the advantage of incorporating into an RNA chain with minimal structural perturbation and with similar base-pairing properties, reducing the likelihood that substitution will impair RNA interactions or activities.{26732}
Brand:CaymanSKU:-Out of stock
4-Thiouridine (4-SU) is a photoactivatable ribonucleoside analog that is widely used for RNA analysis, including short-range RNA-RNA crosslinking and nascent RNA labeling.{26731,26729,26732} The crosslinking thio moiety is attached directly to the nucleotide base, thus 4-SU differs from uridine only by a single sulfur substitution. This offers the advantage of incorporating into an RNA chain with minimal structural perturbation and with similar base-pairing properties, reducing the likelihood that substitution will impair RNA interactions or activities.{26732}
Brand:CaymanSKU:-Out of stock
4,4′-Dicyanobenzhydrol (Item No. 21316) is an analytical reference standard that is a metabolite of letrozole (Item No. 11568), an aromatase inhibitor that has been abused during sports doping cycles to reduce gynecomastia associated with androgen abuse.{38772} 4,4′-Dicyanobenzhydrol has been used as a marker of letrozole use in athletes. This product is intended for research and forensic applications.
Brand:CaymanSKU:21316 -Out of stock
4,4′-Dicyanobenzhydrol (Item No. 21316) is an analytical reference standard that is a metabolite of letrozole (Item No. 11568), an aromatase inhibitor that has been abused during sports doping cycles to reduce gynecomastia associated with androgen abuse.{38772} 4,4′-Dicyanobenzhydrol has been used as a marker of letrozole use in athletes. This product is intended for research and forensic applications.
Brand:CaymanSKU:21316 -Out of stock
4,4′-Dicyanobenzhydrol (Item No. 21316) is an analytical reference standard that is a metabolite of letrozole (Item No. 11568), an aromatase inhibitor that has been abused during sports doping cycles to reduce gynecomastia associated with androgen abuse.{38772} 4,4′-Dicyanobenzhydrol has been used as a marker of letrozole use in athletes. This product is intended for research and forensic applications.
Brand:CaymanSKU:21316 -Out of stock
4,4′-Dicyanobenzhydrol (Item No. 21316) is an analytical reference standard that is a metabolite of letrozole (Item No. 11568), an aromatase inhibitor that has been abused during sports doping cycles to reduce gynecomastia associated with androgen abuse.{38772} 4,4′-Dicyanobenzhydrol has been used as a marker of letrozole use in athletes. This product is intended for research and forensic applications.
Brand:CaymanSKU:21316 -Out of stock
4,4′-Dimethoxyoctafluorobiphenyl is a compound that has been used to investigate the relationship between intramolecular rotational dynamics and molecular and crystal structure using NMR spin-lattice relaxation experiments.{30248}
Brand:CaymanSKU:-Available on backorder
4,4′-Dimethoxyoctafluorobiphenyl is a compound that has been used to investigate the relationship between intramolecular rotational dynamics and molecular and crystal structure using NMR spin-lattice relaxation experiments.{30248}
Brand:CaymanSKU:-Available on backorder
4,4′-Dimethylaminorex (4,4’-DMAR) is a designer drug and para-methyl derivative of 4-methylaminorex, an amphetamine-like stimulant.{27514,27515} 4,4’-DMAR is a less common alternative to 4-methylaminorex, although the latter is an internationally controlled substance.{27513} The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:- 4,4′-Dimethylaminorex (4,4’-DMAR) is a designer drug and para-methyl derivative of 4-methylaminorex, an amphetamine-like stimulant.{27514,27515} 4,4’-DMAR is a less common alternative to 4-methylaminorex, although the latter is an internationally controlled substance.{27513} The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:- 4,4′-Dimethylaminorex (4,4’-DMAR) is a designer drug and para-methyl derivative of 4-methylaminorex, an amphetamine-like stimulant.{27514,27515} 4,4’-DMAR is a less common alternative to 4-methylaminorex, although the latter is an internationally controlled substance.{27513} The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:-
4,5-Dicaffeoylquinic acid (4,5-DCQA) is a polyphenol originally isolated from G. fagetorum and G. pseudomollugo that has diverse biological activities, including anti-HIV replication, antioxidative, anti-inflammatory, and anti-melanogenic properties.{48456,36685,43194,48457,47056} It inhibits HIV-1 integrase 3′ end processing, 3’ end joining, and disintegration with IC50 values of 0.13, 0.24, and 0.3 μg/ml, respectively.{43194} It also inhibits HIV-1 replication in MT-2 T lymphoblastoid cells with an EC50 value of 2 μg/ml. 4,5-DCQA scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay (IC50 = 19.8 μM) and inhibits superoxide production in human neutrophils activated by N-formyl-Met-Leu-Phe (fMLF; Item No. 21495) and cytochalasin B (Item No. 11328; IC50 = 1.49 μM).{36685} It decreases prostaglandin E2 (PGE2; Item No. 14010) production in LPS-stimulated U937 cells when used at concentrations of 5 and 10 µg/ml but increases it when used at 200 µg/ml and increases production of TNF-α at concentrations ranging from 5 to 200 µg/ml.{48457} It inhibits the synthesis of MCP3 in U937 cells. 4,5-DCQA (25 µM) inhibits melanogenesis by 84% and decreases the levels of proteins involved in melanin biosynthesis, including tyrosinase, TRP-1, DCT, and MITF in B16F1 murine melanocytes.{47056}
Brand:CaymanSKU:27892 - 10 mgAvailable on backorder
4,5-Dicaffeoylquinic acid (4,5-DCQA) is a polyphenol originally isolated from G. fagetorum and G. pseudomollugo that has diverse biological activities, including anti-HIV replication, antioxidative, anti-inflammatory, and anti-melanogenic properties.{48456,36685,43194,48457,47056} It inhibits HIV-1 integrase 3′ end processing, 3’ end joining, and disintegration with IC50 values of 0.13, 0.24, and 0.3 μg/ml, respectively.{43194} It also inhibits HIV-1 replication in MT-2 T lymphoblastoid cells with an EC50 value of 2 μg/ml. 4,5-DCQA scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay (IC50 = 19.8 μM) and inhibits superoxide production in human neutrophils activated by N-formyl-Met-Leu-Phe (fMLF; Item No. 21495) and cytochalasin B (Item No. 11328; IC50 = 1.49 μM).{36685} It decreases prostaglandin E2 (PGE2; Item No. 14010) production in LPS-stimulated U937 cells when used at concentrations of 5 and 10 µg/ml but increases it when used at 200 µg/ml and increases production of TNF-α at concentrations ranging from 5 to 200 µg/ml.{48457} It inhibits the synthesis of MCP3 in U937 cells. 4,5-DCQA (25 µM) inhibits melanogenesis by 84% and decreases the levels of proteins involved in melanin biosynthesis, including tyrosinase, TRP-1, DCT, and MITF in B16F1 murine melanocytes.{47056}
Brand:CaymanSKU:27892 - 25 mgAvailable on backorder
4,5-Dicaffeoylquinic acid (4,5-DCQA) is a polyphenol originally isolated from G. fagetorum and G. pseudomollugo that has diverse biological activities, including anti-HIV replication, antioxidative, anti-inflammatory, and anti-melanogenic properties.{48456,36685,43194,48457,47056} It inhibits HIV-1 integrase 3′ end processing, 3’ end joining, and disintegration with IC50 values of 0.13, 0.24, and 0.3 μg/ml, respectively.{43194} It also inhibits HIV-1 replication in MT-2 T lymphoblastoid cells with an EC50 value of 2 μg/ml. 4,5-DCQA scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay (IC50 = 19.8 μM) and inhibits superoxide production in human neutrophils activated by N-formyl-Met-Leu-Phe (fMLF; Item No. 21495) and cytochalasin B (Item No. 11328; IC50 = 1.49 μM).{36685} It decreases prostaglandin E2 (PGE2; Item No. 14010) production in LPS-stimulated U937 cells when used at concentrations of 5 and 10 µg/ml but increases it when used at 200 µg/ml and increases production of TNF-α at concentrations ranging from 5 to 200 µg/ml.{48457} It inhibits the synthesis of MCP3 in U937 cells. 4,5-DCQA (25 µM) inhibits melanogenesis by 84% and decreases the levels of proteins involved in melanin biosynthesis, including tyrosinase, TRP-1, DCT, and MITF in B16F1 murine melanocytes.{47056}
Brand:CaymanSKU:27892 - 5 mgAvailable on backorder
4,5-Dicaffeoylquinic acid (4,5-DCQA) is a polyphenol originally isolated from G. fagetorum and G. pseudomollugo that has diverse biological activities, including anti-HIV replication, antioxidative, anti-inflammatory, and anti-melanogenic properties.{48456,36685,43194,48457,47056} It inhibits HIV-1 integrase 3′ end processing, 3’ end joining, and disintegration with IC50 values of 0.13, 0.24, and 0.3 μg/ml, respectively.{43194} It also inhibits HIV-1 replication in MT-2 T lymphoblastoid cells with an EC50 value of 2 μg/ml. 4,5-DCQA scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay (IC50 = 19.8 μM) and inhibits superoxide production in human neutrophils activated by N-formyl-Met-Leu-Phe (fMLF; Item No. 21495) and cytochalasin B (Item No. 11328; IC50 = 1.49 μM).{36685} It decreases prostaglandin E2 (PGE2; Item No. 14010) production in LPS-stimulated U937 cells when used at concentrations of 5 and 10 µg/ml but increases it when used at 200 µg/ml and increases production of TNF-α at concentrations ranging from 5 to 200 µg/ml.{48457} It inhibits the synthesis of MCP3 in U937 cells. 4,5-DCQA (25 µM) inhibits melanogenesis by 84% and decreases the levels of proteins involved in melanin biosynthesis, including tyrosinase, TRP-1, DCT, and MITF in B16F1 murine melanocytes.{47056}
Brand:CaymanSKU:27892 - 50 mgAvailable on backorder
4,5-MDAI (hydrochloride) (Item No. 9002653) is an analytical reference standard categorized as an amphetamine.{20175} This product is intended for research and forensic applications.
Brand:CaymanSKU:9002653 - 1 mgAvailable on backorder
4,5-MDAI (hydrochloride) (Item No. 9002653) is an analytical reference standard categorized as an amphetamine.{20175} This product is intended for research and forensic applications.
Brand:CaymanSKU:9002653 - 5 mgAvailable on backorder
Casein kinase 2 (CK2) is a constitutive protein kinase involved in many signal transduction pathways. CK2 is known to negatively regulate apoptosis, and its activity is increased in many proliferating tissues and tumors. 4,5,6,7-Tetrabromobenzimidazole is a selective, ATP-competitive inhibitor of CK2 with Ki values ranging from 0.5-1 µM in rat liver, S. cerevisiae, C. tropicalis, and N. crassa.{30429} It is inactive against PKA and PKC and a relatively weak inhibitor of CK1 (Ki = 54.4-64.2 µM).{30429}
Brand:CaymanSKU:-Available on backorder
Casein kinase 2 (CK2) is a constitutive protein kinase involved in many signal transduction pathways. CK2 is known to negatively regulate apoptosis, and its activity is increased in many proliferating tissues and tumors. 4,5,6,7-Tetrabromobenzimidazole is a selective, ATP-competitive inhibitor of CK2 with Ki values ranging from 0.5-1 µM in rat liver, S. cerevisiae, C. tropicalis, and N. crassa.{30429} It is inactive against PKA and PKC and a relatively weak inhibitor of CK1 (Ki = 54.4-64.2 µM).{30429}
Brand:CaymanSKU:-Available on backorder
Brand:CaymanSKU:-Available on backorder
Brand:CaymanSKU:-Available on backorder
Brand:CaymanSKU:-Available on backorder
Brand:CaymanSKU:-Available on backorder
4,9-Anhydrotetrodotoxin (4,9-anhydro-TTX) is a derivative of TTX that selectively blocks inward sodium current through Nav1.6 voltage-activated sodium channels (IC50 = 7.8 nM in Xenopus oocytes).{30519,30520,23790} It demonstrates IC50 values of 1.3, 0.34, 0.99, 78.5, 1.3, and >30 µM for Nav1.2, Nav1.3, Nav1.4, Nav1.5, Nav1.7, and Nav1.8, respectively.{30519}
Brand:CaymanSKU:-Available on backorder
4′-Aminomethyl-4,5′,8-trimethylpsoralen is a bifunctional photoreactive agent for crosslinking nucleic acids.{28101,28103} In the dark, it intercalates into double-stranded regions in DNA or RNA. Upon long wavelength UV irradiation (e.g., 365 nm), 4′-aminomethyl-4,5′,8-trimethylpsoralen first forms a covalent monoadduct with a pyrimidine base, followed by covalently linking with an adjacent pyrimidine on the opposite strand.{28101,28103} Short wavelength UV irradiation (e.g., 254 nm) reverses this reaction. 4′-Aminomethyl-4,5′,8-trimethylpsoralen has a high binding affinity for RNA and has been used to study different types of RNA from diverse organisms, including viruses.{28099,28100,28102}
Brand:CaymanSKU:-Out of stock
4′-Aminomethyl-4,5′,8-trimethylpsoralen is a bifunctional photoreactive agent for crosslinking nucleic acids.{28101,28103} In the dark, it intercalates into double-stranded regions in DNA or RNA. Upon long wavelength UV irradiation (e.g., 365 nm), 4′-aminomethyl-4,5′,8-trimethylpsoralen first forms a covalent monoadduct with a pyrimidine base, followed by covalently linking with an adjacent pyrimidine on the opposite strand.{28101,28103} Short wavelength UV irradiation (e.g., 254 nm) reverses this reaction. 4′-Aminomethyl-4,5′,8-trimethylpsoralen has a high binding affinity for RNA and has been used to study different types of RNA from diverse organisms, including viruses.{28099,28100,28102}
Brand:CaymanSKU:-Out of stock
4′-Aminomethyl-4,5′,8-trimethylpsoralen is a bifunctional photoreactive agent for crosslinking nucleic acids.{28101,28103} In the dark, it intercalates into double-stranded regions in DNA or RNA. Upon long wavelength UV irradiation (e.g., 365 nm), 4′-aminomethyl-4,5′,8-trimethylpsoralen first forms a covalent monoadduct with a pyrimidine base, followed by covalently linking with an adjacent pyrimidine on the opposite strand.{28101,28103} Short wavelength UV irradiation (e.g., 254 nm) reverses this reaction. 4′-Aminomethyl-4,5′,8-trimethylpsoralen has a high binding affinity for RNA and has been used to study different types of RNA from diverse organisms, including viruses.{28099,28100,28102}
Brand:CaymanSKU:-Out of stock
4’-bromo-Resveratrol is a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3).{33950} It is a brominated derivative of resveratrol, a polyphenol found in red wine, which activates SIRT1 and inhibits SIRT3. The use of 4’-bromo-resveratrol in an SIRT3 crystal binding study revealed two compound binding sites which, combined with homology modeling, suggested that the second site may account for the paradoxical activation of SIRT1 by unmodified resveratrol.{33950}
Brand:CaymanSKU:20541 -Available on backorder
4’-bromo-Resveratrol is a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3).{33950} It is a brominated derivative of resveratrol, a polyphenol found in red wine, which activates SIRT1 and inhibits SIRT3. The use of 4’-bromo-resveratrol in an SIRT3 crystal binding study revealed two compound binding sites which, combined with homology modeling, suggested that the second site may account for the paradoxical activation of SIRT1 by unmodified resveratrol.{33950}
Brand:CaymanSKU:20541 -Available on backorder
4’-bromo-Resveratrol is a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3).{33950} It is a brominated derivative of resveratrol, a polyphenol found in red wine, which activates SIRT1 and inhibits SIRT3. The use of 4’-bromo-resveratrol in an SIRT3 crystal binding study revealed two compound binding sites which, combined with homology modeling, suggested that the second site may account for the paradoxical activation of SIRT1 by unmodified resveratrol.{33950}
Brand:CaymanSKU:20541 -Available on backorder
4′-chloro-α-Pyrrolidinopropiophenone is a halogen-substituted form of the stimulant α-Pyrrolidinopropiophenone (Item No. 10445). The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:9002179 - 10 mgAvailable on backorder
4′-chloro-α-Pyrrolidinopropiophenone is a halogen-substituted form of the stimulant α-Pyrrolidinopropiophenone (Item No. 10445). The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:9002179 - 5 mgAvailable on backorder
4′-chloro-α-Pyrrolidinopropiophenone is a halogen-substituted form of the stimulant α-Pyrrolidinopropiophenone (Item No. 10445). The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:9002179 - 50 mgAvailable on backorder
4′-Demethylepipodophyllotoxin is an inhibitor of tubulin polymerization (IC50 = 13 μM).{48556} It inhibits the growth of human HepG2 liver, HeLa cervical, A549 lung, and BGC-823 stomach cancer cells in vitro (IC50s = 18.74, 15.96, 52.08, and 21.26 μM, respectively).{48557} 4′-Demethylepipodophyllotoxin also inhibits the growth of non-cancerous human HL-7702 liver cells (IC50 = 13.04 μM).
Brand:CaymanSKU:28393 - 1 gAvailable on backorder
4′-Demethylepipodophyllotoxin is an inhibitor of tubulin polymerization (IC50 = 13 μM).{48556} It inhibits the growth of human HepG2 liver, HeLa cervical, A549 lung, and BGC-823 stomach cancer cells in vitro (IC50s = 18.74, 15.96, 52.08, and 21.26 μM, respectively).{48557} 4′-Demethylepipodophyllotoxin also inhibits the growth of non-cancerous human HL-7702 liver cells (IC50 = 13.04 μM).
Brand:CaymanSKU:28393 - 10 gAvailable on backorder
4′-Demethylepipodophyllotoxin is an inhibitor of tubulin polymerization (IC50 = 13 μM).{48556} It inhibits the growth of human HepG2 liver, HeLa cervical, A549 lung, and BGC-823 stomach cancer cells in vitro (IC50s = 18.74, 15.96, 52.08, and 21.26 μM, respectively).{48557} 4′-Demethylepipodophyllotoxin also inhibits the growth of non-cancerous human HL-7702 liver cells (IC50 = 13.04 μM).
Brand:CaymanSKU:28393 - 25 gAvailable on backorder
4′-Demethylepipodophyllotoxin is an inhibitor of tubulin polymerization (IC50 = 13 μM).{48556} It inhibits the growth of human HepG2 liver, HeLa cervical, A549 lung, and BGC-823 stomach cancer cells in vitro (IC50s = 18.74, 15.96, 52.08, and 21.26 μM, respectively).{48557} 4′-Demethylepipodophyllotoxin also inhibits the growth of non-cancerous human HL-7702 liver cells (IC50 = 13.04 μM).
Brand:CaymanSKU:28393 - 5 gAvailable on backorder