Chemicals
Showing 6001–6150 of 41137 results
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4-Methylaminoantipyrine is a major active metabolite of the non-opioid prodrug metamizole (Item No. 15771).{25749} It is formed from metamizole by non-enzymatic hydrolysis in the gastrointestinal tract.{57230} 4-Methylaminoantipyrine (0.1 mM) inhibits production of prostaglandin E2 (PGE2; Item No. 14010) induced by the calcium ionophore A23187 (Item Nos. 11016 | 22030) in isolated mouse peritoneal macrophages.{57231} It increases the paw withdrawal threshold in a rat model of carrageenan-induced hyperalgesia when administered at a dose of 160 µg/paw.{57232} 4-Methylaminoantipyrine (60, 90, and 120 mg/kg) reduces LPS-induced pyrexia in rats.{57233} It is also a potential impurity found in commercial preparations of metamizole.{57234}
Brand:CaymanSKU:31612 - 1 mgAvailable on backorder
4-Methylaminoantipyrine is a major active metabolite of the non-opioid prodrug metamizole (Item No. 15771).{25749} It is formed from metamizole by non-enzymatic hydrolysis in the gastrointestinal tract.{57230} 4-Methylaminoantipyrine (0.1 mM) inhibits production of prostaglandin E2 (PGE2; Item No. 14010) induced by the calcium ionophore A23187 (Item Nos. 11016 | 22030) in isolated mouse peritoneal macrophages.{57231} It increases the paw withdrawal threshold in a rat model of carrageenan-induced hyperalgesia when administered at a dose of 160 µg/paw.{57232} 4-Methylaminoantipyrine (60, 90, and 120 mg/kg) reduces LPS-induced pyrexia in rats.{57233} It is also a potential impurity found in commercial preparations of metamizole.{57234}
Brand:CaymanSKU:31612 - 10 mgAvailable on backorder
4-Methylaminoantipyrine is a major active metabolite of the non-opioid prodrug metamizole (Item No. 15771).{25749} It is formed from metamizole by non-enzymatic hydrolysis in the gastrointestinal tract.{57230} 4-Methylaminoantipyrine (0.1 mM) inhibits production of prostaglandin E2 (PGE2; Item No. 14010) induced by the calcium ionophore A23187 (Item Nos. 11016 | 22030) in isolated mouse peritoneal macrophages.{57231} It increases the paw withdrawal threshold in a rat model of carrageenan-induced hyperalgesia when administered at a dose of 160 µg/paw.{57232} 4-Methylaminoantipyrine (60, 90, and 120 mg/kg) reduces LPS-induced pyrexia in rats.{57233} It is also a potential impurity found in commercial preparations of metamizole.{57234}
Brand:CaymanSKU:31612 - 5 mgAvailable on backorder
4-Methylamphetamine (4-MA) (hydrochloride) (Item No. 14215) is an analytical reference standard categorized as an amphetamine. 4-MA acts on norepinephrine (NE), dopamine (DA), and serotonin (5-HT) transporters to increase extracellular levels of these neurotransmitters. In vitro, the potencies of 4-MA for NE and DA release are similar to those of D-amphetamine with EC50 values of 22.2 and 7.2 nM for NE and 44.1 and 8.0 nM for DA, respectively.{36006} 4-MA is more potent than D-amphetamine at releasing serotonin (EC50s = 53.4 and 1,756 nM, respectively). In rats, 4-MA acts as an agonist at 5-HT1A receptors and induces hypothermia.{36005} It is found as a contaminant in amphetamine, and ingestion has been associated with severe intoxication and fatalities.{36004} This product is intended for research and forensic applications.
Brand:CaymanSKU:- 4-Methylamphetamine (4-MA) (hydrochloride) (Item No. 14215) is an analytical reference standard categorized as an amphetamine. 4-MA acts on norepinephrine (NE), dopamine (DA), and serotonin (5-HT) transporters to increase extracellular levels of these neurotransmitters. In vitro, the potencies of 4-MA for NE and DA release are similar to those of D-amphetamine with EC50 values of 22.2 and 7.2 nM for NE and 44.1 and 8.0 nM for DA, respectively.{36006} 4-MA is more potent than D-amphetamine at releasing serotonin (EC50s = 53.4 and 1,756 nM, respectively). In rats, 4-MA acts as an agonist at 5-HT1A receptors and induces hypothermia.{36005} It is found as a contaminant in amphetamine, and ingestion has been associated with severe intoxication and fatalities.{36004} This product is intended for research and forensic applications.
Brand:CaymanSKU:-
Brand:CaymanSKU:- Brand:CaymanSKU:-
4-Methylbenzylidene camphor is an ultraviolet light blocker used in cosmetics and sunscreen preparations that also has estrogenic activities.{20419,20420} It has estrogenic activity in fish and in mammals, binding competitively to estrogen receptors and stimulating transactivation.{20419} In addition to reducing receptor sensitivity to estradiol, 4-MBC directs dose-dependent changes in the expression of estrogen receptor subtypes, progesterone receptor, and androgen receptor.{20419,20420} This results in changes in reproductive organ and brain development in both males and females.{20419,20420} When applied topically, it is absorbed systemically and can be detected in urine.{20421}
Brand:CaymanSKU:- 4-Methylbenzylidene camphor is an ultraviolet light blocker used in cosmetics and sunscreen preparations that also has estrogenic activities.{20419,20420} It has estrogenic activity in fish and in mammals, binding competitively to estrogen receptors and stimulating transactivation.{20419} In addition to reducing receptor sensitivity to estradiol, 4-MBC directs dose-dependent changes in the expression of estrogen receptor subtypes, progesterone receptor, and androgen receptor.{20419,20420} This results in changes in reproductive organ and brain development in both males and females.{20419,20420} When applied topically, it is absorbed systemically and can be detected in urine.{20421}
Brand:CaymanSKU:- 4-Methylbenzylidene camphor is an ultraviolet light blocker used in cosmetics and sunscreen preparations that also has estrogenic activities.{20419,20420} It has estrogenic activity in fish and in mammals, binding competitively to estrogen receptors and stimulating transactivation.{20419} In addition to reducing receptor sensitivity to estradiol, 4-MBC directs dose-dependent changes in the expression of estrogen receptor subtypes, progesterone receptor, and androgen receptor.{20419,20420} This results in changes in reproductive organ and brain development in both males and females.{20419,20420} When applied topically, it is absorbed systemically and can be detected in urine.{20421}
Brand:CaymanSKU:-
4-Methylethcathinone (4-MEC) is a cathinone derivative identified in several designer, recreational drugs that are sold as “legal high” replacements for controlled stimulants such as methamphetamine and 3,4-methylenedioxymethamphetamine.{19500,19914,19498} The hydrochloride formulation of this compound is intended for use as a standard for the forensic analysis of samples that may contain 4-MEC.
Brand:CaymanSKU:-
4-Methylhistamine is a histamine H4 receptor agonist (Ki = 50 nM).{36324} It is >100-fold selective for H4 over other histamine receptors. 4-Methylhistamine inhibits CRE-β-galactosidase activity induced by forskolin (Item No. 11018) with an EC50 value of 39.8 nM in SK-N-MC cells transfected with the human H4 receptor. It induces a change in eosinophil shape (EC50 = 0.36 μM) and stimulates migration of murine bone marrow mast cells (EC50 = 12 μM), activities that can be inhibited by the histamine H4 antagonist JNJ-7777120 (Item No. 10011925). Intratracheal administration of 4-methylhistamine (10 μg/animal) reduces airway resistance and inflammation and increases the number of CD4+CD25+FoxP3+ regulatory T cells in a mouse model of allergic asthma.{36323} 4-Methylhistamine also reduces epidermal hyperplasis, hyperkeratosis, and lymphocyte infiltration and increases the number of CD4+CD25+FoxP3+ regulatory T cells in a mouse model of psoriasis induced by imiquimod (Item No. 14956).{36325}
Brand:CaymanSKU:23761 - 1 mgAvailable on backorder
4-Methylhistamine is a histamine H4 receptor agonist (Ki = 50 nM).{36324} It is >100-fold selective for H4 over other histamine receptors. 4-Methylhistamine inhibits CRE-β-galactosidase activity induced by forskolin (Item No. 11018) with an EC50 value of 39.8 nM in SK-N-MC cells transfected with the human H4 receptor. It induces a change in eosinophil shape (EC50 = 0.36 μM) and stimulates migration of murine bone marrow mast cells (EC50 = 12 μM), activities that can be inhibited by the histamine H4 antagonist JNJ-7777120 (Item No. 10011925). Intratracheal administration of 4-methylhistamine (10 μg/animal) reduces airway resistance and inflammation and increases the number of CD4+CD25+FoxP3+ regulatory T cells in a mouse model of allergic asthma.{36323} 4-Methylhistamine also reduces epidermal hyperplasis, hyperkeratosis, and lymphocyte infiltration and increases the number of CD4+CD25+FoxP3+ regulatory T cells in a mouse model of psoriasis induced by imiquimod (Item No. 14956).{36325}
Brand:CaymanSKU:23761 - 10 mgAvailable on backorder
4-Methylhistamine is a histamine H4 receptor agonist (Ki = 50 nM).{36324} It is >100-fold selective for H4 over other histamine receptors. 4-Methylhistamine inhibits CRE-β-galactosidase activity induced by forskolin (Item No. 11018) with an EC50 value of 39.8 nM in SK-N-MC cells transfected with the human H4 receptor. It induces a change in eosinophil shape (EC50 = 0.36 μM) and stimulates migration of murine bone marrow mast cells (EC50 = 12 μM), activities that can be inhibited by the histamine H4 antagonist JNJ-7777120 (Item No. 10011925). Intratracheal administration of 4-methylhistamine (10 μg/animal) reduces airway resistance and inflammation and increases the number of CD4+CD25+FoxP3+ regulatory T cells in a mouse model of allergic asthma.{36323} 4-Methylhistamine also reduces epidermal hyperplasis, hyperkeratosis, and lymphocyte infiltration and increases the number of CD4+CD25+FoxP3+ regulatory T cells in a mouse model of psoriasis induced by imiquimod (Item No. 14956).{36325}
Brand:CaymanSKU:23761 - 5 mgAvailable on backorder
Mephedrone (Item No. 10801) is a designer drug of the phenethylamine class with putative stimulant and entactogen-like properties.{19656,19498,19193} 4-Methylmethamphetamine (4-MMA) is a metabolite of mephedrone that lacks the β-keto moiety.{19964} This product is intended for forensic and research applications.
Brand:CaymanSKU:9001345 - 10 mgAvailable on backorder
Mephedrone (Item No. 10801) is a designer drug of the phenethylamine class with putative stimulant and entactogen-like properties.{19656,19498,19193} 4-Methylmethamphetamine (4-MMA) is a metabolite of mephedrone that lacks the β-keto moiety.{19964} This product is intended for forensic and research applications.
Brand:CaymanSKU:9001345 - 5 mgAvailable on backorder
Mephedrone (Item No. 10801) is a designer drug of the phenethylamine class with putative stimulant and entactogen-like properties.{19656,19498,19193} 4-Methylmethamphetamine (4-MMA) is a metabolite of mephedrone that lacks the β-keto moiety.{19964} This product is intended for forensic and research applications.
Brand:CaymanSKU:9001345 - 50 mgAvailable on backorder
4-Methylpentanoic acid-d12 is intended for use as an internal standard for the quantification of 4-methylpentanoic acid by GC- or LC-MS. 4-Methylpentanoic acid is a short-chain volatile fatty acid that is produced during wastewater treatment using anaerobic membrane bioreactors.{46333} It is a synthetic intermediate in the synthesis of biodiesel, polyhydroxyalkanoate (PHA) biopolymers, and various organic compounds.
Brand:CaymanSKU:27873 - 100 mgAvailable on backorder
4-Methylpentanoic acid-d12 is intended for use as an internal standard for the quantification of 4-methylpentanoic acid by GC- or LC-MS. 4-Methylpentanoic acid is a short-chain volatile fatty acid that is produced during wastewater treatment using anaerobic membrane bioreactors.{46333} It is a synthetic intermediate in the synthesis of biodiesel, polyhydroxyalkanoate (PHA) biopolymers, and various organic compounds.
Brand:CaymanSKU:27873 - 250 mgAvailable on backorder
4-Methylpentanoic acid-d12 is intended for use as an internal standard for the quantification of 4-methylpentanoic acid by GC- or LC-MS. 4-Methylpentanoic acid is a short-chain volatile fatty acid that is produced during wastewater treatment using anaerobic membrane bioreactors.{46333} It is a synthetic intermediate in the synthesis of biodiesel, polyhydroxyalkanoate (PHA) biopolymers, and various organic compounds.
Brand:CaymanSKU:27873 - 50 mgAvailable on backorder
4-Methylpentanoic acid-d12 is intended for use as an internal standard for the quantification of 4-methylpentanoic acid by GC- or LC-MS. 4-Methylpentanoic acid is a short-chain volatile fatty acid that is produced during wastewater treatment using anaerobic membrane bioreactors.{46333} It is a synthetic intermediate in the synthesis of biodiesel, polyhydroxyalkanoate (PHA) biopolymers, and various organic compounds.
Brand:CaymanSKU:27873 - 500 mgAvailable on backorder
4-Methylumbelliferone (4-ΜU) is a synthetic coumarin with diverse biological activities.{52251,52252,27251} It inhibits hyaluronic acid synthesis in PC3-ML and DU145 cells (IC50s = ~0.4 mM for both).{52251} 4-MU inhibits the growth of PC3-ML, DU145, C4-2B, LNCaP, and LAPC-4 prostate cancer cells (IC50s = 0.2-0.4 mM) and invasion and chemotactic motility of PC3-ML and DU145 cells in vitro. It reduces tumor growth and microvessel density in a PC3-ML mouse xenograft model when administered at doses of 225 and 450 mg/kg twice per day. 4-ΜU is active against H. pylori and V. cholerae in vitro (MICs = 59 and 100-200 μg/ml, respectively).{52252} Derivatives and conjugates of 4-ΜU have been used as fluorogenic substrates to measure enzyme activity.{39610,26284,47304} Upon enzymatic cleavage, 4-ΜU is released and its fluorescence can be used to quantify enzyme activity. 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high pH (7.12-10.3), respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases.{27251}
Brand:CaymanSKU:29603 - 100 gAvailable on backorder
4-Methylumbelliferone (4-ΜU) is a synthetic coumarin with diverse biological activities.{52251,52252,27251} It inhibits hyaluronic acid synthesis in PC3-ML and DU145 cells (IC50s = ~0.4 mM for both).{52251} 4-MU inhibits the growth of PC3-ML, DU145, C4-2B, LNCaP, and LAPC-4 prostate cancer cells (IC50s = 0.2-0.4 mM) and invasion and chemotactic motility of PC3-ML and DU145 cells in vitro. It reduces tumor growth and microvessel density in a PC3-ML mouse xenograft model when administered at doses of 225 and 450 mg/kg twice per day. 4-ΜU is active against H. pylori and V. cholerae in vitro (MICs = 59 and 100-200 μg/ml, respectively).{52252} Derivatives and conjugates of 4-ΜU have been used as fluorogenic substrates to measure enzyme activity.{39610,26284,47304} Upon enzymatic cleavage, 4-ΜU is released and its fluorescence can be used to quantify enzyme activity. 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high pH (7.12-10.3), respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases.{27251}
Brand:CaymanSKU:29603 - 250 gAvailable on backorder
4-Methylumbelliferone (4-ΜU) is a synthetic coumarin with diverse biological activities.{52251,52252,27251} It inhibits hyaluronic acid synthesis in PC3-ML and DU145 cells (IC50s = ~0.4 mM for both).{52251} 4-MU inhibits the growth of PC3-ML, DU145, C4-2B, LNCaP, and LAPC-4 prostate cancer cells (IC50s = 0.2-0.4 mM) and invasion and chemotactic motility of PC3-ML and DU145 cells in vitro. It reduces tumor growth and microvessel density in a PC3-ML mouse xenograft model when administered at doses of 225 and 450 mg/kg twice per day. 4-ΜU is active against H. pylori and V. cholerae in vitro (MICs = 59 and 100-200 μg/ml, respectively).{52252} Derivatives and conjugates of 4-ΜU have been used as fluorogenic substrates to measure enzyme activity.{39610,26284,47304} Upon enzymatic cleavage, 4-ΜU is released and its fluorescence can be used to quantify enzyme activity. 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high pH (7.12-10.3), respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases.{27251}
Brand:CaymanSKU:29603 - 50 gAvailable on backorder
4-Methylumbelliferone (4-ΜU) is a synthetic coumarin with diverse biological activities.{52251,52252,27251} It inhibits hyaluronic acid synthesis in PC3-ML and DU145 cells (IC50s = ~0.4 mM for both).{52251} 4-MU inhibits the growth of PC3-ML, DU145, C4-2B, LNCaP, and LAPC-4 prostate cancer cells (IC50s = 0.2-0.4 mM) and invasion and chemotactic motility of PC3-ML and DU145 cells in vitro. It reduces tumor growth and microvessel density in a PC3-ML mouse xenograft model when administered at doses of 225 and 450 mg/kg twice per day. 4-ΜU is active against H. pylori and V. cholerae in vitro (MICs = 59 and 100-200 μg/ml, respectively).{52252} Derivatives and conjugates of 4-ΜU have been used as fluorogenic substrates to measure enzyme activity.{39610,26284,47304} Upon enzymatic cleavage, 4-ΜU is released and its fluorescence can be used to quantify enzyme activity. 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high pH (7.12-10.3), respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases.{27251}
Brand:CaymanSKU:29603 - 500 gAvailable on backorder
4-Methylumbelliferyl 2-acetoamido-2-deoxy-α-D-galactopyranoside (4-MU-2-acetoamido-2-deoxy-α-Gal) is a fluorogenic substrate used to quantify α- and β-galactopyranosaminidase activity.{41895} 4-MU-2-acetoamido-2-deoxy-α-Gal is cleaved by α- and β-galactopyranosaminidase to release the fluorescent moiety 4-MU. 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases.{27251}
Brand:CaymanSKU:23099 - 1 mgAvailable on backorder
4-Methylumbelliferyl 2-acetoamido-2-deoxy-α-D-galactopyranoside (4-MU-2-acetoamido-2-deoxy-α-Gal) is a fluorogenic substrate used to quantify α- and β-galactopyranosaminidase activity.{41895} 4-MU-2-acetoamido-2-deoxy-α-Gal is cleaved by α- and β-galactopyranosaminidase to release the fluorescent moiety 4-MU. 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases.{27251}
Brand:CaymanSKU:23099 - 10 mgAvailable on backorder
4-Methylumbelliferyl 2-acetoamido-2-deoxy-α-D-galactopyranoside (4-MU-2-acetoamido-2-deoxy-α-Gal) is a fluorogenic substrate used to quantify α- and β-galactopyranosaminidase activity.{41895} 4-MU-2-acetoamido-2-deoxy-α-Gal is cleaved by α- and β-galactopyranosaminidase to release the fluorescent moiety 4-MU. 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases.{27251}
Brand:CaymanSKU:23099 - 25 mgAvailable on backorder
4-Methylumbelliferyl 2-acetoamido-2-deoxy-α-D-galactopyranoside (4-MU-2-acetoamido-2-deoxy-α-Gal) is a fluorogenic substrate used to quantify α- and β-galactopyranosaminidase activity.{41895} 4-MU-2-acetoamido-2-deoxy-α-Gal is cleaved by α- and β-galactopyranosaminidase to release the fluorescent moiety 4-MU. 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases.{27251}
Brand:CaymanSKU:23099 - 5 mgAvailable on backorder
4-Methylumbelliferyl 2-sulfamino-2-deoxy-α-D-Glucopyranoside (4-MU-α-GlcNS) is a fluorogenic substrate of heparin sulphamidase.{39610} Heparin sulphamidase cleaves 4-MU-α-GlcNS to yield 4-MU-α-GlcNH2, which is then cleaved by α-glucosaminidase to release the fluorescent product 4-MU, which displays an emission maxima of 445-454 nm.{39610,27251} The excitation maxima for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively.{27251} 4-MU-α-GlcNS has been used to quantify heparin sulphamidase deficiencies associated with Mucopolisaccaridosis IIIA and other lysosomal disorders.{39611}
Brand:CaymanSKU:24931 - 1 mgAvailable on backorder
4-Methylumbelliferyl 2-sulfamino-2-deoxy-α-D-Glucopyranoside (4-MU-α-GlcNS) is a fluorogenic substrate of heparin sulphamidase.{39610} Heparin sulphamidase cleaves 4-MU-α-GlcNS to yield 4-MU-α-GlcNH2, which is then cleaved by α-glucosaminidase to release the fluorescent product 4-MU, which displays an emission maxima of 445-454 nm.{39610,27251} The excitation maxima for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively.{27251} 4-MU-α-GlcNS has been used to quantify heparin sulphamidase deficiencies associated with Mucopolisaccaridosis IIIA and other lysosomal disorders.{39611}
Brand:CaymanSKU:24931 - 500 µgAvailable on backorder
4-Methylumbelliferyl 6-thio-palmitate-β-D-glucopyranoside is a fluorogenic substrate of palmitoyl-protein thioesterase (PPT, also known as CLN1), a lysosomal hydrolase that removes long-chain fatty acyl groups from modified cysteine residues in proteins. 4-Methylumbelliferyl 6-thio-palmitate-β-D-glucopyranoside is cleaved by PPT/CLN1 to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases.{27251} This substrate is used in assays that measure PPT activity, which is commonly deficient in the neurodegenerative disorder known as infantile neuronal ceroid lipofuscinosis.{31634,31635}
Brand:CaymanSKU:-Available on backorder
4-Methylumbelliferyl 6-thio-palmitate-β-D-glucopyranoside is a fluorogenic substrate of palmitoyl-protein thioesterase (PPT, also known as CLN1), a lysosomal hydrolase that removes long-chain fatty acyl groups from modified cysteine residues in proteins. 4-Methylumbelliferyl 6-thio-palmitate-β-D-glucopyranoside is cleaved by PPT/CLN1 to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases.{27251} This substrate is used in assays that measure PPT activity, which is commonly deficient in the neurodegenerative disorder known as infantile neuronal ceroid lipofuscinosis.{31634,31635}
Brand:CaymanSKU:-Available on backorder
4-Methylumbelliferyl 6-thio-palmitate-β-D-glucopyranoside is a fluorogenic substrate of palmitoyl-protein thioesterase (PPT, also known as CLN1), a lysosomal hydrolase that removes long-chain fatty acyl groups from modified cysteine residues in proteins. 4-Methylumbelliferyl 6-thio-palmitate-β-D-glucopyranoside is cleaved by PPT/CLN1 to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases.{27251} This substrate is used in assays that measure PPT activity, which is commonly deficient in the neurodegenerative disorder known as infantile neuronal ceroid lipofuscinosis.{31634,31635}
Brand:CaymanSKU:-Available on backorder
4-Methylumbelliferyl caprylate (MUCAP) is a fluorogenic substrate for C8 esterase.{42625} MUCAP is cleaved by C8 esterase to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases.{27251}
Brand:CaymanSKU:26802 - 1 gAvailable on backorder
4-Methylumbelliferyl caprylate (MUCAP) is a fluorogenic substrate for C8 esterase.{42625} MUCAP is cleaved by C8 esterase to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases.{27251}
Brand:CaymanSKU:26802 - 10 gAvailable on backorder
4-Methylumbelliferyl caprylate (MUCAP) is a fluorogenic substrate for C8 esterase.{42625} MUCAP is cleaved by C8 esterase to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases.{27251}
Brand:CaymanSKU:26802 - 25 gAvailable on backorder
4-Methylumbelliferyl caprylate (MUCAP) is a fluorogenic substrate for C8 esterase.{42625} MUCAP is cleaved by C8 esterase to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases.{27251}
Brand:CaymanSKU:26802 - 5 gAvailable on backorder
4-Methylumbelliferyl (4-MU) oleate is a fluorogenic substrate for acid and alkaline lipases.{31463,31464,31465} It is cleaved by lipases, liberating 4-MU, which has an emission maximum at 445-454 nm. The excitation maximum for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively.{27251}
Brand:CaymanSKU:19590 -Available on backorder
4-Methylumbelliferyl (4-MU) oleate is a fluorogenic substrate for acid and alkaline lipases.{31463,31464,31465} It is cleaved by lipases, liberating 4-MU, which has an emission maximum at 445-454 nm. The excitation maximum for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively.{27251}
Brand:CaymanSKU:19590 -Available on backorder
4-Methylumbelliferyl (4-MU) oleate is a fluorogenic substrate for acid and alkaline lipases.{31463,31464,31465} It is cleaved by lipases, liberating 4-MU, which has an emission maximum at 445-454 nm. The excitation maximum for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively.{27251}
Brand:CaymanSKU:19590 -Available on backorder
4-Methylumbelliferyl (4-MU) oleate is a fluorogenic substrate for acid and alkaline lipases.{31463,31464,31465} It is cleaved by lipases, liberating 4-MU, which has an emission maximum at 445-454 nm. The excitation maximum for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively.{27251}
Brand:CaymanSKU:19590 -Available on backorder
Cholesterol ester storage disease and Wolman disease are recessive autosomal disorders caused by a deficiency in lysosomal acid lipase (LAL), also known as cholesteryl ester hydrolase.{26282,26283} 4-Methylumbelliferyl palmitate (4-MUP) is a fluorogenic substrate for lysosomal acid lypase (LAL).{26284} 4-MUP is cleaved by LAL to release the fluorescent moiety 4-MU. 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases.{27251} 4-MUP may also be cleaved by other acid lipases.{26285,26286} Recent advances allow the assessment of LAL activity in very small blood volumes using 4-MUP.{26282,26283}
Brand:CaymanSKU:- Cholesterol ester storage disease and Wolman disease are recessive autosomal disorders caused by a deficiency in lysosomal acid lipase (LAL), also known as cholesteryl ester hydrolase.{26282,26283} 4-Methylumbelliferyl palmitate (4-MUP) is a fluorogenic substrate for lysosomal acid lypase (LAL).{26284} 4-MUP is cleaved by LAL to release the fluorescent moiety 4-MU. 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases.{27251} 4-MUP may also be cleaved by other acid lipases.{26285,26286} Recent advances allow the assessment of LAL activity in very small blood volumes using 4-MUP.{26282,26283}
Brand:CaymanSKU:- Cholesterol ester storage disease and Wolman disease are recessive autosomal disorders caused by a deficiency in lysosomal acid lipase (LAL), also known as cholesteryl ester hydrolase.{26282,26283} 4-Methylumbelliferyl palmitate (4-MUP) is a fluorogenic substrate for lysosomal acid lypase (LAL).{26284} 4-MUP is cleaved by LAL to release the fluorescent moiety 4-MU. 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases.{27251} 4-MUP may also be cleaved by other acid lipases.{26285,26286} Recent advances allow the assessment of LAL activity in very small blood volumes using 4-MUP.{26282,26283}
Brand:CaymanSKU:- Cholesterol ester storage disease and Wolman disease are recessive autosomal disorders caused by a deficiency in lysosomal acid lipase (LAL), also known as cholesteryl ester hydrolase.{26282,26283} 4-Methylumbelliferyl palmitate (4-MUP) is a fluorogenic substrate for lysosomal acid lypase (LAL).{26284} 4-MUP is cleaved by LAL to release the fluorescent moiety 4-MU. 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases.{27251} 4-MUP may also be cleaved by other acid lipases.{26285,26286} Recent advances allow the assessment of LAL activity in very small blood volumes using 4-MUP.{26282,26283}
Brand:CaymanSKU:-
4-Methylumbelliferyl β-D-Galactopyranoside-6-sulfate (sodium salt) (4-MU-Gal-6S) is a fluorogenic substrate used to quantify N-acetylgalactosamine-6-sulphatase (GALNS) activity.{41061} 4-MU-Gal-6S is cleaved by GALNS to release the fluorescent moiety 4-MU. 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases.{27251} It has been used to detect Morquio disease type A, a lysosomal storage disorder in which GALNS is deficient.{41061} 4-MU-Gal-6S can be used to assess GALNS activity in a very small blood volume to determine the extent of deficiency.{41060}
Brand:CaymanSKU:20907 -Out of stock
4-Methylumbelliferyl β-D-Galactopyranoside-6-sulfate (sodium salt) (4-MU-Gal-6S) is a fluorogenic substrate used to quantify N-acetylgalactosamine-6-sulphatase (GALNS) activity.{41061} 4-MU-Gal-6S is cleaved by GALNS to release the fluorescent moiety 4-MU. 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases.{27251} It has been used to detect Morquio disease type A, a lysosomal storage disorder in which GALNS is deficient.{41061} 4-MU-Gal-6S can be used to assess GALNS activity in a very small blood volume to determine the extent of deficiency.{41060}
Brand:CaymanSKU:20907 -Out of stock
4-Methylumbelliferyl β-D-Galactopyranoside-6-sulfate (sodium salt) (4-MU-Gal-6S) is a fluorogenic substrate used to quantify N-acetylgalactosamine-6-sulphatase (GALNS) activity.{41061} 4-MU-Gal-6S is cleaved by GALNS to release the fluorescent moiety 4-MU. 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases.{27251} It has been used to detect Morquio disease type A, a lysosomal storage disorder in which GALNS is deficient.{41061} 4-MU-Gal-6S can be used to assess GALNS activity in a very small blood volume to determine the extent of deficiency.{41060}
Brand:CaymanSKU:20907 -Out of stock
4-Methylumbelliferyl β-D-N,N’-diacetylchitobioside (4-ΜU-(GlcNAc)2) is a fluorogenic substrate for chitinases and chitobiosidases.{45280,45281} 4-ΜU-(GlcNAc)2 is cleaved by chitinases and chitobiosidases to release the fluorescent moiety 4-ΜU. 4-ΜU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high pH (7.12-10.3), respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases.
Brand:CaymanSKU:27730 - 1 mgAvailable on backorder
4-Methylumbelliferyl β-D-N,N’-diacetylchitobioside (4-ΜU-(GlcNAc)2) is a fluorogenic substrate for chitinases and chitobiosidases.{45280,45281} 4-ΜU-(GlcNAc)2 is cleaved by chitinases and chitobiosidases to release the fluorescent moiety 4-ΜU. 4-ΜU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high pH (7.12-10.3), respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases.
Brand:CaymanSKU:27730 - 10 mgAvailable on backorder
4-Methylumbelliferyl β-D-N,N’-diacetylchitobioside (4-ΜU-(GlcNAc)2) is a fluorogenic substrate for chitinases and chitobiosidases.{45280,45281} 4-ΜU-(GlcNAc)2 is cleaved by chitinases and chitobiosidases to release the fluorescent moiety 4-ΜU. 4-ΜU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high pH (7.12-10.3), respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases.
Brand:CaymanSKU:27730 - 5 mgAvailable on backorder
4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-glucopyranoside is a fluorogenic substrate for β-hexosaminidases.{47303,47304} Upon enzymatic cleavage by β-hexosaminidases, 4-methylumbelliferone (4-ΜU) is released and its fluorescence can be used to quantify β-hexosaminidase activity. 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high pH (7.12-10.3), respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases.{27251} 4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-glucopyranoside has been used to quantify β-hexosaminidase activity in serum or leukocytes from patients with GM2 gangliosidoses such as Tay-Sachs disease, which is characterized by defects in the α subunit of β-hexosaminidase.{47304,40891}
Brand:CaymanSKU:26953 - 1 gAvailable on backorder
4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-glucopyranoside is a fluorogenic substrate for β-hexosaminidases.{47303,47304} Upon enzymatic cleavage by β-hexosaminidases, 4-methylumbelliferone (4-ΜU) is released and its fluorescence can be used to quantify β-hexosaminidase activity. 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high pH (7.12-10.3), respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases.{27251} 4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-glucopyranoside has been used to quantify β-hexosaminidase activity in serum or leukocytes from patients with GM2 gangliosidoses such as Tay-Sachs disease, which is characterized by defects in the α subunit of β-hexosaminidase.{47304,40891}
Brand:CaymanSKU:26953 - 100 mgAvailable on backorder
4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-glucopyranoside is a fluorogenic substrate for β-hexosaminidases.{47303,47304} Upon enzymatic cleavage by β-hexosaminidases, 4-methylumbelliferone (4-ΜU) is released and its fluorescence can be used to quantify β-hexosaminidase activity. 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high pH (7.12-10.3), respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases.{27251} 4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-glucopyranoside has been used to quantify β-hexosaminidase activity in serum or leukocytes from patients with GM2 gangliosidoses such as Tay-Sachs disease, which is characterized by defects in the α subunit of β-hexosaminidase.{47304,40891}
Brand:CaymanSKU:26953 - 250 mgAvailable on backorder
4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-glucopyranoside is a fluorogenic substrate for β-hexosaminidases.{47303,47304} Upon enzymatic cleavage by β-hexosaminidases, 4-methylumbelliferone (4-ΜU) is released and its fluorescence can be used to quantify β-hexosaminidase activity. 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high pH (7.12-10.3), respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases.{27251} 4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-glucopyranoside has been used to quantify β-hexosaminidase activity in serum or leukocytes from patients with GM2 gangliosidoses such as Tay-Sachs disease, which is characterized by defects in the α subunit of β-hexosaminidase.{47304,40891}
Brand:CaymanSKU:26953 - 500 mgAvailable on backorder
4-Methylumbelliferyl-N-acetyl-α-D-neuraminic acid is a fluorogenic substrate of neuraminidases.{27249} 4-Methylumbelliferyl-N-acetyl-α-D-neuraminic acid is cleaved by neuraminidases to release the fluorescence moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases. 4-Methylumbelliferyl-N-acetyl-α-D-neuraminic acid has been used to quantify neuraminidase activity in mammalian cells and clinical isolates of influenza virus.{27250,27253,27252}
Brand:CaymanSKU:-Out of stock
4-Methylumbelliferyl-N-acetyl-α-D-neuraminic acid is a fluorogenic substrate of neuraminidases.{27249} 4-Methylumbelliferyl-N-acetyl-α-D-neuraminic acid is cleaved by neuraminidases to release the fluorescence moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases. 4-Methylumbelliferyl-N-acetyl-α-D-neuraminic acid has been used to quantify neuraminidase activity in mammalian cells and clinical isolates of influenza virus.{27250,27253,27252}
Brand:CaymanSKU:-Out of stock
4-Methylumbelliferyl-N-acetyl-α-D-neuraminic acid is a fluorogenic substrate of neuraminidases.{27249} 4-Methylumbelliferyl-N-acetyl-α-D-neuraminic acid is cleaved by neuraminidases to release the fluorescence moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases. 4-Methylumbelliferyl-N-acetyl-α-D-neuraminic acid has been used to quantify neuraminidase activity in mammalian cells and clinical isolates of influenza virus.{27250,27253,27252}
Brand:CaymanSKU:-Out of stock
4-Methylumbelliferyl-N-acetyl-α-D-neuraminic acid is a fluorogenic substrate of neuraminidases.{27249} 4-Methylumbelliferyl-N-acetyl-α-D-neuraminic acid is cleaved by neuraminidases to release the fluorescence moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases. 4-Methylumbelliferyl-N-acetyl-α-D-neuraminic acid has been used to quantify neuraminidase activity in mammalian cells and clinical isolates of influenza virus.{27250,27253,27252}
Brand:CaymanSKU:-Out of stock
4-Methylumbelliferyl-α-D-galactopyranoside (4-MU-α-Gal) is a fluorogenic substrate of α-galactosidase.{33136,33137} In addition to its use in characterizing novel α-galactosidases, 4-MU-α-Gal is used in assays to evaluate deficiency in α-galactosidase activity related to Fabry disease.{33138} Hydrolysis of 4-MU-α-Gal releases the fluorescent product 4-MU, which has an emission maximum at 445-454 nm. The excitation maximum for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively.{27251}
Brand:CaymanSKU:-Out of stock
4-Methylumbelliferyl-α-D-galactopyranoside (4-MU-α-Gal) is a fluorogenic substrate of α-galactosidase.{33136,33137} In addition to its use in characterizing novel α-galactosidases, 4-MU-α-Gal is used in assays to evaluate deficiency in α-galactosidase activity related to Fabry disease.{33138} Hydrolysis of 4-MU-α-Gal releases the fluorescent product 4-MU, which has an emission maximum at 445-454 nm. The excitation maximum for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively.{27251}
Brand:CaymanSKU:-Out of stock
4-Methylumbelliferyl-α-D-galactopyranoside (4-MU-α-Gal) is a fluorogenic substrate of α-galactosidase.{33136,33137} In addition to its use in characterizing novel α-galactosidases, 4-MU-α-Gal is used in assays to evaluate deficiency in α-galactosidase activity related to Fabry disease.{33138} Hydrolysis of 4-MU-α-Gal releases the fluorescent product 4-MU, which has an emission maximum at 445-454 nm. The excitation maximum for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively.{27251}
Brand:CaymanSKU:-Out of stock
4-Methylumbelliferyl-α-D-galactopyranoside (4-MU-α-Gal) is a fluorogenic substrate of α-galactosidase.{33136,33137} In addition to its use in characterizing novel α-galactosidases, 4-MU-α-Gal is used in assays to evaluate deficiency in α-galactosidase activity related to Fabry disease.{33138} Hydrolysis of 4-MU-α-Gal releases the fluorescent product 4-MU, which has an emission maximum at 445-454 nm. The excitation maximum for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively.{27251}
Brand:CaymanSKU:-Out of stock
4-Methylumbelliferyl-α-D-glucopyranoside is a fluorogenic substrate for α-glucosidase.{49104,49103} 4-Methylumbelliferyl-α-D-glucopyranoside is cleaved by α-glucosidase to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high pH (7.12-10.3), respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases.{27251} 4-Methylumbelliferyl-α-D-glucopyranoside has been used to quantify α-glucosidase activity in infant blood spot samples as a biomarker of Fabry and Pompe diseases, lysosomal storage disorders characterized by a deficiency in the enzyme.{49104,49103}
Brand:CaymanSKU:26810 - 100 mgAvailable on backorder
4-Methylumbelliferyl-α-D-glucopyranoside is a fluorogenic substrate for α-glucosidase.{49104,49103} 4-Methylumbelliferyl-α-D-glucopyranoside is cleaved by α-glucosidase to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high pH (7.12-10.3), respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases.{27251} 4-Methylumbelliferyl-α-D-glucopyranoside has been used to quantify α-glucosidase activity in infant blood spot samples as a biomarker of Fabry and Pompe diseases, lysosomal storage disorders characterized by a deficiency in the enzyme.{49104,49103}
Brand:CaymanSKU:26810 - 25 mgAvailable on backorder
4-Methylumbelliferyl-α-D-glucopyranoside is a fluorogenic substrate for α-glucosidase.{49104,49103} 4-Methylumbelliferyl-α-D-glucopyranoside is cleaved by α-glucosidase to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high pH (7.12-10.3), respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases.{27251} 4-Methylumbelliferyl-α-D-glucopyranoside has been used to quantify α-glucosidase activity in infant blood spot samples as a biomarker of Fabry and Pompe diseases, lysosomal storage disorders characterized by a deficiency in the enzyme.{49104,49103}
Brand:CaymanSKU:26810 - 50 mgAvailable on backorder
4-Methylumbelliferyl-α-L-iduronide (free acid) is a fluorogenic substrate for α-L-iduronidase, an enzyme found in cell lysosomes that is involved in the degradation of glycosaminoglycans such as dermatan sulfate and heparin sulfate. 4-Methylumbelliferyl-α-L-iduronide is cleaved by α-L-iduronidase to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases.{27251} This substrate is used in assays that measure the activity of α-L-iduronidase, which is commonly deficient in a type of lysosomal storage disease called mucopolysaccharidosis.{31700}
Brand:CaymanSKU:-Available on backorder
4-Methylumbelliferyl-α-L-iduronide (free acid) is a fluorogenic substrate for α-L-iduronidase, an enzyme found in cell lysosomes that is involved in the degradation of glycosaminoglycans such as dermatan sulfate and heparin sulfate. 4-Methylumbelliferyl-α-L-iduronide is cleaved by α-L-iduronidase to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases.{27251} This substrate is used in assays that measure the activity of α-L-iduronidase, which is commonly deficient in a type of lysosomal storage disease called mucopolysaccharidosis.{31700}
Brand:CaymanSKU:-Available on backorder
4-Methylumbelliferyl-α-L-iduronide (free acid) is a fluorogenic substrate for α-L-iduronidase, an enzyme found in cell lysosomes that is involved in the degradation of glycosaminoglycans such as dermatan sulfate and heparin sulfate. 4-Methylumbelliferyl-α-L-iduronide is cleaved by α-L-iduronidase to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases.{27251} This substrate is used in assays that measure the activity of α-L-iduronidase, which is commonly deficient in a type of lysosomal storage disease called mucopolysaccharidosis.{31700}
Brand:CaymanSKU:-Available on backorder
4-Methylumbelliferyl-β-D-Glucopyranoside (4-MUG) is a fluorogenic substrate of β-glucosidase and β-glucocerebrosidase (also known as glucosylceramidase). In addition to its use in characterizing novel β-glucosidases, 4-MUG is used in assays to evaluate deficiency in β- glucocerebrosidase activity related to Gaucher disease.{32719,32720,32721} Hydrolysis of 4-MUG releases the fluorescent product 4-MU, which has an emission maximum at 445-454 nm. The excitation maximum for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively.{27251}
Brand:CaymanSKU:20948 -Out of stock
4-Methylumbelliferyl-β-D-Glucopyranoside (4-MUG) is a fluorogenic substrate of β-glucosidase and β-glucocerebrosidase (also known as glucosylceramidase). In addition to its use in characterizing novel β-glucosidases, 4-MUG is used in assays to evaluate deficiency in β- glucocerebrosidase activity related to Gaucher disease.{32719,32720,32721} Hydrolysis of 4-MUG releases the fluorescent product 4-MU, which has an emission maximum at 445-454 nm. The excitation maximum for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively.{27251}
Brand:CaymanSKU:20948 -Out of stock
4-Methylumbelliferyl-β-D-Glucopyranoside (4-MUG) is a fluorogenic substrate of β-glucosidase and β-glucocerebrosidase (also known as glucosylceramidase). In addition to its use in characterizing novel β-glucosidases, 4-MUG is used in assays to evaluate deficiency in β- glucocerebrosidase activity related to Gaucher disease.{32719,32720,32721} Hydrolysis of 4-MUG releases the fluorescent product 4-MU, which has an emission maximum at 445-454 nm. The excitation maximum for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively.{27251}
Brand:CaymanSKU:20948 -Out of stock
4-Methylumbelliferyl-β-D-Glucopyranoside (4-MUG) is a fluorogenic substrate of β-glucosidase and β-glucocerebrosidase (also known as glucosylceramidase). In addition to its use in characterizing novel β-glucosidases, 4-MUG is used in assays to evaluate deficiency in β- glucocerebrosidase activity related to Gaucher disease.{32719,32720,32721} Hydrolysis of 4-MUG releases the fluorescent product 4-MU, which has an emission maximum at 445-454 nm. The excitation maximum for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively.{27251}
Brand:CaymanSKU:20948 -Out of stock
4-Methylumbelliferyl-β-D-N,N’,N”-triacetylchitotrioside is a fluorogenic substrate for chitinases and chitotriosidases.{31643,31644,31645} 4-Methylumbelliferyl-β-D-N,N’,N”-triacetylchitotrioside is cleaved by chitinases and chitotriosidases to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases.{27251} It has been used to screen plasma samples for reduced chitotriosidase activity that may be indicative of lysosomal storage disorders.{31643}
Brand:CaymanSKU:19715 -Available on backorder
4-Methylumbelliferyl-β-D-N,N’,N”-triacetylchitotrioside is a fluorogenic substrate for chitinases and chitotriosidases.{31643,31644,31645} 4-Methylumbelliferyl-β-D-N,N’,N”-triacetylchitotrioside is cleaved by chitinases and chitotriosidases to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases.{27251} It has been used to screen plasma samples for reduced chitotriosidase activity that may be indicative of lysosomal storage disorders.{31643}
Brand:CaymanSKU:19715 -Available on backorder
4-Methylumbelliferyl-β-D-N,N’,N”-triacetylchitotrioside is a fluorogenic substrate for chitinases and chitotriosidases.{31643,31644,31645} 4-Methylumbelliferyl-β-D-N,N’,N”-triacetylchitotrioside is cleaved by chitinases and chitotriosidases to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases.{27251} It has been used to screen plasma samples for reduced chitotriosidase activity that may be indicative of lysosomal storage disorders.{31643}
Brand:CaymanSKU:19715 -Available on backorder
4-MTA is a methylthio analog of para-methoxyamphetamine (PMA), a hallucinogenic drug that has been scheduled in many countries.{19874} In animal models, the effects of 4-MTA are qualitatively and quantitatively indistinguishable from those of PMA.{19874} The metabolism of this compound has recently been described.{19874} This product is intended for forensic applications.
Brand:CaymanSKU:11555 - 1 mgAvailable on backorder
4-MTA is a methylthio analog of para-methoxyamphetamine (PMA), a hallucinogenic drug that has been scheduled in many countries.{19874} In animal models, the effects of 4-MTA are qualitatively and quantitatively indistinguishable from those of PMA.{19874} The metabolism of this compound has recently been described.{19874} This product is intended for forensic applications.
Brand:CaymanSKU:11555 - 10 mgAvailable on backorder
4-MTA is a methylthio analog of para-methoxyamphetamine (PMA), a hallucinogenic drug that has been scheduled in many countries.{19874} In animal models, the effects of 4-MTA are qualitatively and quantitatively indistinguishable from those of PMA.{19874} The metabolism of this compound has recently been described.{19874} This product is intended for forensic applications.
Brand:CaymanSKU:11555 - 5 mgAvailable on backorder
4-MTA, is a selective serotonergic agent which increases serotonin release, blocks its re-uptake (IC50 = 102 nM), and inhibits monoamine oxidase A.{21516,21515,19874} The detection of this designer drug in serum and urine has been described, as has its metabolism. {21281,21517,21514,19874} This product is intended for research and forensic applications.
Brand:CaymanSKU:11862 - 1 mgAvailable on backorder