Chemicals
Showing 5101–5250 of 41137 results
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3-Bromotyrosine is a product of protein oxidation found after activation of eosinophils during an allergic response.{39006,39007,39009} It has been used as a marker of eosinophil peroxidase-induced protein oxidation in vitro and in vivo.{39007,39010} In addition to its production in eosinophils, 3-bromotyrosine is found at 5-fold higher levels in peritoneal exudate from mice infected with K. pneumoniae compared with uninfected animals, suggesting neutrophils release higher levels of oxidized products during inflammation.{39011} In a human study, 3-bromotyrosine was increased 10-fold in allergen-challenged lung samples from subjects with allergen-induced asthma.{39007}
Brand:CaymanSKU:22606 -Out of stock
3-Bromotyrosine is a product of protein oxidation found after activation of eosinophils during an allergic response.{39006,39007,39009} It has been used as a marker of eosinophil peroxidase-induced protein oxidation in vitro and in vivo.{39007,39010} In addition to its production in eosinophils, 3-bromotyrosine is found at 5-fold higher levels in peritoneal exudate from mice infected with K. pneumoniae compared with uninfected animals, suggesting neutrophils release higher levels of oxidized products during inflammation.{39011} In a human study, 3-bromotyrosine was increased 10-fold in allergen-challenged lung samples from subjects with allergen-induced asthma.{39007}
Brand:CaymanSKU:22606 -Out of stock
3-Bromotyrosine is a product of protein oxidation found after activation of eosinophils during an allergic response.{39006,39007,39009} It has been used as a marker of eosinophil peroxidase-induced protein oxidation in vitro and in vivo.{39007,39010} In addition to its production in eosinophils, 3-bromotyrosine is found at 5-fold higher levels in peritoneal exudate from mice infected with K. pneumoniae compared with uninfected animals, suggesting neutrophils release higher levels of oxidized products during inflammation.{39011} In a human study, 3-bromotyrosine was increased 10-fold in allergen-challenged lung samples from subjects with allergen-induced asthma.{39007}
Brand:CaymanSKU:22606 -Out of stock
3-chloro PCP (hydrochloride) (Item No. 31475) is an analytical reference standard categorized as an arylcyclohexylamine. This product is intended for research and forensic applications.
Brand:CaymanSKU:31475 - 1 mgAvailable on backorder
3-chloro PCP (hydrochloride) (Item No. 31475) is an analytical reference standard categorized as an arylcyclohexylamine. This product is intended for research and forensic applications.
Brand:CaymanSKU:31475 - 5 mgAvailable on backorder
GPR81, also known as hydroxycarboxylic acid receptor 1 (HCAR1), is a recently de-orphanized receptor that is activated by lactic acid (EC50 ~ 1.5 mM) but not by other hydroxycarboxylic acids.{24565,27421} 3-chloro-5-hydroxy Benzoic Acid (3-chloro-5-hydroxy BA) is an agonist of GPR81 (EC50 = 16 µM) that is inactive against the related GPR109a (HCAR2) receptor.{27419} It is similarly effective at GPR81 receptors from a variety of mammalian species and is bioavailable, stimulating lipolysis (increased serum free fatty acids) in mice fed high fat chow for 10 weeks.{27419} 3-chloro-5-hydroxy BA, like lactate, blocks basal ghrelin secretion by primary gastric mucosal cells.{27420}
Brand:CaymanSKU:-Out of stock
GPR81, also known as hydroxycarboxylic acid receptor 1 (HCAR1), is a recently de-orphanized receptor that is activated by lactic acid (EC50 ~ 1.5 mM) but not by other hydroxycarboxylic acids.{24565,27421} 3-chloro-5-hydroxy Benzoic Acid (3-chloro-5-hydroxy BA) is an agonist of GPR81 (EC50 = 16 µM) that is inactive against the related GPR109a (HCAR2) receptor.{27419} It is similarly effective at GPR81 receptors from a variety of mammalian species and is bioavailable, stimulating lipolysis (increased serum free fatty acids) in mice fed high fat chow for 10 weeks.{27419} 3-chloro-5-hydroxy BA, like lactate, blocks basal ghrelin secretion by primary gastric mucosal cells.{27420}
Brand:CaymanSKU:-Out of stock
GPR81, also known as hydroxycarboxylic acid receptor 1 (HCAR1), is a recently de-orphanized receptor that is activated by lactic acid (EC50 ~ 1.5 mM) but not by other hydroxycarboxylic acids.{24565,27421} 3-chloro-5-hydroxy Benzoic Acid (3-chloro-5-hydroxy BA) is an agonist of GPR81 (EC50 = 16 µM) that is inactive against the related GPR109a (HCAR2) receptor.{27419} It is similarly effective at GPR81 receptors from a variety of mammalian species and is bioavailable, stimulating lipolysis (increased serum free fatty acids) in mice fed high fat chow for 10 weeks.{27419} 3-chloro-5-hydroxy BA, like lactate, blocks basal ghrelin secretion by primary gastric mucosal cells.{27420}
Brand:CaymanSKU:-Out of stock
GPR81, also known as hydroxycarboxylic acid receptor 1 (HCAR1), is a recently de-orphanized receptor that is activated by lactic acid (EC50 ~ 1.5 mM) but not by other hydroxycarboxylic acids.{24565,27421} 3-chloro-5-hydroxy Benzoic Acid (3-chloro-5-hydroxy BA) is an agonist of GPR81 (EC50 = 16 µM) that is inactive against the related GPR109a (HCAR2) receptor.{27419} It is similarly effective at GPR81 receptors from a variety of mammalian species and is bioavailable, stimulating lipolysis (increased serum free fatty acids) in mice fed high fat chow for 10 weeks.{27419} 3-chloro-5-hydroxy BA, like lactate, blocks basal ghrelin secretion by primary gastric mucosal cells.{27420}
Brand:CaymanSKU:-Out of stock
3-chloro-N,N-Dimethylcathinone (hydrochloride) (Item No. 24847) is an analytical reference standard categorized as a cathinone. This product is intended for research and forensic applications.
Brand:CaymanSKU:24847 - 1 mgAvailable on backorder
3-chloro-N,N-Dimethylcathinone (hydrochloride) (Item No. 24847) is an analytical reference standard categorized as a cathinone. This product is intended for research and forensic applications.
Brand:CaymanSKU:24847 - 5 mgAvailable on backorder
3-Chloroamphetamine (3-CA) is a derivative of amphetamine that acts as a central nervous system stimulant by releasing serotonin and dopamine.{25535} It has been detected in urine samples, along with the related compound 4-CA, as an apparent designer drug.{25534} This product is intended only for forensic and research purposes.
Brand:CaymanSKU:9001855 - 10 mgAvailable on backorder
3-Chloroamphetamine (3-CA) is a derivative of amphetamine that acts as a central nervous system stimulant by releasing serotonin and dopamine.{25535} It has been detected in urine samples, along with the related compound 4-CA, as an apparent designer drug.{25534} This product is intended only for forensic and research purposes.
Brand:CaymanSKU:9001855 - 5 mgAvailable on backorder
3-Chloroamphetamine (3-CA) is a derivative of amphetamine that acts as a central nervous system stimulant by releasing serotonin and dopamine.{25535} It has been detected in urine samples, along with the related compound 4-CA, as an apparent designer drug.{25534} This product is intended only for forensic and research purposes.
Brand:CaymanSKU:9001855 - 50 mgAvailable on backorder
3-Cyano-7-ethoxycoumarin is a fluorogenic probe that acts as a substrate for the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2 and is metabolized to a lesser extent by CYP2D6 and CYP2C19.{27560,42278} It is metabolized to 3-cyano-7-hydroxycoumarin, which displays excitation/emission maxima of 408/450 nm, respectively.{42279} 3-Cyano-7-ethoxycoumarin has also been used to quantify mixed function oxidase activity.
Brand:CaymanSKU:25441 - 10 mgAvailable on backorder
3-Cyano-7-ethoxycoumarin is a fluorogenic probe that acts as a substrate for the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2 and is metabolized to a lesser extent by CYP2D6 and CYP2C19.{27560,42278} It is metabolized to 3-cyano-7-hydroxycoumarin, which displays excitation/emission maxima of 408/450 nm, respectively.{42279} 3-Cyano-7-ethoxycoumarin has also been used to quantify mixed function oxidase activity.
Brand:CaymanSKU:25441 - 25 mgAvailable on backorder
3-Cyano-7-ethoxycoumarin is a fluorogenic probe that acts as a substrate for the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2 and is metabolized to a lesser extent by CYP2D6 and CYP2C19.{27560,42278} It is metabolized to 3-cyano-7-hydroxycoumarin, which displays excitation/emission maxima of 408/450 nm, respectively.{42279} 3-Cyano-7-ethoxycoumarin has also been used to quantify mixed function oxidase activity.
Brand:CaymanSKU:25441 - 5 mgAvailable on backorder
3-Cyano-7-ethoxycoumarin is a fluorogenic probe that acts as a substrate for the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2 and is metabolized to a lesser extent by CYP2D6 and CYP2C19.{27560,42278} It is metabolized to 3-cyano-7-hydroxycoumarin, which displays excitation/emission maxima of 408/450 nm, respectively.{42279} 3-Cyano-7-ethoxycoumarin has also been used to quantify mixed function oxidase activity.
Brand:CaymanSKU:25441 - 50 mgAvailable on backorder
3-Cysteinylacetaminophen is an acetaminophen-protein adduct formed during the metabolism of acetaminophen (Item No. 10024).{32385,47103} 3-Cysteinylacetaminophen has been found in isolated human serum following therapeutic and supratherapeutic doses of acetaminophen and in the presence and absence of hepatotoxicity.{47104,47105} In mice, 3-cysteinylacetaminophen decreases renal glutathione (GSH) levels, an effect that can be blocked by the γ-glutamyl inhibitor acivicin (Item No. 14003).
Brand:CaymanSKU:26388 - 1 mgAvailable on backorder
3-Cysteinylacetaminophen is an acetaminophen-protein adduct formed during the metabolism of acetaminophen (Item No. 10024).{32385,47103} 3-Cysteinylacetaminophen has been found in isolated human serum following therapeutic and supratherapeutic doses of acetaminophen and in the presence and absence of hepatotoxicity.{47104,47105} In mice, 3-cysteinylacetaminophen decreases renal glutathione (GSH) levels, an effect that can be blocked by the γ-glutamyl inhibitor acivicin (Item No. 14003).
Brand:CaymanSKU:26388 - 10 mgAvailable on backorder
3-Cysteinylacetaminophen is an acetaminophen-protein adduct formed during the metabolism of acetaminophen (Item No. 10024).{32385,47103} 3-Cysteinylacetaminophen has been found in isolated human serum following therapeutic and supratherapeutic doses of acetaminophen and in the presence and absence of hepatotoxicity.{47104,47105} In mice, 3-cysteinylacetaminophen decreases renal glutathione (GSH) levels, an effect that can be blocked by the γ-glutamyl inhibitor acivicin (Item No. 14003).
Brand:CaymanSKU:26388 - 5 mgAvailable on backorder
3-Deaza-2’-deoxyadenosine strongly inhibits lymphocyte-mediated cytolysis with low cytotoxicity when applied at 100 μM.{19423} This nucleoside can also be used to evaluate the role of the adenine N3 nitrogen in DNA structure and function.{19422,19421}
Brand:CaymanSKU:9000786 - 1 mgAvailable on backorder
3-Deaza-2’-deoxyadenosine strongly inhibits lymphocyte-mediated cytolysis with low cytotoxicity when applied at 100 μM.{19423} This nucleoside can also be used to evaluate the role of the adenine N3 nitrogen in DNA structure and function.{19422,19421}
Brand:CaymanSKU:9000786 - 10 mgAvailable on backorder
3-Deaza-2’-deoxyadenosine strongly inhibits lymphocyte-mediated cytolysis with low cytotoxicity when applied at 100 μM.{19423} This nucleoside can also be used to evaluate the role of the adenine N3 nitrogen in DNA structure and function.{19422,19421}
Brand:CaymanSKU:9000786 - 25 mgAvailable on backorder
3-Deaza-2’-deoxyadenosine strongly inhibits lymphocyte-mediated cytolysis with low cytotoxicity when applied at 100 μM.{19423} This nucleoside can also be used to evaluate the role of the adenine N3 nitrogen in DNA structure and function.{19422,19421}
Brand:CaymanSKU:9000786 - 5 mgAvailable on backorder
S-Adenosylhomocysteine (SAH) hydrolase catalyzes the reversible hydrolysis of SAH to adenosine and homocysteine. The inhibition of SAH hydrolase causes the intracellular accumulation of SAH, elevating the ratio of SAH to S-adenosylmethionine (SAM) and inhibiting SAM-dependent methyltransferases. 3-Deazaadenosine (3-DZA) is an inhibitor of SAH hydrolase (Ki = 3.9 μM).{19419,19418} It has anti-inflammatory properties, inhibiting leukocyte adhesion and chemotaxis, lymphocyte-mediated cytolysis, phagocytosis, degranulation, and NF-κB signaling.{19415,19416} 3-DZA also has antiviral and antibacterial activities.{19419,19414,19417}
Brand:CaymanSKU:9000785 - 1 mgAvailable on backorder
S-Adenosylhomocysteine (SAH) hydrolase catalyzes the reversible hydrolysis of SAH to adenosine and homocysteine. The inhibition of SAH hydrolase causes the intracellular accumulation of SAH, elevating the ratio of SAH to S-adenosylmethionine (SAM) and inhibiting SAM-dependent methyltransferases. 3-Deazaadenosine (3-DZA) is an inhibitor of SAH hydrolase (Ki = 3.9 μM).{19419,19418} It has anti-inflammatory properties, inhibiting leukocyte adhesion and chemotaxis, lymphocyte-mediated cytolysis, phagocytosis, degranulation, and NF-κB signaling.{19415,19416} 3-DZA also has antiviral and antibacterial activities.{19419,19414,19417}
Brand:CaymanSKU:9000785 - 10 mgAvailable on backorder
S-Adenosylhomocysteine (SAH) hydrolase catalyzes the reversible hydrolysis of SAH to adenosine and homocysteine. The inhibition of SAH hydrolase causes the intracellular accumulation of SAH, elevating the ratio of SAH to S-adenosylmethionine (SAM) and inhibiting SAM-dependent methyltransferases. 3-Deazaadenosine (3-DZA) is an inhibitor of SAH hydrolase (Ki = 3.9 μM).{19419,19418} It has anti-inflammatory properties, inhibiting leukocyte adhesion and chemotaxis, lymphocyte-mediated cytolysis, phagocytosis, degranulation, and NF-κB signaling.{19415,19416} 3-DZA also has antiviral and antibacterial activities.{19419,19414,19417}
Brand:CaymanSKU:9000785 - 5 mgAvailable on backorder
3-Deazaadenosine (3-DZA) is an inhibitor of S-adenosylhomocysteine hydrolase (Ki = 3.9 μM).{19419,19418} It has anti-inflammatory properties, inhibiting leukocyte adhesion and chemotaxis, lymphocyte-mediated cytolysis, phagocytosis, degranulation, and NF-κB signaling.{19415,19416} 3-DZA also has antiviral and antibacterial activities.{19419,19414,19417}
Brand:CaymanSKU:30969 - 1 mgAvailable on backorder
3-Deazaadenosine (3-DZA) is an inhibitor of S-adenosylhomocysteine hydrolase (Ki = 3.9 μM).{19419,19418} It has anti-inflammatory properties, inhibiting leukocyte adhesion and chemotaxis, lymphocyte-mediated cytolysis, phagocytosis, degranulation, and NF-κB signaling.{19415,19416} 3-DZA also has antiviral and antibacterial activities.{19419,19414,19417}
Brand:CaymanSKU:30969 - 10 mgAvailable on backorder
3-Deazaadenosine (3-DZA) is an inhibitor of S-adenosylhomocysteine hydrolase (Ki = 3.9 μM).{19419,19418} It has anti-inflammatory properties, inhibiting leukocyte adhesion and chemotaxis, lymphocyte-mediated cytolysis, phagocytosis, degranulation, and NF-κB signaling.{19415,19416} 3-DZA also has antiviral and antibacterial activities.{19419,19414,19417}
Brand:CaymanSKU:30969 - 5 mgAvailable on backorder
3-Deazaneplanocin A is a cyclopentenyl analog of 3-deazaadenosine, originally synthesized as an inhibitor of S-adenosyl-L-homocysteine hydrolase.{18484} It has been shown to deplete EZH2 levels and to inhibit trimethylation of lysine 27 on histone H3 in cultured human acute myeloid leukemia (AML) HL-60 and OCI-AML3 cells and in primary AML cells in a dose-dependent manner (0.2-1 μM).{18478} 3-Deazaneplanocin A treatment of cultured human AML cells induces increased expression of the cell-cycle regulators p21, p27, and FBXO32, leading to cell cycle arrest and apoptosis.{18478} When used in combination with the pan-histone deacetylase inhibitor panobinostat (10 mg/kg), 3-deazaneplanocin A’s (1 mg/kg) antileukemic effects are synergistically enhanced in mice implanted with AML cells.{18478,18398}
Brand:CaymanSKU:- 3-Deazaneplanocin A is a cyclopentenyl analog of 3-deazaadenosine, originally synthesized as an inhibitor of S-adenosyl-L-homocysteine hydrolase.{18484} It has been shown to deplete EZH2 levels and to inhibit trimethylation of lysine 27 on histone H3 in cultured human acute myeloid leukemia (AML) HL-60 and OCI-AML3 cells and in primary AML cells in a dose-dependent manner (0.2-1 μM).{18478} 3-Deazaneplanocin A treatment of cultured human AML cells induces increased expression of the cell-cycle regulators p21, p27, and FBXO32, leading to cell cycle arrest and apoptosis.{18478} When used in combination with the pan-histone deacetylase inhibitor panobinostat (10 mg/kg), 3-deazaneplanocin A’s (1 mg/kg) antileukemic effects are synergistically enhanced in mice implanted with AML cells.{18478,18398}
Brand:CaymanSKU:- 3-Deazaneplanocin A is a cyclopentenyl analog of 3-deazaadenosine, originally synthesized as an inhibitor of S-adenosyl-L-homocysteine hydrolase.{18484} It has been shown to deplete EZH2 levels and to inhibit trimethylation of lysine 27 on histone H3 in cultured human acute myeloid leukemia (AML) HL-60 and OCI-AML3 cells and in primary AML cells in a dose-dependent manner (0.2-1 μM).{18478} 3-Deazaneplanocin A treatment of cultured human AML cells induces increased expression of the cell-cycle regulators p21, p27, and FBXO32, leading to cell cycle arrest and apoptosis.{18478} When used in combination with the pan-histone deacetylase inhibitor panobinostat (10 mg/kg), 3-deazaneplanocin A’s (1 mg/kg) antileukemic effects are synergistically enhanced in mice implanted with AML cells.{18478,18398}
Brand:CaymanSKU:- 3-Deazaneplanocin A is a cyclopentenyl analog of 3-deazaadenosine, originally synthesized as an inhibitor of S-adenosyl-L-homocysteine hydrolase.{18484} It has been shown to deplete EZH2 levels and to inhibit trimethylation of lysine 27 on histone H3 in cultured human acute myeloid leukemia (AML) HL-60 and OCI-AML3 cells and in primary AML cells in a dose-dependent manner (0.2-1 μM).{18478} 3-Deazaneplanocin A treatment of cultured human AML cells induces increased expression of the cell-cycle regulators p21, p27, and FBXO32, leading to cell cycle arrest and apoptosis.{18478} When used in combination with the pan-histone deacetylase inhibitor panobinostat (10 mg/kg), 3-deazaneplanocin A’s (1 mg/kg) antileukemic effects are synergistically enhanced in mice implanted with AML cells.{18478,18398}
Brand:CaymanSKU:-
The lysine methyltransferase EZH2 (KMT6), part of the polycomb repressive complex 2, catalyzes trimethylation of lysine 27 on histone H3 and is involved in proliferation and aggressive cell growth associated with neoplastic cells.{18930} 3-Deazaneplanocin A is a cyclopentenyl analog of 3-deazaadenosine, originally synthesized as an inhibitor of S-adenosyl-L-homocysteine hydrolase.{18484} It has been shown to deplete EZH2 levels and to inhibit trimethylation of lysine 27 on histone H3 in cultured human acute myeloid leukemia (AML) HL-60 and OCI-AML3 cells and in primary AML cells in a dose-dependent manner (0.2-1 μM).{18478} 3-Deazaneplanocin A treatment of cultured human AML cells induces increased expression of the cell-cycle regulators p21, p27, and FBXO32, leading to cell cycle arrest and apoptosis.{18478} When used in combination with the pan-histone deacetylase inhibitor panobinostat (10 mg/kg), 3-deazaneplanocin A’s (1 mg/kg) antileukemic effects are synergistically enhanced in mice implanted with AML cells.{18478,18398}
Brand:CaymanSKU:11102 - 1 mgAvailable on backorder
The lysine methyltransferase EZH2 (KMT6), part of the polycomb repressive complex 2, catalyzes trimethylation of lysine 27 on histone H3 and is involved in proliferation and aggressive cell growth associated with neoplastic cells.{18930} 3-Deazaneplanocin A is a cyclopentenyl analog of 3-deazaadenosine, originally synthesized as an inhibitor of S-adenosyl-L-homocysteine hydrolase.{18484} It has been shown to deplete EZH2 levels and to inhibit trimethylation of lysine 27 on histone H3 in cultured human acute myeloid leukemia (AML) HL-60 and OCI-AML3 cells and in primary AML cells in a dose-dependent manner (0.2-1 μM).{18478} 3-Deazaneplanocin A treatment of cultured human AML cells induces increased expression of the cell-cycle regulators p21, p27, and FBXO32, leading to cell cycle arrest and apoptosis.{18478} When used in combination with the pan-histone deacetylase inhibitor panobinostat (10 mg/kg), 3-deazaneplanocin A’s (1 mg/kg) antileukemic effects are synergistically enhanced in mice implanted with AML cells.{18478,18398}
Brand:CaymanSKU:11102 - 5 mgAvailable on backorder
The lysine methyltransferase EZH2 (KMT6), part of the polycomb repressive complex 2, catalyzes trimethylation of lysine 27 on histone H3 and is involved in proliferation and aggressive cell growth associated with neoplastic cells.{18930} 3-Deazaneplanocin A is a cyclopentenyl analog of 3-deazaadenosine, originally synthesized as an inhibitor of S-adenosyl-L-homocysteine hydrolase.{18484} It has been shown to deplete EZH2 levels and to inhibit trimethylation of lysine 27 on histone H3 in cultured human acute myeloid leukemia (AML) HL-60 and OCI-AML3 cells and in primary AML cells in a dose-dependent manner (0.2-1 μM).{18478} 3-Deazaneplanocin A treatment of cultured human AML cells induces increased expression of the cell-cycle regulators p21, p27, and FBXO32, leading to cell cycle arrest and apoptosis.{18478} When used in combination with the pan-histone deacetylase inhibitor panobinostat (10 mg/kg), 3-deazaneplanocin A’s (1 mg/kg) antileukemic effects are synergistically enhanced in mice implanted with AML cells.{18478,18398}
Brand:CaymanSKU:11102 - 500 µgAvailable on backorder
3-Deazauridine is a nucleoside analog.{41307} It is converted intracellularly to 3-deazauridine triphosphate, which competitively inhibits cytidine triphosphate synthetase thereby inhibiting biosynthesis of the nucleic acid cytidine 5’-triphosphate (CTP). 3-Deazauridine inhibits the growth of L1210 leukemia cells when used at a concentration of 6 µM and dose-dependently reduces mortality in a mouse model of leukemia.{41306} It also enhances the incorporation of decitabine (Item No. 11166) into DNA in HL-60 myeloid and MOLT-3 lymphoid leukemia cells when used at a concentration of 20 µM. 3-Deazauridine (100 or 150 mg/kg), when combined with decitabine, reduces mortality in an L1210 leukemia mouse model.{41308}
Brand:CaymanSKU:23125 - 10 mgAvailable on backorder
3-Deazauridine is a nucleoside analog.{41307} It is converted intracellularly to 3-deazauridine triphosphate, which competitively inhibits cytidine triphosphate synthetase thereby inhibiting biosynthesis of the nucleic acid cytidine 5’-triphosphate (CTP). 3-Deazauridine inhibits the growth of L1210 leukemia cells when used at a concentration of 6 µM and dose-dependently reduces mortality in a mouse model of leukemia.{41306} It also enhances the incorporation of decitabine (Item No. 11166) into DNA in HL-60 myeloid and MOLT-3 lymphoid leukemia cells when used at a concentration of 20 µM. 3-Deazauridine (100 or 150 mg/kg), when combined with decitabine, reduces mortality in an L1210 leukemia mouse model.{41308}
Brand:CaymanSKU:23125 - 25 mgAvailable on backorder
3-Deazauridine is a nucleoside analog.{41307} It is converted intracellularly to 3-deazauridine triphosphate, which competitively inhibits cytidine triphosphate synthetase thereby inhibiting biosynthesis of the nucleic acid cytidine 5’-triphosphate (CTP). 3-Deazauridine inhibits the growth of L1210 leukemia cells when used at a concentration of 6 µM and dose-dependently reduces mortality in a mouse model of leukemia.{41306} It also enhances the incorporation of decitabine (Item No. 11166) into DNA in HL-60 myeloid and MOLT-3 lymphoid leukemia cells when used at a concentration of 20 µM. 3-Deazauridine (100 or 150 mg/kg), when combined with decitabine, reduces mortality in an L1210 leukemia mouse model.{41308}
Brand:CaymanSKU:23125 - 5 mgAvailable on backorder
3-Deazauridine is a nucleoside analog.{41307} It is converted intracellularly to 3-deazauridine triphosphate, which competitively inhibits cytidine triphosphate synthetase thereby inhibiting biosynthesis of the nucleic acid cytidine 5’-triphosphate (CTP). 3-Deazauridine inhibits the growth of L1210 leukemia cells when used at a concentration of 6 µM and dose-dependently reduces mortality in a mouse model of leukemia.{41306} It also enhances the incorporation of decitabine (Item No. 11166) into DNA in HL-60 myeloid and MOLT-3 lymphoid leukemia cells when used at a concentration of 20 µM. 3-Deazauridine (100 or 150 mg/kg), when combined with decitabine, reduces mortality in an L1210 leukemia mouse model.{41308}
Brand:CaymanSKU:23125 - 50 mgAvailable on backorder
3-deoxy Galactosone is a 1,2-dicarbonyl compound originating from the degradation of galactose. It can be formed by Maillard or caramelization reactions.{27450} 3-deoxy Galactosone has been detected in various food items, including milk, apple juice, and beer, as well as in heat-sterilized dialysis fluids.{27450,27451}
Brand:CaymanSKU:-Out of stock
3-deoxy Galactosone is a 1,2-dicarbonyl compound originating from the degradation of galactose. It can be formed by Maillard or caramelization reactions.{27450} 3-deoxy Galactosone has been detected in various food items, including milk, apple juice, and beer, as well as in heat-sterilized dialysis fluids.{27450,27451}
Brand:CaymanSKU:-Out of stock
3-deoxy Galactosone is a 1,2-dicarbonyl compound originating from the degradation of galactose. It can be formed by Maillard or caramelization reactions.{27450} 3-deoxy Galactosone has been detected in various food items, including milk, apple juice, and beer, as well as in heat-sterilized dialysis fluids.{27450,27451}
Brand:CaymanSKU:-Out of stock
3-deoxy Glucosone is a highly reactive 2-oxoaldehyde intermediate of the Maillard reaction produced during oxidative stress in response to excess sugar consumption and in association with diabetes.{26738,26741,26740} It is a precursor for the formation of advanced glycation endproducts and because it readily reacts with protein amino groups is also used for crosslinking studies.{26739} 3-deoxy Glucosone can be used as a reference for the analysis and detection of glucose degradation products and glycating agents.
Brand:CaymanSKU:-Out of stock
3-deoxy Glucosone is a highly reactive 2-oxoaldehyde intermediate of the Maillard reaction produced during oxidative stress in response to excess sugar consumption and in association with diabetes.{26738,26741,26740} It is a precursor for the formation of advanced glycation endproducts and because it readily reacts with protein amino groups is also used for crosslinking studies.{26739} 3-deoxy Glucosone can be used as a reference for the analysis and detection of glucose degradation products and glycating agents.
Brand:CaymanSKU:-Out of stock
3-deoxy Glucosone is a highly reactive 2-oxoaldehyde intermediate of the Maillard reaction produced during oxidative stress in response to excess sugar consumption and in association with diabetes.{26738,26741,26740} It is a precursor for the formation of advanced glycation endproducts and because it readily reacts with protein amino groups is also used for crosslinking studies.{26739} 3-deoxy Glucosone can be used as a reference for the analysis and detection of glucose degradation products and glycating agents.
Brand:CaymanSKU:-Out of stock
Sialic acids, commonly present as terminal carbohydrates on glycoconjugates, are essential for a variety of cellular functions including cell adhesion and signal recognition, as well as the formation and progression of tumors. 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid is a deaminated sialic acid that was first identified at the nonreducing ends of oligosialyl chains in rainbow trout egg glycoprotein.{29281} It is thought to be a precursor for the biosynthesis of other members of the sialic acid family.{26786} 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid can be used to analyze nonulosonic acid residues in polysialoglycoproteins.{29281}
Brand:CaymanSKU:-Available on backorder
Sialic acids, commonly present as terminal carbohydrates on glycoconjugates, are essential for a variety of cellular functions including cell adhesion and signal recognition, as well as the formation and progression of tumors. 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid is a deaminated sialic acid that was first identified at the nonreducing ends of oligosialyl chains in rainbow trout egg glycoprotein.{29281} It is thought to be a precursor for the biosynthesis of other members of the sialic acid family.{26786} 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid can be used to analyze nonulosonic acid residues in polysialoglycoproteins.{29281}
Brand:CaymanSKU:-Available on backorder
Sialic acids, commonly present as terminal carbohydrates on glycoconjugates, are essential for a variety of cellular functions including cell adhesion and signal recognition, as well as the formation and progression of tumors. 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid is a deaminated sialic acid that was first identified at the nonreducing ends of oligosialyl chains in rainbow trout egg glycoprotein.{29281} It is thought to be a precursor for the biosynthesis of other members of the sialic acid family.{26786} 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid can be used to analyze nonulosonic acid residues in polysialoglycoproteins.{29281}
Brand:CaymanSKU:-Available on backorder
Sialic acids, commonly present as terminal carbohydrates on glycoconjugates, are essential for a variety of cellular functions including cell adhesion and signal recognition, as well as the formation and progression of tumors. 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid is a deaminated sialic acid that was first identified at the nonreducing ends of oligosialyl chains in rainbow trout egg glycoprotein.{29281} It is thought to be a precursor for the biosynthesis of other members of the sialic acid family.{26786} 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid can be used to analyze nonulosonic acid residues in polysialoglycoproteins.{29281}
Brand:CaymanSKU:-Available on backorder
C-12 NBD cholesterol is a fluorescently tagged cholesterol with the hydrophilic NBD fluorophore attached to the hydrophilic end of cholesterol, separated by a 12-carbon spacer. This design allows the cholesterol to properly orient in membrane bilayers while the fluorescent tag is presented outside of the bilayer. This should model the behavior of cholesterol in membranes better than the previously used 25-NBD cholesterol, which positions NBD directly on the 25th carbon of cholesterol at the hydrophobic terminus. NBD has excitation/emission maxima of 465/535 nm, respectively. Fluorescently tagged lipids have been used to study their interactions with proteins, their utilization by cells and liposomes, and for the development of assays for lipid metabolism.{16838,12304,1683913590,14063}
Brand:CaymanSKU:- C-12 NBD cholesterol is a fluorescently tagged cholesterol with the hydrophilic NBD fluorophore attached to the hydrophilic end of cholesterol, separated by a 12-carbon spacer. This design allows the cholesterol to properly orient in membrane bilayers while the fluorescent tag is presented outside of the bilayer. This should model the behavior of cholesterol in membranes better than the previously used 25-NBD cholesterol, which positions NBD directly on the 25th carbon of cholesterol at the hydrophobic terminus. NBD has excitation/emission maxima of 465/535 nm, respectively. Fluorescently tagged lipids have been used to study their interactions with proteins, their utilization by cells and liposomes, and for the development of assays for lipid metabolism.{16838,12304,1683913590,14063}
Brand:CaymanSKU:- C-12 NBD cholesterol is a fluorescently tagged cholesterol with the hydrophilic NBD fluorophore attached to the hydrophilic end of cholesterol, separated by a 12-carbon spacer. This design allows the cholesterol to properly orient in membrane bilayers while the fluorescent tag is presented outside of the bilayer. This should model the behavior of cholesterol in membranes better than the previously used 25-NBD cholesterol, which positions NBD directly on the 25th carbon of cholesterol at the hydrophobic terminus. NBD has excitation/emission maxima of 465/535 nm, respectively. Fluorescently tagged lipids have been used to study their interactions with proteins, their utilization by cells and liposomes, and for the development of assays for lipid metabolism.{16838,12304,1683913590,14063}
Brand:CaymanSKU:-
3-Ethylethcathinone (hydrochloride) is a substituted cathinone with potential for abuse. Its biological and toxicological properties have not been evaluated. This product is intended for forensic applications.
Brand:CaymanSKU:11198 - 10 mgAvailable on backorder
3-Ethylethcathinone (hydrochloride) is a substituted cathinone with potential for abuse. Its biological and toxicological properties have not been evaluated. This product is intended for forensic applications.
Brand:CaymanSKU:11198 - 5 mgAvailable on backorder
3-Ethylethcathinone (hydrochloride) is a substituted cathinone with potential for abuse. Its biological and toxicological properties have not been evaluated. This product is intended for forensic applications.
Brand:CaymanSKU:11198 - 50 mgAvailable on backorder
3-fluoro PCP (hydrochloride) (Item No. 31042) is an analytical reference standard categorized as an arylcyclohexylamine.{56179} 3-fluoro PCP induces discriminative stimulus effects in rats comparable with those induced by PCP (Item Nos. ISO60194 | 14276). This product is intended for research and forensic applications.
Brand:CaymanSKU:31042 - 1 mgAvailable on backorder
3-fluoro PCP (hydrochloride) (Item No. 31042) is an analytical reference standard categorized as an arylcyclohexylamine.{56179} 3-fluoro PCP induces discriminative stimulus effects in rats comparable with those induced by PCP (Item Nos. ISO60194 | 14276). This product is intended for research and forensic applications.
Brand:CaymanSKU:31042 - 5 mgAvailable on backorder
Halogenated amphetamines, including 4-fluoroamphetamine (4-FA), are psychostimulatory designer drugs which inhibit the uptake of monoamine neurotransmitters.{20299,19913} 3-Fluoroamphetamine (hydrochloride) is a structural isomer of 4-FA, having the fluorine at the 3, rather than the 4, position. The physiological and toxicological properties of 3-FA are not known. This product is intended for research and forensic applications.
Brand:CaymanSKU:9001191 - 10 mgAvailable on backorder
Halogenated amphetamines, including 4-fluoroamphetamine (4-FA), are psychostimulatory designer drugs which inhibit the uptake of monoamine neurotransmitters.{20299,19913} 3-Fluoroamphetamine (hydrochloride) is a structural isomer of 4-FA, having the fluorine at the 3, rather than the 4, position. The physiological and toxicological properties of 3-FA are not known. This product is intended for research and forensic applications.
Brand:CaymanSKU:9001191 - 5 mgAvailable on backorder
Halogenated amphetamines, including 4-fluoroamphetamine (4-FA), are psychostimulatory designer drugs which inhibit the uptake of monoamine neurotransmitters.{20299,19913} 3-Fluoroamphetamine (hydrochloride) is a structural isomer of 4-FA, having the fluorine at the 3, rather than the 4, position. The physiological and toxicological properties of 3-FA are not known. This product is intended for research and forensic applications.
Brand:CaymanSKU:9001191 - 50 mgAvailable on backorder
3-Fluoroethamphetamine (hydrochloride) (Item No. 23819) is an analytical reference standard categorized as an amphetamine.{43331} This product is intended for research and forensic applications.
Brand:CaymanSKU:23819 - 1 mgAvailable on backorder
3-Fluoroethamphetamine (hydrochloride) (Item No. 23819) is an analytical reference standard categorized as an amphetamine.{43331} This product is intended for research and forensic applications.
Brand:CaymanSKU:23819 - 5 mgAvailable on backorder
4-Fluoromethamphetamine (4-FMA) is a stimulant drug related to methamphetamine and 4-fluoroamphetamine.{19913} It has been identified as a component of designer drugs sold as bath salts or powders.{19913} 3-FMA is an isomer of 4-FMA characterized by having fluorine at the 3 position of the phenyl group. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:9001185 - 10 mgAvailable on backorder
4-Fluoromethamphetamine (4-FMA) is a stimulant drug related to methamphetamine and 4-fluoroamphetamine.{19913} It has been identified as a component of designer drugs sold as bath salts or powders.{19913} 3-FMA is an isomer of 4-FMA characterized by having fluorine at the 3 position of the phenyl group. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:9001185 - 5 mgAvailable on backorder
4-Fluoromethamphetamine (4-FMA) is a stimulant drug related to methamphetamine and 4-fluoroamphetamine.{19913} It has been identified as a component of designer drugs sold as bath salts or powders.{19913} 3-FMA is an isomer of 4-FMA characterized by having fluorine at the 3 position of the phenyl group. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:9001185 - 50 mgAvailable on backorder
3-Fluoromethcathinone (3-FMC) is a cathinone derivative identified in several designer, recreational drugs that are marketed as plant feeders.{18958} There is not much known of the effects of cathinone derivatives in humans. 3-Fluoromethcathinone (3-FMC) is a cathinone derivative identified in several designer, recreational drugs that are marketed as plant feeders.{18958} There is not much known of the effects of cathinone derivatives in humans. This compound is for use as a standard for the forensic analysis of samples that may contain 3-FMC.
Brand:CaymanSKU:-
3-formyl Rifamycin is an intermediate of rifampicin (Item No. 14423) that has been used to develop several rifamycin derivatives with antibiotic activity that targets RNA synthesis.{32302}
Brand:CaymanSKU:20260 -Available on backorder
3-formyl Rifamycin is an intermediate of rifampicin (Item No. 14423) that has been used to develop several rifamycin derivatives with antibiotic activity that targets RNA synthesis.{32302}
Brand:CaymanSKU:20260 -Available on backorder
3-formyl Rifamycin is an intermediate of rifampicin (Item No. 14423) that has been used to develop several rifamycin derivatives with antibiotic activity that targets RNA synthesis.{32302}
Brand:CaymanSKU:20260 -Available on backorder
3-formyl Rifamycin is an intermediate of rifampicin (Item No. 14423) that has been used to develop several rifamycin derivatives with antibiotic activity that targets RNA synthesis.{32302}
Brand:CaymanSKU:20260 -Available on backorder
3-Formylsalicylic acid is a non-competitive inhibitor of estrone sulfatase (IC50 = 150 nM; Ki = 120 nM), the enzyme that converts estrone sulfate to estrone.{38869} 3-Formylsalicylic acid has been used in the synthesis of Schiff bases.{38870,38871}
Brand:CaymanSKU:23368 - 1 mgAvailable on backorder
3-Formylsalicylic acid is a non-competitive inhibitor of estrone sulfatase (IC50 = 150 nM; Ki = 120 nM), the enzyme that converts estrone sulfate to estrone.{38869} 3-Formylsalicylic acid has been used in the synthesis of Schiff bases.{38870,38871}
Brand:CaymanSKU:23368 - 10 mgAvailable on backorder
3-Formylsalicylic acid is a non-competitive inhibitor of estrone sulfatase (IC50 = 150 nM; Ki = 120 nM), the enzyme that converts estrone sulfate to estrone.{38869} 3-Formylsalicylic acid has been used in the synthesis of Schiff bases.{38870,38871}
Brand:CaymanSKU:23368 - 25 mgAvailable on backorder
3-Formylsalicylic acid is a non-competitive inhibitor of estrone sulfatase (IC50 = 150 nM; Ki = 120 nM), the enzyme that converts estrone sulfate to estrone.{38869} 3-Formylsalicylic acid has been used in the synthesis of Schiff bases.{38870,38871}
Brand:CaymanSKU:23368 - 5 mgAvailable on backorder
3-Guanidinopropionic acid is a creatine analog that alters skeletal muscle energy expenditure. It reduces cellular ATP, creatine, and phosphocreatine levels and stimulates AMP-activated protein kinase (AMPK), activating PPARγ coactivator 1α (PGC-1α).{27453,27454,27456,27452} PGC-1α activation results in enhanced expression of AMPK, as well as genes for oxidative phosphorylation, electron transport chain, and mitochondrial biogenesis, increasing oxidative muscle fibers, numbers of mitochondria, and motor performance.{27453,27455} 3-Guanidinopropionic acid evokes a shift from glycolytic to oxidative metabolism, increased cellular glucose uptake, and increased fatigue tolerance.{27454} In aged rats, reduced mitochondrial biogenesis in response to chronic activation of AMPK with 3-guanidinopropionic acid leads to metabolic insufficiency that can contribute to muscle loss.{27457,27455}
Brand:CaymanSKU:-Out of stock
3-Guanidinopropionic acid is a creatine analog that alters skeletal muscle energy expenditure. It reduces cellular ATP, creatine, and phosphocreatine levels and stimulates AMP-activated protein kinase (AMPK), activating PPARγ coactivator 1α (PGC-1α).{27453,27454,27456,27452} PGC-1α activation results in enhanced expression of AMPK, as well as genes for oxidative phosphorylation, electron transport chain, and mitochondrial biogenesis, increasing oxidative muscle fibers, numbers of mitochondria, and motor performance.{27453,27455} 3-Guanidinopropionic acid evokes a shift from glycolytic to oxidative metabolism, increased cellular glucose uptake, and increased fatigue tolerance.{27454} In aged rats, reduced mitochondrial biogenesis in response to chronic activation of AMPK with 3-guanidinopropionic acid leads to metabolic insufficiency that can contribute to muscle loss.{27457,27455}
Brand:CaymanSKU:-Out of stock
3-Guanidinopropionic acid is a creatine analog that alters skeletal muscle energy expenditure. It reduces cellular ATP, creatine, and phosphocreatine levels and stimulates AMP-activated protein kinase (AMPK), activating PPARγ coactivator 1α (PGC-1α).{27453,27454,27456,27452} PGC-1α activation results in enhanced expression of AMPK, as well as genes for oxidative phosphorylation, electron transport chain, and mitochondrial biogenesis, increasing oxidative muscle fibers, numbers of mitochondria, and motor performance.{27453,27455} 3-Guanidinopropionic acid evokes a shift from glycolytic to oxidative metabolism, increased cellular glucose uptake, and increased fatigue tolerance.{27454} In aged rats, reduced mitochondrial biogenesis in response to chronic activation of AMPK with 3-guanidinopropionic acid leads to metabolic insufficiency that can contribute to muscle loss.{27457,27455}
Brand:CaymanSKU:-Out of stock
3-Guanidinopropionic acid is a creatine analog that alters skeletal muscle energy expenditure. It reduces cellular ATP, creatine, and phosphocreatine levels and stimulates AMP-activated protein kinase (AMPK), activating PPARγ coactivator 1α (PGC-1α).{27453,27454,27456,27452} PGC-1α activation results in enhanced expression of AMPK, as well as genes for oxidative phosphorylation, electron transport chain, and mitochondrial biogenesis, increasing oxidative muscle fibers, numbers of mitochondria, and motor performance.{27453,27455} 3-Guanidinopropionic acid evokes a shift from glycolytic to oxidative metabolism, increased cellular glucose uptake, and increased fatigue tolerance.{27454} In aged rats, reduced mitochondrial biogenesis in response to chronic activation of AMPK with 3-guanidinopropionic acid leads to metabolic insufficiency that can contribute to muscle loss.{27457,27455}
Brand:CaymanSKU:-Out of stock